UniProtKB - Q06455 (MTG8_HUMAN)
Protein CBFA2T1
RUNX1T1
Functioni
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654).
Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
Can repress transactivation mediated by TCF12 (PubMed:16803958).
Acts as a negative regulator of adipogenesis (By similarity).
The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).
2 PublicationsBy similarity5 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 515 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 518 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 526 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 529 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 535 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 539 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 547 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 551 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 515 – 551 | MYND-typePROSITE-ProRule annotationAdd BLAST | 37 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- negative regulation of fat cell differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q06455 |
SignaLinki | Q06455 |
SIGNORi | Q06455 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein CBFA2T1Alternative name(s): Cyclin-D-related protein Eight twenty one protein Protein ETO Protein MTG8 Zinc finger MYND domain-containing protein 2 |
Gene namesi | Name:RUNX1T1 Synonyms:AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1535, RUNX1T1 |
MIMi | 133435, gene |
neXtProti | NX_Q06455 |
VEuPathDBi | HostDB:ENSG00000079102 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Note: Colocalizes with ATN1 in discrete nuclear dots.
Nucleus
- nuclear matrix Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 125 | K → A or D: Loss of interaction with TCF12. 1 Publication | 1 | |
Mutagenesisi | 126 | L → A: Loss of interaction with TCF12. 1 Publication | 1 | |
Mutagenesisi | 128 | R → D: Loss of interaction with TCF12. 1 Publication | 1 | |
Mutagenesisi | 129 | F → A: Loss of interaction with TCF12. 2 Publications | 1 | |
Mutagenesisi | 129 | F → K: Abolishes interaction with corepressor. 2 Publications | 1 | |
Mutagenesisi | 136 | F → A: Abolishes interaction with corepressor. 1 Publication | 1 | |
Mutagenesisi | 170 | Q → A: Abolishes interaction with corepressor. 1 Publication | 1 | |
Mutagenesisi | 173 | T → Q: Abolishes interaction with corepressor. 1 Publication | 1 | |
Mutagenesisi | 175 | F → A: Abolishes interaction with corepressor. 1 Publication | 1 | |
Mutagenesisi | 177 | L → A: Abolishes interaction with corepressor. 1 Publication | 1 | |
Mutagenesisi | 178 | R → A or D: Loss of interaction with TCF12. 1 Publication | 1 | |
Mutagenesisi | 184 | F → A: Loss of interaction with TCF12. 1 Publication | 1 | |
Mutagenesisi | 345 | L → E: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with R-357; R-360; E-361; E-375; R-378 and R-389. 2 Publications | 1 | |
Mutagenesisi | 352 – 353 | EE → AA: Decreases interaction with TCF12, no effect on oligomerization. Impairs AML1-MTG8/ETO activity in hematopoietic stem/progenitor cell self-renewal but no effect in inhibiting differentiation; when associated with 379-A--A-381. 1 Publication | 2 | |
Mutagenesisi | 357 | L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-360; E- 61; E-375; R-378 and R-389. 2 Publications | 1 | |
Mutagenesisi | 360 | L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; E-361; E-375; R-378 and R-389. 2 Publications | 1 | |
Mutagenesisi | 361 | L → E: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; R-360; E-375; R-378 and R-389. 2 Publications | 1 | |
Mutagenesisi | 375 | L → E: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; R-360; E-361; R-378 and R-389. 2 Publications | 1 | |
Mutagenesisi | 378 | L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2 when associated with E-345; R-357; R-360; E-361; E-375 and R-389. 2 Publications | 1 | |
Mutagenesisi | 379 – 381 | RRC → AAA: Disrupts interaction with TCF12, no effect on oligomerization. Impairs AML1-MTG8/ETO activity in hematopoietic stem/progenitor cell self-renewal but no effect in inhibiting differentiation; when associated with 352-E-E-353. 1 Publication | 3 | |
Mutagenesisi | 389 | L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; R-360; E-361; E-375 and R-378. 2 Publications | 1 | |
Mutagenesisi | 547 | H → A: Causes unfolding of the MYND-type zinc finger domain. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 30 – 31 | Breakpoint for translocation to form AML1-MTG8 in AML-M21 Publication | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 862 |
MalaCardsi | RUNX1T1 |
OpenTargetsi | ENSG00000079102 |
Orphaneti | 102724, Acute myeloid leukemia with t(8;21)(q22;q22) translocation |
PharmGKBi | PA26111 |
Miscellaneous databases
Pharosi | Q06455, Tbio |
Genetic variation databases
BioMutai | RUNX1T1 |
DMDMi | 2498595 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218299 | 1 – 604 | Protein CBFA2T1Add BLAST | 604 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineCombined sources | 1 | |
Modified residuei | 417 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q06455 |
jPOSTi | Q06455 |
MassIVEi | Q06455 |
MaxQBi | Q06455 |
PaxDbi | Q06455 |
PeptideAtlasi | Q06455 |
PRIDEi | Q06455 |
ProteomicsDBi | 17401 58447 [Q06455-1] 58448 [Q06455-2] 69196 |
PTM databases
GlyGeni | Q06455, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q06455 |
PhosphoSitePlusi | Q06455 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000079102, Expressed in forebrain and 240 other tissues |
ExpressionAtlasi | Q06455, baseline and differential |
Genevisiblei | Q06455, HS |
Organism-specific databases
HPAi | ENSG00000079102, Tissue enriched (brain) |
Interactioni
Subunit structurei
Homooligomer. Homotetramerization is mediated by nervy homology region 2 (NRH2). Can interact with CBFA2T2 and CBFA2T3; heterotetramerization between members of the CBFA2T family is proposed.
Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1, NCOR2.
Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression.
Interacts (via its N-terminus) with ZBTB16; the interaction increases the transcription repression activity of ZBTB16 (PubMed:10688654). AML1-MTG8/ETO fusion protein interacts with CBFB. AML1-MTG8/ETO is part of a stable transcription factor complex AETFC in leukemic cells; AETFC formation seems to be involved in recruitment of EP300. AML1-MTG8/ETO nervy homology region 2-mediated oligomerization is proposed to be homotypic, required for AML1-MTG8/ETO-mediated transformation of primary hematopoietic cells and is required for AML1-MTG8/ETO interaction with TCF12.
9 PublicationsBinary interactionsi
Q06455
With | #Exp. | IntAct |
---|---|---|
NCOR1 [O75376] | 5 | EBI-743342,EBI-347233 |
SP1 [P08047] | 2 | EBI-743342,EBI-298336 |
Son [Q9QX47] from Mus musculus. | 4 | EBI-743342,EBI-643037 |
Isoform MTG8A [Q06455-2]
Isoform 4 [Q06455-4]
GO - Molecular functioni
- DNA-binding transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107310, 110 interactors |
DIPi | DIP-29401N |
ELMi | Q06455 |
IntActi | Q06455, 89 interactors |
MINTi | Q06455 |
STRINGi | 9606.ENSP00000402257 |
Miscellaneous databases
RNActi | Q06455, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q06455 |
BMRBi | Q06455 |
SMRi | Q06455 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q06455 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 120 – 215 | TAFHPROSITE-ProRule annotationAdd BLAST | 96 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 114 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 230 – 298 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 337 – 383 | Important for oligomerizationAdd BLAST | 47 | |
Regioni | 337 – 383 | Nervy homology region 2 (NHR2)1 PublicationAdd BLAST | 47 | |
Regioni | 401 – 423 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 443 – 492 | Nervy homology region 3 (NHR3)1 PublicationAdd BLAST | 50 | |
Regioni | 557 – 604 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 65 – 114 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 235 – 263 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 270 – 287 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 515 – 551 | MYND-typePROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QTD6, Eukaryota |
GeneTreei | ENSGT00950000183176 |
HOGENOMi | CLU_022077_2_0_1 |
InParanoidi | Q06455 |
OMAi | SFQNRRH |
OrthoDBi | 334242at2759 |
PhylomeDBi | Q06455 |
TreeFami | TF106303 |
Family and domain databases
Gene3Di | 1.20.120.1110, 1 hit |
IDEALi | IID00381 |
InterProi | View protein in InterPro IPR013290, CBFA2T1 IPR013289, CBFA2T1/2/3 IPR014896, NHR2 IPR037249, TAFH/NHR1_dom_sf IPR003894, TAFH_NHR1 IPR002893, Znf_MYND |
PANTHERi | PTHR10379, PTHR10379, 1 hit PTHR10379:SF5, PTHR10379:SF5, 1 hit |
Pfami | View protein in Pfam PF08788, NHR2, 1 hit PF07531, TAFH, 1 hit PF01753, zf-MYND, 1 hit |
PRINTSi | PR01875, ETOFAMILY PR01876, MTG8PROTEIN |
SMARTi | View protein in SMART SM00549, TAFH, 1 hit |
SUPFAMi | SSF158553, SSF158553, 1 hit |
PROSITEi | View protein in PROSITE PS51119, TAFH, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 28 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MISVKRNTWR ALSLVIGDCR KKGNFEYCQD RTEKHSTMPD SPVDVKTQSR
60 70 80 90 100
LTPPTMPPPP TTQGAPRTSS FTPTTLTNGT SHSPTALNGA PSPPNGFSNG
110 120 130 140 150
PSSSSSSSLA NQQLPPACGA RQLSKLKRFL TTLQQFGNDI SPEIGERVRT
160 170 180 190 200
LVLGLVNSTL TIEEFHSKLQ EATNFPLRPF VIPFLKANLP LLQRELLHCA
210 220 230 240 250
RLAKQNPAQY LAQHEQLLLD ASTTSPVDSS ELLLDVNENG KRRTPDRTKE
260 270 280 290 300
NGFDREPLHS EHPSKRPCTI SPGQRYSPNN GLSYQPNGLP HPTPPPPQHY
310 320 330 340 350
RLDDMAIAHH YRDSYRHPSH RDLRDRNRPM GLHGTRQEEM IDHRLTDREW
360 370 380 390 400
AEEWKHLDHL LNCIMDMVEK TRRSLTVLRR CQEADREELN YWIRRYSDAE
410 420 430 440 450
DLKKGGGSSS SHSRQQSPVN PDPVALDAHR EFLHRPASGY VPEEIWKKAE
460 470 480 490 500
EAVNEVKRQA MTELQKAVSE AERKAHDMIT TERAKMERTV AEAKRQAAED
510 520 530 540 550
ALAVINQQED SSESCWNCGR KASETCSGCN TARYCGSFCQ HKDWEKHHHI
560 570 580 590 600
CGQTLQAQQQ GDTPAVSSSV TPNSGAGSPM DTPPAATPRS TTPGTPSTIE
TTPR
The sequence of this isoform differs from the canonical sequence as follows:
1-29: MISVKRNTWRALSLVIGDCRKKGNFEYCQ → MP
The sequence of this isoform differs from the canonical sequence as follows:
427-427: D → G
428-604: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-29: MISVKRNTWRALSLVIGDCRKKGNFEYCQ → MP
427-427: D → G
428-604: Missing.
Computationally mapped potential isoform sequencesi
There are 28 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSU1 | A0A0A0MSU1_HUMAN | Protein CBFA2T1 | RUNX1T1 | 663 | Annotation score: | ||
A0A087WWT6 | A0A087WWT6_HUMAN | Protein CBFA2T1 | RUNX1T1 hCG_20715 | 584 | Annotation score: | ||
E5RG85 | E5RG85_HUMAN | Protein CBFA2T1 | RUNX1T1 | 171 | Annotation score: | ||
E5RHJ8 | E5RHJ8_HUMAN | Protein CBFA2T1 | RUNX1T1 | 210 | Annotation score: | ||
E7ETA8 | E7ETA8_HUMAN | Protein CBFA2T1 | RUNX1T1 | 229 | Annotation score: | ||
E5RH30 | E5RH30_HUMAN | Protein CBFA2T1 | RUNX1T1 | 120 | Annotation score: | ||
E7EWJ9 | E7EWJ9_HUMAN | Protein CBFA2T1 | RUNX1T1 | 169 | Annotation score: | ||
E7EQW3 | E7EQW3_HUMAN | Protein CBFA2T1 | RUNX1T1 | 156 | Annotation score: | ||
E5RH72 | E5RH72_HUMAN | Protein CBFA2T1 | RUNX1T1 | 46 | Annotation score: | ||
E5RI38 | E5RI38_HUMAN | Protein CBFA2T1 | RUNX1T1 | 79 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 455 | E → G in BAH12630 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 506 | N → S in BAH12630 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036321 | 386 | R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1301792645Ensembl. | 1 | |
Natural variantiVAR_036322 | 395 | R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1448417558Ensembl. | 1 | |
Natural variantiVAR_036323 | 471 | A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1462140811Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045442 | 1 – 37 | Missing in isoform 4. 2 PublicationsAdd BLAST | 37 | |
Alternative sequenceiVSP_044558 | 1 – 29 | MISVK…FEYCQ → MCHPDKAFTSDKLQCVFNEY KAAVWVPPRPRPLSRAPLPE in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_003327 | 1 – 29 | MISVK…FEYCQ → MP in isoform MTG8A and isoform MTG8A-2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_058512 | 427 | D → G in isoform MTG8B-2 and isoform MTG8A-2. 1 Publication | 1 | |
Alternative sequenceiVSP_058513 | 428 – 604 | Missing in isoform MTG8B-2 and isoform MTG8A-2. 1 PublicationAdd BLAST | 177 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WQ6 | X-ray | 2.00 | A/B | 335-403 | [»] | |
2DJ8 | NMR | - | A | 505-551 | [»] | |
2H7B | NMR | - | A | 120-222 | [»] | |
2KNH | NMR | - | A | 119-216 | [»] | |
2KYG | NMR | - | C | 437-467 | [»] | |
2OD1 | NMR | - | A | 510-559 | [»] | |
2ODD | NMR | - | A | 510-559 | [»] | |
2PP4 | NMR | - | A | 119-225 | [»] | |
4JOL | X-ray | 2.91 | A/B/C/D | 338-400 | [»] | |
AlphaFoldDBi | Q06455 | |||||
BMRBi | Q06455 | |||||
SMRi | Q06455 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107310, 110 interactors |
DIPi | DIP-29401N |
ELMi | Q06455 |
IntActi | Q06455, 89 interactors |
MINTi | Q06455 |
STRINGi | 9606.ENSP00000402257 |
PTM databases
GlyGeni | Q06455, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q06455 |
PhosphoSitePlusi | Q06455 |
Genetic variation databases
BioMutai | RUNX1T1 |
DMDMi | 2498595 |
Proteomic databases
EPDi | Q06455 |
jPOSTi | Q06455 |
MassIVEi | Q06455 |
MaxQBi | Q06455 |
PaxDbi | Q06455 |
PeptideAtlasi | Q06455 |
PRIDEi | Q06455 |
ProteomicsDBi | 17401 58447 [Q06455-1] 58448 [Q06455-2] 69196 |
Protocols and materials databases
Antibodypediai | 25672, 282 antibodies from 34 providers |
DNASUi | 862 |
Genome annotation databases
Organism-specific databases
CTDi | 862 |
DisGeNETi | 862 |
GeneCardsi | RUNX1T1 |
HGNCi | HGNC:1535, RUNX1T1 |
HPAi | ENSG00000079102, Tissue enriched (brain) |
MalaCardsi | RUNX1T1 |
MIMi | 133435, gene |
neXtProti | NX_Q06455 |
OpenTargetsi | ENSG00000079102 |
Orphaneti | 102724, Acute myeloid leukemia with t(8;21)(q22;q22) translocation |
PharmGKBi | PA26111 |
VEuPathDBi | HostDB:ENSG00000079102 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTD6, Eukaryota |
GeneTreei | ENSGT00950000183176 |
HOGENOMi | CLU_022077_2_0_1 |
InParanoidi | Q06455 |
OMAi | SFQNRRH |
OrthoDBi | 334242at2759 |
PhylomeDBi | Q06455 |
TreeFami | TF106303 |
Enzyme and pathway databases
PathwayCommonsi | Q06455 |
SignaLinki | Q06455 |
SIGNORi | Q06455 |
Miscellaneous databases
BioGRID-ORCSi | 862, 15 hits in 1080 CRISPR screens |
ChiTaRSi | RUNX1T1, human |
EvolutionaryTracei | Q06455 |
GeneWikii | RUNX1T1 |
GenomeRNAii | 862 |
Pharosi | Q06455, Tbio |
PROi | PR:Q06455 |
RNActi | Q06455, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079102, Expressed in forebrain and 240 other tissues |
ExpressionAtlasi | Q06455, baseline and differential |
Genevisiblei | Q06455, HS |
Family and domain databases
Gene3Di | 1.20.120.1110, 1 hit |
IDEALi | IID00381 |
InterProi | View protein in InterPro IPR013290, CBFA2T1 IPR013289, CBFA2T1/2/3 IPR014896, NHR2 IPR037249, TAFH/NHR1_dom_sf IPR003894, TAFH_NHR1 IPR002893, Znf_MYND |
PANTHERi | PTHR10379, PTHR10379, 1 hit PTHR10379:SF5, PTHR10379:SF5, 1 hit |
Pfami | View protein in Pfam PF08788, NHR2, 1 hit PF07531, TAFH, 1 hit PF01753, zf-MYND, 1 hit |
PRINTSi | PR01875, ETOFAMILY PR01876, MTG8PROTEIN |
SMARTi | View protein in SMART SM00549, TAFH, 1 hit |
SUPFAMi | SSF158553, SSF158553, 1 hit |
PROSITEi | View protein in PROSITE PS51119, TAFH, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTG8_HUMAN | |
Accessioni | Q06455Primary (citable) accession number: Q06455 Secondary accession number(s): B7Z4P4 Q9BRZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 215 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families