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Entry version 139 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein CFT1

Gene

CFT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.2 Publications

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-29861-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-SCE-77595, Processing of Intronless Pre-mRNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein CFT1
Alternative name(s):
Cleavage factor two protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFT1
Synonyms:YHH1
Ordered Locus Names:YDR301W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YDR301W

Saccharomyces Genome Database

More...
SGDi
S000002709, CFT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762031 – 1357Protein CFT1Add BLAST1357

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q06632

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q06632

PRoteomics IDEntifications database

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PRIDEi
Q06632

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06632

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of at least PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1.

Interacts with the phosphorylated CTD domain of RPB1/RNA polymerase II.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
32353, 106 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1053, Cleavage and polyadenylation specificity factor complex

Database of interacting proteins

More...
DIPi
DIP-2467N

Protein interaction database and analysis system

More...
IntActi
Q06632, 34 interactors

Molecular INTeraction database

More...
MINTi
Q06632

STRING: functional protein association networks

More...
STRINGi
4932.YDR301W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06632, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q06632

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CFT1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1896, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002414_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q06632

KEGG Orthology (KO)

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KOi
K14401

Identification of Orthologs from Complete Genome Data

More...
OMAi
DLTIYEP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03178, CPSF_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVYDDVLDA TVVSHSLATH FTTSDYEELL VVRTNILSVY RPTRDGKLYL
60 70 80 90 100
TDEFKFHGLI TDIGLIPQKD SPLSCLLLCT GVAKISILKF NTLTNSIDTL
110 120 130 140 150
SLHYYEGKFK GKSLVELAKI STLRMDPGSS CALLFNNDII AFLPFHVNKN
160 170 180 190 200
DDDEEEEDED ENIDDSELIH SMNQKSQGTN TFNKRKRTKL GDKFTAPSVV
210 220 230 240 250
LVASELYEGA KNIIDIQFLK NFTKPTIALL YQPKLVWAGN TTISKLPTQY
260 270 280 290 300
VILTLNIQPA ESATKIESTT IAFVKELPWD LHTIVPVSNG AIIVGTNELA
310 320 330 340 350
FLDNTGVLQS TVLLNSFADK ELQKTKIINN SSLEIMFREK NTTSIWIPSS
360 370 380 390 400
KSKNGGSNND ETLLLMDLKS NIYYIQMEAE GRLLIKFDIF KLPIVNDLLK
410 420 430 440 450
ENSNPKCITR LNATNSNKNM DLFIGFGSGN ALVLRLNNLK STIETREAHN
460 470 480 490 500
PSSGTNSLMD INDDDDEEMD DLYADEAPEN GLTTNDSKGT VETVQPFDIE
510 520 530 540 550
LLSSLRNVGP ITSLTVGKVS SIDDVVKGLP NPNKNEYSLV ATSGNGSGSH
560 570 580 590 600
LTVIQTSVQP EIELALKFIS ITQIWNLKIK GRDRYLITTD STKSRSDIYE
610 620 630 640 650
SDNNFKLHKG GRLRRDATTV YISMFGEEKR IIQVTTNHLY LYDTHFRRLT
660 670 680 690 700
TIKFDYEVIH VSVMDPYILV TVSRGDIKIF ELEEKNKRKL LKVDLPEILN
710 720 730 740 750
EMVITSGLIL KSNMCNEFLI GLSKSQEEQL LFTFVTADNQ IIFFTKDHND
760 770 780 790 800
RIFQLNGVDQ LNESLYISTY QLGDEIVPDP SIKQVMINKL GHDNKEEYLT
810 820 830 840 850
ILTFGGEIYQ YRKLPQRRSR FYRNVTRNDL AITGAPDNAY AKGVSSIERI
860 870 880 890 900
MHYFPDYNGY SVIFVTGSVP YILIKEDDST PKIFKFGNIP LVSVTPWSER
910 920 930 940 950
SVMCVDDIKN ARVYTLTTDN MYYGNKLPLK QIKISNVLDD YKTLQKLVYH
960 970 980 990 1000
ERAQLFLVSY CKRVPYEALG EDGEKVIGYD ENVPHAEGFQ SGILLINPKS
1010 1020 1030 1040 1050
WKVIDKIDFP KNSVVNEMRS SMIQINSKTK RKREYIIAGV ANATTEDTPP
1060 1070 1080 1090 1100
TGAFHIYDVI EVVPEPGKPD TNYKLKEIFQ EEVSGTVSTV CEVSGRFMIS
1110 1120 1130 1140 1150
QSQKVLVRDI QEDNSVIPVA FLDIPVFVTD SKSFGNLLII GDAMQGFQFI
1160 1170 1180 1190 1200
GFDAEPYRMI SLGRSMSKFQ TMSLEFLVNG GDMYFAATDA DRNVHVLKYA
1210 1220 1230 1240 1250
PDEPNSLSGQ RLVHCSSFTL HSTNSCMMLL PRNEEFGSPQ VPSFQNVGGQ
1260 1270 1280 1290 1300
VDGSVFKIVP LSEEKYRRLY VIQQQIIDRE LQLGGLNPRM ERLANDFYQM
1310 1320 1330 1340 1350
GHSMRPMLDF NVIRRFCGLA IDRRKSIAQK AGRHAHFEAW RDIINIEFSM

RSLCQGK
Length:1,357
Mass (Da):153,405
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC50D3770E9E758E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28374 Genomic DNA Translation: AAB64737.1
BK006938 Genomic DNA Translation: DAA12140.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61187

NCBI Reference Sequences

More...
RefSeqi
NP_010587.1, NM_001180609.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR301W_mRNA; YDR301W; YDR301W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR301W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28374 Genomic DNA Translation: AAB64737.1
BK006938 Genomic DNA Translation: DAA12140.1
PIRiS61187
RefSeqiNP_010587.1, NM_001180609.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EOJelectron microscopy3.55A1-1357[»]
SMRiQ06632
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32353, 106 interactors
ComplexPortaliCPX-1053, Cleavage and polyadenylation specificity factor complex
DIPiDIP-2467N
IntActiQ06632, 34 interactors
MINTiQ06632
STRINGi4932.YDR301W

PTM databases

iPTMnetiQ06632

Proteomic databases

MaxQBiQ06632
PaxDbiQ06632
PRIDEiQ06632

Genome annotation databases

EnsemblFungiiYDR301W_mRNA; YDR301W; YDR301W
GeneIDi851895
KEGGisce:YDR301W

Organism-specific databases

EuPathDBiFungiDB:YDR301W
SGDiS000002709, CFT1

Phylogenomic databases

eggNOGiKOG1896, Eukaryota
GeneTreeiENSGT00950000183151
HOGENOMiCLU_002414_0_0_1
InParanoidiQ06632
KOiK14401
OMAiDLTIYEP

Enzyme and pathway databases

BioCyciYEAST:G3O-29861-MONOMER
ReactomeiR-SCE-77595, Processing of Intronless Pre-mRNAs

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06632
RNActiQ06632, protein

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF03178, CPSF_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06632
Secondary accession number(s): D6VST0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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