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Protein

Nuclear distribution protein nudE homolog 1

Gene

NDL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for nuclear migration to the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.1 Publication

GO - Molecular functioni

  • microtubule plus-end binding Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • nuclear migration along microtubule Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32358-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear distribution protein nudE homolog 1
Alternative name(s):
Nuclear distribution protein nudE-like 1
Gene namesi
Name:NDL1
Ordered Locus Names:YLR254C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR254C
SGDiS000004244 NDL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002402291 – 189Nuclear distribution protein nudE homolog 1Add BLAST189

Proteomic databases

MaxQBiQ06568
PaxDbiQ06568
PRIDEiQ06568

Interactioni

Subunit structurei

Self-associates. Interacts with PAC1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31521, 293 interactors
DIPiDIP-1486N
IntActiQ06568, 5 interactors
MINTiQ06568
STRINGi4932.YLR254C

Structurei

3D structure databases

ProteinModelPortaliQ06568
SMRiQ06568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 121Sequence analysisAdd BLAST118

Sequence similaritiesi

Belongs to the nudE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000067725
InParanoidiQ06568
OMAiHELYDAK
OrthoDBiEOG092C4U0V

Sequencei

Sequence statusi: Complete.

Q06568-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPNLDLETA IQIISSLETQ LSELEGATKE YENDLEQVIS KLKSDLLESQ
60 70 80 90 100
QQNKCNKKQI TDLEIQVDEL ENENIQLRNK IETLQLESDR RLERNVLLEH
110 120 130 140 150
ELLDTKEALQ KLRVSKEEAT SGETRRNTRS LPSQNKKMKL FKDTIKVSTT
160 170 180
SSTLYLQNMA KTNNAARSHC NIPNTQITQS TVIATTSSV
Length:189
Mass (Da):21,530
Last modified:November 1, 1996 - v1
Checksum:iE3E6EAC07C5B595A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA Translation: AAB67401.1
AY558212 Genomic DNA Translation: AAS56538.1
BK006945 Genomic DNA Translation: DAA09567.1
PIRiS59399
RefSeqiNP_013355.1, NM_001182141.1

Genome annotation databases

EnsemblFungiiYLR254C; YLR254C; YLR254C
GeneIDi850956
KEGGisce:YLR254C

Similar proteinsi

Entry informationi

Entry nameiNDE1_YEAST
AccessioniPrimary (citable) accession number: Q06568
Secondary accession number(s): D6VYQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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