Atf4

Functionⁱ

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.7 Publications

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12749859
- 15724149
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23663782
leucine zipper domain binding Source: MGI
protein C-terminus binding Source: MGI
protein heterodimerization activity
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 14729979
protein kinase binding Source: MGI
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21768648
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 27812542
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI
RNA polymerase II transcription factor binding Source: MGI
sequence-specific DNA binding Source: MGI
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 15788408
transcription factor binding Source: MGI
transcription regulatory region DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular calcium ion homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 27812542
cellular response to amino acid starvation
Source: UniProtKB
Inferred from direct assayⁱ
- 11106749
cellular response to dopamine Source: MGI
cellular response to glucose starvation Source: MGI
cellular response to oxygen-glucose deprivation Source: Ensembl
circadian regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21768648
circadian rhythm
Source: UniProtKB
Inferred from expression patternⁱ
- 21768648
gamma-aminobutyric acid signaling pathway Source: MGI
gluconeogenesis
Source: MGI
Inferred from direct assayⁱ
- 11916968
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21159964
mRNA transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11106749
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 22980225
negative regulation of oxidative stress-induced neuron death Source: MGI
negative regulation of potassium ion transport Source: MGI
neuron differentiation Source: Ensembl
PERK-mediated unfolded protein response
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 14729979
positive regulation of biomineral tissue development
Source: MGI
Inferred from mutant phenotypeⁱ
- 27812542
positive regulation of gene expression
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 14729979
positive regulation of neuron apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21159964
positive regulation of sodium-dependent phosphate transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 27812542
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 21768648
positive regulation of transcription by RNA polymerase I Source: MGI
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 23663782
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 12871976
- 21113145
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: MGI
positive regulation of vascular associated smooth muscle cell apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 27812542
positive regulation of vascular endothelial growth factor production Source: MGI
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 11916968
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 12749859
response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from direct assayⁱ
- 11106749
- 21159964
response to manganese-induced endoplasmic reticulum stress Source: Ensembl
response to toxic substance Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclic AMP-dependent transcription factor ATF-4 Short name: cAMP-dependent transcription factor ATF-4 Alternative name(s): Activating transcription factor 4 C/EBP-related ATF Short name: C/ATF Tax-responsive enhancer element-binding protein 67 homolog Short name: TaxREB67 homolog
Gene namesⁱ	Name:Atf4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:88096 Atf4

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Null mice exhibit an increase in serum insulin levels and low blood glucose levels. There is a decrease in total fat content, gonadal fat, lean mass and body weight. Serum levels of osteocalcin/BGLAP are decreased. PBK/AKT1-mediated phosphorylation of FOXO1 at 'Ser-258' is increased with a subsequent decrease of FOXO1-mediated transcriptional activity.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	212	T → A: Promotes stabilization due to impaired ubiquitination; when associated with A-223; A-230; A-234 and A-247. 1 Publication	1
Mutagenesisⁱ	218	S → A: Promotes stabilization due to impaired ubiquitination. 1 Publication	1
Mutagenesisⁱ	223	S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-230; A-234 and A-247. 1 Publication	1
Mutagenesisⁱ	230	S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-234 and A-247. 1 Publication	1
Mutagenesisⁱ	234	S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-247. 1 Publication	1
Mutagenesisⁱ	247	S → A: Promotes stabilization due to impaired ubiquitination; when associated with A-212; A-223; A-230 and A-234. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076585	1 – 349	Cyclic AMP-dependent transcription factor ATF-4Add BLAST		349

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	212	Phosphothreonine1 Publication	1
Modified residueⁱ	218	Phosphoserine1 Publication	1
Modified residueⁱ	223	Phosphoserine1 Publication	1
Modified residueⁱ	230	Phosphoserine1 Publication	1
Modified residueⁱ	234	Phosphoserine1 Publication	1
Modified residueⁱ	247	Phosphoserine1 Publication	1
Cross-linkⁱ	258	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	270	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Phosphorylated by NEK6 (By similarity). Phosphorylated on the betaTrCP degron motif at Ser-218, followed by phosphorylation at Thr-212, Ser-223, Ser-230, Ser-234 and Ser-247, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1.By similarity1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q06507
PRIDEⁱ	Q06507

PTM databases

iPTMnetⁱ	Q06507
PhosphoSitePlusⁱ	Q06507

Expressionⁱ

Developmental stageⁱ

At E16.5, expressed in osteoblasts surrounding newly formed trabecular bone. At postnatal day 2, detected in most osteoblasts and lining cells. By postnatal week 4, is detected in fewer osteoblasts, but remains present in lining cells (at protein level).1 Publication

Inductionⁱ

By ER stress. Expressed in a circadian manner in the liver with an increased expression seen during the light phase. Expressed in a circadian manner in the midbrain with an increased expression seen during the dark phase (at protein level). Expressed in a circadian manner also in the suprachiasmatic nucleus (SCN) of the brain, cerebral cortex, kidney and small intestine.3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000042406 Expressed in 334 organ(s), highest expression level in retina
CleanExⁱ	MM_ATF4
Genevisibleⁱ	Q06507 MM

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer and as a heterodimer (By similarity). Interacts with CEBPB and binds DNA as a heterodimer with CEBPB (PubMed:11018027). Interacts with CEP290 (via an N-terminal region). Interacts with NEK6, DAPK2 (isoform 2) and ZIPK/DAPK3. Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via their C-termini) (By similarity). Forms a heterodimer with TXLNG in osteoblasts (PubMed:15911876). Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin production (PubMed:22298775). Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors (PubMed:16751105). Interacts with DDIT3/CHOP (By similarity). Interacts with ABRAXAS2 (PubMed:22974638).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Dapk3	O54784	3	EBI-77383,EBI-77359
Ddit3	P35639	3	EBI-77383,EBI-10636142
Trib3	Q8K4K2	3	EBI-77383,EBI-448962

GO - Molecular functionⁱ

leucine zipper domain binding Source: MGI
protein C-terminus binding Source: MGI
protein heterodimerization activity
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 14729979
protein kinase binding Source: MGI
RNA polymerase II transcription factor binding Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198235, 11 interactors
ComplexPortalⁱ	CPX-6 ATF4-CREB1 transcription factor complex CPX-7 ATF1-ATF4 transcription factor complex
CORUMⁱ	Q06507
Database of interacting proteins More...DIPⁱ	DIP-30969N
IntActⁱ	Q06507, 9 interactors
STRINGⁱ	10090.ENSMUSP00000105234

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q06507
SMRⁱ	Q06507
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	276 – 339	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	278 – 298	Basic motifPROSITE-ProRule annotationAdd BLAST	21
Regionⁱ	303 – 339	Interaction with GABBR1By similarityAdd BLAST	37
Regionⁱ	304 – 332	Leucine-zipperPROSITE-ProRule annotationAdd BLAST	29

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	214 – 223	BetaTrCP degron motif		10

Domainⁱ

Sequence similaritiesⁱ

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4571 Eukaryota ENOG4111ZXT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063801
HOVERGENⁱ	HBG004301
InParanoidⁱ	Q06507
KEGG Orthology (KO) More...KOⁱ	K04374
OMAⁱ	AFSGMDW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FNW
TreeFamⁱ	TF316136

Family and domain databases

InterProⁱ	View protein in InterPro IPR029811 ATF4 IPR004827 bZIP
PANTHERⁱ	PTHR13044:SF2 PTHR13044:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q06507-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTEMSFLNSE VLAGDLMSPF DQSGLGAEES LGLLDDYLEV AKHLKPHGFS 
        60         70         80         90        100
SDKAGSSEWP AMDDGLASAS DTGKEDAFSG TDWMLEKMDL KEFDFDALFR 
       110        120        130        140        150
MDDLETMPDE LLTTLDDTCD LFAPLVQETN KEPPQTVNPI GHLPESLIKV 
       160        170        180        190        200
DQVAPFTFLQ PFPCSPGVLS STPEHSFSLE LGSEVDISEG DRKPDSAAYI 
       210        220        230        240        250
TLIPPCVKEE DTPSDNDSGI CMSPESYLGS PQHSPSTSRA PPDNLPSPGG 
       260        270        280        290        300
SRGSPRPKPY DPPGVSLTAK VKTEKLDKKL KKMEQNKTAA TRYRQKKRAE 
       310        320        330        340 
QEALTGECKE LEKKNEALKE KADSLAKEIQ YLKDLIEEVR KARGKKRVP

Length:349

Mass (Da):38,355

Last modified:July 27, 2011 - v2

Checksum:ⁱ0C3F895755B1C7B9

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A2R8VI82	A0A2R8VI82_MOUSE		Cyclic AMP-dependent transcription ... Cyclic AMP-dependent transcription factor ATF-4	Atf4	116	Annotation score:

Sequence cautionⁱ

The sequence AAA53043 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	345	K → Q in AAA40476 (PubMed:8506317).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13791 mRNA Translation: AAA40476.1 M94087 mRNA Translation: AAA53043.1 Different initiation. AK138657 mRNA Translation: BAE23736.1 AK144777 mRNA Translation: BAE26060.1 AK146193 mRNA Translation: BAE26967.1 AK156298 mRNA Translation: BAE33662.1 CH466550 Genomic DNA Translation: EDL04604.1 CH466550 Genomic DNA Translation: EDL04605.1 BC085169 mRNA Translation: AAH85169.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37145.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001274109.1, NM_001287180.1 NP_033846.2, NM_009716.3
UniGeneⁱ	Mm.641

Genome annotation databases

Ensemblⁱ	ENSMUST00000109605; ENSMUSP00000105234; ENSMUSG00000042406
GeneIDⁱ	11911
KEGGⁱ	mmu:11911
UCSC genome browser More...UCSCⁱ	uc007wvl.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q06507	Cyclic AMP-dependent transcription factor ATF-4 (Fragment)		MOUSE		116	UniRef100_Q06507
Uncharacterized protein (Fragment)		MOUSE		153

Protein	Similar proteins		Species	Score	Length	Source
Q06507	Cyclic AMP-dependent transcription factor ATF-4		RAT		347	UniRef90_Q06507
Cyclic AMP-dependent transcription factor ATF-4 (Fragment)		MOUSE		116
Cyclic AMP-dependent transcription factor ATF-4-like protein		Daphnia magna		67
UPI000A313B2D		MUSPA		350
UPI000A314AE0		MUSCR		349
+6

Protein	Similar proteins		Species	Score	Length	Source
Q06507	Cyclic AMP-dependent transcription factor ATF-4	)	HUMAN		351	UniRef50_P18848
Cyclic AMP-dependent transcription factor ATF-4		BOVIN		348
Cyclic AMP-dependent transcription factor ATF-4		RAT		347
Uncharacterized protein		OTOGA		352
Activating transcription factor 4		PONAB		352
+262

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13791 mRNA Translation: AAA40476.1 M94087 mRNA Translation: AAA53043.1 Different initiation. AK138657 mRNA Translation: BAE23736.1 AK144777 mRNA Translation: BAE26060.1 AK146193 mRNA Translation: BAE26967.1 AK156298 mRNA Translation: BAE33662.1 CH466550 Genomic DNA Translation: EDL04604.1 CH466550 Genomic DNA Translation: EDL04605.1 BC085169 mRNA Translation: AAH85169.1
CCDSⁱ	CCDS37145.1
RefSeqⁱ	NP_001274109.1, NM_001287180.1 NP_033846.2, NM_009716.3
UniGeneⁱ	Mm.641

3D structure databases

ProteinModelPortalⁱ	Q06507
SMRⁱ	Q06507
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198235, 11 interactors
ComplexPortalⁱ	CPX-6 ATF4-CREB1 transcription factor complex CPX-7 ATF1-ATF4 transcription factor complex
CORUMⁱ	Q06507
DIPⁱ	DIP-30969N
IntActⁱ	Q06507, 9 interactors
STRINGⁱ	10090.ENSMUSP00000105234

PTM databases

iPTMnetⁱ	Q06507
PhosphoSitePlusⁱ	Q06507

Proteomic databases

PaxDbⁱ	Q06507
PRIDEⁱ	Q06507

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000109605; ENSMUSP00000105234; ENSMUSG00000042406
GeneIDⁱ	11911
KEGGⁱ	mmu:11911
UCSCⁱ	uc007wvl.2 mouse

Organism-specific databases

CTDⁱ	468
MGIⁱ	MGI:88096 Atf4

Phylogenomic databases

eggNOGⁱ	KOG4571 Eukaryota ENOG4111ZXT LUCA
GeneTreeⁱ	ENSGT00530000063801
HOVERGENⁱ	HBG004301
InParanoidⁱ	Q06507
KOⁱ	K04374
OMAⁱ	AFSGMDW
OrthoDBⁱ	EOG091G0FNW
TreeFamⁱ	TF316136

Miscellaneous databases

ChiTaRSⁱ	Atf4 mouse
Protein Ontology More...PROⁱ	PR:Q06507
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042406 Expressed in 334 organ(s), highest expression level in retina
CleanExⁱ	MM_ATF4
Genevisibleⁱ	Q06507 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR029811 ATF4 IPR004827 bZIP
PANTHERⁱ	PTHR13044:SF2 PTHR13044:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATF4_MOUSE
Accessionⁱ	Q06507Primary (citable) accession number: Q06507 Secondary accession number(s): Q5U4B2, Q61906
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	July 27, 2011
	Last modified:	October 10, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q06507 (ATF4_MOUSE)

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Cyclic AMP-dependent transcription factor ATF-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Plasma membrane

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ