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Protein

Zinc finger protein 33A

Gene

ZNF33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri692 – 714C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri720 – 742C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA-binding transcription factor activity Source: UniProtKB
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 33A
Alternative name(s):
Zinc finger and ZAK-associated protein with KRAB domain
Short name:
ZZaPK
Zinc finger protein 11A
Zinc finger protein KOX31
Gene namesi
Name:ZNF33A
Synonyms:KIAA0065, KOX31, ZNF11, ZNF11A, ZNF33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000189180.15
HGNCiHGNC:13096 ZNF33A
MIMi194521 gene
neXtProtiNX_Q06730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189180
PharmGKBiPA37671

Polymorphism and mutation databases

BioMutaiZNF33A
DMDMi11140929

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473631 – 810Zinc finger protein 33AAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki312Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki456Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q06730-2)
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ06730
MaxQBiQ06730
PaxDbiQ06730
PeptideAtlasiQ06730
PRIDEiQ06730
ProteomicsDBi58475

PTM databases

iPTMnetiQ06730
PhosphoSitePlusiQ06730

Expressioni

Gene expression databases

BgeeiENSG00000189180 Expressed in 204 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF33A
ExpressionAtlasiQ06730 baseline and differential
GenevisibleiQ06730 HS

Organism-specific databases

HPAiHPA056638

Interactioni

Subunit structurei

Interacts with MAP3K20/ZAK.1 Publication

Protein-protein interaction databases

BioGridi113410, 8 interactors
IntActiQ06730, 5 interactors
STRINGi9606.ENSP00000363747

Structurei

3D structure databases

ProteinModelPortaliQ06730
SMRiQ06730
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 83KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri692 – 714C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri720 – 742C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150832
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ06730
KOiK09228
PhylomeDBiQ06730
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q06730-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKVEQKSQE SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS
60 70 80 90 100
VGYCVHKPEV IFRLQQGEEP WKQEEEFPSQ SFPVWTADHL KERSQENQSK
110 120 130 140 150
HLWEVVFINN EMLTKEQGDV IGIPFNVDVS SFPSRKMFCQ CDSCGMSFNT
160 170 180 190 200
VSELVISKIN YLGKKSDEFN ACGKLLLNIK HDETHTQEKN EVLKNRNTLS
210 220 230 240 250
HHEETLQHEK IQTLEHNFEY SICQETLLEK AVFNTQKREN AEENNCDYNE
260 270 280 290 300
FGRTLCDSSS LLFHQISPSR DNHYEFSDCE KFLCVKSTLS KPHGVSMKHY
310 320 330 340 350
DCGESGNNFR RKLCLSHLQK GDKGEKHFEC NECGKAFWEK SHLTRHQRVH
360 370 380 390 400
TGQKPFQCNE CEKAFWDKSN LTKHQRSHTG EKPFECNECG KAFSHKSALT
410 420 430 440 450
LHQRTHTGEK PYQCNACGKT FCQKSDLTKH QRTHTGLKPY ECYECGKSFR
460 470 480 490 500
VTSHLKVHQR THTGEKPFEC LECGKSFSEK SNLTQHQRIH IGDKSYECNA
510 520 530 540 550
CGKTFYHKSL LTRHQIIHTG WKPYECYECG KTFCLKSDLT VHQRTHTGQK
560 570 580 590 600
PFACPECGKF FSHKSTLSQH YRTHTGEKPY ECHECGKIFY NKSYLTKHNR
610 620 630 640 650
THTGEKPYEC NECGKAFYQK SQLTQHQRIH IGEKPYKCNE CGKAFCHKSA
660 670 680 690 700
LIVHQRTHTQ EKPYKCNECG KSFCVKSGLI FHERKHTGEK PYECNECGKF
710 720 730 740 750
FRHKSSLTVH HRAHTGEKSC QCNECGKIFY RKSELAQHQR SHTGEKPYEC
760 770 780 790 800
NTCRKTFSQK SNLIVHQRRH IGENLMNEMD IRNFQPQVSL HNASEYSHCG
810
ESPDDILNVQ
Length:810
Mass (Da):94,384
Last modified:December 1, 2000 - v3
Checksum:i96AD969EF541B73E
GO
Isoform 2 (identifier: Q06730-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-83: P → PE

Note: No experimental confirmation available.Combined sources
Show »
Length:811
Mass (Da):94,513
Checksum:i639D2A6A5315F7FB
GO
Isoform 3 (identifier: Q06730-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MNK → MANATRRGSG

Show »
Length:817
Mass (Da):95,013
Checksum:iA45C996AB65DB86B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR11A0A0A0MR11_HUMAN
Zinc finger protein 33A
ZNF33A
829Annotation score:
Q9H5I4Q9H5I4_HUMAN
Zinc finger protein 33A, isoform CR...
ZNF33A hCG_2017529
138Annotation score:
A0A0A0MRS1A0A0A0MRS1_HUMAN
Zinc finger protein 33A
ZNF33A
699Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129V → A in BAG64490 (PubMed:14702039).Curated1
Sequence conflicti389C → R in BAG64490 (PubMed:14702039).Curated1
Sequence conflicti721Q → H in BAF85533 (PubMed:14702039).Curated1
Sequence conflicti745E → K in BAF85533 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052749549Q → E1 PublicationCorresponds to variant dbSNP:rs2505232Ensembl.1
Natural variantiVAR_052750614G → R. Corresponds to variant dbSNP:rs12256916Ensembl.1
Natural variantiVAR_052751804D → H. Corresponds to variant dbSNP:rs10508862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551651 – 3MNK → MANATRRGSG in isoform 3. 1 Publication3
Alternative sequenceiVSP_04642083P → PE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184389 mRNA Translation: AAO24702.1
D31763 mRNA Translation: BAA06541.1
AK292844 mRNA Translation: BAF85533.1
AK303445 mRNA Translation: BAG64490.1
AL161931 Genomic DNA No translation available.
AL117337 Genomic DNA No translation available.
X68686 Genomic DNA Translation: CAA48645.1
X68687 mRNA Translation: CAA48646.1
X68689 Genomic DNA Translation: CAA48648.1
CCDSiCCDS31182.1 [Q06730-1]
CCDS44372.1 [Q06730-2]
CCDS60514.1 [Q06730-3]
PIRiS33991
S33992 S33990
RefSeqiNP_001265099.1, NM_001278170.1 [Q06730-3]
NP_001265100.1, NM_001278171.1
NP_001265102.1, NM_001278173.1
NP_001265103.1, NM_001278174.1
NP_001265104.1, NM_001278175.1
NP_001265105.1, NM_001278176.1
NP_001265106.1, NM_001278177.1
NP_001265107.1, NM_001278178.1
NP_001265108.1, NM_001278179.1
NP_008885.1, NM_006954.1 [Q06730-2]
NP_008905.1, NM_006974.2 [Q06730-1]
XP_011517952.1, XM_011519650.2 [Q06730-2]
XP_011517953.1, XM_011519651.2 [Q06730-1]
UniGeneiHs.435774

Genome annotation databases

EnsembliENST00000432900; ENSP00000402467; ENSG00000189180 [Q06730-2]
ENST00000458705; ENSP00000387713; ENSG00000189180 [Q06730-1]
ENST00000628825; ENSP00000485869; ENSG00000189180 [Q06730-3]
GeneIDi7581
KEGGihsa:7581
UCSCiuc001izg.4 human [Q06730-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184389 mRNA Translation: AAO24702.1
D31763 mRNA Translation: BAA06541.1
AK292844 mRNA Translation: BAF85533.1
AK303445 mRNA Translation: BAG64490.1
AL161931 Genomic DNA No translation available.
AL117337 Genomic DNA No translation available.
X68686 Genomic DNA Translation: CAA48645.1
X68687 mRNA Translation: CAA48646.1
X68689 Genomic DNA Translation: CAA48648.1
CCDSiCCDS31182.1 [Q06730-1]
CCDS44372.1 [Q06730-2]
CCDS60514.1 [Q06730-3]
PIRiS33991
S33992 S33990
RefSeqiNP_001265099.1, NM_001278170.1 [Q06730-3]
NP_001265100.1, NM_001278171.1
NP_001265102.1, NM_001278173.1
NP_001265103.1, NM_001278174.1
NP_001265104.1, NM_001278175.1
NP_001265105.1, NM_001278176.1
NP_001265106.1, NM_001278177.1
NP_001265107.1, NM_001278178.1
NP_001265108.1, NM_001278179.1
NP_008885.1, NM_006954.1 [Q06730-2]
NP_008905.1, NM_006974.2 [Q06730-1]
XP_011517952.1, XM_011519650.2 [Q06730-2]
XP_011517953.1, XM_011519651.2 [Q06730-1]
UniGeneiHs.435774

3D structure databases

ProteinModelPortaliQ06730
SMRiQ06730
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113410, 8 interactors
IntActiQ06730, 5 interactors
STRINGi9606.ENSP00000363747

PTM databases

iPTMnetiQ06730
PhosphoSitePlusiQ06730

Polymorphism and mutation databases

BioMutaiZNF33A
DMDMi11140929

Proteomic databases

EPDiQ06730
MaxQBiQ06730
PaxDbiQ06730
PeptideAtlasiQ06730
PRIDEiQ06730
ProteomicsDBi58475

Protocols and materials databases

DNASUi7581
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432900; ENSP00000402467; ENSG00000189180 [Q06730-2]
ENST00000458705; ENSP00000387713; ENSG00000189180 [Q06730-1]
ENST00000628825; ENSP00000485869; ENSG00000189180 [Q06730-3]
GeneIDi7581
KEGGihsa:7581
UCSCiuc001izg.4 human [Q06730-1]

Organism-specific databases

CTDi7581
EuPathDBiHostDB:ENSG00000189180.15
GeneCardsiZNF33A
HGNCiHGNC:13096 ZNF33A
HPAiHPA056638
MIMi194521 gene
neXtProtiNX_Q06730
OpenTargetsiENSG00000189180
PharmGKBiPA37671
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150832
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ06730
KOiK09228
PhylomeDBiQ06730
TreeFamiTF337898

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF33A human
GeneWikiiZNF33A
GenomeRNAii7581
PROiPR:Q06730
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189180 Expressed in 204 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF33A
ExpressionAtlasiQ06730 baseline and differential
GenevisibleiQ06730 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN33A_HUMAN
AccessioniPrimary (citable) accession number: Q06730
Secondary accession number(s): A8K9X9
, B4E0M8, F6TH33, F8WAJ5, P17013, Q5VZ86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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