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UniProtKB - Q06538 (CSC1_YEAST)

Entry version 131 (10 Feb 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Calcium permeable stress-gated cation channel 1

Gene

CSC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by hyperosmotic shock after mannitol treatment.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.17.5.11, the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium permeable stress-gated cation channel 1
Short name:
ScCSC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSC1
Ordered Locus Names:YLR241W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000004231, CSC1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YLR241W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 116CytoplasmicSequence analysisAdd BLAST61
Transmembranei117 – 139HelicalSequence analysisAdd BLAST23
Topological domaini140 – 181ExtracellularSequence analysisAdd BLAST42
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 440CytoplasmicSequence analysisAdd BLAST238
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 485ExtracellularSequence analysisAdd BLAST24
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 530CytoplasmicSequence analysisAdd BLAST24
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 578ExtracellularSequence analysisAdd BLAST27
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Topological domaini600 – 621CytoplasmicSequence analysisAdd BLAST22
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 648ExtracellularSequence analysis6
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 681CytoplasmicSequence analysisAdd BLAST12
Transmembranei682 – 702HelicalSequence analysisAdd BLAST21
Topological domaini703 – 709ExtracellularSequence analysis7
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 782CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002471731 – 782Calcium permeable stress-gated cation channel 1Add BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q06538

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06538

PRoteomics IDEntifications database

More...PRIDEi		Q06538

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q06538

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		31508, 47 interactors

Database of interacting proteins

More...DIPi		DIP-3791N

Protein interaction database and analysis system

More...IntActi		Q06538, 3 interactors

Molecular INTeraction database

More...MINTi		Q06538

STRING: functional protein association networks

More...STRINGi		4932.YLR241W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q06538, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSC1 (TC 1.A.17) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1134, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002458_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q06538

Identification of Orthologs from Complete Genome Data

More...OMAi		WLWVHTI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06538-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSYIERLKS AASYLDTVPD EHHDFRKPTA KVVTTQLTIA TSLGIFALLS 
        60         70         80         90        100
FSILLKKWPR LYASRRYKDD GNLRLPSWNQ SSLFGWLTVL YKIRDEQILE 
       110        120        130        140        150
YAGLDAYVFL SFFKMCIKLL SIFCFFSVCV ISPVRYHFTG KIDDGNDDDD 
       160        170        180        190        200
SESSLIHLVK RIVEGSGDGD NHSAPERTNV YLWMYVLFTY FFTFIAIKMA 
       210        220        230        240        250
VAETKHVVST RQAYLGKQNT ITDRTIRLSG IPIELRDSEA LKTRIEQLKI 
       260        270        280        290        300
GTVSSITICR EWGPLNKLFH CRKKILKNLE LKYSECPREL RTRQPYSENY 
       310        320        330        340        350
HLLGNEQSGA VTHGENVPSS NNNDEDTILY SQISLGERPK MKIGYRGIFG 
       360        370        380        390        400
KEVDAIEYLE QQLKFIDAEI IEARKQHYSA TPTAFVTMDS VANAQMAAQA 
       410        420        430        440        450
VLDPRVHYFI TRLAPAPHDI KWDHVCLSRK DRLTKVYSTT VFIGLSSLFL 
       460        470        480        490        500
VIPVSYLATL LNLKTLSKFW PSVGQLLKDH QWAANIVTGL LPTYLFTLLN 
       510        520        530        540        550
FGIPYFYEYL TSYQGLVSYS EEEISLVSKN FFYIFVNLFL VFTLAGTASN 
       560        570        580        590        600
YWAYLSDTTK IAYQLATSVK EFSLFYVDLI ILQGIGMFPF KLLLVGSLIG 
       610        620        630        640        650
FPLVKIKAKT PRQRNELYNP PIFNFGLQLP QPILILIITL IYSVMSTKIL 
       660        670        680        690        700
TSGLAYFIIG FYVYKYQLIF ATDHLPHSTG KVWPLIFRRI IVGLLLFQLT 
       710        720        730        740        750
MTGTLAGFEG GWVLSSCLFP LPVVTLCFLY DFEKNYLPLS KYIALSSIRE 
       760        770        780 
YERDNSTVNS ANEEESYAYP YAVSELEGPM LD
Length:782
Mass (Da):89,344
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DFD926B98FA15DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U20865 Genomic DNA Translation: AAB67395.1
BK006945 Genomic DNA Translation: DAA09555.1

Protein sequence database of the Protein Information Resource

More...PIRi		S59387

NCBI Reference Sequences

More...RefSeqi		NP_013342.1, NM_001182128.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YLR241W_mRNA; YLR241W; YLR241W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		850942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YLR241W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20865 Genomic DNA Translation: AAB67395.1
BK006945 Genomic DNA Translation: DAA09555.1
PIRiS59387
RefSeqiNP_013342.1, NM_001182128.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31508, 47 interactors
DIPiDIP-3791N
IntActiQ06538, 3 interactors
MINTiQ06538
STRINGi4932.YLR241W

Protein family/group databases

TCDBi1.A.17.5.11, the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetiQ06538

Proteomic databases

MaxQBiQ06538
PaxDbiQ06538
PRIDEiQ06538

Genome annotation databases

EnsemblFungiiYLR241W_mRNA; YLR241W; YLR241W
GeneIDi850942
KEGGisce:YLR241W

Organism-specific databases

SGDiS000004231, CSC1
VEuPathDBiFungiDB:YLR241W

Phylogenomic databases

eggNOGiKOG1134, Eukaryota
HOGENOMiCLU_002458_0_2_1
InParanoidiQ06538
OMAiWLWVHTI

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q06538
RNActiQ06538, protein

Family and domain databases

InterProiView protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM
PfamiView protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSC1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06538
Secondary accession number(s): D6VYN9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: February 10, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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