UniProtKB - Q06538 (CSC1_YEAST)
Protein
Calcium permeable stress-gated cation channel 1
Gene
CSC1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Acts as an osmosensitive calcium-permeable cation channel.1 Publication
Activity regulationi
Activated by hyperosmotic shock after mannitol treatment.1 Publication
GO - Molecular functioni
- calcium activated cation channel activity Source: UniProtKB
GO - Biological processi
- cation transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Ligand | Calcium |
Protein family/group databases
TCDBi | 1.A.17.5.11, the calcium-dependent chloride channel (ca-clc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium permeable stress-gated cation channel 1Short name: ScCSC1 |
Gene namesi | Name:CSC1 Ordered Locus Names:YLR241W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004231, CSC1 |
VEuPathDBi | FungiDB:YLR241W |
Subcellular locationi
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Plasma Membrane
- plasma membrane Source: GO_Central
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 116 | CytoplasmicSequence analysisAdd BLAST | 61 | |
Transmembranei | 117 – 139 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 140 – 181 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 182 – 202 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 440 | CytoplasmicSequence analysisAdd BLAST | 238 | |
Transmembranei | 441 – 461 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 462 – 485 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 486 – 506 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 507 – 530 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 531 – 551 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 552 – 578 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 579 – 599 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 600 – 621 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 622 – 642 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 643 – 648 | ExtracellularSequence analysis | 6 | |
Transmembranei | 649 – 669 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 670 – 681 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 682 – 702 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 703 – 709 | ExtracellularSequence analysis | 7 | |
Transmembranei | 710 – 730 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 731 – 782 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247173 | 1 – 782 | Calcium permeable stress-gated cation channel 1Add BLAST | 782 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 171 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q06538 |
PaxDbi | Q06538 |
PRIDEi | Q06538 |
PTM databases
iPTMneti | Q06538 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 31508, 47 interactors |
DIPi | DIP-3791N |
IntActi | Q06538, 3 interactors |
MINTi | Q06538 |
STRINGi | 4932.YLR241W |
Miscellaneous databases
RNActi | Q06538, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1134, Eukaryota |
HOGENOMi | CLU_002458_0_2_1 |
InParanoidi | Q06538 |
OMAi | WLWVHTI |
Family and domain databases
InterProi | View protein in InterPro IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06538-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSYIERLKS AASYLDTVPD EHHDFRKPTA KVVTTQLTIA TSLGIFALLS
60 70 80 90 100
FSILLKKWPR LYASRRYKDD GNLRLPSWNQ SSLFGWLTVL YKIRDEQILE
110 120 130 140 150
YAGLDAYVFL SFFKMCIKLL SIFCFFSVCV ISPVRYHFTG KIDDGNDDDD
160 170 180 190 200
SESSLIHLVK RIVEGSGDGD NHSAPERTNV YLWMYVLFTY FFTFIAIKMA
210 220 230 240 250
VAETKHVVST RQAYLGKQNT ITDRTIRLSG IPIELRDSEA LKTRIEQLKI
260 270 280 290 300
GTVSSITICR EWGPLNKLFH CRKKILKNLE LKYSECPREL RTRQPYSENY
310 320 330 340 350
HLLGNEQSGA VTHGENVPSS NNNDEDTILY SQISLGERPK MKIGYRGIFG
360 370 380 390 400
KEVDAIEYLE QQLKFIDAEI IEARKQHYSA TPTAFVTMDS VANAQMAAQA
410 420 430 440 450
VLDPRVHYFI TRLAPAPHDI KWDHVCLSRK DRLTKVYSTT VFIGLSSLFL
460 470 480 490 500
VIPVSYLATL LNLKTLSKFW PSVGQLLKDH QWAANIVTGL LPTYLFTLLN
510 520 530 540 550
FGIPYFYEYL TSYQGLVSYS EEEISLVSKN FFYIFVNLFL VFTLAGTASN
560 570 580 590 600
YWAYLSDTTK IAYQLATSVK EFSLFYVDLI ILQGIGMFPF KLLLVGSLIG
610 620 630 640 650
FPLVKIKAKT PRQRNELYNP PIFNFGLQLP QPILILIITL IYSVMSTKIL
660 670 680 690 700
TSGLAYFIIG FYVYKYQLIF ATDHLPHSTG KVWPLIFRRI IVGLLLFQLT
710 720 730 740 750
MTGTLAGFEG GWVLSSCLFP LPVVTLCFLY DFEKNYLPLS KYIALSSIRE
760 770 780
YERDNSTVNS ANEEESYAYP YAVSELEGPM LD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20865 Genomic DNA Translation: AAB67395.1 BK006945 Genomic DNA Translation: DAA09555.1 |
PIRi | S59387 |
RefSeqi | NP_013342.1, NM_001182128.1 |
Genome annotation databases
EnsemblFungii | YLR241W_mRNA; YLR241W; YLR241W |
GeneIDi | 850942 |
KEGGi | sce:YLR241W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20865 Genomic DNA Translation: AAB67395.1 BK006945 Genomic DNA Translation: DAA09555.1 |
PIRi | S59387 |
RefSeqi | NP_013342.1, NM_001182128.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 31508, 47 interactors |
DIPi | DIP-3791N |
IntActi | Q06538, 3 interactors |
MINTi | Q06538 |
STRINGi | 4932.YLR241W |
Protein family/group databases
TCDBi | 1.A.17.5.11, the calcium-dependent chloride channel (ca-clc) family |
PTM databases
iPTMneti | Q06538 |
Proteomic databases
MaxQBi | Q06538 |
PaxDbi | Q06538 |
PRIDEi | Q06538 |
Genome annotation databases
EnsemblFungii | YLR241W_mRNA; YLR241W; YLR241W |
GeneIDi | 850942 |
KEGGi | sce:YLR241W |
Organism-specific databases
SGDi | S000004231, CSC1 |
VEuPathDBi | FungiDB:YLR241W |
Phylogenomic databases
eggNOGi | KOG1134, Eukaryota |
HOGENOMi | CLU_002458_0_2_1 |
InParanoidi | Q06538 |
OMAi | WLWVHTI |
Miscellaneous databases
PROi | PR:Q06538 |
RNActi | Q06538, protein |
Family and domain databases
InterProi | View protein in InterPro IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSC1_YEAST | |
Accessioni | Q06538Primary (citable) accession number: Q06538 Secondary accession number(s): D6VYN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - SIMILARITY comments
Index of protein domains and families