LTB

Functionⁱ

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 7916655
tumor necrosis factor receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 7916655
gene expression Source: Ensembl
immune response Source: InterPro
lymph node development Source: Ensembl
positive regulation of interleukin-12 biosynthetic process Source: UniProtKB
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7916655
skin development Source: Ensembl
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SIGNORⁱ	Q06643

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lymphotoxin-beta Short name: LT-beta Alternative name(s): Tumor necrosis factor C Short name: TNF-C Tumor necrosis factor ligand superfamily member 3
Gene namesⁱ	Name:LTB Synonyms:TNFC, TNFSF3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000227507.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6711 LTB
MIMⁱ	600978 gene
neXtProtⁱ	NX_Q06643

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 18	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	19 – 48	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	30
Topological domainⁱ	49 – 244	ExtracellularSequence analysisAdd BLAST	196

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4050
Open Targets More...OpenTargetsⁱ	ENSG00000227507
PharmGKBⁱ	PA30475

Chemistry databases

ChEMBLⁱ	CHEMBL3833421

ChEMBLⁱ

CHEMBL3833421

Polymorphism and mutation databases

BioMutaⁱ	LTB
DMDMⁱ	549088

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185486	1 – 244	Lymphotoxin-betaAdd BLAST		244

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	222	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q06643
PeptideAtlas More...PeptideAtlasⁱ	Q06643
PRIDEⁱ	Q06643
ProteomicsDBⁱ	58468 58469 [Q06643-2]

PTM databases

PhosphoSitePlusⁱ	Q06643

PhosphoSitePlusⁱ

Q06643

Expressionⁱ

Tissue specificityⁱ

Spleen and thymus.

Gene expression databases

Bgeeⁱ	ENSG00000227507
CleanExⁱ	HS_LTB
ExpressionAtlasⁱ	Q06643 baseline and differential
Genevisibleⁱ	Q06643 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048884

HPAⁱ

HPA048884

Interactionⁱ

Subunit structureⁱ

Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 7916655
tumor necrosis factor receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110228, 2 interactors
CORUMⁱ	Q06643
Database of interacting proteins More...DIPⁱ	DIP-2996N
IntActⁱ	Q06643, 5 interactors
STRINGⁱ	9606.ENSP00000410481

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q06643
SMRⁱ	Q06643
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tumor necrosis factor family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJP9 Eukaryota ENOG410ZHBF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007066
HOGENOMⁱ	HOG000273916
HOVERGENⁱ	HBG000209
InParanoidⁱ	Q06643
KEGG Orthology (KO) More...KOⁱ	K03157
OMAⁱ	YCHVGYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J9M
PhylomeDBⁱ	Q06643
TreeFamⁱ	TF337780

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR006053 TNF IPR002961 TNF_C IPR021184 TNF_CS IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
PANTHERⁱ	PTHR11471:SF29 PTHR11471:SF29, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
PRINTSⁱ	PR01234 TNECROSISFCT PR01237 TNFC
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS00251 TNF_1, 1 hit PS50049 TNF_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q06643-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD 
        60         70         80         90        100
QGGLVTETAD PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ 
       110        120        130        140        150
GLGWETTKEQ AFLTSGTQFS DAEGLALPQD GLYYLYCLVG YRGRAPPGGG 
       160        170        180        190        200
DPQGRSVTLR SSLYRAGGAY GPGTPELLLE GAETVTPVLD PARRQGYGPL 
       210        220        230        240 
WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA VMVG

Length:244

Mass (Da):25,390

Last modified:June 1, 1994 - v1

Checksum:ⁱF41569459830ED4C

GO

Isoform 2 (identifier: Q06643-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
53-77: GLVTETADPGAQAQQGLGFQKLPEE → GLGFRSCQRRSQKQISAPGSQLPTS
78-244: Missing.

« Hide

        10         20         30         40         50
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD 
        60         70 
QGGLGFRSCQ RRSQKQISAP GSQLPTS

Show »

Length:77

Mass (Da):7,780

Checksum:ⁱ8F1256D793D85397

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	60 – 69	DPGAQAQQGL → GLSAPGSGRT in AAB37342 (PubMed:9299492).Curated		10

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013025	70	G → E1 PublicationCorresponds to variant dbSNP:rs3093554Ensembl.	1
Natural variantⁱVAR_016331	84	S → R1 PublicationCorresponds to variant dbSNP:rs4647186Ensembl.	1
Natural variantⁱVAR_016332	87	L → F1 PublicationCorresponds to variant dbSNP:rs4647187Ensembl.	1
Natural variantⁱVAR_013026	111	A → P1 PublicationCorresponds to variant dbSNP:rs3093555Ensembl.	1
Natural variantⁱVAR_029145	122	A → D. Corresponds to variant dbSNP:rs2229699Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006441	53 – 77	GLVTE…KLPEE → GLGFRSCQRRSQKQISAPGS QLPTS in isoform 2. 3 PublicationsAdd BLAST		25
Alternative sequenceⁱVSP_006442	78 – 244	Missing in isoform 2. 3 PublicationsAdd BLAST		167

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L11016 Genomic DNA Translation: AAA99888.1 U89922 mRNA Translation: AAC51769.1 U79029 mRNA Translation: AAB37342.1 L11015 mRNA Translation: AAA36191.1 Y14768 Genomic DNA Translation: CAA75069.1 AF129756 Genomic DNA Translation: AAD18089.1 BA000025 Genomic DNA Translation: BAB63395.1 AY070219 Genomic DNA Translation: AAL49954.1 AY070219 Genomic DNA Translation: AAL49955.1 AY216497 Genomic DNA Translation: AAO21134.1 AK312210 mRNA Translation: BAG35143.1 CH471081 Genomic DNA Translation: EAX03425.1 BC069330 mRNA Translation: AAH69330.1 BC093783 mRNA Translation: AAH93783.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4703.1 [Q06643-1] CCDS4704.1 [Q06643-2]
PIRⁱ	A46066 JC5645
NCBI Reference Sequences More...RefSeqⁱ	NP_002332.1, NM_002341.1 [Q06643-1] NP_033666.1, NM_009588.1 [Q06643-2]
UniGeneⁱ	Hs.376208

Genome annotation databases

Ensemblⁱ	ENST00000376117; ENSP00000365285; ENSG00000204487 [Q06643-1] ENST00000383493; ENSP00000372985; ENSG00000206437 [Q06643-1] ENST00000420402; ENSP00000398741; ENSG00000223448 [Q06643-1] ENST00000421268; ENSP00000393693; ENSG00000238114 [Q06643-1] ENST00000429299; ENSP00000410481; ENSG00000227507 [Q06643-1] ENST00000444479; ENSP00000395102; ENSG00000236925 [Q06643-1] ENST00000446745; ENSP00000416113; ENSG00000227507 [Q06643-2] ENST00000456113; ENSP00000404014; ENSG00000236237 [Q06643-1] ENST00000457552; ENSP00000404450; ENSG00000231314 [Q06643-1]
GeneIDⁱ	4050
KEGGⁱ	hsa:4050
UCSC genome browser More...UCSCⁱ	uc003nul.4 human [Q06643-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q06643	LTB protein		HUMAN		244
Lymphotoxin beta		GORGO		244
Tumor necrosis factor ligand 1C		HUMAN		256
Q06643-2	LTB isoform 2		PANTR		77
Lymphotoxin beta		PANPA		77
Lymphotoxin beta		GORGO		77
UPI0007DBA8EE		PANTR		89

Protein	Similar proteins		Species	Score	Length
Q06643	LTB protein		HUMAN		244
Lymphotoxin beta		GORGO		244
Lymphotoxin beta		PONAB		256
Lymphotoxin beta		RHIRO		256
Lymphotoxin beta		RHIBE		244
+24
Q06643-2	Lymphotoxin-beta		MACMU		77
Lymphotoxin beta		COLAP		77
Lymphotoxin beta		RHIRO		77
Lymphotoxin beta		PAPAN		77
Lymphotoxin beta		MACFA		77
+15

Protein	Similar proteins		Species	Score	Length
Q06643	LTB protein		HUMAN		244
Lymphotoxin beta		GORGO		244
Lymphotoxin beta		NOMLE		256
UPI000C2A5C95		Ugandan red Colobus		256
Lymphotoxin beta		RHIRO		256
+73
Q06643-2	Lymphotoxin-beta		MACMU		77
Lymphotoxin beta		COLAP		77
Lymphotoxin beta		RHIRO		77
Lymphotoxin beta		PAPAN		77
Lymphotoxin beta		MACFA		77
+50

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L11016 Genomic DNA Translation: AAA99888.1 U89922 mRNA Translation: AAC51769.1 U79029 mRNA Translation: AAB37342.1 L11015 mRNA Translation: AAA36191.1 Y14768 Genomic DNA Translation: CAA75069.1 AF129756 Genomic DNA Translation: AAD18089.1 BA000025 Genomic DNA Translation: BAB63395.1 AY070219 Genomic DNA Translation: AAL49954.1 AY070219 Genomic DNA Translation: AAL49955.1 AY216497 Genomic DNA Translation: AAO21134.1 AK312210 mRNA Translation: BAG35143.1 CH471081 Genomic DNA Translation: EAX03425.1 BC069330 mRNA Translation: AAH69330.1 BC093783 mRNA Translation: AAH93783.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4703.1 [Q06643-1] CCDS4704.1 [Q06643-2]
PIRⁱ	A46066 JC5645
NCBI Reference Sequences More...RefSeqⁱ	NP_002332.1, NM_002341.1 [Q06643-1] NP_033666.1, NM_009588.1 [Q06643-2]
UniGeneⁱ	Hs.376208

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4MXW	X-ray	3.60	B/D/Y/Z	86-244	[»]
ProteinModelPortalⁱ	Q06643
SMRⁱ	Q06643
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110228, 2 interactors
CORUMⁱ	Q06643
Database of interacting proteins More...DIPⁱ	DIP-2996N
IntActⁱ	Q06643, 5 interactors
STRINGⁱ	9606.ENSP00000410481

Chemistry databases

ChEMBLⁱ	CHEMBL3833421

ChEMBLⁱ

CHEMBL3833421

PTM databases

PhosphoSitePlusⁱ	Q06643

PhosphoSitePlusⁱ

Q06643

Polymorphism and mutation databases

BioMutaⁱ	LTB
DMDMⁱ	549088

Proteomic databases

PaxDbⁱ	Q06643
PeptideAtlas More...PeptideAtlasⁱ	Q06643
PRIDEⁱ	Q06643
ProteomicsDBⁱ	58468 58469 [Q06643-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000376117; ENSP00000365285; ENSG00000204487 [Q06643-1] ENST00000383493; ENSP00000372985; ENSG00000206437 [Q06643-1] ENST00000420402; ENSP00000398741; ENSG00000223448 [Q06643-1] ENST00000421268; ENSP00000393693; ENSG00000238114 [Q06643-1] ENST00000429299; ENSP00000410481; ENSG00000227507 [Q06643-1] ENST00000444479; ENSP00000395102; ENSG00000236925 [Q06643-1] ENST00000446745; ENSP00000416113; ENSG00000227507 [Q06643-2] ENST00000456113; ENSP00000404014; ENSG00000236237 [Q06643-1] ENST00000457552; ENSP00000404450; ENSG00000231314 [Q06643-1]
GeneIDⁱ	4050
KEGGⁱ	hsa:4050
UCSC genome browser More...UCSCⁱ	uc003nul.4 human [Q06643-1]

Organism-specific databases

CTDⁱ	4050
DisGeNET More...DisGeNETⁱ	4050
EuPathDBⁱ	HostDB:ENSG00000227507.2
GeneCardsⁱ	LTB
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6711 LTB
Human Protein Atlas More...HPAⁱ	HPA048884
MIMⁱ	600978 gene
neXtProtⁱ	NX_Q06643
Open Targets More...OpenTargetsⁱ	ENSG00000227507
PharmGKBⁱ	PA30475
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJP9 Eukaryota ENOG410ZHBF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007066
HOGENOMⁱ	HOG000273916
HOVERGENⁱ	HBG000209
InParanoidⁱ	Q06643
KEGG Orthology (KO) More...KOⁱ	K03157
OMAⁱ	YCHVGYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J9M
PhylomeDBⁱ	Q06643
TreeFamⁱ	TF337780

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SIGNORⁱ	Q06643

Miscellaneous databases

ChiTaRSⁱ	LTB human
GeneWikiⁱ	Lymphotoxin_beta
GenomeRNAiⁱ	4050
Protein Ontology More...PROⁱ	PR:Q06643
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000227507
CleanExⁱ	HS_LTB
ExpressionAtlasⁱ	Q06643 baseline and differential
Genevisibleⁱ	Q06643 HS

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR006053 TNF IPR002961 TNF_C IPR021184 TNF_CS IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
PANTHERⁱ	PTHR11471:SF29 PTHR11471:SF29, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
PRINTSⁱ	PR01234 TNECROSISFCT PR01237 TNFC
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS00251 TNF_1, 1 hit PS50049 TNF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNFC_HUMAN
Accessionⁱ	Q06643Primary (citable) accession number: Q06643 Secondary accession number(s): P78370, Q52LU8, Q99761
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	June 20, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q06643 (TNFC_HUMAN)

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Lymphotoxin-beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Chemistry databases

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Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ