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UniProtKB - Q06497 (ANT1_YEAST)
Protein
Peroxisomal adenine nucleotide transporter 1
Gene
ANT1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation.
4 PublicationsMiscellaneous
Present with 2250 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- adenine nucleotide transmembrane transporter activity Source: SGD
- ADP transmembrane transporter activity Source: GO_Central
- ATP transmembrane transporter activity Source: GO_Central
GO - Biological processi
- ADP transport Source: GO_Central
- ATP transport Source: SGD
- fatty acid beta-oxidation Source: SGD
- peroxisome organization Source: SGD
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Protein family/group databases
TCDBi | 2.A.29.17.1, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal adenine nucleotide transporter 1 |
Gene namesi | Name:ANT1 Ordered Locus Names:YPR128C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006332, ANT1 |
VEuPathDBi | FungiDB:YPR128C |
Subcellular locationi
Peroxisome
- Peroxisome membrane 3 Publications; Multi-pass membrane protein 3 Publications
Peroxisome
- integral component of peroxisomal membrane Source: SGD
Other locations
- cytoplasm Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 128 – 148 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 185 – 202 | Helical; Name=4Sequence analysisAdd BLAST | 18 | |
Transmembranei | 226 – 246 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 277 – 297 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227603 | 1 – 328 | Peroxisomal adenine nucleotide transporter 1Add BLAST | 328 |
Proteomic databases
MaxQBi | Q06497 |
PaxDbi | Q06497 |
PRIDEi | Q06497 |
PTM databases
iPTMneti | Q06497 |
Expressioni
Inductioni
Induced by oleic acid, through its ORE-like (oleate responsive element) promoter element and the PIP2-OAF1 transcription factors.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 36295, 98 interactors |
DIPi | DIP-8825N |
IntActi | Q06497, 2 interactors |
MINTi | Q06497 |
STRINGi | 4932.YPR128C |
Miscellaneous databases
RNActi | Q06497, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1 – 101 | Solcar 1Add BLAST | 101 | |
Repeati | 122 – 208 | Solcar 2Add BLAST | 87 | |
Repeati | 220 – 304 | Solcar 3Add BLAST | 85 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0769, Eukaryota |
HOGENOMi | CLU_015166_6_3_1 |
InParanoidi | Q06497 |
OMAi | PHYTSTW |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR045900, Peroxisomal_Ade_carrier |
PANTHERi | PTHR46650, PTHR46650, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q06497-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTLESALTG AVASAMANIA VYPLDLSKTI IQSQVSPSSS EDSNEGKVLP
60 70 80 90 100
NRRYKNVVDC MINIFKEKGI LGLYQGMTVT TVATFVQNFV YFFWYTFIRK
110 120 130 140 150
SYMKHKLLGL QSLKNRDGPI TPSTIEELVL GVAAASISQL FTSPMAVVAT
160 170 180 190 200
RQQTVHSAES AKFTNVIKDI YRENNGDITA FWKGLRTGLA LTINPSITYA
210 220 230 240 250
SFQRLKEVFF HDHSNDAGSL SAVQNFILGV LSKMISTLVT QPLIVAKAML
260 270 280 290 300
QSAGSKFTTF QEALLYLYKN EGLKSLWKGV LPQLTKGVIV QGLLFAFRGE
310 320
LTKSLKRLIF LYSSFFLKHN GQRKLAST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40829 Genomic DNA Translation: AAB68270.1 BK006949 Genomic DNA Translation: DAA11541.1 |
PIRi | S69019 |
RefSeqi | NP_015453.1, NM_001184225.1 |
Genome annotation databases
EnsemblFungii | YPR128C_mRNA; YPR128C; YPR128C |
GeneIDi | 856246 |
KEGGi | sce:YPR128C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40829 Genomic DNA Translation: AAB68270.1 BK006949 Genomic DNA Translation: DAA11541.1 |
PIRi | S69019 |
RefSeqi | NP_015453.1, NM_001184225.1 |
3D structure databases
SMRi | Q06497 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36295, 98 interactors |
DIPi | DIP-8825N |
IntActi | Q06497, 2 interactors |
MINTi | Q06497 |
STRINGi | 4932.YPR128C |
Protein family/group databases
TCDBi | 2.A.29.17.1, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q06497 |
Proteomic databases
MaxQBi | Q06497 |
PaxDbi | Q06497 |
PRIDEi | Q06497 |
Genome annotation databases
EnsemblFungii | YPR128C_mRNA; YPR128C; YPR128C |
GeneIDi | 856246 |
KEGGi | sce:YPR128C |
Organism-specific databases
SGDi | S000006332, ANT1 |
VEuPathDBi | FungiDB:YPR128C |
Phylogenomic databases
eggNOGi | KOG0769, Eukaryota |
HOGENOMi | CLU_015166_6_3_1 |
InParanoidi | Q06497 |
OMAi | PHYTSTW |
Miscellaneous databases
PROi | PR:Q06497 |
RNActi | Q06497, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR045900, Peroxisomal_Ade_carrier |
PANTHERi | PTHR46650, PTHR46650, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ANT1_YEAST | |
Accessioni | Q06497Primary (citable) accession number: Q06497 Secondary accession number(s): D6W4C5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families