Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q06643 (TNFC_HUMAN)

Entry version 187 (23 Feb 2022)
Sequence version 1 (01 Jun 1994)
Previous versions | rss
Add a publicationFeedback
Protein

Lymphotoxin-beta

Gene

LTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q06643

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q06643

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q06643

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lymphotoxin-beta
Short name:
LT-beta
Alternative name(s):
Tumor necrosis factor C
Short name:
TNF-C
Tumor necrosis factor ligand superfamily member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTB
Synonyms:TNFC, TNFSF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6711, LTB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600978, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q06643

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000227507

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST30
Topological domaini49 – 244ExtracellularSequence analysisAdd BLAST196

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4050

Open Targets

More...OpenTargetsi		ENSG00000227507

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30475

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q06643, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3833421

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LTB

Domain mapping of disease mutations (DMDM)

More...DMDMi		549088

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854861 – 244Lymphotoxin-betaAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q06643

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06643

PeptideAtlas

More...PeptideAtlasi		Q06643

PRoteomics IDEntifications database

More...PRIDEi		Q06643

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58468 [Q06643-1]
58469 [Q06643-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q06643, 1 site

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q06643

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Spleen and thymus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000227507, Expressed in adrenal gland and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q06643, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q06643, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000227507, Group enriched (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110228, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q06643

Database of interacting proteins

More...DIPi		DIP-2996N

Protein interaction database and analysis system

More...IntActi		Q06643, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000410481

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q06643, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q06643

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SMSQ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01040000240509

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_096531_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q06643

Identification of Orthologs from Complete Genome Data

More...OMAi		RPQGRGC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q06643

TreeFam database of animal gene trees

More...TreeFami		TF337780

Family and domain databases

Conserved Domains Database

More...CDDi		cd00184, TNF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006053, TNF
IPR002961, TNF_C
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom

The PANTHER Classification System

More...PANTHERi		PTHR11471:SF29, PTHR11471:SF29, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00229, TNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01234, TNECROSISFCT
PR01237, TNFC

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00207, TNF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49842, SSF49842, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q06643-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD 
        60         70         80         90        100
QGGLVTETAD PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ 
       110        120        130        140        150
GLGWETTKEQ AFLTSGTQFS DAEGLALPQD GLYYLYCLVG YRGRAPPGGG 
       160        170        180        190        200
DPQGRSVTLR SSLYRAGGAY GPGTPELLLE GAETVTPVLD PARRQGYGPL 
       210        220        230        240 
WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA VMVG
Length:244
Mass (Da):25,390
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF41569459830ED4C
GO
Isoform 2 (identifier: Q06643-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-77: GLVTETADPGAQAQQGLGFQKLPEE → GLGFRSCQRRSQKQISAPGSQLPTS
     78-244: Missing.

Show »
Length:77
Mass (Da):7,780
Checksum:i8F1256D793D85397
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60 – 69DPGAQAQQGL → GLSAPGSGRT in AAB37342 (PubMed:9299492).Curated10

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01302570G → E1 PublicationCorresponds to variant dbSNP:rs3093554Ensembl.1
Natural variantiVAR_01633184S → R1 PublicationCorresponds to variant dbSNP:rs4647186Ensembl.1
Natural variantiVAR_01633287L → F1 PublicationCorresponds to variant dbSNP:rs4647187EnsemblClinVar.1
Natural variantiVAR_013026111A → P1 PublicationCorresponds to variant dbSNP:rs3093555Ensembl.1
Natural variantiVAR_029145122A → D. Corresponds to variant dbSNP:rs2229699Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00644153 – 77GLVTE…KLPEE → GLGFRSCQRRSQKQISAPGS QLPTS in isoform 2. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_00644278 – 244Missing in isoform 2. 3 PublicationsAdd BLAST167

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L11016 Genomic DNA Translation: AAA99888.1
U89922 mRNA Translation: AAC51769.1
U79029 mRNA Translation: AAB37342.1
L11015 mRNA Translation: AAA36191.1
Y14768 Genomic DNA Translation: CAA75069.1
AF129756 Genomic DNA Translation: AAD18089.1
BA000025 Genomic DNA Translation: BAB63395.1
AY070219 Genomic DNA Translation: AAL49954.1
AY070219 Genomic DNA Translation: AAL49955.1
AY216497 Genomic DNA Translation: AAO21134.1
AK312210 mRNA Translation: BAG35143.1
CH471081 Genomic DNA Translation: EAX03425.1
BC069330 mRNA Translation: AAH69330.1
BC093783 mRNA Translation: AAH93783.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4703.1 [Q06643-1]
CCDS4704.1 [Q06643-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A46066
JC5645

NCBI Reference Sequences

More...RefSeqi		NP_002332.1, NM_002341.1 [Q06643-1]
NP_033666.1, NM_009588.1 [Q06643-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376117; ENSP00000365285; ENSG00000204487
ENST00000383493; ENSP00000372985; ENSG00000206437
ENST00000420402; ENSP00000398741; ENSG00000223448
ENST00000421268; ENSP00000393693; ENSG00000238114
ENST00000429299; ENSP00000410481; ENSG00000227507
ENST00000444479; ENSP00000395102; ENSG00000236925
ENST00000446745; ENSP00000416113; ENSG00000227507 [Q06643-2]
ENST00000456113; ENSP00000404014; ENSG00000236237
ENST00000457552; ENSP00000404450; ENSG00000231314

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4050

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000429299.3; ENSP00000410481.3; NM_002341.2; NP_002332.1

UCSC genome browser

More...UCSCi		uc003nul.4, human [Q06643-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11016 Genomic DNA Translation: AAA99888.1
U89922 mRNA Translation: AAC51769.1
U79029 mRNA Translation: AAB37342.1
L11015 mRNA Translation: AAA36191.1
Y14768 Genomic DNA Translation: CAA75069.1
AF129756 Genomic DNA Translation: AAD18089.1
BA000025 Genomic DNA Translation: BAB63395.1
AY070219 Genomic DNA Translation: AAL49954.1
AY070219 Genomic DNA Translation: AAL49955.1
AY216497 Genomic DNA Translation: AAO21134.1
AK312210 mRNA Translation: BAG35143.1
CH471081 Genomic DNA Translation: EAX03425.1
BC069330 mRNA Translation: AAH69330.1
BC093783 mRNA Translation: AAH93783.1
CCDSiCCDS4703.1 [Q06643-1]
CCDS4704.1 [Q06643-2]
PIRiA46066
JC5645
RefSeqiNP_002332.1, NM_002341.1 [Q06643-1]
NP_033666.1, NM_009588.1 [Q06643-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MXWX-ray3.60B/D/Y/Z86-244[»]
SMRiQ06643
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110228, 2 interactors
CORUMiQ06643
DIPiDIP-2996N
IntActiQ06643, 6 interactors
STRINGi9606.ENSP00000410481

Chemistry databases

ChEMBLiCHEMBL3833421

PTM databases

GlyGeniQ06643, 1 site
PhosphoSitePlusiQ06643

Genetic variation databases

BioMutaiLTB
DMDMi549088

Proteomic databases

MassIVEiQ06643
PaxDbiQ06643
PeptideAtlasiQ06643
PRIDEiQ06643
ProteomicsDBi58468 [Q06643-1]
58469 [Q06643-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q06643, 8 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27204, 205 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		4050

Genome annotation databases

EnsembliENST00000376117; ENSP00000365285; ENSG00000204487
ENST00000383493; ENSP00000372985; ENSG00000206437
ENST00000420402; ENSP00000398741; ENSG00000223448
ENST00000421268; ENSP00000393693; ENSG00000238114
ENST00000429299; ENSP00000410481; ENSG00000227507
ENST00000444479; ENSP00000395102; ENSG00000236925
ENST00000446745; ENSP00000416113; ENSG00000227507 [Q06643-2]
ENST00000456113; ENSP00000404014; ENSG00000236237
ENST00000457552; ENSP00000404450; ENSG00000231314
GeneIDi4050
KEGGihsa:4050
MANE-SelectiENST00000429299.3; ENSP00000410481.3; NM_002341.2; NP_002332.1
UCSCiuc003nul.4, human [Q06643-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4050
DisGeNETi4050

GeneCards: human genes, protein and diseases

More...GeneCardsi		LTB
HGNCiHGNC:6711, LTB
HPAiENSG00000227507, Group enriched (intestine, lymphoid tissue)
MIMi600978, gene
neXtProtiNX_Q06643
OpenTargetsiENSG00000227507
PharmGKBiPA30475
VEuPathDBiHostDB:ENSG00000227507

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SMSQ, Eukaryota
GeneTreeiENSGT01040000240509
HOGENOMiCLU_096531_0_0_1
InParanoidiQ06643
OMAiRPQGRGC
PhylomeDBiQ06643
TreeFamiTF337780

Enzyme and pathway databases

PathwayCommonsiQ06643
ReactomeiR-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SignaLinkiQ06643
SIGNORiQ06643

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4050, 5 hits in 1035 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LTB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Lymphotoxin_beta

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4050
PharosiQ06643, Tbio

Protein Ontology

More...PROi		PR:Q06643
RNActiQ06643, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000227507, Expressed in adrenal gland and 179 other tissues
ExpressionAtlasiQ06643, baseline and differential
GenevisibleiQ06643, HS

Family and domain databases

CDDicd00184, TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053, TNF
IPR002961, TNF_C
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF29, PTHR11471:SF29, 1 hit
PfamiView protein in Pfam
PF00229, TNF, 1 hit
PRINTSiPR01234, TNECROSISFCT
PR01237, TNFC
SMARTiView protein in SMART
SM00207, TNF, 1 hit
SUPFAMiSSF49842, SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNFC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06643
Secondary accession number(s): P78370, Q52LU8, Q99761
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 23, 2022
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again