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Entry version 199 (31 Jul 2019)
Sequence version 2 (01 Oct 1996)
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Protein

Amyloid-like protein 2

Gene

APLP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi163CopperPROSITE-ProRule annotation1
Metal bindingi167CopperPROSITE-ProRule annotation1
Metal bindingi184CopperPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei186Required for Cu(2+) reductionPROSITE-ProRule annotation1
Sitei320 – 321Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Protease inhibitor, Serine protease inhibitor
LigandCopper, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q06481

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q06481

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid-like protein 2
Short name:
APLP-2
Alternative name(s):
APPH
Amyloid protein homolog
CDEI box-binding protein
Short name:
CDEBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APLP2
Synonyms:APPL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:598 APLP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
104776 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q06481

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 692ExtracellularSequence analysisAdd BLAST661
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei693 – 716HelicalSequence analysisAdd BLAST24
Topological domaini717 – 763CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
334

Open Targets

More...
OpenTargetsi
ENSG00000084234

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24885

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APLP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1703344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000020732 – 763Amyloid-like protein 2Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 80PROSITE-ProRule annotation
Disulfide bondi91 ↔ 133PROSITE-ProRule annotation
Disulfide bondi116 ↔ 123PROSITE-ProRule annotation
Disulfide bondi149 ↔ 203PROSITE-ProRule annotation
Disulfide bondi160 ↔ 190PROSITE-ProRule annotation
Disulfide bondi174 ↔ 202PROSITE-ProRule annotation
Disulfide bondi310 ↔ 360PROSITE-ProRule annotation
Disulfide bondi319 ↔ 343PROSITE-ProRule annotation
Disulfide bondi335 ↔ 356PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei590Phosphoserine; by FAM20C1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The BPTI/Kunitz inhibitor domain is O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q06481

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q06481

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06481

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06481

PeptideAtlas

More...
PeptideAtlasi
Q06481

PRoteomics IDEntifications database

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PRIDEi
Q06481

ProteomicsDB human proteome resource

More...
ProteomicsDBi
43292
58449 [Q06481-1]
58450 [Q06481-2]
58451 [Q06481-3]
58452 [Q06481-4]
58453 [Q06481-5]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q06481-5 [Q06481-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1008

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06481

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q06481

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q06481

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000084234 Expressed in 249 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q06481 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q06481 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA039319

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPEB1.

Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106831, 37 interactors

Database of interacting proteins

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DIPi
DIP-31047N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q06481

Protein interaction database and analysis system

More...
IntActi
Q06481, 25 interactors

Molecular INTeraction database

More...
MINTi
Q06481

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263574

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1763
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06481

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 205E1PROSITE-ProRule annotationAdd BLAST160
Domaini306 – 364BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST59
Domaini373 – 564E2PROSITE-ProRule annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 139GFLD subdomainPROSITE-ProRule annotationAdd BLAST94
Regioni147 – 205CuBD subdomainPROSITE-ProRule annotationAdd BLAST59
Regioni749 – 763Interaction with DAB2By similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi750 – 755NPXY motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 280Asp/Glu-rich (highly acidic)Add BLAST66
Compositional biasi215 – 231Poly-GluAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3540 Eukaryota
ENOG410ZW2A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063252

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232190

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q06481

KEGG Orthology (KO)

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KOi
K08117

Identification of Orthologs from Complete Genome Data

More...
OMAi
CCPQTKV

Database of Orthologous Groups

More...
OrthoDBi
953529at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q06481

TreeFam database of animal gene trees

More...
TreeFami
TF317274

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109 KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036669 Amyloid_Cu-bd_sf
IPR008155 Amyloid_glyco
IPR011178 Amyloid_glyco_Cu-bd
IPR024329 Amyloid_glyco_E2_domain
IPR008154 Amyloid_glyco_extra
IPR015849 Amyloid_glyco_heparin-bd
IPR036454 Amyloid_glyco_heparin-bd_sf
IPR019745 Amyloid_glyco_intracell_CS
IPR019543 APP_amyloid_C
IPR019744 APP_CUBD_CS
IPR036176 E2_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR011993 PH-like_dom_sf
IPR020901 Prtase_inh_Kunz-CS

The PANTHER Classification System

More...
PANTHERi
PTHR23103 PTHR23103, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10515 APP_amyloid, 1 hit
PF12924 APP_Cu_bd, 1 hit
PF12925 APP_E2, 1 hit
PF02177 APP_N, 1 hit
PF00014 Kunitz_BPTI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00203 AMYLOIDA4
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00006 A4_EXTRA, 1 hit
SM00131 KU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109843 SSF109843, 1 hit
SSF56491 SSF56491, 1 hit
SSF57362 SSF57362, 1 hit
SSF89811 SSF89811, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00319 APP_CUBD, 1 hit
PS51869 APP_E1, 1 hit
PS51870 APP_E2, 1 hit
PS00320 APP_INTRA, 1 hit
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q06481-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP
60 70 80 90 100
QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI
110 120 130 140 150
TNVMEANQRV SIDNWCRRDK KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ
160 170 180 190 200
FFHKERMEVC ENHQHWHTVV KEACLTQGMT LYSYGMLLPC GVDQFHGTEY
210 220 230 240 250
VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF PTEADLEDFT
260 270 280 290 300
EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK
310 320 330 340 350
EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF
360 370 380 390 400
ESEDYCMAVC KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR
410 420 430 440 450
HRNRMDRVKK EWEEAELQAK NLPKAERQTL IQHFQAMVKA LEKEAASEKQ
460 470 480 490 500
QLVETHLARV EAMLNDRRRM ALENYLAALQ SDPPRPHRIL QALRRYVRAE
510 520 530 540 550
NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR NQSLSLLYKV
560 570 580 590 600
PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH
610 620 630 640 650
PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD
660 670 680 690 700
ENMVIDETLD VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV
710 720 730 740 750
IAVAIATVIV ISLVMLRKRQ YGTISHGIVE VDPMLTPEER HLNKMQNHGY
760
ENPTYKYLEQ MQI
Length:763
Mass (Da):86,956
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3A7D6DDB8A28D0
GO
Isoform 2 (identifier: Q06481-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-363: Missing.

Show »
Length:707
Mass (Da):80,721
Checksum:i1F45B94DAE88BC23
GO
Isoform 3 (identifier: Q06481-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-624: Missing.

Show »
Length:751
Mass (Da):85,487
Checksum:i788BCDC6E4487E18
GO
Isoform 4 (identifier: Q06481-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-363: Missing.
     364-364: I → V
     613-624: Missing.

Show »
Length:695
Mass (Da):79,238
Checksum:i728CA8ACBB7594FB
GO
Isoform 5 (identifier: Q06481-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-364: Missing.
     613-624: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):59,151
Checksum:i993641BFC15ED6E0
GO
Isoform 6 (identifier: Q06481-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIE → MLRAPGELPR...ASVDRGNPLW
     613-624: Missing.

Show »
Length:761
Mass (Da):87,215
Checksum:iE87786F52F076C41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQS3E9PQS3_HUMAN
Amyloid-like protein 2
APLP2
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK76E9PK76_HUMAN
Amyloid-like protein 2
APLP2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSC7E9PSC7_HUMAN
Amyloid-like protein 2
APLP2
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9UED0Q9UED0_HUMAN
Amyloid-like protein 2
APLP2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPD0E9PPD0_HUMAN
Amyloid-like protein 2
APLP2
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG54641 differs from that shown. Reason: Frameshift at position 81.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224E → D in AAD47291 (PubMed:7651835).Curated1
Sequence conflicti226 – 227Missing in BAG54641 (PubMed:14702039).Curated2
Sequence conflicti543S → I in AAA35526 (PubMed:8485127).Curated1
Sequence conflicti543S → T in AAH04371 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022039632D → N. Corresponds to variant dbSNP:rs3740881Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468811 – 35MAATG…AGYIE → MLRAPGELPRQAARCSLCRL GPGRGRAFFKWRCLPASVDR GNPLW in isoform 6. CuratedAdd BLAST35
Alternative sequenceiVSP_030921136 – 364Missing in isoform 5. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_000018308 – 363Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_046882364I → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_000019613 – 624Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S60099 mRNA Translation: AAC60589.1
L09209 mRNA Translation: AAA35526.1
L27631 mRNA Translation: AAC41701.1
Z22572 mRNA Translation: CAA80295.1
AK128162 mRNA Translation: BAG54641.1 Frameshift.
L19597 mRNA Translation: AAA35601.1
L23113 mRNA Translation: AAA36032.1
L23114 mRNA Translation: AAA36130.1
AF168956 mRNA Translation: AAD47291.1
AP001183 Genomic DNA No translation available.
AP003041 Genomic DNA No translation available.
BC000373 mRNA Translation: AAH00373.1
BC004371 mRNA Translation: AAH04371.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44773.1 [Q06481-3]
CCDS44774.1 [Q06481-4]
CCDS44775.1 [Q06481-5]
CCDS58196.1 [Q06481-6]
CCDS8486.1 [Q06481-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49321
S41082

NCBI Reference Sequences

More...
RefSeqi
NP_001135748.1, NM_001142276.1 [Q06481-3]
NP_001135749.1, NM_001142277.1 [Q06481-4]
NP_001135750.1, NM_001142278.1 [Q06481-5]
NP_001230228.1, NM_001243299.1 [Q06481-6]
NP_001633.1, NM_001642.2 [Q06481-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263574; ENSP00000263574; ENSG00000084234 [Q06481-1]
ENST00000278756; ENSP00000278756; ENSG00000084234 [Q06481-6]
ENST00000338167; ENSP00000345444; ENSG00000084234 [Q06481-3]
ENST00000345598; ENSP00000263575; ENSG00000084234 [Q06481-5]
ENST00000528499; ENSP00000435914; ENSG00000084234 [Q06481-4]
ENST00000650012; ENSP00000497691; ENSG00000084234 [Q06481-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
334

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:334

UCSC genome browser

More...
UCSCi
uc001qfp.4 human [Q06481-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60099 mRNA Translation: AAC60589.1
L09209 mRNA Translation: AAA35526.1
L27631 mRNA Translation: AAC41701.1
Z22572 mRNA Translation: CAA80295.1
AK128162 mRNA Translation: BAG54641.1 Frameshift.
L19597 mRNA Translation: AAA35601.1
L23113 mRNA Translation: AAA36032.1
L23114 mRNA Translation: AAA36130.1
AF168956 mRNA Translation: AAD47291.1
AP001183 Genomic DNA No translation available.
AP003041 Genomic DNA No translation available.
BC000373 mRNA Translation: AAH00373.1
BC004371 mRNA Translation: AAH04371.1
CCDSiCCDS44773.1 [Q06481-3]
CCDS44774.1 [Q06481-4]
CCDS44775.1 [Q06481-5]
CCDS58196.1 [Q06481-6]
CCDS8486.1 [Q06481-1]
PIRiA49321
S41082
RefSeqiNP_001135748.1, NM_001142276.1 [Q06481-3]
NP_001135749.1, NM_001142277.1 [Q06481-4]
NP_001135750.1, NM_001142278.1 [Q06481-5]
NP_001230228.1, NM_001243299.1 [Q06481-6]
NP_001633.1, NM_001642.2 [Q06481-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JBTX-ray1.40X307-320[»]
Y323-360[»]
5TPTX-ray2.42A/B373-569[»]
SMRiQ06481
ModBaseiSearch...

Protein-protein interaction databases

BioGridi106831, 37 interactors
DIPiDIP-31047N
ELMiQ06481
IntActiQ06481, 25 interactors
MINTiQ06481
STRINGi9606.ENSP00000263574

Protein family/group databases

MEROPSiI02.016

PTM databases

GlyConnecti1008
iPTMnetiQ06481
PhosphoSitePlusiQ06481

Polymorphism and mutation databases

BioMutaiAPLP2
DMDMi1703344

Proteomic databases

EPDiQ06481
jPOSTiQ06481
MaxQBiQ06481
PaxDbiQ06481
PeptideAtlasiQ06481
PRIDEiQ06481
ProteomicsDBi43292
58449 [Q06481-1]
58450 [Q06481-2]
58451 [Q06481-3]
58452 [Q06481-4]
58453 [Q06481-5]
TopDownProteomicsiQ06481-5 [Q06481-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
334
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263574; ENSP00000263574; ENSG00000084234 [Q06481-1]
ENST00000278756; ENSP00000278756; ENSG00000084234 [Q06481-6]
ENST00000338167; ENSP00000345444; ENSG00000084234 [Q06481-3]
ENST00000345598; ENSP00000263575; ENSG00000084234 [Q06481-5]
ENST00000528499; ENSP00000435914; ENSG00000084234 [Q06481-4]
ENST00000650012; ENSP00000497691; ENSG00000084234 [Q06481-1]
GeneIDi334
KEGGihsa:334
UCSCiuc001qfp.4 human [Q06481-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
334
DisGeNETi334

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APLP2
HGNCiHGNC:598 APLP2
HPAiHPA039319
MIMi104776 gene
neXtProtiNX_Q06481
OpenTargetsiENSG00000084234
PharmGKBiPA24885

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3540 Eukaryota
ENOG410ZW2A LUCA
GeneTreeiENSGT00530000063252
HOGENOMiHOG000232190
InParanoidiQ06481
KOiK08117
OMAiCCPQTKV
OrthoDBi953529at2759
PhylomeDBiQ06481
TreeFamiTF317274

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SignaLinkiQ06481
SIGNORiQ06481

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
APLP2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
APLP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
334
PMAP-CutDBiQ06481

Protein Ontology

More...
PROi
PR:Q06481

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000084234 Expressed in 249 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ06481 baseline and differential
GenevisibleiQ06481 HS

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR036669 Amyloid_Cu-bd_sf
IPR008155 Amyloid_glyco
IPR011178 Amyloid_glyco_Cu-bd
IPR024329 Amyloid_glyco_E2_domain
IPR008154 Amyloid_glyco_extra
IPR015849 Amyloid_glyco_heparin-bd
IPR036454 Amyloid_glyco_heparin-bd_sf
IPR019745 Amyloid_glyco_intracell_CS
IPR019543 APP_amyloid_C
IPR019744 APP_CUBD_CS
IPR036176 E2_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR011993 PH-like_dom_sf
IPR020901 Prtase_inh_Kunz-CS
PANTHERiPTHR23103 PTHR23103, 1 hit
PfamiView protein in Pfam
PF10515 APP_amyloid, 1 hit
PF12924 APP_Cu_bd, 1 hit
PF12925 APP_E2, 1 hit
PF02177 APP_N, 1 hit
PF00014 Kunitz_BPTI, 1 hit
PRINTSiPR00203 AMYLOIDA4
PR00759 BASICPTASE
SMARTiView protein in SMART
SM00006 A4_EXTRA, 1 hit
SM00131 KU, 1 hit
SUPFAMiSSF109843 SSF109843, 1 hit
SSF56491 SSF56491, 1 hit
SSF57362 SSF57362, 1 hit
SSF89811 SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319 APP_CUBD, 1 hit
PS51869 APP_E1, 1 hit
PS51870 APP_E2, 1 hit
PS00320 APP_INTRA, 1 hit
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPLP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06481
Secondary accession number(s): B3KXX9
, H7BXI4, Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: July 31, 2019
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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