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UniProtKB - Q06453 (AL_DROME)
Protein
Homeobox protein aristaless
Gene
al
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 85 – 144 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- antennal morphogenesis Source: FlyBase
- chaeta development Source: FlyBase
- elongation of arista core Source: FlyBase
- imaginal disc-derived leg morphogenesis Source: FlyBase
- leg disc development Source: FlyBase
- negative regulation of transcription, DNA-templated Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein aristaless |
Gene namesi | Name:al ORF Names:CG3935 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000061, al |
VEuPathDBi | VectorBase:FBgn0000061 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- protein-containing complex Source: FlyBase
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Flies display a reduction in size of the arista and scutellum, a reduction or complete absence of the tarsal claws, irregularities of the sternopleural bristles and of the wing vein, and a bending of the wing blade.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048811 | 1 – 408 | Homeobox protein aristalessAdd BLAST | 408 |
Proteomic databases
PaxDbi | Q06453 |
Expressioni
Tissue specificityi
Expressed during embryonic development, in distinct epidermal patterns in head, thorax and abdomen and in an endodermal pattern in the anterior intestinal tract.1 Publication
Developmental stagei
First expressed in 4-8 hours old embryos, peaks in 8-12 hours old embryos and continues through development up to late larval stage. In the head region, detected at stage 10 in the maxillary and labial segment primordia, and in later stages, in the prospective antennal and mandibular segment. In the epidermis, expression is seen from stage 11 in thoracic and abdominal lateral patches. Expression in the intestinal tract begins at stage 13, continues through stages 14 and 15 in the endoderm of the anterior midgut and at stage 16, is found in the posterior end. Expression in the imaginal disks is seen from late third-instar larvae in the prospective thorax, claw organ, antenna, scutellum and wing blade.1 Publication
Gene expression databases
Bgeei | FBgn0000061, Expressed in wing disc (Drosophila) and 42 other tissues |
Genevisiblei | Q06453, DM |
Interactioni
Binary interactionsi
Q06453
With | #Exp. | IntAct |
---|---|---|
Ubx [P83949] | 3 | EBI-188244,EBI-202590 |
Protein-protein interaction databases
BioGRIDi | 59464, 24 interactors |
DIPi | DIP-23247N |
IntActi | Q06453, 3 interactors |
MINTi | Q06453 |
STRINGi | 7227.FBpp0077713 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q06453 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q06453 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 82 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 258 – 313 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 331 – 379 | DisorderedSequence analysisAdd BLAST | 49 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 378 – 391 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 50 – 71 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 275 – 294 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 295 – 309 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 331 – 354 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 355 – 371 | Pro residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000165209 |
HOGENOMi | CLU_816884_0_0_1 |
InParanoidi | Q06453 |
OMAi | MASMYSP |
OrthoDBi | 1085093at2759 |
PhylomeDBi | Q06453 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06453-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGISEEIKLE ELPQEAKLAH PDAVVLVDRA PGSSAASAGA ALTVSMSVSG
60 70 80 90 100
GAPSGASGAS GGTNSPVSDG NSDCEADEYA PKRKQRRYRT TFTSFQLEEL
110 120 130 140 150
EKAFSRTHYP DVFTREELAM KIGLTEARIQ VWFQNRRAKW RKQEKVGPQS
160 170 180 190 200
HPYNPYLPGG AATMQTVVGA ALPPNPFTHL GFQLRKPFDA QHAANLAAFR
210 220 230 240 250
YPHLSAAPMI PSGYFNQFQR APPHMLPHGM AGMYSPSSSF QSLLANMTAV
260 270 280 290 300
PRGTPLGKPP ALLVGSPDLH SPNHMLASPP TSPASGHASQ HQQHPTAHPP
310 320 330 340 350
PPQAPPQMPV GVQPAQLSPQ HLVGIALTQQ ASSLSPTQTS PVALTLSHSP
360 370 380 390 400
QRQLPPPSHQ APPPPPRAAT PPEDRRTSSI AALRLKAREH ELKLELLRQN
GHGNDVVS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 254 | T → P in AAA28840 (PubMed:8093690).Curated | 1 | |
Sequence conflicti | 321 | H → Q in AAA28840 (PubMed:8093690).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08401 mRNA Translation: AAA28840.1 AE014134 Genomic DNA Translation: AAF51505.1 AY121696 mRNA Translation: AAM52023.1 |
PIRi | A40685 |
RefSeqi | NP_722629.1, NM_164382.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0078053; FBpp0077713; FBgn0000061 |
GeneIDi | 33208 |
KEGGi | dme:Dmel_CG3935 |
UCSCi | CG3935-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08401 mRNA Translation: AAA28840.1 AE014134 Genomic DNA Translation: AAF51505.1 AY121696 mRNA Translation: AAM52023.1 |
PIRi | A40685 |
RefSeqi | NP_722629.1, NM_164382.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3A01 | X-ray | 2.70 | B/F | 80-146 | [»] | |
3A02 | X-ray | 1.00 | A | 91-146 | [»] | |
3LNQ | X-ray | 2.25 | A | 87-144 | [»] | |
SMRi | Q06453 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 59464, 24 interactors |
DIPi | DIP-23247N |
IntActi | Q06453, 3 interactors |
MINTi | Q06453 |
STRINGi | 7227.FBpp0077713 |
Proteomic databases
PaxDbi | Q06453 |
Genome annotation databases
EnsemblMetazoai | FBtr0078053; FBpp0077713; FBgn0000061 |
GeneIDi | 33208 |
KEGGi | dme:Dmel_CG3935 |
UCSCi | CG3935-RA, d. melanogaster |
Organism-specific databases
CTDi | 33208 |
FlyBasei | FBgn0000061, al |
VEuPathDBi | VectorBase:FBgn0000061 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000165209 |
HOGENOMi | CLU_816884_0_0_1 |
InParanoidi | Q06453 |
OMAi | MASMYSP |
OrthoDBi | 1085093at2759 |
PhylomeDBi | Q06453 |
Miscellaneous databases
BioGRID-ORCSi | 33208, 0 hits in 3 CRISPR screens |
EvolutionaryTracei | Q06453 |
GenomeRNAii | 33208 |
PROi | PR:Q06453 |
Gene expression databases
Bgeei | FBgn0000061, Expressed in wing disc (Drosophila) and 42 other tissues |
Genevisiblei | Q06453, DM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AL_DROME | |
Accessioni | Q06453Primary (citable) accession number: Q06453 Secondary accession number(s): Q9VPP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | March 1, 2005 | |
Last modified: | September 29, 2021 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families