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UniProtKB - Q06752 (SYC_BACSU)
Protein
Cysteine--tRNA ligase
Gene
cysS
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalytic activityi
- EC:6.1.1.16
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 29 | ZincBy similarity | 1 | |
Metal bindingi | 209 | ZincBy similarity | 1 | |
Metal bindingi | 234 | ZincBy similarity | 1 | |
Metal bindingi | 238 | ZincBy similarity | 1 | |
Binding sitei | 269 | ATPBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: GO_Central
- cysteine-tRNA ligase activity Source: GO_Central
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- cysteinyl-tRNA aminoacylation Source: GO_Central
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BioCyci | BSUB:BSU00940-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine--tRNA ligase (EC:6.1.1.16)Alternative name(s): Cysteinyl-tRNA synthetase Short name: CysRS |
Gene namesi | Name:cysS Synonyms:spnA Ordered Locus Names:BSU00940 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159352 | 1 – 466 | Cysteine--tRNA ligaseAdd BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 270 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q06752 |
PaxDbi | Q06752 |
PRIDEi | Q06752 |
PTM databases
iPTMneti | Q06752 |
Interactioni
Subunit structurei
Monomer.
Protein-protein interaction databases
IntActi | Q06752, 1 interactor |
MINTi | Q06752 |
STRINGi | 224308.BSU00940 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 31 – 41 | 'HIGH' regionAdd BLAST | 11 | |
Motifi | 266 – 270 | 'KMSKS' region | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | COG0215, Bacteria |
InParanoidi | Q06752 |
OMAi | AKYWMHN |
PhylomeDBi | Q06752 |
Family and domain databases
CDDi | cd00672, CysRS_core, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_00041, Cys_tRNA_synth, 1 hit |
InterProi | View protein in InterPro IPR015803, Cys-tRNA-ligase IPR015273, Cys-tRNA-synt_Ia_DALR IPR024909, Cys-tRNA/MSH_ligase IPR014729, Rossmann-like_a/b/a_fold IPR032678, tRNA-synt_1_cat_dom IPR009080, tRNAsynth_Ia_anticodon-bd |
PANTHERi | PTHR10890, PTHR10890, 1 hit |
Pfami | View protein in Pfam PF09190, DALR_2, 1 hit PF01406, tRNA-synt_1e, 1 hit |
PRINTSi | PR00983, TRNASYNTHCYS |
SMARTi | View protein in SMART SM00840, DALR_2, 1 hit |
SUPFAMi | SSF47323, SSF47323, 1 hit |
TIGRFAMsi | TIGR00435, cysS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06752-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTITLYNTLT RQKETFVPLE EGKVKMYVCG PTVYNYIHIG NARPAIVYDT
60 70 80 90 100
VRNYLEYKGY DVQYVSNFTD VDDKLIKAAN ELGEDVPTIS ERFIKAYFED
110 120 130 140 150
VGALGCRKAD LHPRVMENMD AIIEFVDQLV KKGYAYESEG DVYFKTRAFE
160 170 180 190 200
GYGKLSQQSI DELRSGARIR VGEKKEDALD FALWKAAKEG EISWDSPWGK
210 220 230 240 250
GRPGWHIECS AMVKKYLGDQ IDIHAGGQDL TFPHHENEIA QSEALTGKTF
260 270 280 290 300
AKYWLHNGYI NIDNEKMSKS LGNFVLVHDI IKQHDPQLLR FFMLSVHYRH
310 320 330 340 350
PINYSEELLE NTKSAFSRLK TAYSNLQHRL NSSTNLTEDD DQWLEKVEEH
360 370 380 390 400
RKAFEEEMDD DFNTANAISV LFDLAKHANY YLQKDHTADH VITAFIEMFD
410 420 430 440 450
RIVSVLGFSL GEQELLDQEI EDLIEKRNEA RRNRDFALSD QIRDQLKSMN
460
IILEDTAQGT RWKRGE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14580 Genomic DNA Translation: AAA21798.1 D26185 Genomic DNA Translation: BAA05328.1 X73989 Genomic DNA Translation: CAA52167.1 AL009126 Genomic DNA Translation: CAB11870.1 |
PIRi | C53402 |
RefSeqi | NP_387975.1, NC_000964.3 WP_004399682.1, NZ_JNCM01000029.1 |
Genome annotation databases
EnsemblBacteriai | CAB11870; CAB11870; BSU_00940 |
GeneIDi | 936859 |
KEGGi | bsu:BSU00940 |
PATRICi | fig|224308.179.peg.97 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14580 Genomic DNA Translation: AAA21798.1 D26185 Genomic DNA Translation: BAA05328.1 X73989 Genomic DNA Translation: CAA52167.1 AL009126 Genomic DNA Translation: CAB11870.1 |
PIRi | C53402 |
RefSeqi | NP_387975.1, NC_000964.3 WP_004399682.1, NZ_JNCM01000029.1 |
3D structure databases
SMRi | Q06752 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q06752, 1 interactor |
MINTi | Q06752 |
STRINGi | 224308.BSU00940 |
PTM databases
iPTMneti | Q06752 |
Proteomic databases
jPOSTi | Q06752 |
PaxDbi | Q06752 |
PRIDEi | Q06752 |
Genome annotation databases
EnsemblBacteriai | CAB11870; CAB11870; BSU_00940 |
GeneIDi | 936859 |
KEGGi | bsu:BSU00940 |
PATRICi | fig|224308.179.peg.97 |
Phylogenomic databases
eggNOGi | COG0215, Bacteria |
InParanoidi | Q06752 |
OMAi | AKYWMHN |
PhylomeDBi | Q06752 |
Enzyme and pathway databases
BioCyci | BSUB:BSU00940-MONOMER |
Family and domain databases
CDDi | cd00672, CysRS_core, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_00041, Cys_tRNA_synth, 1 hit |
InterProi | View protein in InterPro IPR015803, Cys-tRNA-ligase IPR015273, Cys-tRNA-synt_Ia_DALR IPR024909, Cys-tRNA/MSH_ligase IPR014729, Rossmann-like_a/b/a_fold IPR032678, tRNA-synt_1_cat_dom IPR009080, tRNAsynth_Ia_anticodon-bd |
PANTHERi | PTHR10890, PTHR10890, 1 hit |
Pfami | View protein in Pfam PF09190, DALR_2, 1 hit PF01406, tRNA-synt_1e, 1 hit |
PRINTSi | PR00983, TRNASYNTHCYS |
SMARTi | View protein in SMART SM00840, DALR_2, 1 hit |
SUPFAMi | SSF47323, SSF47323, 1 hit |
TIGRFAMsi | TIGR00435, cysS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYC_BACSU | |
Accessioni | Q06752Primary (citable) accession number: Q06752 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - SIMILARITY comments
Index of protein domains and families