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Protein

Condensin complex subunit 3

Gene

YCG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic chromosome condensation Source: SGD
  • meiotic chromosome separation Source: SGD
  • mitotic chromosome condensation Source: SGD
  • mitotic sister chromatid segregation Source: SGD
  • negative regulation of meiotic DNA double-strand break formation Source: SGD
  • rDNA condensation Source: SGD
  • synaptonemal complex assembly Source: SGD
  • tRNA gene clustering Source: SGD

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29882-MONOMER
ReactomeiR-SCE-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 3
Alternative name(s):
CAPG homolog
Gene namesi
Name:YCG1
Synonyms:YCS5
Ordered Locus Names:YDR325W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR325W
SGDiS000002733 YCG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950481 – 1035Condensin complex subunit 3Add BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1
Modified residuei981PhosphoserineCombined sources1
Modified residuei1008PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06680
PaxDbiQ06680
PRIDEiQ06680

PTM databases

iPTMnetiQ06680

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32383, 218 interactors
ComplexPortaliCPX-1869 Nuclear condensin complex
IntActiQ06680, 9 interactors
MINTiQ06680
STRINGi4932.YDR325W

Structurei

Secondary structure

11035
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 24Combined sources16
Helixi31 – 47Combined sources17
Helixi51 – 63Combined sources13
Turni64 – 67Combined sources4
Helixi73 – 98Combined sources26
Helixi107 – 123Combined sources17
Turni124 – 127Combined sources4
Helixi131 – 144Combined sources14
Helixi145 – 147Combined sources3
Helixi153 – 166Combined sources14
Beta strandi169 – 171Combined sources3
Helixi172 – 183Combined sources12
Helixi206 – 216Combined sources11
Helixi220 – 229Combined sources10
Turni234 – 236Combined sources3
Helixi237 – 241Combined sources5
Helixi242 – 245Combined sources4
Beta strandi246 – 248Combined sources3
Helixi249 – 257Combined sources9
Helixi259 – 263Combined sources5
Helixi264 – 268Combined sources5
Helixi273 – 285Combined sources13
Helixi289 – 300Combined sources12
Helixi302 – 306Combined sources5
Turni307 – 309Combined sources3
Helixi311 – 318Combined sources8
Helixi320 – 322Combined sources3
Helixi326 – 336Combined sources11
Helixi338 – 341Combined sources4
Helixi348 – 353Combined sources6
Helixi356 – 371Combined sources16
Helixi375 – 378Combined sources4
Turni379 – 381Combined sources3
Helixi385 – 400Combined sources16
Helixi415 – 430Combined sources16
Helixi437 – 451Combined sources15
Helixi458 – 471Combined sources14
Beta strandi472 – 474Combined sources3
Helixi475 – 497Combined sources23
Helixi572 – 586Combined sources15
Helixi593 – 595Combined sources3
Helixi597 – 605Combined sources9
Helixi607 – 612Combined sources6
Helixi616 – 630Combined sources15
Helixi634 – 639Combined sources6
Helixi641 – 649Combined sources9
Helixi653 – 670Combined sources18
Helixi671 – 674Combined sources4
Beta strandi675 – 677Combined sources3
Helixi683 – 694Combined sources12
Helixi700 – 715Combined sources16
Helixi722 – 733Combined sources12
Helixi736 – 739Combined sources4
Helixi741 – 757Combined sources17
Helixi759 – 782Combined sources24
Helixi793 – 795Combined sources3
Helixi799 – 809Combined sources11
Helixi812 – 814Combined sources3
Beta strandi819 – 821Combined sources3
Helixi827 – 838Combined sources12
Helixi839 – 841Combined sources3
Helixi845 – 853Combined sources9
Helixi855 – 857Combined sources3
Helixi866 – 878Combined sources13
Helixi889 – 910Combined sources22

3D structure databases

ProteinModelPortaliQ06680
SMRiQ06680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati113 – 150HEAT 1Add BLAST38
Repeati153 – 191HEAT 2Add BLAST39
Repeati201 – 239HEAT 3Add BLAST39
Repeati597 – 635HEAT 4Add BLAST39
Repeati827 – 864HEAT 5Add BLAST38

Sequence similaritiesi

Belongs to the CND3 (condensin subunit 3) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000001577
HOGENOMiHOG000001059
InParanoidiQ06680
KOiK06678
OMAiTNQECFE
OrthoDBiEOG092C0M39

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR027165 CND3
IPR025977 Cnd3_C
PANTHERiPTHR14418 PTHR14418, 1 hit
PfamiView protein in Pfam
PF12719 Cnd3, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q06680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPDGIDIN TKIFNSVAEV FQKAQGSYAG HRKHIAVLKK IQSKAVEQGY
60 70 80 90 100
EDAFNFWFDK LVTKILPLKK NEIIGDRIVK LVAAFIASLE RELILAKKQN
110 120 130 140 150
YKLTNDEEGI FSRFVDQFIR HVLRGVESPD KNVRFRVLQL LAVIMDNIGE
160 170 180 190 200
IDESLFNLLI LSLNKRIYDR EPTVRIQAVF CLTKFQDEEQ TEHLTELSDN
210 220 230 240 250
EENFEATRTL VASIQNDPSA EVRRAAMLNL INDNNTRPYI LERARDVNIV
260 270 280 290 300
NRRLVYSRIL KSMGRKCFDD IEPHIFDQLI EWGLEDRELS VRNACKRLIA
310 320 330 340 350
HDWLNALDGD LIELLEKLDV SRSSVCVKAI EALFQSRPDI LSKIKFPESI
360 370 380 390 400
WKDFTVEIAF LFRAIYLYCL DNNITEMLEE NFPEASKLSE HLNHYILLRY
410 420 430 440 450
HHNDISNDSQ SHFDYNTLEF IIEQLSIAAE RYDYSDEVGR RSMLTVVRNM
460 470 480 490 500
LALTTLSEPL IKIGIRVMKS LSINEKDFVT MAIEIINDIR DDDIEKQEQE
510 520 530 540 550
EKIKSKKINR RNETSVDEED ENGTHNDEVN EDEEDDNISS FHSAVENLVQ
560 570 580 590 600
GNGNVSESDI INNLPPEKEA SSATIVLCLT RSSYMLELVN TPLTENILIA
610 620 630 640 650
SLMDTLITPA VRNTAPNIRE LGVKNLGLCC LLDVKLAIDN MYILGMCVSK
660 670 680 690 700
GNASLKYIAL QVIVDIFSVH GNTVVDGEGK VDSISLHKIF YKVLKNNGLP
710 720 730 740 750
ECQVIAAEGL CKLFLADVFT DDDLFETLVL SYFSPINSSN EALVQAFAFC
760 770 780 790 800
IPVYCFSHPA HQQRMSRTAA DILLRLCVLW DDLQSSVIPE VDREAMLKPN
810 820 830 840 850
IIFQQLLFWT DPRNLVNQTG STKKDTVQLT FLIDVLKIYA QIEKKEIKKM
860 870 880 890 900
IITNINAIFL SSEQDYSTLK ELLEYSDDIA ENDNLDNVSK NALDKLRNNL
910 920 930 940 950
NSLIEEINER SETQTKDENN TANDQYSSIL GNSFNKSSND TIEHAADITD
960 970 980 990 1000
GNNTELTKTT VNISAVDNTT EQSNSRKRTR SEAEQIDTSK NLENMSIQDT
1010 1020 1030
STVAKNVSFV LPDEKSDAMS IDEEDKDSES FSEVC
Length:1,035
Mass (Da):117,851
Last modified:March 1, 2003 - v2
Checksum:iD3EF17EDFA769FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32517 Genomic DNA Translation: AAB64761.2
BK006938 Genomic DNA Translation: DAA12168.1
RefSeqiNP_010612.2, NM_001180633.1

Genome annotation databases

EnsemblFungiiYDR325W; YDR325W; YDR325W
GeneIDi851925
KEGGisce:YDR325W

Similar proteinsi

Entry informationi

Entry nameiCND3_YEAST
AccessioniPrimary (citable) accession number: Q06680
Secondary accession number(s): D6VSV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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