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Protein

ATP synthase subunit O, mitochondrial

Gene

Atp5po

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210 Formation of ATP by chemiosmotic coupling
R-RNO-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit O, mitochondrialCurated
Alternative name(s):
ATP synthase peripheral stalk subunit OSCPCurated
Oligomycin sensitivity conferral protein
Short name:
OSCP
Sperm flagella protein 4
Gene namesi
Name:Atp5poImported
Synonyms:Atp5o
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621379 Atp5po

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionAdd BLAST23
ChainiPRO_000000264924 – 213ATP synthase subunit O, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60N6-acetyllysineBy similarity1
Modified residuei70N6-acetyllysineBy similarity1
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei90N6-succinyllysineBy similarity1
Modified residuei100N6-acetyllysine; alternateBy similarity1
Modified residuei100N6-succinyllysine; alternateBy similarity1
Modified residuei158N6-acetyllysine; alternateBy similarity1
Modified residuei158N6-succinyllysine; alternateBy similarity1
Modified residuei176N6-acetyllysineBy similarity1
Modified residuei192N6-acetyllysineBy similarity1
Modified residuei199N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ06647
PRIDEiQ06647

PTM databases

CarbonylDBiQ06647
iPTMnetiQ06647
PhosphoSitePlusiQ06647
SwissPalmiQ06647

Expressioni

Tissue specificityi

Expressed by the principal cells of the epididymis. Detected in flagella of epididymal sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000001991 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiQ06647 RN

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and MP68.1 Publication

Protein-protein interaction databases

CORUMiQ06647
IntActiQ06647, 6 interactors
MINTiQ06647
STRINGi10116.ENSRNOP00000002732

Structurei

3D structure databases

ProteinModelPortaliQ06647
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase delta chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1662 Eukaryota
COG0712 LUCA
GeneTreeiENSGT00390000015060
HOGENOMiHOG000075825
HOVERGENiHBG004309
InParanoidiQ06647
KOiK02137
OMAiMVDNIQD
OrthoDBiEOG091G0L4M
PhylomeDBiQ06647
TreeFamiTF106241

Family and domain databases

Gene3Di1.10.520.20, 1 hit
HAMAPiMF_01416 ATP_synth_delta_bact, 1 hit
InterProiView protein in InterPro
IPR026015 ATP_synth_OSCP/delta_N_sf
IPR020781 ATPase_OSCP/d_CS
IPR000711 ATPase_OSCP/dsu
PANTHERiPTHR11910 PTHR11910, 1 hit
PfamiView protein in Pfam
PF00213 OSCP, 1 hit
PRINTSiPR00125 ATPASEDELTA
SUPFAMiSSF47928 SSF47928, 1 hit
TIGRFAMsiTIGR01145 ATP_synt_delta, 1 hit
PROSITEiView protein in PROSITE
PS00389 ATPASE_DELTA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06647-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPATSVLS RQVRSFSTSV VRPFSKLVRP PVQVYGIEGR YATALYSAAS
60 70 80 90 100
KQKRLDQVEK ELLRVGQLLK DPKVSLAVLN PYIKRSIKVK SLKDITTKEK
110 120 130 140 150
FSPLTANLMN LLAENGRLGN TQGVISAFST IMSVHRGEVP CTVTTAFPLD
160 170 180 190 200
EAVLSELKTV LNSFLSKGQI LNLEVKTDPS IMGGMIVRIG EKYVDMSAKS
210
KIQKLSKAMR DLL
Length:213
Mass (Da):23,398
Last modified:June 1, 1994 - v1
Checksum:iBBAB7331A715E686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13127 mRNA Translation: BAA02429.1
BC060544 mRNA Translation: AAH60544.1
PIRiS30181
RefSeqiNP_620238.1, NM_138883.1
UniGeneiRn.1817

Genome annotation databases

EnsembliENSRNOT00000002732; ENSRNOP00000002732; ENSRNOG00000001991
GeneIDi192241
KEGGirno:192241
UCSCiRGD:621379 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13127 mRNA Translation: BAA02429.1
BC060544 mRNA Translation: AAH60544.1
PIRiS30181
RefSeqiNP_620238.1, NM_138883.1
UniGeneiRn.1817

3D structure databases

ProteinModelPortaliQ06647
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ06647
IntActiQ06647, 6 interactors
MINTiQ06647
STRINGi10116.ENSRNOP00000002732

PTM databases

CarbonylDBiQ06647
iPTMnetiQ06647
PhosphoSitePlusiQ06647
SwissPalmiQ06647

Proteomic databases

PaxDbiQ06647
PRIDEiQ06647

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002732; ENSRNOP00000002732; ENSRNOG00000001991
GeneIDi192241
KEGGirno:192241
UCSCiRGD:621379 rat

Organism-specific databases

CTDi539
RGDi621379 Atp5po

Phylogenomic databases

eggNOGiKOG1662 Eukaryota
COG0712 LUCA
GeneTreeiENSGT00390000015060
HOGENOMiHOG000075825
HOVERGENiHBG004309
InParanoidiQ06647
KOiK02137
OMAiMVDNIQD
OrthoDBiEOG091G0L4M
PhylomeDBiQ06647
TreeFamiTF106241

Enzyme and pathway databases

ReactomeiR-RNO-163210 Formation of ATP by chemiosmotic coupling
R-RNO-8949613 Cristae formation

Miscellaneous databases

PROiPR:Q06647

Gene expression databases

BgeeiENSRNOG00000001991 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiQ06647 RN

Family and domain databases

Gene3Di1.10.520.20, 1 hit
HAMAPiMF_01416 ATP_synth_delta_bact, 1 hit
InterProiView protein in InterPro
IPR026015 ATP_synth_OSCP/delta_N_sf
IPR020781 ATPase_OSCP/d_CS
IPR000711 ATPase_OSCP/dsu
PANTHERiPTHR11910 PTHR11910, 1 hit
PfamiView protein in Pfam
PF00213 OSCP, 1 hit
PRINTSiPR00125 ATPASEDELTA
SUPFAMiSSF47928 SSF47928, 1 hit
TIGRFAMsiTIGR01145 ATP_synt_delta, 1 hit
PROSITEiView protein in PROSITE
PS00389 ATPASE_DELTA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATPO_RAT
AccessioniPrimary (citable) accession number: Q06647
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 10, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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