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Protein

Corticosteroid-binding globulin

Gene

Serpina6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei243Conserved cysteine within steroid binding domain1
Binding sitei247CorticosteroidBy similarity1
Binding sitei279CorticosteroidBy similarity1
Binding sitei385CorticosteroidBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central
  • steroid binding Source: MGI

GO - Biological processi

  • glucocorticoid metabolic process Source: MGI
  • negative regulation of endopeptidase activity Source: GO_Central

Keywordsi

Biological processTransport
LigandLipid-binding, Steroid-binding

Protein family/group databases

MEROPSiI04.954

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid-binding globulin
Short name:
CBG
Alternative name(s):
Serpin A6
Transcortin
Gene namesi
Name:Serpina6
Synonyms:Cbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:88278 Serpina6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003243123 – 397Corticosteroid-binding globulinAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi232N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ06770
PaxDbiQ06770
PeptideAtlasiQ06770
PRIDEiQ06770

PTM databases

iPTMnetiQ06770
PhosphoSitePlusiQ06770

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000060807 Expressed in 48 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ06770 baseline and differential
GenevisibleiQ06770 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044033

Structurei

3D structure databases

ProteinModelPortaliQ06770
SMRiQ06770
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ06770
KOiK04525
OMAiLPCQLVQ
OrthoDBiEOG091G0ION
PhylomeDBiQ06770
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q06770-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLALYTCLF WLCTSGLWTT QAVTDEDSSS HRDLAPTNVD FAFNLYKRLV
60 70 80 90 100
ALNSDKNTLI SPVSISMALA MLSLSTRGST QYLENLGFNM SKMSEAEIHQ
110 120 130 140 150
GFQYLNSLLQ QSDTGLEMNM GNVMFLLQNL KLKDSFLADT KHYYESEALT
160 170 180 190 200
IPSKDWTKAG EQINNHVKNK TQGKIEHVVS DLDSSATLIL INYIFLKGIW
210 220 230 240 250
KLPFSPENTR EEDFYVNETS TVKVPMMVQS GNISYFRDSA IPCQMVQMNY
260 270 280 290 300
VGNGTTFIIL PDQGQMDTVV AALNRDTIDR WGKLMIPRQM NLYIPKFSMS
310 320 330 340 350
DTYDLQDVLA DVGIKDLFTN QSDFADTTKD TPLTLTVLHK AMLQLDEGNV
360 370 380 390
LPAATNGPPV HLPSESFTLK YNRPFIFLAF DKYTWSSLMM SQVMNPA
Length:397
Mass (Da):44,769
Last modified:June 1, 1994 - v1
Checksum:iF44255FE690458AF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2I9D3Z2I9_MOUSE
Corticosteroid-binding globulin
Serpina6
38Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70533 mRNA Translation: CAA49934.1
CCDSiCCDS26135.1
PIRiS33415
RefSeqiNP_031644.1, NM_007618.3
UniGeneiMm.290079

Genome annotation databases

EnsembliENSMUST00000044159; ENSMUSP00000044033; ENSMUSG00000060807
GeneIDi12401
KEGGimmu:12401
UCSCiuc007owa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70533 mRNA Translation: CAA49934.1
CCDSiCCDS26135.1
PIRiS33415
RefSeqiNP_031644.1, NM_007618.3
UniGeneiMm.290079

3D structure databases

ProteinModelPortaliQ06770
SMRiQ06770
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044033

Protein family/group databases

MEROPSiI04.954

PTM databases

iPTMnetiQ06770
PhosphoSitePlusiQ06770

Proteomic databases

MaxQBiQ06770
PaxDbiQ06770
PeptideAtlasiQ06770
PRIDEiQ06770

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044159; ENSMUSP00000044033; ENSMUSG00000060807
GeneIDi12401
KEGGimmu:12401
UCSCiuc007owa.1 mouse

Organism-specific databases

CTDi866
MGIiMGI:88278 Serpina6

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ06770
KOiK04525
OMAiLPCQLVQ
OrthoDBiEOG091G0ION
PhylomeDBiQ06770
TreeFamiTF343201

Miscellaneous databases

PROiPR:Q06770
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060807 Expressed in 48 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ06770 baseline and differential
GenevisibleiQ06770 MM

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBG_MOUSE
AccessioniPrimary (citable) accession number: Q06770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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