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Entry version 174 (07 Apr 2021)
Sequence version 2 (24 May 2005)
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Protein

Zinc finger protein 33B

Gene

ZNF33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri329 – 351C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q06732

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 33B
Alternative name(s):
Zinc finger protein 11B
Zinc finger protein KOX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF33B
Synonyms:KOX2, ZNF11B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13097, ZNF33B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
194522, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q06732

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000196693.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196693

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37672

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q06732, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF33B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
66774229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473341 – 778Zinc finger protein 33BAdd BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki677Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q06732

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q06732

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06732

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q06732

PeptideAtlas

More...
PeptideAtlasi
Q06732

PRoteomics IDEntifications database

More...
PRIDEi
Q06732

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58476

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06732

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q06732

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196693, Expressed in body of pancreas and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q06732, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q06732, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196693, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113411, 5 interactors

Protein interaction database and analysis system

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IntActi
Q06732, 7 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000352444

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06732, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q06732

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 83KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri329 – 351C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162173

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06732

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q06732

TreeFam database of animal gene trees

More...
TreeFami
TF337898

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q06732-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS
60 70 80 90 100
VGYCAHKPEV IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS
110 120 130 140 150
KHLWEVVFIN NEMLTKEQGN VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN
160 170 180 190 200
TVSELVISKI NYLGKKSDEF NACGKLLLNI KHDETHTREK NEVLKNRNTL
210 220 230 240 250
SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE NAEENNCDYN
260 270 280 290 300
EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH
310 320 330 340 350
YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV
360 370 380 390 400
HTGEKHFQCN QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL
410 420 430 440 450
TLHQRTHTGE KPYQCNACGK TFYQKSDLTK HQRTHTGQKP YECYECGKSF
460 470 480 490 500
CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ KSHLTQHQRT HIGDKPYECN
510 520 530 540 550
ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL TIHQRTHTGE
560 570 580 590 600
KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN
610 620 630 640 650
RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS
660 670 680 690 700
ALIVHQRTHT QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK
710 720 730 740 750
SFSHKSSLTV HHRAHTGEKS CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE
760 770
CNTCRKTFSQ KSNLIVHQRT HIGEKPYE
Length:778
Mass (Da):90,683
Last modified:May 24, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD53D23909751DCEF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXT3A0A087WXT3_HUMAN
Zinc finger protein 33B
ZNF33B
778Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVA3A0A087WVA3_HUMAN
Zinc finger protein 33B
ZNF33B
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXF4A0A087WXF4_HUMAN
Zinc finger protein 33B
ZNF33B
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1D4A0A087X1D4_HUMAN
Zinc finger protein 33B
ZNF33B
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH48313 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti392K → E in CAA36559 (PubMed:2288909).Curated1
Sequence conflicti420K → E in CAA36559 (PubMed:2288909).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024192145R → C2 PublicationsCorresponds to variant dbSNP:rs210280Ensembl.1
Natural variantiVAR_052752356H → R. Corresponds to variant dbSNP:rs7914982EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ491697 mRNA Translation: CAD36956.1
AL022345 Genomic DNA No translation available.
BC048313 mRNA Translation: AAH48313.1 Sequence problems.
X68684 mRNA Translation: CAA48643.1
X68685 Genomic DNA Translation: CAA48644.1
X68688 Genomic DNA Translation: CAA48647.1
X52333 mRNA Translation: CAA36559.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7198.1

Protein sequence database of the Protein Information Resource

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PIRi
I37959
S33989, S33994
S33993

NCBI Reference Sequences

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RefSeqi
NP_001291962.1, NM_001305033.1
NP_001291964.1, NM_001305035.1
NP_001291965.1, NM_001305036.1
NP_001291966.1, NM_001305037.1
NP_001291967.1, NM_001305038.1
NP_001291968.1, NM_001305039.1
NP_001291969.1, NM_001305040.1
NP_008886.1, NM_006955.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359467; ENSP00000352444; ENSG00000196693

Database of genes from NCBI RefSeq genomes

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GeneIDi
7582

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7582

UCSC genome browser

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UCSCi
uc001jaf.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491697 mRNA Translation: CAD36956.1
AL022345 Genomic DNA No translation available.
BC048313 mRNA Translation: AAH48313.1 Sequence problems.
X68684 mRNA Translation: CAA48643.1
X68685 Genomic DNA Translation: CAA48644.1
X68688 Genomic DNA Translation: CAA48647.1
X52333 mRNA Translation: CAA36559.1
CCDSiCCDS7198.1
PIRiI37959
S33989, S33994
S33993
RefSeqiNP_001291962.1, NM_001305033.1
NP_001291964.1, NM_001305035.1
NP_001291965.1, NM_001305036.1
NP_001291966.1, NM_001305037.1
NP_001291967.1, NM_001305038.1
NP_001291968.1, NM_001305039.1
NP_001291969.1, NM_001305040.1
NP_008886.1, NM_006955.2

3D structure databases

SMRiQ06732
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113411, 5 interactors
IntActiQ06732, 7 interactors
STRINGi9606.ENSP00000352444

PTM databases

iPTMnetiQ06732
PhosphoSitePlusiQ06732

Genetic variation databases

BioMutaiZNF33B
DMDMi66774229

Proteomic databases

jPOSTiQ06732
MassIVEiQ06732
MaxQBiQ06732
PaxDbiQ06732
PeptideAtlasiQ06732
PRIDEiQ06732
ProteomicsDBi58476

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
55057, 8 antibodies

Genome annotation databases

EnsembliENST00000359467; ENSP00000352444; ENSG00000196693
GeneIDi7582
KEGGihsa:7582
UCSCiuc001jaf.1, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7582

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF33B
HGNCiHGNC:13097, ZNF33B
HPAiENSG00000196693, Low tissue specificity
MIMi194522, gene
neXtProtiNX_Q06732
OpenTargetsiENSG00000196693
PharmGKBiPA37672
VEuPathDBiHostDB:ENSG00000196693.14

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162173
InParanoidiQ06732
OrthoDBi1318335at2759
PhylomeDBiQ06732
TreeFamiTF337898

Enzyme and pathway databases

PathwayCommonsiQ06732
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7582, 25 hits in 909 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF33B, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF33B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7582
PharosiQ06732, Tbio

Protein Ontology

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PROi
PR:Q06732
RNActiQ06732, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196693, Expressed in body of pancreas and 193 other tissues
ExpressionAtlasiQ06732, baseline and differential
GenevisibleiQ06732, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN33B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06732
Secondary accession number(s): Q06731
, Q32MA2, Q86XY8, Q8NDW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: April 7, 2021
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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