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Entry version 123 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Oligopeptide transporter 2

Gene

OPT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports tetra- and pentapeptides. Does not transport glutathione.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.67.1.4, the oligopeptide transporter (opt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oligopeptide transporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OPT2
Ordered Locus Names:YPR194C
ORF Names:P9677.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YPR194C

Saccharomyces Genome Database

More...
SGDi
S000006398, OPT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 167CytoplasmicSequence analysisAdd BLAST167
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189ExtracellularSequence analysis1
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 240CytoplasmicSequence analysisAdd BLAST30
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 272ExtracellularSequence analysisAdd BLAST11
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 334CytoplasmicSequence analysisAdd BLAST41
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 374ExtracellularSequence analysisAdd BLAST19
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 404CytoplasmicSequence analysis9
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 480ExtracellularSequence analysisAdd BLAST55
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 553CytoplasmicSequence analysisAdd BLAST52
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 582ExtracellularSequence analysis8
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 614CytoplasmicSequence analysisAdd BLAST11
Transmembranei615 – 635HelicalSequence analysisAdd BLAST21
Topological domaini636 – 671ExtracellularSequence analysisAdd BLAST36
Transmembranei672 – 692HelicalSequence analysisAdd BLAST21
Topological domaini693 – 730CytoplasmicSequence analysisAdd BLAST38
Transmembranei731 – 751HelicalSequence analysisAdd BLAST21
Topological domaini752 – 766ExtracellularSequence analysisAdd BLAST15
Transmembranei767 – 789HelicalSequence analysisAdd BLAST23
Topological domaini790 – 811CytoplasmicSequence analysisAdd BLAST22
Transmembranei812 – 832HelicalSequence analysisAdd BLAST21
Topological domaini833 – 877ExtracellularSequence analysisAdd BLAST45

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002627331 – 877Oligopeptide transporter 2Add BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi860N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06593

PRoteomics IDEntifications database

More...
PRIDEi
Q06593

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36366, 104 interactors

Database of interacting proteins

More...
DIPi
DIP-5482N

Protein interaction database and analysis system

More...
IntActi
Q06593, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YPR194C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06593, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06593

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2262, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176656

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004965_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06593

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRKSTYD

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004648, Oligpept_transpt
IPR004813, OPT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03169, OPT, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00727, ISP4_OPT, 1 hit
TIGR00728, OPT_sfam, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06593-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETVKDKVI IDEKVSTKGT VDYAEGAEYS ERLSNHSSDF SQWYTDEQIL
60 70 80 90 100
HFMKKLGYEN RTLYDIPEDV AYILKKMPEL TLEDSFKILK DSIIYFKDDE
110 120 130 140 150
NIPHDQYEEW KRLVDLEDLD SKEGIDEYDS FDIRAFASAI KFHSPYQEVR
160 170 180 190 200
AVVDPEDDPT IPVETFRAYF LAIIWSVIGS GFNEFFSHRV VSISLNTPII
210 220 230 240 250
QMFLYICGKA WAKTIPCWTI TIRGRKYGIN IDKPWTQKEQ MFSTLLYAIC
260 270 280 290 300
QGAFYTHYNI LTQKLFYHSA FSFGYQFLLS LSVQFIGFGF AGILRKFVVY
310 320 330 340 350
PARALWPTVM PTIAINKALL GKEKHESGMS RYKFFFLTFF IMFIYNWFPT
360 370 380 390 400
YIINILNTFN WMTWIKPSNI NLANITGGVT GLGINPISSF DWNVISFNSP
410 420 430 440 450
LVYPFWSYLT QYLGCILAAL IVIAVYYSNY MSCQYLPIFT NSLYTNTGHS
460 470 480 490 500
FKVTEVLDSD NKLDVKKYQS YSPPYYSAGN LVSYGAFICA YPLMITWSFI
510 520 530 540 550
VHSKLLFNAF KDWALNLWAM RKLKSWVTMF KSDYRALDDY DDPHSNAMKN
560 570 580 590 600
YKEVPDWWYF AILIGSLVVG IAVVEHYPTN TPVWGLFVCL GFNFVFLIPT
610 620 630 640 650
TILQATTGYS FGLNLLIEMV MGYALPGNPI AIMILKAFGY NIDGQADNYV
660 670 680 690 700
SNLKIAHYCK IPPMALFRGQ CVIVFIQIFV NLGVLNWQIS NIKDFCTPHQ
710 720 730 740 750
NAKFTCPDAV TYYNASVVWG AIGPKRIFNY IYPIFKWCWL IGACIGIFFG
760 770 780 790 800
VWKRWGKFYP RYFDPMLFVG GMLNMSPPYN LMYYTSGMIV SYISQYYMKR
810 820 830 840 850
HHLNLWEKYN YVLSAGFSTG LVLSAIIIFF AVQYKDTAFN WWGNTVPYAG
860 870
ADGVGYPLKN ITDTANGYFG YAPGHYP
Length:877
Mass (Da):101,261
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3524D342E7EE4B50
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25841 Genomic DNA Translation: AAB64623.1
BK006949 Genomic DNA Translation: DAA11610.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S58824

NCBI Reference Sequences

More...
RefSeqi
NP_015520.1, NM_001184291.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR194C_mRNA; YPR194C; YPR194C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR194C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25841 Genomic DNA Translation: AAB64623.1
BK006949 Genomic DNA Translation: DAA11610.1
PIRiS58824
RefSeqiNP_015520.1, NM_001184291.1

3D structure databases

SMRiQ06593
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36366, 104 interactors
DIPiDIP-5482N
IntActiQ06593, 2 interactors
STRINGi4932.YPR194C

Protein family/group databases

TCDBi2.A.67.1.4, the oligopeptide transporter (opt) family

Proteomic databases

PaxDbiQ06593
PRIDEiQ06593

Genome annotation databases

EnsemblFungiiYPR194C_mRNA; YPR194C; YPR194C
GeneIDi856324
KEGGisce:YPR194C

Organism-specific databases

EuPathDBiFungiDB:YPR194C
SGDiS000006398, OPT2

Phylogenomic databases

eggNOGiKOG2262, Eukaryota
GeneTreeiENSGT00940000176656
HOGENOMiCLU_004965_1_0_1
InParanoidiQ06593
OMAiFRKSTYD

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06593
RNActiQ06593, protein

Family and domain databases

InterProiView protein in InterPro
IPR004648, Oligpept_transpt
IPR004813, OPT
PfamiView protein in Pfam
PF03169, OPT, 1 hit
TIGRFAMsiTIGR00727, ISP4_OPT, 1 hit
TIGR00728, OPT_sfam, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPT2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06593
Secondary accession number(s): D6W4J4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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