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UniProtKB - Q06546 (GABPA_HUMAN)
Protein
GA-binding protein alpha chain
Gene
GABPA
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 320 – 400 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription cis-regulatory region binding Source: MGI
GO - Biological processi
- blastocyst formation Source: Ensembl
- cell differentiation Source: GO_Central
- cellular response to dopamine Source: CAFA
- negative regulation of megakaryocyte differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of gene expression Source: CAFA
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q06546 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis |
SignaLinki | Q06546 |
Names & Taxonomyi
Protein namesi | Recommended name: GA-binding protein alpha chainShort name: GABP subunit alpha Alternative name(s): Nuclear respiratory factor 2 subunit alpha Transcription factor E4TF1-60 |
Gene namesi | Name:GABPA Synonyms:E4TF1A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4071, GABPA |
MIMi | 600609, gene |
neXtProti | NX_Q06546 |
VEuPathDBi | HostDB:ENSG00000154727 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- chromatin Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2551 |
OpenTargetsi | ENSG00000154727 |
PharmGKBi | PA28485 |
Miscellaneous databases
Pharosi | Q06546, Tbio |
Genetic variation databases
BioMutai | GABPA |
DMDMi | 729553 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204127 | 1 – 454 | GA-binding protein alpha chainAdd BLAST | 454 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 303 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q06546 |
jPOSTi | Q06546 |
MassIVEi | Q06546 |
MaxQBi | Q06546 |
PaxDbi | Q06546 |
PeptideAtlasi | Q06546 |
PRIDEi | Q06546 |
ProteomicsDBi | 58457 |
PTM databases
GlyGeni | Q06546, 4 sites, 2 O-linked glycans (4 sites) |
iPTMneti | Q06546 |
PhosphoSitePlusi | Q06546 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154727, Expressed in calcaneal tendon and 219 other tissues |
ExpressionAtlasi | Q06546, baseline and differential |
Genevisiblei | Q06546, HS |
Organism-specific databases
HPAi | ENSG00000154727, Low tissue specificity |
Interactioni
Subunit structurei
Heterotetramer of two alpha and two beta subunits.
Binary interactionsi
Q06546
Protein-protein interaction databases
BioGRIDi | 108826, 101 interactors |
DIPi | DIP-33980N |
IntActi | Q06546, 26 interactors |
MINTi | Q06546 |
STRINGi | 9606.ENSP00000346886 |
Miscellaneous databases
RNActi | Q06546, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 168 – 251 | PNTPROSITE-ProRule annotationAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 297 – 316 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000155799 |
HOGENOMi | CLU_037064_0_0_1 |
InParanoidi | Q06546 |
OMAi | YSFWLQD |
OrthoDBi | 526256at2759 |
PhylomeDBi | Q06546 |
TreeFami | TF350537 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR046328, ETS_fam IPR024668, GABP_asu_N IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016312, TF_GA-bd_asu IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849, PTHR11849, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF11620, GABP-alpha, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF001703, GABP_alpha, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06546-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN
60 70 80 90 100
LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS
110 120 130 140 150
YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK
160 170 180 190 200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW
210 220 230 240 250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY
260 270 280 290 300
VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP
310 320 330 340 350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL
360 370 380 390 400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV
410 420 430 440 450
CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT
EKDN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 289 – 290 | SS → RC in AAA65706 (PubMed:7799916).Curated | 2 | |
Sequence conflicti | 440 | A → V in AAA65706 (PubMed:7799916).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020315 | 291 | A → V. Corresponds to variant dbSNP:rs2829897Ensembl. | 1 | |
Natural variantiVAR_020316 | 345 | E → K. Corresponds to variant dbSNP:rs2829900Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13318 mRNA Translation: BAA02575.1 U13044 mRNA Translation: AAA65706.1 |
CCDSi | CCDS13575.1 |
PIRi | A48146 I38739 |
RefSeqi | NP_001184226.1, NM_001197297.1 NP_002031.2, NM_002040.3 XP_005260995.1, XM_005260938.4 XP_011527822.1, XM_011529520.2 XP_011527823.1, XM_011529521.2 XP_016883802.1, XM_017028313.1 |
Genome annotation databases
Ensembli | ENST00000354828.7; ENSP00000346886.3; ENSG00000154727.11 ENST00000400075.4; ENSP00000382948.3; ENSG00000154727.11 |
GeneIDi | 2551 |
KEGGi | hsa:2551 |
MANE-Selecti | ENST00000400075.4; ENSP00000382948.3; NM_002040.4; NP_002031.2 |
UCSCi | uc002ylx.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13318 mRNA Translation: BAA02575.1 U13044 mRNA Translation: AAA65706.1 |
CCDSi | CCDS13575.1 |
PIRi | A48146 I38739 |
RefSeqi | NP_001184226.1, NM_001197297.1 NP_002031.2, NM_002040.3 XP_005260995.1, XM_005260938.4 XP_011527822.1, XM_011529520.2 XP_011527823.1, XM_011529521.2 XP_016883802.1, XM_017028313.1 |
3D structure databases
AlphaFoldDBi | Q06546 |
BMRBi | Q06546 |
SMRi | Q06546 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108826, 101 interactors |
DIPi | DIP-33980N |
IntActi | Q06546, 26 interactors |
MINTi | Q06546 |
STRINGi | 9606.ENSP00000346886 |
PTM databases
GlyGeni | Q06546, 4 sites, 2 O-linked glycans (4 sites) |
iPTMneti | Q06546 |
PhosphoSitePlusi | Q06546 |
Genetic variation databases
BioMutai | GABPA |
DMDMi | 729553 |
Proteomic databases
EPDi | Q06546 |
jPOSTi | Q06546 |
MassIVEi | Q06546 |
MaxQBi | Q06546 |
PaxDbi | Q06546 |
PeptideAtlasi | Q06546 |
PRIDEi | Q06546 |
ProteomicsDBi | 58457 |
Protocols and materials databases
Antibodypediai | 919, 408 antibodies from 32 providers |
DNASUi | 2551 |
Genome annotation databases
Ensembli | ENST00000354828.7; ENSP00000346886.3; ENSG00000154727.11 ENST00000400075.4; ENSP00000382948.3; ENSG00000154727.11 |
GeneIDi | 2551 |
KEGGi | hsa:2551 |
MANE-Selecti | ENST00000400075.4; ENSP00000382948.3; NM_002040.4; NP_002031.2 |
UCSCi | uc002ylx.5, human |
Organism-specific databases
CTDi | 2551 |
DisGeNETi | 2551 |
GeneCardsi | GABPA |
HGNCi | HGNC:4071, GABPA |
HPAi | ENSG00000154727, Low tissue specificity |
MIMi | 600609, gene |
neXtProti | NX_Q06546 |
OpenTargetsi | ENSG00000154727 |
PharmGKBi | PA28485 |
VEuPathDBi | HostDB:ENSG00000154727 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000155799 |
HOGENOMi | CLU_037064_0_0_1 |
InParanoidi | Q06546 |
OMAi | YSFWLQD |
OrthoDBi | 526256at2759 |
PhylomeDBi | Q06546 |
TreeFami | TF350537 |
Enzyme and pathway databases
PathwayCommonsi | Q06546 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis |
SignaLinki | Q06546 |
Miscellaneous databases
BioGRID-ORCSi | 2551, 523 hits in 1078 CRISPR screens |
ChiTaRSi | GABPA, human |
GeneWikii | GABPA |
GenomeRNAii | 2551 |
Pharosi | Q06546, Tbio |
PROi | PR:Q06546 |
RNActi | Q06546, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154727, Expressed in calcaneal tendon and 219 other tissues |
ExpressionAtlasi | Q06546, baseline and differential |
Genevisiblei | Q06546, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR046328, ETS_fam IPR024668, GABP_asu_N IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016312, TF_GA-bd_asu IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849, PTHR11849, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF11620, GABP-alpha, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF001703, GABP_alpha, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GABPA_HUMAN | |
Accessioni | Q06546Primary (citable) accession number: Q06546 Secondary accession number(s): Q12939 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 205 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families