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UniProtKB - Q06710 (PAX8_HUMAN)
Protein
Paired box protein Pax-8
Gene
PAX8
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 9 – 135 | PairedPROSITE-ProRule annotationAdd BLAST | 127 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- thyroid-stimulating hormone receptor activity Source: ProtInc
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- anatomical structure development Source: GO_Central
- anatomical structure morphogenesis Source: ProtInc
- branching involved in ureteric bud morphogenesis Source: UniProtKB
- cellular response to gonadotropin stimulus Source: UniProtKB
- central nervous system development Source: UniProtKB
- inner ear morphogenesis Source: UniProtKB
- kidney development Source: UniProtKB
- mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
- mesonephros development Source: UniProtKB
- metanephric comma-shaped body morphogenesis Source: UniProtKB
- metanephric distal convoluted tubule development Source: UniProtKB
- metanephric epithelium development Source: UniProtKB
- metanephric nephron tubule formation Source: UniProtKB
- metanephric S-shaped body morphogenesis Source: UniProtKB
- negative regulation of apoptotic process involved in metanephric collecting duct development Source: UniProtKB
- negative regulation of apoptotic process involved in metanephric nephron tubule development Source: UniProtKB
- negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
- negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Source: UniProtKB
- negative regulation of mesenchymal cell apoptotic process involved in metanephros development Source: UniProtKB
- otic vesicle development Source: UniProtKB
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
- positive regulation of metanephric DCT cell differentiation Source: UniProtKB
- positive regulation of thyroid hormone generation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- pronephric field specification Source: UniProtKB
- pronephros development Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
- regulation of metanephric nephron tubule epithelial cell differentiation Source: UniProtKB
- regulation of thyroid-stimulating hormone secretion Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- sulfur compound metabolic process Source: Ensembl
- thyroid gland development Source: UniProtKB
- transcription, DNA-templated Source: UniProtKB
- urogenital system development Source: UniProtKB
- ventricular septum development Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q06710 |
SignaLinki | Q06710 |
SIGNORi | Q06710 |
Names & Taxonomyi
Protein namesi | Recommended name: Paired box protein Pax-8 |
Gene namesi | Name:PAX8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8622, PAX8 |
MIMi | 167415, gene |
neXtProti | NX_Q06710 |
VEuPathDBi | HostDB:ENSG00000125618 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Hypothyroidism, congenital, non-goitrous, 2 (CHNG2)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012769 | 31 | R → H in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893657EnsemblClinVar. | 1 | |
Natural variantiVAR_012770 | 40 | Q → P in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893656EnsemblClinVar. | 1 | |
Natural variantiVAR_012771 | 57 | C → Y in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893659EnsemblClinVar. | 1 | |
Natural variantiVAR_012772 | 62 | L → R in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893658EnsemblClinVar. | 1 |
Keywords - Diseasei
Congenital hypothyroidism, Disease variantOrganism-specific databases
DisGeNETi | 7849 |
MalaCardsi | PAX8 |
MIMi | 218700, phenotype |
OpenTargetsi | ENSG00000125618 |
Orphaneti | 95713, Athyreosis 146, Differentiated thyroid carcinoma 95712, Thyroid ectopia 95720, Thyroid hypoplasia |
PharmGKBi | PA32962 |
Miscellaneous databases
Pharosi | Q06710, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2362980 |
Genetic variation databases
BioMutai | PAX8 |
DMDMi | 215273928 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050197 | 1 – 450 | Paired box protein Pax-8Add BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 303 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q06710 |
PaxDbi | Q06710 |
PeptideAtlasi | Q06710 |
PRIDEi | Q06710 |
ProteomicsDBi | 58470 [Q06710-1] 58471 [Q06710-2] 58472 [Q06710-3] 58473 [Q06710-4] 58474 [Q06710-5] |
PTM databases
iPTMneti | Q06710 |
PhosphoSitePlusi | Q06710 |
Expressioni
Tissue specificityi
Expressed in the excretory system, thyroid gland and Wilms tumors.
Developmental stagei
In developing excretory system, during thyroid differentiation and in adult thyroid.
Gene expression databases
Bgeei | ENSG00000125618, Expressed in right lobe of thyroid gland and 229 other tissues |
ExpressionAtlasi | Q06710, baseline and differential |
Genevisiblei | Q06710, HS |
Organism-specific databases
HPAi | ENSG00000125618, Group enriched (kidney, thyroid gland) |
Interactioni
Subunit structurei
Interacts with WWTR1.
1 PublicationBinary interactionsi
Q06710
Protein-protein interaction databases
BioGRIDi | 113604, 27 interactors |
IntActi | Q06710, 102 interactors |
STRINGi | 9606.ENSP00000263334 |
Miscellaneous databases
RNActi | Q06710, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q06710 |
BMRBi | Q06710 |
SMRi | Q06710 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q06710 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 68 | PAI subdomainPROSITE-ProRule annotationAdd BLAST | 57 | |
Regioni | 87 – 135 | RED subdomainPROSITE-ProRule annotationAdd BLAST | 49 | |
Regioni | 159 – 222 | DisorderedSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 159 – 186 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 207 – 222 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Paired boxPhylogenomic databases
eggNOGi | KOG3862, Eukaryota |
GeneTreei | ENSGT00940000161868 |
HOGENOMi | CLU_019281_1_3_1 |
InParanoidi | Q06710 |
OMAi | QLRTEAY |
PhylomeDBi | Q06710 |
TreeFami | TF315397 |
Family and domain databases
CDDi | cd00131, PAX, 1 hit |
DisProti | DP01517 |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR043182, PAIRED_DNA-bd_dom IPR001523, Paired_dom IPR022130, Pax2_C IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00292, PAX, 1 hit PF12403, Pax2_C, 1 hit |
PRINTSi | PR00027, PAIREDBOX |
SMARTi | View protein in SMART SM00351, PAX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00034, PAIRED_1, 1 hit PS51057, PAIRED_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q06710-1) [UniParc]FASTAAdd to basket
Also known as: Pax8a
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ
60 70 80 90 100
LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP
110 120 130 140 150
TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT
160 170 180 190 200
KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGSDKRKMDD
210 220 230 240 250
SDQDSCRLSI DSQSSSSGPR KHLRTDAFSQ HHLEPLECPF ERQHYPEAYA
260 270 280 290 300
SPSHTKGEQG LYPLPLLNST LDDGKATLTP SNTPLGRNLS THQTYPVVAD
310 320 330 340 350
PHSPFAIKQE TPEVSSSSST PSSLSSSAFL DLQQVGSGVP PFNAFPHAAS
360 370 380 390 400
VYGQFTGQAL LSGREMVGPT LPGYPPHIPT SGQGSYASSA IAGMVAGSEY
410 420 430 440 450
SGNAYGHTPY SSYSEAWRFP NSSLLSSPYY YSSTSRPSAP PTTATAFDHL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V3F3 | G3V3F3_HUMAN | Paired box protein Pax-8 | PAX8 | 116 | Annotation score: | ||
A0A7P0T907 | A0A7P0T907_HUMAN | Paired box protein Pax-8 | PAX8 | 453 | Annotation score: | ||
H0YJZ5 | H0YJZ5_HUMAN | Paired box protein Pax-8 | PAX8 | 98 | Annotation score: | ||
H0YJD1 | H0YJD1_HUMAN | Paired box protein Pax-8 | PAX8 | 173 | Annotation score: | ||
A0A140TA56 | A0A140TA56_HUMAN | Paired box protein Pax-8 | PAX8 | 85 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 305 | F → L in X69699 (PubMed:1337742).Curated | 1 | |
Sequence conflicti | 322 | S → C in X69699 (PubMed:1337742).Curated | 1 | |
Sequence conflicti | 418 | R → G in X69699 (PubMed:1337742).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012769 | 31 | R → H in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893657EnsemblClinVar. | 1 | |
Natural variantiVAR_012770 | 40 | Q → P in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893656EnsemblClinVar. | 1 | |
Natural variantiVAR_012771 | 57 | C → Y in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893659EnsemblClinVar. | 1 | |
Natural variantiVAR_012772 | 62 | L → R in CHNG2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104893658EnsemblClinVar. | 1 | |
Natural variantiVAR_012773 | 329 | F → L1 PublicationCorresponds to variant dbSNP:rs3188996EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002374 | 260 – 450 | GLYPL…AFDHL → GERWWGPRCPDTHPTSPPAD RAAMPPLPSQAWWQEVNTLA MPMATPPTPPTARPGASPTP AC in isoform 4. 1 PublicationAdd BLAST | 191 | |
Alternative sequenceiVSP_002375 | 260 – 450 | GLYPL…AFDHL → EVNTLAMPMATPPTPPTARP GASPTPAC in isoform 5. 1 PublicationAdd BLAST | 191 | |
Alternative sequenceiVSP_002373 | 300 – 450 | DPHSP…AFDHL → APPFWICSKSAPGSRPSMPF PMLPPCTGSSRARPSSQGER WWGPRCPDTHPTSPPADRAA MPPLPSQAWWQEVNTLAMPM ATPPTPPTARPGASPTPAC in isoform 3. 1 PublicationAdd BLAST | 151 | |
Alternative sequenceiVSP_002372 | 300 – 362 | Missing in isoform 2. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69699 mRNA No translation available. L19606 mRNA Translation: AAA03539.1 S77904 mRNA Translation: AAB34216.1 S77905 mRNA Translation: AAB34217.2 S77906 mRNA Translation: AAB34218.2 AK292191 mRNA Translation: BAF84880.1 AC016683 Genomic DNA Translation: AAX88880.1 CH471217 Genomic DNA Translation: EAW73629.1 BC001060 mRNA Translation: AAH01060.1 |
CCDSi | CCDS42735.1 [Q06710-5] CCDS42736.1 [Q06710-4] CCDS46398.1 [Q06710-1] CCDS46399.1 [Q06710-3] |
PIRi | A54429 I53340 |
RefSeqi | NP_003457.1, NM_003466.3 [Q06710-1] NP_039246.1, NM_013952.3 [Q06710-3] NP_039247.1, NM_013953.3 [Q06710-4] NP_054698.1, NM_013992.3 [Q06710-5] |
Genome annotation databases
Ensembli | ENST00000263334.9; ENSP00000263334.6; ENSG00000125618.18 ENST00000263335.11; ENSP00000263335.7; ENSG00000125618.18 [Q06710-4] ENST00000348715.9; ENSP00000314750.5; ENSG00000125618.18 [Q06710-3] ENST00000397647.7; ENSP00000380768.3; ENSG00000125618.18 [Q06710-5] ENST00000429538.8; ENSP00000395498.3; ENSG00000125618.18 |
GeneIDi | 7849 |
KEGGi | hsa:7849 |
MANE-Selecti | ENST00000429538.8; ENSP00000395498.3; NM_003466.4; NP_003457.1 |
UCSCi | uc002tjm.4, human [Q06710-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69699 mRNA No translation available. L19606 mRNA Translation: AAA03539.1 S77904 mRNA Translation: AAB34216.1 S77905 mRNA Translation: AAB34217.2 S77906 mRNA Translation: AAB34218.2 AK292191 mRNA Translation: BAF84880.1 AC016683 Genomic DNA Translation: AAX88880.1 CH471217 Genomic DNA Translation: EAW73629.1 BC001060 mRNA Translation: AAH01060.1 |
CCDSi | CCDS42735.1 [Q06710-5] CCDS42736.1 [Q06710-4] CCDS46398.1 [Q06710-1] CCDS46399.1 [Q06710-3] |
PIRi | A54429 I53340 |
RefSeqi | NP_003457.1, NM_003466.3 [Q06710-1] NP_039246.1, NM_013952.3 [Q06710-3] NP_039247.1, NM_013953.3 [Q06710-4] NP_054698.1, NM_013992.3 [Q06710-5] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K27 | NMR | - | A | 1-143 | [»] | |
AlphaFoldDBi | Q06710 | |||||
BMRBi | Q06710 | |||||
SMRi | Q06710 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113604, 27 interactors |
IntActi | Q06710, 102 interactors |
STRINGi | 9606.ENSP00000263334 |
Chemistry databases
ChEMBLi | CHEMBL2362980 |
PTM databases
iPTMneti | Q06710 |
PhosphoSitePlusi | Q06710 |
Genetic variation databases
BioMutai | PAX8 |
DMDMi | 215273928 |
Proteomic databases
MassIVEi | Q06710 |
PaxDbi | Q06710 |
PeptideAtlasi | Q06710 |
PRIDEi | Q06710 |
ProteomicsDBi | 58470 [Q06710-1] 58471 [Q06710-2] 58472 [Q06710-3] 58473 [Q06710-4] 58474 [Q06710-5] |
Protocols and materials databases
Antibodypediai | 9626, 870 antibodies from 47 providers |
DNASUi | 7849 |
Genome annotation databases
Ensembli | ENST00000263334.9; ENSP00000263334.6; ENSG00000125618.18 ENST00000263335.11; ENSP00000263335.7; ENSG00000125618.18 [Q06710-4] ENST00000348715.9; ENSP00000314750.5; ENSG00000125618.18 [Q06710-3] ENST00000397647.7; ENSP00000380768.3; ENSG00000125618.18 [Q06710-5] ENST00000429538.8; ENSP00000395498.3; ENSG00000125618.18 |
GeneIDi | 7849 |
KEGGi | hsa:7849 |
MANE-Selecti | ENST00000429538.8; ENSP00000395498.3; NM_003466.4; NP_003457.1 |
UCSCi | uc002tjm.4, human [Q06710-1] |
Organism-specific databases
CTDi | 7849 |
DisGeNETi | 7849 |
GeneCardsi | PAX8 |
HGNCi | HGNC:8622, PAX8 |
HPAi | ENSG00000125618, Group enriched (kidney, thyroid gland) |
MalaCardsi | PAX8 |
MIMi | 167415, gene 218700, phenotype |
neXtProti | NX_Q06710 |
OpenTargetsi | ENSG00000125618 |
Orphaneti | 95713, Athyreosis 146, Differentiated thyroid carcinoma 95712, Thyroid ectopia 95720, Thyroid hypoplasia |
PharmGKBi | PA32962 |
VEuPathDBi | HostDB:ENSG00000125618 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3862, Eukaryota |
GeneTreei | ENSGT00940000161868 |
HOGENOMi | CLU_019281_1_3_1 |
InParanoidi | Q06710 |
OMAi | QLRTEAY |
PhylomeDBi | Q06710 |
TreeFami | TF315397 |
Enzyme and pathway databases
PathwayCommonsi | Q06710 |
SignaLinki | Q06710 |
SIGNORi | Q06710 |
Miscellaneous databases
BioGRID-ORCSi | 7849, 53 hits in 1094 CRISPR screens |
ChiTaRSi | PAX8, human |
EvolutionaryTracei | Q06710 |
GeneWikii | PAX8 |
GenomeRNAii | 7849 |
Pharosi | Q06710, Tchem |
PROi | PR:Q06710 |
RNActi | Q06710, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125618, Expressed in right lobe of thyroid gland and 229 other tissues |
ExpressionAtlasi | Q06710, baseline and differential |
Genevisiblei | Q06710, HS |
Family and domain databases
CDDi | cd00131, PAX, 1 hit |
DisProti | DP01517 |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR043182, PAIRED_DNA-bd_dom IPR001523, Paired_dom IPR022130, Pax2_C IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00292, PAX, 1 hit PF12403, Pax2_C, 1 hit |
PRINTSi | PR00027, PAIREDBOX |
SMARTi | View protein in SMART SM00351, PAX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00034, PAIRED_1, 1 hit PS51057, PAIRED_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAX8_HUMAN | |
Accessioni | Q06710Primary (citable) accession number: Q06710 Secondary accession number(s): Q09155 Q96J49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references