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UniProtKB - Q06494 (PLR1_YEAST)
Protein
Putative pyridoxal reductase
Gene
YPR127W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP+.
By similarityMiscellaneous
Present with 2190 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.1.1.65
: B6 vitamer degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes pyridoxal from pyridoxine (dehydrogenase route). This subpathway is part of the pathway B6 vitamer degradation, which is itself part of Cofactor degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal from pyridoxine (dehydrogenase route), the pathway B6 vitamer degradation and in Cofactor degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 60 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- aldo-keto reductase (NADP) activity Source: GO_Central
- D-threo-aldose 1-dehydrogenase activity Source: InterPro
- pyridoxine:NADP 4-dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- vitamin B6 catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00192;UER00307 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative pyridoxal reductase (EC:1.1.1.65)Short name: PL reductase Short name: PL-red |
Gene namesi | Ordered Locus Names:YPR127W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006331, YPR127W |
VEuPathDBi | FungiDB:YPR127W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000257816 | 1 – 345 | Putative pyridoxal reductaseAdd BLAST | 345 |
Proteomic databases
MaxQBi | Q06494 |
PaxDbi | Q06494 |
PRIDEi | Q06494 |
PTM databases
iPTMneti | Q06494 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36294, 31 interactors |
IntActi | Q06494, 1 interactor |
STRINGi | 4932.YPR127W |
Miscellaneous databases
RNActi | Q06494, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldo/keto reductase family.Curated
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
HOGENOMi | CLU_023205_2_1_1 |
InParanoidi | Q06494 |
OMAi | RRSIDDC |
Family and domain databases
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
SUPFAMi | SSF51430, SSF51430, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06494-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVADLKNNI HKLDTGYGLM SLTWRAEPIP QSQAFEAMHR VVELSRERGH
60 70 80 90 100
KAFFNVGEFY GPDFINLSYV HDFFAKYPDL RKDVVISCKG GADNATLTPR
110 120 130 140 150
GSHDDVVQSV KNSVSAIGGY IDIFEVARID TSLCTKGEVY PYESFEALAE
160 170 180 190 200
MISEGVIGGI SLSEVNEEQI RAIHKDWGKF LTCVEVELSL FSNDILHNGI
210 220 230 240 250
AKTCAELGLS IICYSPLGRG LLTGQLKSNA DIPEGDFRKS LKRFSDESLK
260 270 280 290 300
KNLTLVRFLQ EEIVDKRPQN NSITLAQLAL GWVKHWNKVP EYSGAKFIPI
310 320 330 340
PSGSSISKVN ENFDEQKTKL TDQEFNAINK YLTTFHTVGD RYEMA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40828 Genomic DNA Translation: AAB68066.1 BK006949 Genomic DNA Translation: DAA11540.1 |
PIRi | S69018 |
RefSeqi | NP_015452.1, NM_001184224.1 |
Genome annotation databases
EnsemblFungii | YPR127W_mRNA; YPR127W; YPR127W |
GeneIDi | 856245 |
KEGGi | sce:YPR127W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40828 Genomic DNA Translation: AAB68066.1 BK006949 Genomic DNA Translation: DAA11540.1 |
PIRi | S69018 |
RefSeqi | NP_015452.1, NM_001184224.1 |
3D structure databases
SMRi | Q06494 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36294, 31 interactors |
IntActi | Q06494, 1 interactor |
STRINGi | 4932.YPR127W |
PTM databases
iPTMneti | Q06494 |
Proteomic databases
MaxQBi | Q06494 |
PaxDbi | Q06494 |
PRIDEi | Q06494 |
Genome annotation databases
EnsemblFungii | YPR127W_mRNA; YPR127W; YPR127W |
GeneIDi | 856245 |
KEGGi | sce:YPR127W |
Organism-specific databases
SGDi | S000006331, YPR127W |
VEuPathDBi | FungiDB:YPR127W |
Phylogenomic databases
eggNOGi | KOG1575, Eukaryota |
HOGENOMi | CLU_023205_2_1_1 |
InParanoidi | Q06494 |
OMAi | RRSIDDC |
Enzyme and pathway databases
UniPathwayi | UPA00192;UER00307 |
Miscellaneous databases
PROi | PR:Q06494 |
RNActi | Q06494, protein |
Family and domain databases
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
SUPFAMi | SSF51430, SSF51430, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLR1_YEAST | |
Accessioni | Q06494Primary (citable) accession number: Q06494 Secondary accession number(s): D6W4C4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families