UniProtKB - Q06568 (NDE1_YEAST)
Protein
Nuclear distribution protein nudE homolog 1
Gene
NDL1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for nuclear migration to the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.1 Publication
GO - Molecular functioni
- microtubule plus-end binding Source: SGD
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- nuclear migration along microtubule Source: SGD
Keywordsi
| Biological process | Cell cycle, Cell division, Mitosis, Transport |
Enzyme and pathway databases
| BioCyci | YEAST:G3O-32358-MONOMER |
Names & Taxonomyi
| Protein namesi | Recommended name: Nuclear distribution protein nudE homolog 1Alternative name(s): Nuclear distribution protein nudE-like 1 |
| Gene namesi | Name:NDL1 Ordered Locus Names:YLR254C |
| Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic identifieri | 559292 [NCBI] |
| Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | FungiDB:YLR254C |
| SGDi | S000004244 NDL1 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000240229 | 1 – 189 | Nuclear distribution protein nudE homolog 1Add BLAST | 189 |
Proteomic databases
| MaxQBi | Q06568 |
| PaxDbi | Q06568 |
| PRIDEi | Q06568 |
Interactioni
Subunit structurei
Self-associates. Interacts with PAC1.1 Publication
GO - Molecular functioni
- microtubule plus-end binding Source: SGD
Protein-protein interaction databases
| BioGridi | 31521, 293 interactors |
| DIPi | DIP-1486N |
| IntActi | Q06568, 5 interactors |
| MINTi | Q06568 |
| STRINGi | 4932.YLR254C |
Structurei
3D structure databases
| ProteinModelPortali | Q06568 |
| SMRi | Q06568 |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Coiled coil
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Coiled coili | 4 – 121 | Sequence analysisAdd BLAST | 118 |
Sequence similaritiesi
Belongs to the nudE family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
| HOGENOMi | HOG000067725 |
| InParanoidi | Q06568 |
| OMAi | HELYDAK |
| OrthoDBi | EOG092C4U0V |
Sequencei
Sequence statusi: Complete.
Q06568-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVPNLDLETA IQIISSLETQ LSELEGATKE YENDLEQVIS KLKSDLLESQ
60 70 80 90 100
QQNKCNKKQI TDLEIQVDEL ENENIQLRNK IETLQLESDR RLERNVLLEH
110 120 130 140 150
ELLDTKEALQ KLRVSKEEAT SGETRRNTRS LPSQNKKMKL FKDTIKVSTT
160 170 180
SSTLYLQNMA KTNNAARSHC NIPNTQITQS TVIATTSSV
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20865 Genomic DNA Translation: AAB67401.1 AY558212 Genomic DNA Translation: AAS56538.1 BK006945 Genomic DNA Translation: DAA09567.1 |
| PIRi | S59399 |
| RefSeqi | NP_013355.1, NM_001182141.1 |
Genome annotation databases
| EnsemblFungii | YLR254C; YLR254C; YLR254C |
| GeneIDi | 850956 |
| KEGGi | sce:YLR254C |
Similar proteinsi
Entry informationi
| Entry namei | NDE1_YEAST | |
| Accessioni | Q06568Primary (citable) accession number: Q06568 Secondary accession number(s): D6VYQ1 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
| Last sequence update: | November 1, 1996 | |
| Last modified: | September 12, 2018 | |
| This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Fungal Protein Annotation Program | |



