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Protein

Protein CBFA2T1

Gene

RUNX1T1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).2 PublicationsBy similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri515 – 551MYND-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • transcription corepressor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q06455

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein CBFA2T1
Alternative name(s):
Cyclin-D-related protein
Eight twenty one protein
Protein ETO
Protein MTG8
Zinc finger MYND domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RUNX1T1
Synonyms:AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000079102.16

Human Gene Nomenclature Database

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HGNCi
HGNC:1535 RUNX1T1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
133435 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q06455

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi125K → A or D: Loss of interaction with TCF12. 1 Publication1
Mutagenesisi126L → A: Loss of interaction with TCF12. 1 Publication1
Mutagenesisi128R → D: Loss of interaction with TCF12. 1 Publication1
Mutagenesisi129F → A: Loss of interaction with TCF12. 2 Publications1
Mutagenesisi129F → K: Abolishes interaction with corepressor. 2 Publications1
Mutagenesisi136F → A: Abolishes interaction with corepressor. 1 Publication1
Mutagenesisi170Q → A: Abolishes interaction with corepressor. 1 Publication1
Mutagenesisi173T → Q: Abolishes interaction with corepressor. 1 Publication1
Mutagenesisi175F → A: Abolishes interaction with corepressor. 1 Publication1
Mutagenesisi177L → A: Abolishes interaction with corepressor. 1 Publication1
Mutagenesisi178R → A or D: Loss of interaction with TCF12. 1 Publication1
Mutagenesisi184F → A: Loss of interaction with TCF12. 1 Publication1
Mutagenesisi345L → E: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with R-357; R-360; E-361; E-375; R-378 and R-389. 2 Publications1
Mutagenesisi352 – 353EE → AA: Decreases interaction with TCF12, no effect on oligomerization. Impairs AML1-MTG8/ETO activity in hematopoietic stem/progenitor cell self-renewal but no effect in inhibiting differentiation; when associated with 379-A--A-381. 1 Publication2
Mutagenesisi357L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-360; E- 61; E-375; R-378 and R-389. 2 Publications1
Mutagenesisi360L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; E-361; E-375; R-378 and R-389. 2 Publications1
Mutagenesisi361L → E: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; R-360; E-375; R-378 and R-389. 2 Publications1
Mutagenesisi375L → E: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; R-360; E-361; R-378 and R-389. 2 Publications1
Mutagenesisi378L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2 when associated with E-345; R-357; R-360; E-361; E-375 and R-389. 2 Publications1
Mutagenesisi379 – 381RRC → AAA: Disrupts interaction with TCF12, no effect on oligomerization. Impairs AML1-MTG8/ETO activity in hematopoietic stem/progenitor cell self-renewal but no effect in inhibiting differentiation; when associated with 352-E-E-353. 1 Publication3
Mutagenesisi389L → R: Disrupts tetramerization, disrupts AML1-MTG8/ETO interaction with TCF12, decreases AML1-MTG8/ETO interaction with RUNX1T1, CBFA2T3 and CBFA2T2; when associated with E-345; R-357; R-360; E-361; E-375 and R-378. 2 Publications1
Mutagenesisi547H → A: Causes unfolding of the MYND-type zinc finger domain. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei30 – 31Breakpoint for translocation to form AML1-MTG8 in AML-M21 Publication2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
862

MalaCards human disease database

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MalaCardsi
RUNX1T1

Open Targets

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OpenTargetsi
ENSG00000079102

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
102724 Acute myeloid leukemia with t(8;21)(q22;q22) translocation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26111

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RUNX1T1

Domain mapping of disease mutations (DMDM)

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DMDMi
2498595

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002182991 – 604Protein CBFA2T1Add BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineCombined sources1
Modified residuei417PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q06455

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q06455

PeptideAtlas

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PeptideAtlasi
Q06455

PRoteomics IDEntifications database

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PRIDEi
Q06455

ProteomicsDB human proteome resource

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ProteomicsDBi
58447
58448 [Q06455-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q06455

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q06455

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000079102 Expressed in 228 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q06455 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q06455 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA049852
HPA070951

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer. Homotetramerization is mediated by nervy homology region 2 (NRH2). Can interact with CBFA2T2 and CBFA2T3; heterotetramerization between members of the CBFA2T family is proposed. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1, NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. AML1-MTG8/ETO fusion protein interacts with CBFB. AML1-MTG8/ETO is part of a stable transcription factor complex AETFC in leukemic cells; AETFC formation seems to be involved in recruitment of EP300. AML1-MTG8/ETO nervy homology region 2-mediated oligomerization is proposed to be homotypic, required for AML1-MTG8/ETO-mediated tranformation of primary hematopoietic cells and is required for AML1-MTG8/ETO interaction with TCF12.8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107310, 61 interactors

Database of interacting proteins

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DIPi
DIP-29401N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q06455

Protein interaction database and analysis system

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IntActi
Q06455, 83 interactors

Molecular INTeraction database

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MINTi
Q06455

STRING: functional protein association networks

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STRINGi
9606.ENSP00000402257

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1604
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q06455

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q06455

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q06455

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini120 – 215TAFHPROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni337 – 383Important for oligomerizationAdd BLAST47
Regioni337 – 383Nervy homology region 2 (NHR2)1 PublicationAdd BLAST47
Regioni443 – 492Nervy homology region 3 (NHR3)1 PublicationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 60Poly-Pro4
Compositional biasi102 – 108Poly-Ser7
Compositional biasi290 – 297Poly-Pro8
Compositional biasi408 – 413Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TAFH domain mediates interaction with transcription regulators.1 Publication
Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CBFA2T family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri515 – 551MYND-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG1Z Eukaryota
ENOG410XR30 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049245

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000169

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q06455

KEGG Orthology (KO)

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KOi
K10053

Database for complete collections of gene phylogenies

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PhylomeDBi
Q06455

TreeFam database of animal gene trees

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TreeFami
TF106303

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.1110, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013290 CBFA2T1
IPR013289 CBFA2T1/2/3
IPR014896 NHR2
IPR037249 TAFH/NHR1_dom_sf
IPR003894 TAFH_NHR1
IPR002893 Znf_MYND

The PANTHER Classification System

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PANTHERi
PTHR10379 PTHR10379, 1 hit
PTHR10379:SF5 PTHR10379:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08788 NHR2, 1 hit
PF07531 TAFH, 1 hit
PF01753 zf-MYND, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01875 ETOFAMILY
PR01876 MTG8PROTEIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00549 TAFH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF158553 SSF158553, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51119 TAFH, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 28 potential isoforms that are computationally mapped.Show allAlign All

Isoform MTG8B (identifier: Q06455-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISVKRNTWR ALSLVIGDCR KKGNFEYCQD RTEKHSTMPD SPVDVKTQSR
60 70 80 90 100
LTPPTMPPPP TTQGAPRTSS FTPTTLTNGT SHSPTALNGA PSPPNGFSNG
110 120 130 140 150
PSSSSSSSLA NQQLPPACGA RQLSKLKRFL TTLQQFGNDI SPEIGERVRT
160 170 180 190 200
LVLGLVNSTL TIEEFHSKLQ EATNFPLRPF VIPFLKANLP LLQRELLHCA
210 220 230 240 250
RLAKQNPAQY LAQHEQLLLD ASTTSPVDSS ELLLDVNENG KRRTPDRTKE
260 270 280 290 300
NGFDREPLHS EHPSKRPCTI SPGQRYSPNN GLSYQPNGLP HPTPPPPQHY
310 320 330 340 350
RLDDMAIAHH YRDSYRHPSH RDLRDRNRPM GLHGTRQEEM IDHRLTDREW
360 370 380 390 400
AEEWKHLDHL LNCIMDMVEK TRRSLTVLRR CQEADREELN YWIRRYSDAE
410 420 430 440 450
DLKKGGGSSS SHSRQQSPVN PDPVALDAHR EFLHRPASGY VPEEIWKKAE
460 470 480 490 500
EAVNEVKRQA MTELQKAVSE AERKAHDMIT TERAKMERTV AEAKRQAAED
510 520 530 540 550
ALAVINQQED SSESCWNCGR KASETCSGCN TARYCGSFCQ HKDWEKHHHI
560 570 580 590 600
CGQTLQAQQQ GDTPAVSSSV TPNSGAGSPM DTPPAATPRS TTPGTPSTIE

TTPR
Length:604
Mass (Da):67,566
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3D2452F96E65679
GO
Isoform MTG8A (identifier: Q06455-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MISVKRNTWRALSLVIGDCRKKGNFEYCQ → MP

Show »
Length:577
Mass (Da):64,396
Checksum:i70E84F0120C11C3B
GO
Isoform 3 (identifier: Q06455-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MISVKRNTWRALSLVIGDCRKKGNFEYCQ → MCHPDKAFTSDKLQCVFNEYKAAVWVPPRPRPLSRAPLPE

Show »
Length:615
Mass (Da):68,746
Checksum:i4FB11B0FAEC56B07
GO
Isoform 4 (identifier: Q06455-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Show »
Length:567
Mass (Da):63,212
Checksum:i44AADF2EC7032050
GO
Isoform MTG8B-2 (identifier: Q06455-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: D → G
     428-604: Missing.

Show »
Length:427
Mass (Da):48,146
Checksum:iA4482697E23DD852
GO
Isoform MTG8A-2 (identifier: Q06455-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MISVKRNTWRALSLVIGDCRKKGNFEYCQ → MP
     427-427: D → G
     428-604: Missing.

Show »
Length:400
Mass (Da):44,975
Checksum:i451BFA533E281CDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 28 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSU1A0A0A0MSU1_HUMAN
Protein CBFA2T1
RUNX1T1
663Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWT6A0A087WWT6_HUMAN
Protein CBFA2T1
RUNX1T1 hCG_20715
584Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETA8E7ETA8_HUMAN
Protein CBFA2T1
RUNX1T1
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHJ8E5RHJ8_HUMAN
Protein CBFA2T1
RUNX1T1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG85E5RG85_HUMAN
Protein CBFA2T1
RUNX1T1
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWJ9E7EWJ9_HUMAN
Protein CBFA2T1
RUNX1T1
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQW3E7EQW3_HUMAN
Protein CBFA2T1
RUNX1T1
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH30E5RH30_HUMAN
Protein CBFA2T1
RUNX1T1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI38E5RI38_HUMAN
Protein CBFA2T1
RUNX1T1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ32E5RJ32_HUMAN
Protein CBFA2T1
RUNX1T1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH05850 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA03247 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti455E → G in BAH12630 (PubMed:14702039).Curated1
Sequence conflicti506N → S in BAH12630 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036321386R → W in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036322395R → W in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036323471A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1462140811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454421 – 37Missing in isoform 4. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_0445581 – 29MISVK…FEYCQ → MCHPDKAFTSDKLQCVFNEY KAAVWVPPRPRPLSRAPLPE in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0033271 – 29MISVK…FEYCQ → MP in isoform MTG8A and isoform MTG8A-2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_058512427D → G in isoform MTG8B-2 and isoform MTG8A-2. 1 Publication1
Alternative sequenceiVSP_058513428 – 604Missing in isoform MTG8B-2 and isoform MTG8A-2. 1 PublicationAdd BLAST177

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D14821 mRNA Translation: BAA03558.1
D13979 mRNA Translation: BAA03089.1 Sequence problems.
D14289 mRNA Translation: BAA03247.1 Different initiation.
AF018282
, AF018271, AF018272, AF018273, AF018274, AF018275, AF018276, AF018277, AF018278, AF018279, AF018281 Genomic DNA Translation: AAC28932.1
AF018282
, AF018270, AF018272, AF018273, AF018274, AF018275, AF018276, AF018277, AF018278, AF018279, AF018281 Genomic DNA Translation: AAC28931.1
AF018283 mRNA Translation: AAC26143.1
AK297616 mRNA Translation: BAH12630.1
BT009871 mRNA Translation: AAP88873.1
CR456792 mRNA Translation: CAG33073.1
AC103680 Genomic DNA No translation available.
AC104339 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91685.1
BC005850 mRNA Translation: AAH05850.1 Different initiation.
BC067078 mRNA Translation: AAH67078.2
AF181450 Genomic DNA No translation available.
D43638 mRNA Translation: BAA07755.1
X79990 mRNA Translation: CAA56311.1
S74096 Genomic DNA Translation: AAB32126.1
S74092 Genomic DNA No translation available.
S78158 mRNA Translation: AAB34819.2 Sequence problems.
S78159 mRNA Translation: AAB34820.2 Sequence problems.
D14822 mRNA Translation: BAA03559.1 Sequence problems.
D14823 mRNA Translation: BAA03560.1 Sequence problems.
S50186 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47891.1 [Q06455-2]
CCDS56544.1 [Q06455-3]
CCDS6256.1 [Q06455-1]
CCDS6257.1 [Q06455-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A57784
C57784

NCBI Reference Sequences

More...
RefSeqi
NP_001185554.1, NM_001198625.1 [Q06455-2]
NP_001185555.1, NM_001198626.1 [Q06455-1]
NP_001185556.1, NM_001198627.1 [Q06455-1]
NP_001185557.1, NM_001198628.1 [Q06455-1]
NP_001185558.1, NM_001198629.1 [Q06455-1]
NP_001185559.1, NM_001198630.1 [Q06455-1]
NP_001185560.1, NM_001198631.1 [Q06455-1]
NP_001185561.1, NM_001198632.1 [Q06455-2]
NP_001185562.1, NM_001198633.1
NP_001185563.1, NM_001198634.1 [Q06455-3]
NP_001185608.1, NM_001198679.1
NP_004340.1, NM_004349.3 [Q06455-2]
NP_783552.1, NM_175634.2 [Q06455-1]
NP_783553.1, NM_175635.2 [Q06455-4]
NP_783554.1, NM_175636.2 [Q06455-4]
XP_006716739.1, XM_006716676.3 [Q06455-4]
XP_011515653.1, XM_011517351.2 [Q06455-1]
XP_011515654.1, XM_011517352.2 [Q06455-2]
XP_011515655.1, XM_011517353.2 [Q06455-4]
XP_016869420.1, XM_017013931.1
XP_016869421.1, XM_017013932.1 [Q06455-2]
XP_016869422.1, XM_017013933.1 [Q06455-2]
XP_016869423.1, XM_017013934.1 [Q06455-4]
XP_016869424.1, XM_017013935.1 [Q06455-4]
XP_016869425.1, XM_017013936.1 [Q06455-4]
XP_016869426.1, XM_017013937.1 [Q06455-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.368431
Hs.739194

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265814; ENSP00000265814; ENSG00000079102 [Q06455-1]
ENST00000360348; ENSP00000353504; ENSG00000079102 [Q06455-4]
ENST00000396218; ENSP00000379520; ENSG00000079102 [Q06455-2]
ENST00000422361; ENSP00000390137; ENSG00000079102 [Q06455-4]
ENST00000518844; ENSP00000430728; ENSG00000079102 [Q06455-2]
ENST00000520724; ENSP00000428742; ENSG00000079102 [Q06455-3]
ENST00000523629; ENSP00000428543; ENSG00000079102 [Q06455-1]
ENST00000613302; ENSP00000481799; ENSG00000079102 [Q06455-1]
ENST00000613886; ENSP00000478331; ENSG00000079102 [Q06455-2]
ENST00000614812; ENSP00000481315; ENSG00000079102 [Q06455-1]
ENST00000617740; ENSP00000481112; ENSG00000079102 [Q06455-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:862

UCSC genome browser

More...
UCSCi
uc003yfc.3 human [Q06455-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14821 mRNA Translation: BAA03558.1
D13979 mRNA Translation: BAA03089.1 Sequence problems.
D14289 mRNA Translation: BAA03247.1 Different initiation.
AF018282
, AF018271, AF018272, AF018273, AF018274, AF018275, AF018276, AF018277, AF018278, AF018279, AF018281 Genomic DNA Translation: AAC28932.1
AF018282
, AF018270, AF018272, AF018273, AF018274, AF018275, AF018276, AF018277, AF018278, AF018279, AF018281 Genomic DNA Translation: AAC28931.1
AF018283 mRNA Translation: AAC26143.1
AK297616 mRNA Translation: BAH12630.1
BT009871 mRNA Translation: AAP88873.1
CR456792 mRNA Translation: CAG33073.1
AC103680 Genomic DNA No translation available.
AC104339 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91685.1
BC005850 mRNA Translation: AAH05850.1 Different initiation.
BC067078 mRNA Translation: AAH67078.2
AF181450 Genomic DNA No translation available.
D43638 mRNA Translation: BAA07755.1
X79990 mRNA Translation: CAA56311.1
S74096 Genomic DNA Translation: AAB32126.1
S74092 Genomic DNA No translation available.
S78158 mRNA Translation: AAB34819.2 Sequence problems.
S78159 mRNA Translation: AAB34820.2 Sequence problems.
D14822 mRNA Translation: BAA03559.1 Sequence problems.
D14823 mRNA Translation: BAA03560.1 Sequence problems.
S50186 Genomic DNA No translation available.
CCDSiCCDS47891.1 [Q06455-2]
CCDS56544.1 [Q06455-3]
CCDS6256.1 [Q06455-1]
CCDS6257.1 [Q06455-4]
PIRiA57784
C57784
RefSeqiNP_001185554.1, NM_001198625.1 [Q06455-2]
NP_001185555.1, NM_001198626.1 [Q06455-1]
NP_001185556.1, NM_001198627.1 [Q06455-1]
NP_001185557.1, NM_001198628.1 [Q06455-1]
NP_001185558.1, NM_001198629.1 [Q06455-1]
NP_001185559.1, NM_001198630.1 [Q06455-1]
NP_001185560.1, NM_001198631.1 [Q06455-1]
NP_001185561.1, NM_001198632.1 [Q06455-2]
NP_001185562.1, NM_001198633.1
NP_001185563.1, NM_001198634.1 [Q06455-3]
NP_001185608.1, NM_001198679.1
NP_004340.1, NM_004349.3 [Q06455-2]
NP_783552.1, NM_175634.2 [Q06455-1]
NP_783553.1, NM_175635.2 [Q06455-4]
NP_783554.1, NM_175636.2 [Q06455-4]
XP_006716739.1, XM_006716676.3 [Q06455-4]
XP_011515653.1, XM_011517351.2 [Q06455-1]
XP_011515654.1, XM_011517352.2 [Q06455-2]
XP_011515655.1, XM_011517353.2 [Q06455-4]
XP_016869420.1, XM_017013931.1
XP_016869421.1, XM_017013932.1 [Q06455-2]
XP_016869422.1, XM_017013933.1 [Q06455-2]
XP_016869423.1, XM_017013934.1 [Q06455-4]
XP_016869424.1, XM_017013935.1 [Q06455-4]
XP_016869425.1, XM_017013936.1 [Q06455-4]
XP_016869426.1, XM_017013937.1 [Q06455-4]
UniGeneiHs.368431
Hs.739194

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WQ6X-ray2.00A/B335-403[»]
2DJ8NMR-A505-551[»]
2H7BNMR-A120-222[»]
2KNHNMR-A119-216[»]
2KYGNMR-C437-467[»]
2OD1NMR-A510-559[»]
2ODDNMR-A510-559[»]
2PP4NMR-A119-225[»]
4JOLX-ray2.91A/B/C/D338-400[»]
ProteinModelPortaliQ06455
SMRiQ06455
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107310, 61 interactors
DIPiDIP-29401N
ELMiQ06455
IntActiQ06455, 83 interactors
MINTiQ06455
STRINGi9606.ENSP00000402257

PTM databases

iPTMnetiQ06455
PhosphoSitePlusiQ06455

Polymorphism and mutation databases

BioMutaiRUNX1T1
DMDMi2498595

Proteomic databases

MaxQBiQ06455
PaxDbiQ06455
PeptideAtlasiQ06455
PRIDEiQ06455
ProteomicsDBi58447
58448 [Q06455-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
862
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265814; ENSP00000265814; ENSG00000079102 [Q06455-1]
ENST00000360348; ENSP00000353504; ENSG00000079102 [Q06455-4]
ENST00000396218; ENSP00000379520; ENSG00000079102 [Q06455-2]
ENST00000422361; ENSP00000390137; ENSG00000079102 [Q06455-4]
ENST00000518844; ENSP00000430728; ENSG00000079102 [Q06455-2]
ENST00000520724; ENSP00000428742; ENSG00000079102 [Q06455-3]
ENST00000523629; ENSP00000428543; ENSG00000079102 [Q06455-1]
ENST00000613302; ENSP00000481799; ENSG00000079102 [Q06455-1]
ENST00000613886; ENSP00000478331; ENSG00000079102 [Q06455-2]
ENST00000614812; ENSP00000481315; ENSG00000079102 [Q06455-1]
ENST00000617740; ENSP00000481112; ENSG00000079102 [Q06455-1]
GeneIDi862
KEGGihsa:862
UCSCiuc003yfc.3 human [Q06455-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
862
DisGeNETi862
EuPathDBiHostDB:ENSG00000079102.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RUNX1T1
HGNCiHGNC:1535 RUNX1T1
HPAiHPA049852
HPA070951
MalaCardsiRUNX1T1
MIMi133435 gene
neXtProtiNX_Q06455
OpenTargetsiENSG00000079102
Orphaneti102724 Acute myeloid leukemia with t(8;21)(q22;q22) translocation
PharmGKBiPA26111

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG1Z Eukaryota
ENOG410XR30 LUCA
GeneTreeiENSGT00940000153976
HOGENOMiHOG000049245
HOVERGENiHBG000169
InParanoidiQ06455
KOiK10053
PhylomeDBiQ06455
TreeFamiTF106303

Enzyme and pathway databases

SIGNORiQ06455

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RUNX1T1 human
EvolutionaryTraceiQ06455

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RUNX1T1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
862

Protein Ontology

More...
PROi
PR:Q06455

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000079102 Expressed in 228 organ(s), highest expression level in forebrain
ExpressionAtlasiQ06455 baseline and differential
GenevisibleiQ06455 HS

Family and domain databases

Gene3Di1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR013290 CBFA2T1
IPR013289 CBFA2T1/2/3
IPR014896 NHR2
IPR037249 TAFH/NHR1_dom_sf
IPR003894 TAFH_NHR1
IPR002893 Znf_MYND
PANTHERiPTHR10379 PTHR10379, 1 hit
PTHR10379:SF5 PTHR10379:SF5, 1 hit
PfamiView protein in Pfam
PF08788 NHR2, 1 hit
PF07531 TAFH, 1 hit
PF01753 zf-MYND, 1 hit
PRINTSiPR01875 ETOFAMILY
PR01876 MTG8PROTEIN
SMARTiView protein in SMART
SM00549 TAFH, 1 hit
SUPFAMiSSF158553 SSF158553, 1 hit
PROSITEiView protein in PROSITE
PS51119 TAFH, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTG8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06455
Secondary accession number(s): B7Z4P4
, E7EPN4, O14784, Q06456, Q14873, Q16239, Q16346, Q16347, Q6IBL1, Q6NXH1, Q7Z4J5, Q92479, Q9BRZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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