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UniProtKB - Q06546 (GABPA_HUMAN)

Entry version 205 (25 May 2022)
Sequence version 1 (01 Feb 1995)
Previous versions | rss
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Protein

GA-binding protein alpha chain

Gene

GABPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi320 – 400ETSPROSITE-ProRule annotationAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q06546

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q06546

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GA-binding protein alpha chain
Short name:
GABP subunit alpha
Alternative name(s):
Nuclear respiratory factor 2 subunit alpha
Transcription factor E4TF1-60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GABPA
Synonyms:E4TF1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4071, GABPA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600609, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q06546

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000154727

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2551

Open Targets

More...OpenTargetsi		ENSG00000154727

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28485

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q06546, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GABPA

Domain mapping of disease mutations (DMDM)

More...DMDMi		729553

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041271 – 454GA-binding protein alpha chainAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei303PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q06546

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q06546

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q06546

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q06546

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06546

PeptideAtlas

More...PeptideAtlasi		Q06546

PRoteomics IDEntifications database

More...PRIDEi		Q06546

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58457

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q06546, 4 sites, 2 O-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q06546

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q06546

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154727, Expressed in calcaneal tendon and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q06546, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q06546, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000154727, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two alpha and two beta subunits.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108826, 101 interactors

Database of interacting proteins

More...DIPi		DIP-33980N

Protein interaction database and analysis system

More...IntActi		Q06546, 26 interactors

Molecular INTeraction database

More...MINTi		Q06546

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346886

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q06546, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q06546

Biological Magnetic Resonance Data Bank

More...BMRBi		Q06546

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q06546

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 251PNTPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni297 – 316DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3806, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155799

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_037064_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q06546

Identification of Orthologs from Complete Genome Data

More...OMAi		YSFWLQD

Database of Orthologous Groups

More...OrthoDBi		526256at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q06546

TreeFam database of animal gene trees

More...TreeFami		TF350537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000418, Ets_dom
IPR046328, ETS_fam
IPR024668, GABP_asu_N
IPR003118, Pointed_dom
IPR013761, SAM/pointed_sf
IPR016312, TF_GA-bd_asu
IPR029071, Ubiquitin-like_domsf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR11849, PTHR11849, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00178, Ets, 1 hit
PF11620, GABP-alpha, 1 hit
PF02198, SAM_PNT, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001703, GABP_alpha, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00454, ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00413, ETS, 1 hit
SM00251, SAM_PNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit
SSF47769, SSF47769, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00345, ETS_DOMAIN_1, 1 hit
PS00346, ETS_DOMAIN_2, 1 hit
PS50061, ETS_DOMAIN_3, 1 hit
PS51433, PNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06546-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN 
        60         70         80         90        100
LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS 
       110        120        130        140        150
YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK 
       160        170        180        190        200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW 
       210        220        230        240        250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY 
       260        270        280        290        300
VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 
       310        320        330        340        350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL 
       360        370        380        390        400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV 
       410        420        430        440        450
CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT 

EKDN
Length:454
Mass (Da):51,295
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AF2ABBBC79191DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti289 – 290SS → RC in AAA65706 (PubMed:7799916).Curated2
Sequence conflicti440A → V in AAA65706 (PubMed:7799916).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020315291A → V. Corresponds to variant dbSNP:rs2829897Ensembl.1
Natural variantiVAR_020316345E → K. Corresponds to variant dbSNP:rs2829900Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D13318 mRNA Translation: BAA02575.1
U13044 mRNA Translation: AAA65706.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13575.1

Protein sequence database of the Protein Information Resource

More...PIRi		A48146
I38739

NCBI Reference Sequences

More...RefSeqi		NP_001184226.1, NM_001197297.1
NP_002031.2, NM_002040.3
XP_005260995.1, XM_005260938.4
XP_011527822.1, XM_011529520.2
XP_011527823.1, XM_011529521.2
XP_016883802.1, XM_017028313.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354828.7; ENSP00000346886.3; ENSG00000154727.11
ENST00000400075.4; ENSP00000382948.3; ENSG00000154727.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2551

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2551

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000400075.4; ENSP00000382948.3; NM_002040.4; NP_002031.2

UCSC genome browser

More...UCSCi		uc002ylx.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13318 mRNA Translation: BAA02575.1
U13044 mRNA Translation: AAA65706.1
CCDSiCCDS13575.1
PIRiA48146
I38739
RefSeqiNP_001184226.1, NM_001197297.1
NP_002031.2, NM_002040.3
XP_005260995.1, XM_005260938.4
XP_011527822.1, XM_011529520.2
XP_011527823.1, XM_011529521.2
XP_016883802.1, XM_017028313.1

3D structure databases

AlphaFoldDBiQ06546
BMRBiQ06546
SMRiQ06546
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108826, 101 interactors
DIPiDIP-33980N
IntActiQ06546, 26 interactors
MINTiQ06546
STRINGi9606.ENSP00000346886

PTM databases

GlyGeniQ06546, 4 sites, 2 O-linked glycans (4 sites)
iPTMnetiQ06546
PhosphoSitePlusiQ06546

Genetic variation databases

BioMutaiGABPA
DMDMi729553

Proteomic databases

EPDiQ06546
jPOSTiQ06546
MassIVEiQ06546
MaxQBiQ06546
PaxDbiQ06546
PeptideAtlasiQ06546
PRIDEiQ06546
ProteomicsDBi58457

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		919, 408 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		2551

Genome annotation databases

EnsembliENST00000354828.7; ENSP00000346886.3; ENSG00000154727.11
ENST00000400075.4; ENSP00000382948.3; ENSG00000154727.11
GeneIDi2551
KEGGihsa:2551
MANE-SelectiENST00000400075.4; ENSP00000382948.3; NM_002040.4; NP_002031.2
UCSCiuc002ylx.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2551
DisGeNETi2551

GeneCards: human genes, protein and diseases

More...GeneCardsi		GABPA
HGNCiHGNC:4071, GABPA
HPAiENSG00000154727, Low tissue specificity
MIMi600609, gene
neXtProtiNX_Q06546
OpenTargetsiENSG00000154727
PharmGKBiPA28485
VEuPathDBiHostDB:ENSG00000154727

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3806, Eukaryota
GeneTreeiENSGT00940000155799
HOGENOMiCLU_037064_0_0_1
InParanoidiQ06546
OMAiYSFWLQD
OrthoDBi526256at2759
PhylomeDBiQ06546
TreeFamiTF350537

Enzyme and pathway databases

PathwayCommonsiQ06546
ReactomeiR-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
SignaLinkiQ06546

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2551, 523 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GABPA, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GABPA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2551
PharosiQ06546, Tbio

Protein Ontology

More...PROi		PR:Q06546
RNActiQ06546, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154727, Expressed in calcaneal tendon and 219 other tissues
ExpressionAtlasiQ06546, baseline and differential
GenevisibleiQ06546, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR000418, Ets_dom
IPR046328, ETS_fam
IPR024668, GABP_asu_N
IPR003118, Pointed_dom
IPR013761, SAM/pointed_sf
IPR016312, TF_GA-bd_asu
IPR029071, Ubiquitin-like_domsf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR11849, PTHR11849, 1 hit
PfamiView protein in Pfam
PF00178, Ets, 1 hit
PF11620, GABP-alpha, 1 hit
PF02198, SAM_PNT, 1 hit
PIRSFiPIRSF001703, GABP_alpha, 1 hit
PRINTSiPR00454, ETSDOMAIN
SMARTiView protein in SMART
SM00413, ETS, 1 hit
SM00251, SAM_PNT, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF47769, SSF47769, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00345, ETS_DOMAIN_1, 1 hit
PS00346, ETS_DOMAIN_2, 1 hit
PS50061, ETS_DOMAIN_3, 1 hit
PS51433, PNT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGABPA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06546
Secondary accession number(s): Q12939
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 25, 2022
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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