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Entry version 132 (23 Feb 2022)
Sequence version 1 (01 Nov 1996)
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Protein

DNA repair protein RAD34

Gene

RAD34

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in nucleotide excision repair (NER) of damaged ribosomal DNA (rDNA). Required for the repair of the RNA polymerase I-transcribed strand of rDNA.

1 Publication

Miscellaneous

Present with 78 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-3108214, SUMOylation of DNA damage response and repair proteins
R-SCE-5696395, Formation of Incision Complex in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein RAD34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD34
Ordered Locus Names:YDR314C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002722, RAD34

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDR314C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002538141 – 692DNA repair protein RAD34Add BLAST692

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06665

PRoteomics IDEntifications database

More...
PRIDEi
Q06665

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32367, 61 interactors

Database of interacting proteins

More...
DIPi
DIP-4550N

Protein interaction database and analysis system

More...
IntActi
Q06665, 3 interactors

Molecular INTeraction database

More...
MINTi
Q06665

STRING: functional protein association networks

More...
STRINGi
4932.YDR314C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06665, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15Polar residuesSequence analysisAdd BLAST15
Compositional biasi16 – 30Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPC family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2179, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028212_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06665

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFALPLH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.2460, 1 hit
3.90.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018327, BHD_2
IPR004583, DNA_repair_Rad4
IPR018326, Rad4_beta-hairpin_dom1
IPR018328, Rad4_beta-hairpin_dom3
IPR042488, Rad4_BHD3_sf
IPR036985, Transglutaminase-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12135, PTHR12135, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10403, BHD_1, 1 hit
PF10405, BHD_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01030, BHD_1, 1 hit
SM01031, BHD_2, 1 hit
SM01032, BHD_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06665-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRLLESSQ NDQANRKNSK IEKKEVSFYE EEETDDSFDS FYQDEEDDLS
60 70 80 90 100
DIDWEEVSLD GSLTVTFGNI RRDREKVSKY KRKHNKKAFN YQRLKYGLHL
110 120 130 140 150
IMIPFMLFLL KSRMKWIDDE RLNRRLRRSV PKLIGKKFKD WDVRDPAFKM
160 170 180 190 200
DSLRTLLLGL VLWFRSNYKM NSNGIRQNFN RLQYLIKYAD NQNENSISES
210 220 230 240 250
TYKKVLENQQ EFYGNRPLIN HGVEDIRKMA KRKMANRDIL TLFFFIILEN
260 270 280 290 300
VLPGPKKLYL CFALPLHDYD IRCNKVKWQI EHGIGKVPNR FDSDLIQPYF
310 320 330 340 350
WIELEVPTLS DGELYIIDPI AHLGEREMVL KTREDQFVPT YQPSVDMKYN
360 370 380 390 400
LNQKFHYVVR INHAEKVLQD VSPRYVPNVC YRYFELSESS PILKSKHYTS
410 420 430 440 450
YQYLSKWLKV LNKKKASVHH YAIMKKIALT NFTLPKSVTE IKRTDNFVIP
460 470 480 490 500
SLLKSNEVLK ACAKQAATFT KGDNSQEPIF WRRDVIQLKS KQHWAILGRS
510 520 530 540 550
ILPNAQPLKR KKYLPMRERM VRNLDKYVIK ELFSYEQTMK SPKYPSTYCD
560 570 580 590 600
HLGQEHVITD LSHYKNKFGN IEIYSKETKP DGFELIPLSK EVDIKCLIKE
610 620 630 640 650
YNKGKRKMQK IKYLDVVSGF DFKQKKGHAI PKIESILVKE TDYKAVQLLK
660 670 680 690
QQTKVLLGLS FWDILLRKLR VNDRLNAEYG NVGNNEETLD DH
Length:692
Mass (Da):82,043
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF63BF1F002E7F2D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28374 Genomic DNA Translation: AAB64750.1
BK006938 Genomic DNA Translation: DAA12153.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61200

NCBI Reference Sequences

More...
RefSeqi
NP_010600.1, NM_001180622.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR314C_mRNA; YDR314C; YDR314C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR314C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA Translation: AAB64750.1
BK006938 Genomic DNA Translation: DAA12153.1
PIRiS61200
RefSeqiNP_010600.1, NM_001180622.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi32367, 61 interactors
DIPiDIP-4550N
IntActiQ06665, 3 interactors
MINTiQ06665
STRINGi4932.YDR314C

Proteomic databases

PaxDbiQ06665
PRIDEiQ06665

Genome annotation databases

EnsemblFungiiYDR314C_mRNA; YDR314C; YDR314C
GeneIDi851909
KEGGisce:YDR314C

Organism-specific databases

SGDiS000002722, RAD34
VEuPathDBiFungiDB:YDR314C

Phylogenomic databases

eggNOGiKOG2179, Eukaryota
HOGENOMiCLU_028212_0_0_1
InParanoidiQ06665
OMAiCFALPLH

Enzyme and pathway databases

ReactomeiR-SCE-3108214, SUMOylation of DNA damage response and repair proteins
R-SCE-5696395, Formation of Incision Complex in GG-NER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06665
RNActiQ06665, protein

Family and domain databases

Gene3Di3.30.70.2460, 1 hit
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR018327, BHD_2
IPR004583, DNA_repair_Rad4
IPR018326, Rad4_beta-hairpin_dom1
IPR018328, Rad4_beta-hairpin_dom3
IPR042488, Rad4_BHD3_sf
IPR036985, Transglutaminase-like_sf
PANTHERiPTHR12135, PTHR12135, 2 hits
PfamiView protein in Pfam
PF10403, BHD_1, 1 hit
PF10405, BHD_3, 1 hit
SMARTiView protein in SMART
SM01030, BHD_1, 1 hit
SM01031, BHD_2, 1 hit
SM01032, BHD_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAD34_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06665
Secondary accession number(s): D6VSU3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: February 23, 2022
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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