Sodium-dependent phosphate transport protein 2A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate."
    Lundquist P., Murer H., Biber J.
    Cell Physiol Biochem 19:43-56(2007) [PubMed] [Europe PMC] [Abstract]
  • "Involvement of disulphide bonds in the renal sodium/phosphate co-transporter NaPi-2."
    Xiao Y., Boyer C.J., Vincent E., Dugre A., Vachon V., Potier M., Beliveau R.
    Biochem J 323:401-408(1997) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGDInferred from physical interactionⁱ
  • "Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells."
    McWilliams R.R., Breusegem S.Y., Brodsky K.F., Kim E., Levi M., Doctor R.B.
    Am J Physiol Cell Physiol 289:C1042-51(2005) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis."
    Tanimura A., Yamada F., Saito A., Ito M., Kimura T., Anzai N., Horie D., Yamamoto H., Miyamoto K., Taketani Y., Takeda E.
    J Med Invest 58:140-147(2011) [PubMed] [Europe PMC] [Abstract]
• sodium:phosphate symporter activity Source: UniProtKB

GO - Biological processⁱ

• arsenate ion transmembrane transport Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Arsenate transport by sodium/phosphate cotransporter type IIb."
    Villa-Bellosta R., Sorribas V.
    Toxicol Appl Pharmacol 247:36-40(2010) [PubMed] [Europe PMC] [Abstract]
• bone remodeling Source: RGD
• cellular phosphate ion homeostasis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to metal ion Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells."
    Muller D., Houpert P., Cambar J., Henge-Napoli M.H.
    Toxicol Appl Pharmacol 214:166-177(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to parathyroid hormone stimulus Source: RGDInferred from expression patternⁱ
  • "Overexpression of regucalcin enhances its nuclear localization and suppresses L-type Ca2+ channel and calcium-sensing receptor mRNA expressions in cloned normal rat kidney proximal tubular epithelial NRK52E cells."
    Nakagawa T., Yamaguchi M.
    J Cell Biochem 99:1064-1077(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to staurosporine Source: RGDInferred from expression patternⁱ
  • "Protein kinase C activators induce membrane retrieval of type II Na+-phosphate cotransporters expressed in Xenopus oocytes."
    Forster I.C., Traebert M., Jankowski M., Stange G., Biber J., Murer H.
    J Physiol 517:327-340(1999) [PubMed] [Europe PMC] [Abstract]
• dentinogenesis Source: RGDInferred from expression patternⁱ
  • "Phosphate and calcium uptake by rat odontoblast-like MRPC-1 cells concomitant with mineralization."
    Lundquist P., Ritchie H.H., Moore K., Lundgren T., Linde A.
    J Bone Miner Res 17:1801-1813(2002) [PubMed] [Europe PMC] [Abstract]
• gentamycin metabolic process Source: RGDInferred from expression patternⁱ
  • "Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2)."
    Sorribas V., Halaihel N., Puttaparthi K., Rogers T., Cronin R.E., Alcalde A.I., Aramayona J., Sarasa M., Wang H., Wilson P., Zajicek H., Levi M.
    Kidney Int 59:1024-1036(2001) [PubMed] [Europe PMC] [Abstract]
• glycoprotein metabolic process Source: RGDInferred from expression patternⁱ
  • "Matrix extracellular phosphoglycoprotein inhibits phosphate transport."
    Marks J., Churchill L.J., Debnam E.S., Unwin R.J.
    J. Am. Soc. Nephrol. 19:2313-2320(2008) [PubMed] [Europe PMC] [Abstract]
• indole metabolic process Source: RGDInferred from expression patternⁱ
  • "Protein kinase C activators induce membrane retrieval of type II Na+-phosphate cotransporters expressed in Xenopus oocytes."
    Forster I.C., Traebert M., Jankowski M., Stange G., Biber J., Murer H.
    J Physiol 517:327-340(1999) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: RGDInferred from expression patternⁱ
  • "Distribution of the sodium/phosphate transporter during postnatal ontogeny of the rat kidney."
    Traebert M., Lotscher M., Aschwanden R., Ritthaler T., Biber J., Murer H., Kaissling B.
    J Am Soc Nephrol 10:1407-1415(1999) [PubMed] [Europe PMC] [Abstract]
• ossification Source: RGDInferred from expression patternⁱ
  • "Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate."
    Lundquist P., Murer H., Biber J.
    Cell Physiol Biochem 19:43-56(2007) [PubMed] [Europe PMC] [Abstract]
• phosphate ion homeostasis Source: RGD
• phosphate ion transmembrane transport Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "Expression cloning of human and rat renal cortex Na/Pi cotransport."
    Magagnin S., Werner A., Markovich D., Sorribas V., Stange G., Biber J., Murer H.
    Proc. Natl. Acad. Sci. U.S.A. 90:5979-5983(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
• phosphate ion transport Source: RGD
• positive regulation of membrane potential Source: RGDInferred from direct assayⁱ
  • "Growth-related renal type II Na/Pi cotransporter."
    Segawa H., Kaneko I., Takahashi A., Kuwahata M., Ito M., Ohkido I., Tatsumi S., Miyamoto K.
    J. Biol. Chem. 277:19665-19672(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phosphate transmembrane transport Source: RGDInferred from direct assayⁱ
  • "Akt2/PKBbeta-sensitive regulation of renal phosphate transport."
    Kempe D.S., Ackermann T.F., Boini K.M., Klaus F., Umbach A.T., Dermaku-Sopjani M., Judenhofer M.S., Pichler B.J., Capuano P., Stange G., Wagner C.A., Birnbaum M.J., Pearce D., Foller M., Lang F.
    Acta Physiol (Oxf) 200:75-85(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of sodium-dependent phosphate transport Source: RGDInferred from direct assayⁱ
  • "Essential cysteine residues of the type IIa Na+/Pi cotransporter."
    Kohler K., Forster I.C., Stange G., Biber J., Murer H.
    Pflugers Arch 446:203-210(2003) [PubMed] [Europe PMC] [Abstract]
• response to cadmium ion Source: RGD
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia."
    Faroqui S., Levi M., Soleimani M., Amlal H.
    Kidney Int 73:1141-1150(2008) [PubMed] [Europe PMC] [Abstract]
• response to growth hormone Source: RGDInferred from expression patternⁱ
  • "Regulation of renal NaPi-2 expression and tubular phosphate reabsorption by growth hormone in the juvenile rat."
    Woda C.B., Halaihel N., Wilson P.V., Haramati A., Levi M., Mulroney S.E.
    Am J Physiol Renal Physiol 287:F117-23(2004) [PubMed] [Europe PMC] [Abstract]
• response to lead ion Source: RGD
• response to magnesium ion Source: RGDInferred from expression patternⁱ
  • "Magnesium stimulates renal phosphate reabsorption."
    Thumfart J., Jung S., Amasheh S., Kramer S., Peters H., Sommer K., Biber J., Murer H., Meij I., Querfeld U., Wagner C.A., Muller D.
    Am J Physiol Renal Physiol 295:F1126-33(2008) [PubMed] [Europe PMC] [Abstract]
• response to mercury ion Source: RGD
• response to nutrient Source: RGDInferred from expression patternⁱ
  • "Effects of phosphate intake on distribution of type II Na/Pi cotransporter mRNA in rat kidney."
    Ritthaler T., Traebert M., Lotscher M., Biber J., Murer H., Kaissling B.
    Kidney Int 55:976-983(1999) [PubMed] [Europe PMC] [Abstract]
• response to parathyroid hormone Source: RGDInferred from expression patternⁱ
  • "Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters."
    Picard N., Capuano P., Stange G., Mihailova M., Kaissling B., Murer H., Biber J., Wagner C.A.
    Pflugers Arch 460:677-687(2010) [PubMed] [Europe PMC] [Abstract]
• response to peptide Source: RGDInferred from expression patternⁱ
  • "P-glycoprotein inhibitors stimulate renal phosphate reabsorption in rats."
    Prie D., Couette S., Fernandes I., Silve C., Friedlander G.
    Kidney Int 60:1069-1076(2001) [PubMed] [Europe PMC] [Abstract]
• response to peptide hormone Source: RGDInferred from expression patternⁱ
  • "Effects of angiotensin II on NaPi-IIa co-transporter expression and activity in rat renal cortex."
    Xu L., Dixit M.P., Chen R., Dixit N.M., Collins J.F., Ghishan F.K.
    Biochim Biophys Acta 1667:114-121(2004) [PubMed] [Europe PMC] [Abstract]
• response to potassium ion Source: RGDInferred from expression patternⁱ
  • "Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency."
    Breusegem S.Y., Takahashi H., Giral-Arnal H., Wang X., Jiang T., Verlander J.W., Wilson P., Miyazaki-Anzai S., Sutherland E., Caldas Y., Blaine J.T., Segawa H., Miyamoto K., Barry N.P., Levi M.
    Am J Physiol Renal Physiol 297:F350-61(2009) [PubMed] [Europe PMC] [Abstract]
• response to thyroid hormone Source: RGDInferred from expression patternⁱ
  • "Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats."
    Alcalde A.I., Sarasa M., Raldua D., Aramayona J., Morales R., Biber J., Murer H., Levi M., Sorribas V.
    Endocrinology 140:1544-1551(1999) [PubMed] [Europe PMC] [Abstract]
• response to vitamin A Source: RGDInferred from expression patternⁱ
  • "Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors."
    Masuda M., Yamamoto H., Kozai M., Tanaka S., Ishiguro M., Takei Y., Nakahashi O., Ikeda S., Uebanso T., Taketani Y., Segawa H., Miyamoto K., Takeda E.
    Biochem J 429:583-592(2010) [PubMed] [Europe PMC] [Abstract]
• response to xenobiotic stimulus Source: RGDInferred from expression patternⁱ
  • "Effects of phosphonoformic acid and renagel on renal type IIa sodium-dependent phosphate cotransporter mRNA expression in hyperphosphatemia rats."
    Zeng M., Wang X., Wang X., Zhao X.
    Ren Fail 34:358-363(2012) [PubMed] [Europe PMC] [Abstract]
• sodium-dependent phosphate transport Source: RGDInferred from expression patternⁱ
  • "Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate."
    Lundquist P., Murer H., Biber J.
    Cell Physiol Biochem 19:43-56(2007) [PubMed] [Europe PMC] [Abstract]
• sodium ion import across plasma membrane Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Expression cloning of human and rat renal cortex Na/Pi cotransport."
    Magagnin S., Werner A., Markovich D., Sorribas V., Stange G., Biber J., Murer H.
    Proc. Natl. Acad. Sci. U.S.A. 90:5979-5983(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
• tricarboxylic acid metabolic process Source: RGDInferred from expression patternⁱ
  • Ref.8

    "Cysteine residues and the structure of the rat renal proximal tubular type II sodium phosphate cotransporter (rat NaPi IIa)."
    Lambert G., Forster I.C., Biber J., Murer H.
    J. Membr. Biol. 176:133-141(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISULFIDE BONDS, REVISED TOPOLOGY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGDInferred from physical interactionⁱ
  • "Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate."
    Lundquist P., Murer H., Biber J.
    Cell Physiol Biochem 19:43-56(2007) [PubMed] [Europe PMC] [Abstract]
  • "Involvement of disulphide bonds in the renal sodium/phosphate co-transporter NaPi-2."
    Xiao Y., Boyer C.J., Vincent E., Dugre A., Vachon V., Potier M., Beliveau R.
    Biochem J 323:401-408(1997) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGDInferred from physical interactionⁱ
  • "Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells."
    McWilliams R.R., Breusegem S.Y., Brodsky K.F., Kim E., Levi M., Doctor R.B.
    Am J Physiol Cell Physiol 289:C1042-51(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MMSYSERLGG PAVSPLPVRG RHMVHGAAFA YVPSPQVLHR IPGTTTYAIS 
        60         70         80         90        100
SLSPVALTEH SCPYGEVLEC HDPLPAKLAQ EEEQKPEPRL SQKLAQVGTK 
       110        120        130        140        150
LLKVPLMLGF LYLFVCSLDV LSSAFQLAGG KVAGDIFKDN AILSNPVAGL 
       160        170        180        190        200
VVGILVTVLV QSSSTSTSII VSMVSSGLLE VSSAIPIIMG SNIGTSVTNT 
       210        220        230        240        250
IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA TGYLHHVTGL 
       260        270        280        290        300
VVASFNIRGG RDAPDLLKVI TEPFTKLIIQ LDKSVITSIA VGDESLRNHS 
       310        320        330        340        350
LIRIWCQPET KEASTSMSRV EAIGSLANTT MEKCNHIFVD TGLPDLAVGL 
       360        370        380        390        400
ILLAGSLVVL CTCLILLVKM LNSLLKGQVA NVIQKVINTD FPAPFTWVTG 
       410        420        430        440        450
YFAMVVGASM TFVVQSSSVF TSAITPLIGL GVISIERAYP LTLGSNIGTT 
       460        470        480        490        500
TTAILAALAS PREKLSSSFQ IALCHFFFNI SGILLWYPLP CTRLPIRMAK 
       510        520        530        540        550
ALGKRTAKYR WFAVLYLLVC FLLLPSLVFG ISMAGWQAMV GVGTPFGALL 
       560        570        580        590        600
AFVVLVNVLQ SRSPGHLPKW LQTWDFLPRW MHSLQPLDGL ITRATLCYAR 
       610        620        630 
PEPRSPQLPP RVFLEELPPA TPSPRLALPA HHNATRL               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families