UniProtKB - Q06507 (ATF4_MOUSE)
Cyclic AMP-dependent transcription factor ATF-4
Atf4
Functioni
Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:8506317, PubMed:11106749, PubMed:12667446, PubMed:23624402).
Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (PubMed:8506317, PubMed:23624402).
Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:11106749, PubMed:12667446).
During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:11106749, PubMed:12667446).
Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (PubMed:12667446).
Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (By similarity).
Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:15775988, PubMed:21159964).
However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (By similarity).
Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (PubMed:23624402).
Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988, PubMed:17369260, PubMed:21159964).
May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (By similarity).
In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (PubMed:10096021, PubMed:10885750, PubMed:11806972, PubMed:12925279, PubMed:15109498, PubMed:22298775).
Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498).
Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (PubMed:22298775).
Activates transcription of SIRT4 (PubMed:23663782).
Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (PubMed:21768648, PubMed:22572884).
Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (PubMed:21768648, PubMed:22572884).
Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (PubMed:12925279).
Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471).
By similarity17 PublicationsGO - Molecular functioni
- cAMP response element binding protein binding Source: UniProtKB
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor binding Source: MGI
- general transcription initiation factor binding Source: MGI
- identical protein binding Source: MGI
- leucine zipper domain binding Source: MGI
- promoter-specific chromatin binding Source: MGI
- protein C-terminus binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
GO - Biological processi
- bone mineralization Source: UniProtKB
- cellular calcium ion homeostasis Source: MGI
- cellular response to amino acid starvation Source: UniProtKB
- cellular response to dopamine Source: MGI
- cellular response to glucose starvation Source: MGI
- cellular response to leucine starvation Source: MGI
- cellular response to oxidative stress Source: UniProtKB
- cellular response to oxygen-glucose deprivation Source: Ensembl
- circadian regulation of gene expression Source: UniProtKB
- circadian rhythm Source: UniProtKB
- embryonic hemopoiesis Source: UniProtKB
- endoplasmic reticulum unfolded protein response Source: UniProtKB
- gamma-aminobutyric acid signaling pathway Source: MGI
- gluconeogenesis Source: MGI
- HRI-mediated signaling Source: UniProtKB
- integrated stress response signaling Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
- L-asparagine metabolic process Source: MGI
- lens fiber cell morphogenesis Source: UniProtKB
- mRNA transcription by RNA polymerase II Source: UniProtKB
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of oxidative stress-induced neuron death Source: MGI
- negative regulation of potassium ion transport Source: MGI
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neuron differentiation Source: Ensembl
- PERK-mediated unfolded protein response Source: UniProtKB
- positive regulation of biomineral tissue development Source: MGI
- positive regulation of gene expression Source: ParkinsonsUK-UCL
- positive regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of sodium-dependent phosphate transport Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase I Source: MGI
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: MGI
- positive regulation of vascular associated smooth muscle cell apoptotic process Source: MGI
- positive regulation of vascular endothelial growth factor production Source: MGI
- regulation of osteoblast differentiation Source: UniProtKB
- regulation of synaptic plasticity Source: UniProtKB
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- response to endoplasmic reticulum stress Source: UniProtKB
- response to manganese-induced endoplasmic reticulum stress Source: Ensembl
- response to nutrient levels Source: MGI
- response to toxic substance Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic AMP-dependent transcription factor ATF-4CuratedShort name: cAMP-dependent transcription factor ATF-4Curated Alternative name(s): Activating transcription factor 41 Publication C/EBP-related ATF1 Publication Short name: C/ATF1 Publication Cyclic AMP-responsive element-binding protein 21 Publication Short name: CREB-21 Publication Short name: cAMP-responsive element-binding protein 21 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88096, Atf4 |
VEuPathDBi | HostDB:ENSMUSG00000042406 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
- Nucleus speckle By similarity
Plasma membrane
- Cell membrane By similarity
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoskeleton
- centrosome By similarity
Note: Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Colocalizes with NEK6 in the centrosome (By similarity). Recruited to nuclear speckles following interaction with EP300/p300 (By similarity).By similarity
Cytoskeleton
- centrosome Source: Ensembl
Nucleus
- ATF1-ATF4 transcription factor complex Source: ParkinsonsUK-UCL
- ATF4-CREB1 transcription factor complex Source: ParkinsonsUK-UCL
- CHOP-ATF4 complex Source: MGI
- nuclear periphery Source: MGI
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: MGI
Plasma Membrane
- dendrite membrane Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- Lewy body core Source: MGI
- neuron projection Source: MGI
- protein-containing complex Source: MGI
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 212 | T → A: Promotes stabilization due to impaired ubiquitination; when associated with A-223; A-230; A-234 and A-247. 1 Publication | 1 | |
Mutagenesisi | 218 | S → A: Promotes stabilization due to impaired ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 223 | S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-230; A-234 and A-247. 1 Publication | 1 | |
Mutagenesisi | 230 | S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-234 and A-247. 1 Publication | 1 | |
Mutagenesisi | 234 | S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-247. 1 Publication | 1 | |
Mutagenesisi | 247 | S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-234. Does not affect phosphorylation by RPS6KA3/RSK2. 2 Publications | 1 | |
Mutagenesisi | 251 | S → A, R or D: Abolished phosphorylation by RPS6KA3/RSK2. 1 Publication | 1 | |
Mutagenesisi | 254 | S → A: Does not affect phosphorylation by RPS6KA3/RSK2. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076585 | 1 – 349 | Cyclic AMP-dependent transcription factor ATF-4Add BLAST | 349 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 212 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 214 | PhosphoserineBy similarity | 1 | |
Modified residuei | 218 | Phosphoserine1 Publication | 1 | |
Modified residuei | 223 | Phosphoserine1 Publication | 1 | |
Modified residuei | 230 | Phosphoserine1 Publication | 1 | |
Modified residuei | 234 | Phosphoserine1 Publication | 1 | |
Modified residuei | 235 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 247 | Phosphoserine1 Publication | 1 | |
Modified residuei | 251 | Phosphoserine; by RPS6KA31 Publication | 1 | |
Cross-linki | 258 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 270 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 309 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Hydroxylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q06507 |
PRIDEi | Q06507 |
ProteomicsDBi | 265159 |
PTM databases
iPTMneti | Q06507 |
PhosphoSitePlusi | Q06507 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000042406, Expressed in retina and 353 other tissues |
ExpressionAtlasi | Q06507, baseline and differential |
Genevisiblei | Q06507, MM |
Interactioni
Subunit structurei
Binds DNA as a homodimer and as a heterodimer (PubMed:23624402). Heterodimer; heterodimerizes with CEBPB (PubMed:11018027). Heterodimer; heterodimerizes with DDIT3/CHOP (PubMed:23624402).
Interacts with CEP290 (via an N-terminal region) (By similarity).
Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3 (By similarity).
Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini) (By similarity).
Forms a heterodimer with TXLNG in osteoblasts (PubMed:15911876).
Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production (PubMed:22298775).
Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors (PubMed:16751105).
Interacts with ABRAXAS2 (PubMed:22974638).
Interacts with TRIB3, inhibiting the transactivation activity of ATF4 (PubMed:17369260).
Interacts with DISC1; which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471).
Interacts with EP300/p300; EP300/p300 stabilizes ATF4 and increases its transcriptional activity independently of its catalytic activity by preventing its ubiquitination (By similarity).
By similarity8 PublicationsBinary interactionsi
Q06507
With | #Exp. | IntAct |
---|---|---|
Dapk3 [O54784] | 3 | EBI-77383,EBI-77359 |
Ddit3 [P35639] | 3 | EBI-77383,EBI-10636142 |
Trib3 [Q8K4K2] | 3 | EBI-77383,EBI-448962 |
GO - Molecular functioni
- cAMP response element binding protein binding Source: UniProtKB
- DNA-binding transcription factor binding Source: MGI
- general transcription initiation factor binding Source: MGI
- identical protein binding Source: MGI
- leucine zipper domain binding Source: MGI
- protein C-terminus binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198235, 11 interactors |
ComplexPortali | CPX-6, bZIP transcription factor complex, Atf4-Creb1 CPX-7, bZIP transcription factor complex, Atf1-Atf4 |
CORUMi | Q06507 |
DIPi | DIP-30969N |
IntActi | Q06507, 10 interactors |
STRINGi | 10090.ENSMUSP00000105234 |
Miscellaneous databases
RNActi | Q06507, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q06507 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 276 – 339 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 49 – 75 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 204 – 271 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 278 – 298 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 279 – 298 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 303 – 339 | Interaction with GABBR1By similarityAdd BLAST | 37 | |
Regioni | 304 – 332 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 214 – 223 | BetaTrCP degron motif1 Publication | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 216 – 244 | Polar residuesSequence analysisAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4571, Eukaryota |
GeneTreei | ENSGT00530000063801 |
HOGENOMi | CLU_055748_1_0_1 |
InParanoidi | Q06507 |
OMAi | IVNPIGH |
OrthoDBi | 1524842at2759 |
TreeFami | TF316136 |
Family and domain databases
InterProi | View protein in InterPro IPR029811, ATF4 IPR004827, bZIP |
PANTHERi | PTHR13044:SF32, PTHR13044:SF32, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTEMSFLNSE VLAGDLMSPF DQSGLGAEES LGLLDDYLEV AKHLKPHGFS
60 70 80 90 100
SDKAGSSEWP AMDDGLASAS DTGKEDAFSG TDWMLEKMDL KEFDFDALFR
110 120 130 140 150
MDDLETMPDE LLTTLDDTCD LFAPLVQETN KEPPQTVNPI GHLPESLIKV
160 170 180 190 200
DQVAPFTFLQ PFPCSPGVLS STPEHSFSLE LGSEVDISEG DRKPDSAAYI
210 220 230 240 250
TLIPPCVKEE DTPSDNDSGI CMSPESYLGS PQHSPSTSRA PPDNLPSPGG
260 270 280 290 300
SRGSPRPKPY DPPGVSLTAK VKTEKLDKKL KKMEQNKTAA TRYRQKKRAE
310 320 330 340
QEALTGECKE LEKKNEALKE KADSLAKEIQ YLKDLIEEVR KARGKKRVP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8VI82 | A0A2R8VI82_MOUSE | Cyclic AMP-dependent transcription ... | Atf4 | 116 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 345 | K → Q in AAA40476 (PubMed:8506317).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13791 mRNA Translation: AAA40476.1 M94087 mRNA Translation: AAA53043.1 Different initiation. AK138657 mRNA Translation: BAE23736.1 AK144777 mRNA Translation: BAE26060.1 AK146193 mRNA Translation: BAE26967.1 AK156298 mRNA Translation: BAE33662.1 CH466550 Genomic DNA Translation: EDL04604.1 CH466550 Genomic DNA Translation: EDL04605.1 BC085169 mRNA Translation: AAH85169.1 |
CCDSi | CCDS37145.1 |
RefSeqi | NP_001274109.1, NM_001287180.1 NP_033846.2, NM_009716.3 |
Genome annotation databases
Ensembli | ENSMUST00000109605; ENSMUSP00000105234; ENSMUSG00000042406 |
GeneIDi | 11911 |
KEGGi | mmu:11911 |
UCSCi | uc007wvl.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13791 mRNA Translation: AAA40476.1 M94087 mRNA Translation: AAA53043.1 Different initiation. AK138657 mRNA Translation: BAE23736.1 AK144777 mRNA Translation: BAE26060.1 AK146193 mRNA Translation: BAE26967.1 AK156298 mRNA Translation: BAE33662.1 CH466550 Genomic DNA Translation: EDL04604.1 CH466550 Genomic DNA Translation: EDL04605.1 BC085169 mRNA Translation: AAH85169.1 |
CCDSi | CCDS37145.1 |
RefSeqi | NP_001274109.1, NM_001287180.1 NP_033846.2, NM_009716.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6IRR | NMR | - | A | 314-349 | [»] | |
SMRi | Q06507 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198235, 11 interactors |
ComplexPortali | CPX-6, bZIP transcription factor complex, Atf4-Creb1 CPX-7, bZIP transcription factor complex, Atf1-Atf4 |
CORUMi | Q06507 |
DIPi | DIP-30969N |
IntActi | Q06507, 10 interactors |
STRINGi | 10090.ENSMUSP00000105234 |
PTM databases
iPTMneti | Q06507 |
PhosphoSitePlusi | Q06507 |
Proteomic databases
PaxDbi | Q06507 |
PRIDEi | Q06507 |
ProteomicsDBi | 265159 |
Protocols and materials databases
Antibodypediai | 12687, 1126 antibodies from 46 providers |
DNASUi | 11911 |
Genome annotation databases
Ensembli | ENSMUST00000109605; ENSMUSP00000105234; ENSMUSG00000042406 |
GeneIDi | 11911 |
KEGGi | mmu:11911 |
UCSCi | uc007wvl.2, mouse |
Organism-specific databases
CTDi | 468 |
MGIi | MGI:88096, Atf4 |
VEuPathDBi | HostDB:ENSMUSG00000042406 |
Phylogenomic databases
eggNOGi | KOG4571, Eukaryota |
GeneTreei | ENSGT00530000063801 |
HOGENOMi | CLU_055748_1_0_1 |
InParanoidi | Q06507 |
OMAi | IVNPIGH |
OrthoDBi | 1524842at2759 |
TreeFami | TF316136 |
Miscellaneous databases
BioGRID-ORCSi | 11911, 19 hits in 70 CRISPR screens |
ChiTaRSi | Atf4, mouse |
PROi | PR:Q06507 |
RNActi | Q06507, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042406, Expressed in retina and 353 other tissues |
ExpressionAtlasi | Q06507, baseline and differential |
Genevisiblei | Q06507, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029811, ATF4 IPR004827, bZIP |
PANTHERi | PTHR13044:SF32, PTHR13044:SF32, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATF4_MOUSE | |
Accessioni | Q06507Primary (citable) accession number: Q06507 Secondary accession number(s): Q5U4B2, Q61906 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families