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UniProtKB - Q06587 (RING1_HUMAN)

Entry version 208 (25 May 2022)
Sequence version 2 (21 Mar 2006)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase RING1

Gene

RING1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

1 Publication

Miscellaneous

The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri48 – 88RING-typePROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor, Transferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q06587

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4655427, SUMOylation of DNA methylation proteins
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-8953750, Transcriptional Regulation by E2F6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q06587

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q06587

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RING1 (EC:2.3.2.27)
Alternative name(s):
Polycomb complex protein RING1
RING finger protein 1
RING-type E3 ubiquitin transferase RING1Curated
Really interesting new gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RING1
Synonyms:RNF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10018, RING1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602045, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q06587

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204227

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6015

Open Targets

More...OpenTargetsi		ENSG00000204227

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34393

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q06587, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RING1

Domain mapping of disease mutations (DMDM)

More...DMDMi		90110053

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000563841 – 406E3 ubiquitin-protein ligase RING1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphothreonineCombined sources1
Modified residuei38PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1
Modified residuei220PhosphothreonineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q06587

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q06587

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q06587

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q06587

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06587

PeptideAtlas

More...PeptideAtlasi		Q06587

PRoteomics IDEntifications database

More...PRIDEi		Q06587

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58462 [Q06587-1]
58463 [Q06587-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q06587-1 [Q06587-1]
Q06587-2 [Q06587-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q06587, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q06587

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q06587

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204227, Expressed in olfactory bulb and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q06587, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q06587, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204227, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of chromatin-associated Polycomb (PcG) complexes.

Interacts with BMI1 (By similarity). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2.

Interacts with CBX2 and PCGF6.

Component of a PRC1-like complex.

Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2.

Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8.

Interacts with PHC2 (By similarity).

Interacts with MN1 (PubMed:31839203).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111947, 140 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q06587

Database of interacting proteins

More...DIPi		DIP-42043N

Protein interaction database and analysis system

More...IntActi		Q06587, 115 interactors

Molecular INTeraction database

More...MINTi		Q06587

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363787

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q06587, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q06587

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q06587

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 234Necessary for transcriptional repressionBy similarityAdd BLAST205
Regioni148 – 263DisorderedSequence analysisAdd BLAST116
Regioni230 – 406Necessary for interaction with CBX2By similarityAdd BLAST177
Regioni309 – 354DisorderedSequence analysisAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi201 – 204Nuclear localization signalSequence analysis4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri48 – 88RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0311, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161022

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_056557_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q06587

Identification of Orthologs from Complete Genome Data

More...OMAi		MIVGEVL

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q06587

TreeFam database of animal gene trees

More...TreeFami		TF105501

Family and domain databases

Conserved Domains Database

More...CDDi		cd16739, RING-HC_RING1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032443, RAWUL
IPR043540, RING1/RING2
IPR042741, RING1_RING-HC
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...PANTHERi		PTHR46076, PTHR46076, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16207, RAWUL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q06587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI 
        60         70         80         90        100
CLDMLKNTMT TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD 
       110        120        130        140        150
PNFDALISKI YPSREEYEAH QDRVLIRLSR LHNQQALSSS IEEGLRMQAM 
       160        170        180        190        200
HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE GDGEDVSSDS APDSAPGPAP 
       210        220        230        240        250
KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG GGTLGPPSPP 
       260        270        280        290        300
GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA 
       310        320        330        340        350
LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL 
       360        370        380        390        400
PSLEGVSEKQ YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA 

PTKDPK
Length:406
Mass (Da):42,429
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6959787479DE9DAB
GO
Isoform 2 (identifier: Q06587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:377
Mass (Da):39,146
Checksum:iF406E93593E0CF69
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07661895R → Q1 PublicationCorresponds to variant dbSNP:rs1204881780Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0176941 – 29Missing in isoform 2. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z14000 mRNA Translation: CAA78389.1
BT007352 mRNA Translation: AAP36016.1
AK289355 mRNA Translation: BAF82044.1
AL031228 Genomic DNA Translation: CAA20235.1
AL031228 Genomic DNA Translation: CAI95620.1
AL645940 Genomic DNA No translation available.
AL713971 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
CR547129 Genomic DNA No translation available.
CR759733 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR847841 Genomic DNA No translation available.
BC002922 mRNA Translation: AAH02922.2
BC051866 mRNA Translation: AAH51866.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34424.1 [Q06587-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A47380

NCBI Reference Sequences

More...RefSeqi		NP_002922.2, NM_002931.3 [Q06587-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374656.5; ENSP00000363787.4; ENSG00000204227.5
ENST00000383212.4; ENSP00000372699.4; ENSG00000206287.5
ENST00000415941.2; ENSP00000412190.2; ENSG00000226788.3
ENST00000427374.2; ENSP00000400572.2; ENSG00000231115.3
ENST00000430233.2; ENSP00000396271.2; ENSG00000228520.3
ENST00000436128.2; ENSP00000396439.2; ENSG00000235107.3

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6015

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000374656.5; ENSP00000363787.4; NM_002931.4; NP_002922.2

UCSC genome browser

More...UCSCi		uc003odk.4, human [Q06587-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14000 mRNA Translation: CAA78389.1
BT007352 mRNA Translation: AAP36016.1
AK289355 mRNA Translation: BAF82044.1
AL031228 Genomic DNA Translation: CAA20235.1
AL031228 Genomic DNA Translation: CAI95620.1
AL645940 Genomic DNA No translation available.
AL713971 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
CR547129 Genomic DNA No translation available.
CR759733 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR847841 Genomic DNA No translation available.
BC002922 mRNA Translation: AAH02922.2
BC051866 mRNA Translation: AAH51866.1
CCDSiCCDS34424.1 [Q06587-1]
PIRiA47380
RefSeqiNP_002922.2, NM_002931.3 [Q06587-1]

3D structure databases

AlphaFoldDBiQ06587
SMRiQ06587
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111947, 140 interactors
CORUMiQ06587
DIPiDIP-42043N
IntActiQ06587, 115 interactors
MINTiQ06587
STRINGi9606.ENSP00000363787

PTM databases

GlyGeniQ06587, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ06587
PhosphoSitePlusiQ06587

Genetic variation databases

BioMutaiRING1
DMDMi90110053

Proteomic databases

EPDiQ06587
jPOSTiQ06587
MassIVEiQ06587
MaxQBiQ06587
PaxDbiQ06587
PeptideAtlasiQ06587
PRIDEiQ06587
ProteomicsDBi58462 [Q06587-1]
58463 [Q06587-2]
TopDownProteomicsiQ06587-1 [Q06587-1]
Q06587-2 [Q06587-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1772, 564 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		6015

Genome annotation databases

EnsembliENST00000374656.5; ENSP00000363787.4; ENSG00000204227.5
ENST00000383212.4; ENSP00000372699.4; ENSG00000206287.5
ENST00000415941.2; ENSP00000412190.2; ENSG00000226788.3
ENST00000427374.2; ENSP00000400572.2; ENSG00000231115.3
ENST00000430233.2; ENSP00000396271.2; ENSG00000228520.3
ENST00000436128.2; ENSP00000396439.2; ENSG00000235107.3
GeneIDi6015
KEGGihsa:6015
MANE-SelectiENST00000374656.5; ENSP00000363787.4; NM_002931.4; NP_002922.2
UCSCiuc003odk.4, human [Q06587-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6015
DisGeNETi6015

GeneCards: human genes, protein and diseases

More...GeneCardsi		RING1
HGNCiHGNC:10018, RING1
HPAiENSG00000204227, Low tissue specificity
MIMi602045, gene
neXtProtiNX_Q06587
OpenTargetsiENSG00000204227
PharmGKBiPA34393
VEuPathDBiHostDB:ENSG00000204227

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0311, Eukaryota
GeneTreeiENSGT00940000161022
HOGENOMiCLU_056557_1_0_1
InParanoidiQ06587
OMAiMIVGEVL
PhylomeDBiQ06587
TreeFamiTF105501

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ06587
ReactomeiR-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4655427, SUMOylation of DNA methylation proteins
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-8953750, Transcriptional Regulation by E2F6
SignaLinkiQ06587
SIGNORiQ06587

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6015, 25 hits in 1130 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RING1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RING1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6015
PharosiQ06587, Tbio

Protein Ontology

More...PROi		PR:Q06587
RNActiQ06587, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204227, Expressed in olfactory bulb and 246 other tissues
ExpressionAtlasiQ06587, baseline and differential
GenevisibleiQ06587, HS

Family and domain databases

CDDicd16739, RING-HC_RING1, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR032443, RAWUL
IPR043540, RING1/RING2
IPR042741, RING1_RING-HC
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR46076, PTHR46076, 1 hit
PfamiView protein in Pfam
PF16207, RAWUL, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRING1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06587
Secondary accession number(s): A8JZZ0
, Q5JP96, Q5SQW2, Q86V19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 21, 2006
Last modified: May 25, 2022
This is version 208 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
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