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UniProtKB - Q06481 (APLP2_HUMAN)

Entry version 213 (23 Feb 2022)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
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Protein

Amyloid beta precursor like protein 2

Gene

APLP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi163CopperPROSITE-ProRule annotation1
Metal bindingi167CopperPROSITE-ProRule annotation1
Metal bindingi184CopperPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei186Required for Cu(2+) reductionPROSITE-ProRule annotation1
Sitei320 – 321Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Protease inhibitor, Serine protease inhibitor
LigandCopper, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q06481

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q06481

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q06481

Protein family/group databases

MEROPS protease database

More...MEROPSi		I02.016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid beta precursor like protein 2Imported
Alternative name(s):
APPH
Amyloid beta (A4) precursor-like protein 2By similarity
Amyloid protein homologCurated
Amyloid-like protein 2By similarity
Short name:
APLP-2
CDEI box-binding protein
Short name:
CDEBP
Sperm membrane protein YWK-IIBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APLP2Imported
Synonyms:APPL2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:598, APLP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104776, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q06481

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000084234

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 692ExtracellularSequence analysisAdd BLAST661
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei693 – 716HelicalSequence analysisAdd BLAST24
Topological domaini717 – 763CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		334

Open Targets

More...OpenTargetsi		ENSG00000084234

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24885

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q06481, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		APLP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1703344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000020732 – 763Amyloid beta precursor like protein 2Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 80PROSITE-ProRule annotation
Disulfide bondi91 ↔ 133PROSITE-ProRule annotation
Disulfide bondi116 ↔ 123PROSITE-ProRule annotation
Disulfide bondi149 ↔ 203PROSITE-ProRule annotation
Disulfide bondi160 ↔ 190PROSITE-ProRule annotation
Disulfide bondi174 ↔ 202PROSITE-ProRule annotation
Disulfide bondi310 ↔ 360PROSITE-ProRule annotation
Disulfide bondi319 ↔ 343PROSITE-ProRule annotation
Disulfide bondi335 ↔ 356PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei590Phosphoserine; by FAM20C1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The BPTI/Kunitz inhibitor domain is O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q06481

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q06481

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q06481

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q06481

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06481

PeptideAtlas

More...PeptideAtlasi		Q06481

PRoteomics IDEntifications database

More...PRIDEi		Q06481

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		43292
58449 [Q06481-1]
58450 [Q06481-2]
58451 [Q06481-3]
58452 [Q06481-4]
58453 [Q06481-5]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q06481-5 [Q06481-5]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1008, 4 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q06481, 4 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q06481

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q06481

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000084234, Expressed in pigmented layer of retina and 262 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q06481, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q06481, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000084234, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPEB1.

Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).

Interacts (via cytoplasmic domain) with APBB2/FE65L (PubMed:8855266).

Interacts (via intracellular domain) with APBB3/FE65L2 (PubMed:10081969).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106831, 98 interactors

Database of interacting proteins

More...DIPi		DIP-31047N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q06481

Protein interaction database and analysis system

More...IntActi		Q06481, 54 interactors

Molecular INTeraction database

More...MINTi		Q06481

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263574

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q06481, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1763
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q06481

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 205E1PROSITE-ProRule annotationAdd BLAST160
Domaini306 – 364BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST59
Domaini373 – 564E2PROSITE-ProRule annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 139GFLD subdomainPROSITE-ProRule annotationAdd BLAST94
Regioni147 – 205CuBD subdomainPROSITE-ProRule annotationAdd BLAST59
Regioni211 – 299DisorderedSequence analysisAdd BLAST89
Regioni749 – 763Interaction with DAB2By similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi750 – 755NPXY motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 236Acidic residuesSequence analysisAdd BLAST22
Compositional biasi245 – 270Acidic residuesSequence analysisAdd BLAST26
Compositional biasi271 – 286Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3540, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063252

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014607_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q06481

Identification of Orthologs from Complete Genome Data

More...OMAi		QCRSHIV

Database of Orthologous Groups

More...OrthoDBi		953529at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q06481

TreeFam database of animal gene trees

More...TreeFami		TF317274

Family and domain databases

Conserved Domains Database

More...CDDi		cd00109, KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036669, Amyloid_Cu-bd_sf
IPR008155, Amyloid_glyco
IPR011178, Amyloid_glyco_Cu-bd
IPR024329, Amyloid_glyco_E2_domain
IPR008154, Amyloid_glyco_extra
IPR015849, Amyloid_glyco_heparin-bd
IPR036454, Amyloid_glyco_heparin-bd_sf
IPR019745, Amyloid_glyco_intracell_CS
IPR019543, APP_amyloid_C
IPR019744, APP_CUBD_CS
IPR036176, E2_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR011993, PH-like_dom_sf
IPR020901, Prtase_inh_Kunz-CS

The PANTHER Classification System

More...PANTHERi		PTHR23103, PTHR23103, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10515, APP_amyloid, 1 hit
PF12924, APP_Cu_bd, 1 hit
PF12925, APP_E2, 1 hit
PF02177, APP_N, 1 hit
PF00014, Kunitz_BPTI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00203, AMYLOIDA4
PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00006, A4_EXTRA, 1 hit
SM00131, KU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109843, SSF109843, 1 hit
SSF56491, SSF56491, 1 hit
SSF57362, SSF57362, 1 hit
SSF89811, SSF89811, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00319, APP_CUBD, 1 hit
PS51869, APP_E1, 1 hit
PS51870, APP_E2, 1 hit
PS00320, APP_INTRA, 1 hit
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q06481-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP 
        60         70         80         90        100
QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI 
       110        120        130        140        150
TNVMEANQRV SIDNWCRRDK KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ 
       160        170        180        190        200
FFHKERMEVC ENHQHWHTVV KEACLTQGMT LYSYGMLLPC GVDQFHGTEY 
       210        220        230        240        250
VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF PTEADLEDFT 
       260        270        280        290        300
EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK 
       310        320        330        340        350
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF 
       360        370        380        390        400
ESEDYCMAVC KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR 
       410        420        430        440        450
HRNRMDRVKK EWEEAELQAK NLPKAERQTL IQHFQAMVKA LEKEAASEKQ 
       460        470        480        490        500
QLVETHLARV EAMLNDRRRM ALENYLAALQ SDPPRPHRIL QALRRYVRAE 
       510        520        530        540        550
NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR NQSLSLLYKV 
       560        570        580        590        600
PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH 
       610        620        630        640        650
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD 
       660        670        680        690        700
ENMVIDETLD VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV 
       710        720        730        740        750
IAVAIATVIV ISLVMLRKRQ YGTISHGIVE VDPMLTPEER HLNKMQNHGY 
       760 
ENPTYKYLEQ MQI
Length:763
Mass (Da):86,956
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3A7D6DDB8A28D0
GO
Isoform 2 (identifier: Q06481-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-363: Missing.

Show »
Length:707
Mass (Da):80,721
Checksum:i1F45B94DAE88BC23
GO
Isoform 3 (identifier: Q06481-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-624: Missing.

Show »
Length:751
Mass (Da):85,487
Checksum:i788BCDC6E4487E18
GO
Isoform 4 (identifier: Q06481-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-363: Missing.
     364-364: I → V
     613-624: Missing.

Show »
Length:695
Mass (Da):79,238
Checksum:i728CA8ACBB7594FB
GO
Isoform 5 (identifier: Q06481-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-364: Missing.
     613-624: Missing.

Show »
Length:522
Mass (Da):59,151
Checksum:i993641BFC15ED6E0
GO
Isoform 6 (identifier: Q06481-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIE → MLRAPGELPR...ASVDRGNPLW
     613-624: Missing.

Show »
Length:761
Mass (Da):87,215
Checksum:iE87786F52F076C41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQS3E9PQS3_HUMAN
Amyloid beta precursor-like protein...
APLP2
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSC7E9PSC7_HUMAN
Amyloid beta precursor-like protein...
APLP2
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK76E9PK76_HUMAN
Amyloid beta precursor-like protein...
APLP2
116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPD0E9PPD0_HUMAN
Amyloid beta precursor-like protein...
APLP2
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9UED0Q9UED0_HUMAN
Amyloid beta precursor-like protein...
APLP2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG54641 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224E → D in AAD47291 (PubMed:7651835).Curated1
Sequence conflicti226 – 227Missing in BAG54641 (PubMed:14702039).Curated2
Sequence conflicti543S → I in AAA35526 (PubMed:8485127).Curated1
Sequence conflicti543S → T in AAH04371 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022039632D → N. Corresponds to variant dbSNP:rs3740881Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468811 – 35MAATG…AGYIE → MLRAPGELPRQAARCSLCRL GPGRGRAFFKWRCLPASVDR GNPLW in isoform 6. CuratedAdd BLAST35
Alternative sequenceiVSP_030921136 – 364Missing in isoform 5. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_000018308 – 363Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_046882364I → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_000019613 – 624Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S60099 mRNA Translation: AAC60589.1
L09209 mRNA Translation: AAA35526.1
L27631 mRNA Translation: AAC41701.1
Z22572 mRNA Translation: CAA80295.1
AK128162 mRNA Translation: BAG54641.1 Frameshift.
L19597 mRNA Translation: AAA35601.1
L23113 mRNA Translation: AAA36032.1
L23114 mRNA Translation: AAA36130.1
AF168956 mRNA Translation: AAD47291.1
AP001183 Genomic DNA No translation available.
AP003041 Genomic DNA No translation available.
BC000373 mRNA Translation: AAH00373.1
BC004371 mRNA Translation: AAH04371.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44773.1 [Q06481-3]
CCDS44774.1 [Q06481-4]
CCDS44775.1 [Q06481-5]
CCDS58196.1 [Q06481-6]
CCDS8486.1 [Q06481-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A49321
S41082

NCBI Reference Sequences

More...RefSeqi		NP_001135748.1, NM_001142276.1 [Q06481-3]
NP_001135749.1, NM_001142277.1 [Q06481-4]
NP_001135750.1, NM_001142278.1 [Q06481-5]
NP_001230228.1, NM_001243299.1 [Q06481-6]
NP_001633.1, NM_001642.2 [Q06481-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263574; ENSP00000263574; ENSG00000084234
ENST00000278756; ENSP00000278756; ENSG00000084234 [Q06481-6]
ENST00000338167; ENSP00000345444; ENSG00000084234 [Q06481-3]
ENST00000345598; ENSP00000263575; ENSG00000084234 [Q06481-5]
ENST00000528499; ENSP00000435914; ENSG00000084234 [Q06481-4]
ENST00000650012; ENSP00000497691; ENSG00000084234

Database of genes from NCBI RefSeq genomes

More...GeneIDi		334

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:334

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000338167.10; ENSP00000345444.5; NM_001142276.2; NP_001135748.1 [Q06481-3]

UCSC genome browser

More...UCSCi		uc001qfp.4, human [Q06481-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60099 mRNA Translation: AAC60589.1
L09209 mRNA Translation: AAA35526.1
L27631 mRNA Translation: AAC41701.1
Z22572 mRNA Translation: CAA80295.1
AK128162 mRNA Translation: BAG54641.1 Frameshift.
L19597 mRNA Translation: AAA35601.1
L23113 mRNA Translation: AAA36032.1
L23114 mRNA Translation: AAA36130.1
AF168956 mRNA Translation: AAD47291.1
AP001183 Genomic DNA No translation available.
AP003041 Genomic DNA No translation available.
BC000373 mRNA Translation: AAH00373.1
BC004371 mRNA Translation: AAH04371.1
CCDSiCCDS44773.1 [Q06481-3]
CCDS44774.1 [Q06481-4]
CCDS44775.1 [Q06481-5]
CCDS58196.1 [Q06481-6]
CCDS8486.1 [Q06481-1]
PIRiA49321
S41082
RefSeqiNP_001135748.1, NM_001142276.1 [Q06481-3]
NP_001135749.1, NM_001142277.1 [Q06481-4]
NP_001135750.1, NM_001142278.1 [Q06481-5]
NP_001230228.1, NM_001243299.1 [Q06481-6]
NP_001633.1, NM_001642.2 [Q06481-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JBTX-ray1.40X307-320[»]
Y323-360[»]
5TPTX-ray2.42A/B373-569[»]
SMRiQ06481
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106831, 98 interactors
DIPiDIP-31047N
ELMiQ06481
IntActiQ06481, 54 interactors
MINTiQ06481
STRINGi9606.ENSP00000263574

Chemistry databases

DrugBankiDB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Protein family/group databases

MEROPSiI02.016

PTM databases

GlyConnecti1008, 4 N-Linked glycans (1 site)
GlyGeniQ06481, 4 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (3 sites)
iPTMnetiQ06481
PhosphoSitePlusiQ06481

Genetic variation databases

BioMutaiAPLP2
DMDMi1703344

Proteomic databases

EPDiQ06481
jPOSTiQ06481
MassIVEiQ06481
MaxQBiQ06481
PaxDbiQ06481
PeptideAtlasiQ06481
PRIDEiQ06481
ProteomicsDBi43292
58449 [Q06481-1]
58450 [Q06481-2]
58451 [Q06481-3]
58452 [Q06481-4]
58453 [Q06481-5]
TopDownProteomicsiQ06481-5 [Q06481-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33074, 379 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		334

Genome annotation databases

EnsembliENST00000263574; ENSP00000263574; ENSG00000084234
ENST00000278756; ENSP00000278756; ENSG00000084234 [Q06481-6]
ENST00000338167; ENSP00000345444; ENSG00000084234 [Q06481-3]
ENST00000345598; ENSP00000263575; ENSG00000084234 [Q06481-5]
ENST00000528499; ENSP00000435914; ENSG00000084234 [Q06481-4]
ENST00000650012; ENSP00000497691; ENSG00000084234
GeneIDi334
KEGGihsa:334
MANE-SelectiENST00000338167.10; ENSP00000345444.5; NM_001142276.2; NP_001135748.1 [Q06481-3]
UCSCiuc001qfp.4, human [Q06481-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		334
DisGeNETi334

GeneCards: human genes, protein and diseases

More...GeneCardsi		APLP2
HGNCiHGNC:598, APLP2
HPAiENSG00000084234, Low tissue specificity
MIMi104776, gene
neXtProtiNX_Q06481
OpenTargetsiENSG00000084234
PharmGKBiPA24885
VEuPathDBiHostDB:ENSG00000084234

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3540, Eukaryota
GeneTreeiENSGT00530000063252
HOGENOMiCLU_014607_2_1_1
InParanoidiQ06481
OMAiQCRSHIV
OrthoDBi953529at2759
PhylomeDBiQ06481
TreeFamiTF317274

Enzyme and pathway databases

PathwayCommonsiQ06481
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation
SignaLinkiQ06481
SIGNORiQ06481

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		334, 8 hits in 1050 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APLP2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		APLP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		334
PharosiQ06481, Tbio

Protein Ontology

More...PROi		PR:Q06481
RNActiQ06481, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000084234, Expressed in pigmented layer of retina and 262 other tissues
ExpressionAtlasiQ06481, baseline and differential
GenevisibleiQ06481, HS

Family and domain databases

CDDicd00109, KU, 1 hit
Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR036669, Amyloid_Cu-bd_sf
IPR008155, Amyloid_glyco
IPR011178, Amyloid_glyco_Cu-bd
IPR024329, Amyloid_glyco_E2_domain
IPR008154, Amyloid_glyco_extra
IPR015849, Amyloid_glyco_heparin-bd
IPR036454, Amyloid_glyco_heparin-bd_sf
IPR019745, Amyloid_glyco_intracell_CS
IPR019543, APP_amyloid_C
IPR019744, APP_CUBD_CS
IPR036176, E2_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR011993, PH-like_dom_sf
IPR020901, Prtase_inh_Kunz-CS
PANTHERiPTHR23103, PTHR23103, 1 hit
PfamiView protein in Pfam
PF10515, APP_amyloid, 1 hit
PF12924, APP_Cu_bd, 1 hit
PF12925, APP_E2, 1 hit
PF02177, APP_N, 1 hit
PF00014, Kunitz_BPTI, 1 hit
PRINTSiPR00203, AMYLOIDA4
PR00759, BASICPTASE
SMARTiView protein in SMART
SM00006, A4_EXTRA, 1 hit
SM00131, KU, 1 hit
SUPFAMiSSF109843, SSF109843, 1 hit
SSF56491, SSF56491, 1 hit
SSF57362, SSF57362, 1 hit
SSF89811, SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319, APP_CUBD, 1 hit
PS51869, APP_E1, 1 hit
PS51870, APP_E2, 1 hit
PS00320, APP_INTRA, 1 hit
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPLP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06481
Secondary accession number(s): B3KXX9
, H7BXI4, Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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