GA-binding protein alpha chain

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activating transcription factor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "METTL23, a transcriptional partner of GABPA, is essential for human cognition."
    Reiff R.E., Ali B.R., Baron B., Yu T.W., Ben-Salem S., Coulter M.E., Schubert C.R., Hill R.S., Akawi N.A., Al-Younes B., Kaya N., Evrony G.D., Al-Saffar M., Felie J.M., Partlow J.N., Sunu C.M., Schembri-Wismayer P., Alkuraya F.S.

    , Meyer B.F., Walsh C.A., Al-Gazali L., Mochida G.H.
    Hum. Mol. Genet. 23:3456-3466(2014) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: Ensembl
• DNA binding Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs."
    Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H.
    Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter."
    Pastorcic M., Das H.K.
    Brain Res. Mol. Brain Res. 113:57-66(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: ProtIncTraceable author statementⁱ
  • "Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21."
    Chrast R., Chen H., Morris M.A., Antonarakis S.E.
    Genomics 28:119-122(1995) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs."
    Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H.
    Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter."
    Pastorcic M., Das H.K.
    Brain Res. Mol. Brain Res. 113:57-66(2003) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: ProtIncTraceable author statementⁱ
  • Ref.1

    "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs."
    Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H.
    Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• transcription regulatory region DNA binding Source: MGIInferred from direct assayⁱ
  • "Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals."
    Du K., Leu J.I., Peng Y., Taub R.
    J. Biol. Chem. 273:35208-35215(1998) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• blastocyst formation Source: Ensembl
• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to dopamine Source: CAFA <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling."
    Sidharthan N.P., Minchin R.F., Butcher N.J.
    J. Biol. Chem. 288:34364-34374(2013) [PubMed] [Europe PMC] [Abstract]
• mitochondrion organization Source: Reactome
• negative regulation of megakaryocyte differentiation Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of gene expression Source: CAFAInferred from mutant phenotypeⁱ
  • "Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling."
    Sidharthan N.P., Minchin R.F., Butcher N.J.
    J. Biol. Chem. 288:34364-34374(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • "METTL23, a transcriptional partner of GABPA, is essential for human cognition."
    Reiff R.E., Ali B.R., Baron B., Yu T.W., Ben-Salem S., Coulter M.E., Schubert C.R., Hill R.S., Akawi N.A., Al-Younes B., Kaya N., Evrony G.D., Al-Saffar M., Felie J.M., Partlow J.N., Sunu C.M., Schembri-Wismayer P., Alkuraya F.S.

    , Meyer B.F., Walsh C.A., Al-Gazali L., Mochida G.H.
    Hum. Mol. Genet. 23:3456-3466(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: ProtIncTraceable author statementⁱ
  • Ref.1

    "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs."
    Watanabe H., Sawada J., Yano K., Yamaguchi K., Goto M., Handa H.
    Mol. Cell. Biol. 13:1385-1391(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "METTL23, a transcriptional partner of GABPA, is essential for human cognition."
    Reiff R.E., Ali B.R., Baron B., Yu T.W., Ben-Salem S., Coulter M.E., Schubert C.R., Hill R.S., Akawi N.A., Al-Younes B., Kaya N., Evrony G.D., Al-Saffar M., Felie J.M., Partlow J.N., Sunu C.M., Schembri-Wismayer P., Alkuraya F.S.

    , Meyer B.F., Walsh C.A., Al-Gazali L., Mochida G.H.
    Hum. Mol. Genet. 23:3456-3466(2014) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN 
        60         70         80         90        100
LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS 
       110        120        130        140        150
YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK 
       160        170        180        190        200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW 
       210        220        230        240        250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY 
       260        270        280        290        300
VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 
       310        320        330        340        350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL 
       360        370        380        390        400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV 
       410        420        430        440        450
CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT 

EKDN                                                   

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. Human chromosome 21
   Human chromosome 21: entries, gene names and cross-references to MIM