UniProtKB - Q06479 (YL352_YEAST)
Protein
F-box protein YLR352W
Gene
YLR352W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).By similarity
Miscellaneous
Present with 125 molecules/cell in log phase SD medium.1 Publication
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-SCE-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-SCE-8951664, Neddylation R-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box protein YLR352W |
Gene namesi | Ordered Locus Names:YLR352W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004344, YLR352W |
VEuPathDBi | FungiDB:YLR352W |
Subcellular locationi
Other locations
- SCF ubiquitin ligase complex Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000268189 | 1 – 807 | F-box protein YLR352WAdd BLAST | 807 |
Proteomic databases
MaxQBi | Q06479 |
PaxDbi | Q06479 |
PRIDEi | Q06479 |
PTM databases
iPTMneti | Q06479 |
Interactioni
Subunit structurei
Interacts with SKP1 and CDC53.
Component of the probable SCF(YBR352W) complex containing CDC53, SKP1, RBX1 and YBR352W.
1 PublicationBinary interactionsi
Q06479
With | #Exp. | IntAct |
---|---|---|
SKP1 [P52286] | 3 | EBI-35627,EBI-4090 |
Protein-protein interaction databases
BioGRIDi | 31614, 85 interactors |
ComplexPortali | CPX-3253, SCF-Ylr352w ubiquitin ligase complex |
DIPi | DIP-1631N |
IntActi | Q06479, 7 interactors |
MINTi | Q06479 |
STRINGi | 4932.YLR352W |
Miscellaneous databases
RNActi | Q06479, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 220 – 266 | F-boxAdd BLAST | 47 |
Phylogenomic databases
eggNOGi | ENOG502R9EV, Eukaryota |
HOGENOMi | CLU_348554_0_0_1 |
InParanoidi | Q06479 |
OMAi | ERGMYRY |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf |
i Sequence
Sequence statusi: Complete.
Q06479-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDLKSKTLS SQSLGAAIPP EIVYQILTYQ FRDLLRNDHP GTAEKFNENL
60 70 80 90 100
TTFVKSNLTV NKTFSHICQV LIYRYCNLTT AKRFHGLLQT LKGNRCLCNK
110 120 130 140 150
IEVADFQELT SIGLGRSSEM NKMIKNLTNE TLLEFLMLTK ANLREFLACE
160 170 180 190 200
NIQDDLDDNI IKYILSPGKV LSVVDFCGCS GTTFTESFIK ALDKYYPNKS
210 220 230 240 250
IDQYRLEPIQ QNYQITCLGL NDCIDLPSHV LWKILKMLPE LQKLDLSHTS
260 270 280 290 300
IDDSTLYHGI PHWKNLTHLS LATCLQVTPR AVLEFFSHHP TITDPDNTST
310 320 330 340 350
LEWLNVSVIA HSSSWNEVHT MFLLKKLCQH GHNKTLQYLN IGGLPLHVAP
360 370 380 390 400
SFGEDPISES TYYYQCRDSL QFIKWNFPKL KSLSIKGNSI PISTLVEFLT
410 420 430 440 450
PIDQDHPNCA QKLKFLNISG NSYVNKWTIQ DSLLYTCSPS LVALEVSFDS
460 470 480 490 500
WQQIEKLNDR HEIIAYRYKN PNSVIKDIST AEQVKWKCYI DSSYGRRYWL
510 520 530 540 550
YKTDPFLNRD DLDSKSNLTR YDFEGHKIIE IINQPDFLKF AQSKIMLGCG
560 570 580 590 600
LVPQSGIRRK LCYRDLKPPV SQFLNRKGAI SLGDTPLPII TPTLPRGGWR
610 620 630 640 650
IIHNEDDNNS HVEDSQNHVN AIPRRNSLLS RPTLRSNNGS SSANPFAINV
660 670 680 690 700
SPASQIRDGL YWDRSVHDLR ELSLQEQRIQ ELADEQQELR TIANFEETDD
710 720 730 740 750
EYLHDPDLQR RRSQLHLFES SRSRSGNKTR PSLTGEHSSS ASFLSFSHFN
760 770 780 790 800
HLHKRKNYYF THPDEFVYDP KDPLTTQRYR LHFEIVNEYQ VFGCIERGMY
RYYSLKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19102 Genomic DNA Translation: AAB67750.1 BK006945 Genomic DNA Translation: DAA09656.1 |
PIRi | S51460 |
RefSeqi | NP_013456.1, NM_001182241.1 |
Genome annotation databases
EnsemblFungii | YLR352W_mRNA; YLR352W; YLR352W |
GeneIDi | 851066 |
KEGGi | sce:YLR352W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19102 Genomic DNA Translation: AAB67750.1 BK006945 Genomic DNA Translation: DAA09656.1 |
PIRi | S51460 |
RefSeqi | NP_013456.1, NM_001182241.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 31614, 85 interactors |
ComplexPortali | CPX-3253, SCF-Ylr352w ubiquitin ligase complex |
DIPi | DIP-1631N |
IntActi | Q06479, 7 interactors |
MINTi | Q06479 |
STRINGi | 4932.YLR352W |
PTM databases
iPTMneti | Q06479 |
Proteomic databases
MaxQBi | Q06479 |
PaxDbi | Q06479 |
PRIDEi | Q06479 |
Genome annotation databases
EnsemblFungii | YLR352W_mRNA; YLR352W; YLR352W |
GeneIDi | 851066 |
KEGGi | sce:YLR352W |
Organism-specific databases
SGDi | S000004344, YLR352W |
VEuPathDBi | FungiDB:YLR352W |
Phylogenomic databases
eggNOGi | ENOG502R9EV, Eukaryota |
HOGENOMi | CLU_348554_0_0_1 |
InParanoidi | Q06479 |
OMAi | ERGMYRY |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-SCE-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-SCE-8951664, Neddylation R-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
PROi | PR:Q06479 |
RNActi | Q06479, protein |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YL352_YEAST | |
Accessioni | Q06479Primary (citable) accession number: Q06479 Secondary accession number(s): D6VYZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways