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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 Jun 1994)
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Protein

Thrombospondin-4

Gene

thbs4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response (By similarity). May participate in the genesis and function of cardiac and skeletal muscle.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Mitogen
Biological processCell adhesion, Unfolded protein response
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombospondin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:thbs4
Synonyms:tsp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-17336850, thbs4.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003585625 – 955Thrombospondin-4Add BLAST931

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi256InterchainCurated
Disulfide bondi259InterchainCurated
Disulfide bondi285 ↔ 296PROSITE-ProRule annotation
Disulfide bondi290 ↔ 305PROSITE-ProRule annotation
Disulfide bondi308 ↔ 319PROSITE-ProRule annotation
Disulfide bondi325 ↔ 336PROSITE-ProRule annotation
Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
Disulfide bondi348 ↔ 372PROSITE-ProRule annotation
Disulfide bondi378 ↔ 392PROSITE-ProRule annotation
Disulfide bondi386 ↔ 401PROSITE-ProRule annotation
Disulfide bondi404 ↔ 416PROSITE-ProRule annotation
Disulfide bondi422 ↔ 435PROSITE-ProRule annotation
Disulfide bondi429 ↔ 445PROSITE-ProRule annotation
Disulfide bondi447 ↔ 458PROSITE-ProRule annotation
Disulfide bondi474 ↔ 479PROSITE-ProRule annotation
Disulfide bondi484 ↔ 504PROSITE-ProRule annotation
Disulfide bondi520 ↔ 540PROSITE-ProRule annotation
Disulfide bondi543 ↔ 563PROSITE-ProRule annotation
Disulfide bondi579 ↔ 599PROSITE-ProRule annotation
Disulfide bondi602 ↔ 622PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi640 ↔ 660PROSITE-ProRule annotation
Disulfide bondi680 ↔ 700PROSITE-ProRule annotation
Disulfide bondi716 ↔ 937PROSITE-ProRule annotation
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q06441

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Initial expression during neurulation. Increase during tailbud stages but decrease by the feeding tadpole stage.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked.

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06441

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 192Laminin G-likeAdd BLAST168
Domaini281 – 320EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini321 – 358EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini374 – 415EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini418 – 459EGF-like 4PROSITE-ProRule annotationAdd BLAST42
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati460 – 492TSP type-3 1Add BLAST33
Repeati493 – 528TSP type-3 2Add BLAST36
Repeati529 – 551TSP type-3 3Add BLAST23
Repeati552 – 587TSP type-3 4Add BLAST36
Repeati588 – 610TSP type-3 5Add BLAST23
Repeati611 – 648TSP type-3 6Add BLAST38
Repeati649 – 688TSP type-3 7Add BLAST40
Repeati689 – 724TSP type-3 8Add BLAST36
Domaini728 – 942TSP C-terminalPROSITE-ProRule annotationAdd BLAST215

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04659

Database of Orthologous Groups

More...
OrthoDBi
120983at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1080.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G
IPR024665, Thbs/COMP_coiled-coil
IPR003367, Thrombospondin_3-like_rpt
IPR017897, Thrombospondin_3_rpt
IPR008859, Thrombospondin_C
IPR028974, TSP_type-3_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11598, COMP, 1 hit
PF07645, EGF_CA, 2 hits
PF02412, TSP_3, 6 hits
PF05735, TSP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 3 hits
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103647, SSF103647, 3 hits
SSF49899, SSF49899, 2 hits
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 3 hits
PS01187, EGF_CA, 2 hits
PS51234, TSP3, 8 hits
PS51236, TSP_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q06441-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRKGLCLF LQMLLLHLYG VCQAQPNYQV FDLLSVSVQR QVTSFLQSAL
60 70 80 90 100
SNPSMNEVYV LSTFKLQPKS TVTLFGLYST SDNSRFFEFT VMGRLNKASL
110 120 130 140 150
RYLRSDGKLH SVFFNKLDIA DGKQHALLLH LSGLHRGATF AKLYIDCNPT
160 170 180 190 200
GVVEDLPRPL SGIRLNTGSV HLRTLQKKGQ DSMDELKLVM GGTLSEVGAI
210 220 230 240 250
QECFMQKSEA GQQTGDVSRQ LIGQITQMNQ MLGELRDVMR QQVKETMFLR
260 270 280 290 300
NTIAECQACG LGPDFPLPTK VPQRLATTTP PKPRCDATSC FRGVRCIDTE
310 320 330 340 350
GGFQCGPCPE GYTGNGVICT DVDECRLNPC FLGVRCINTS PGFKCESCPP
360 370 380 390 400
GYTGSTIQGI GINFAKQNKQ VCTDTNECEN GRNGGCTSNS LCINTMGSFR
410 420 430 440 450
CGGCKPGYVG DQIKGCKPEK SCRHGQNPCH ASAQCSEEKD GDVTCTCSVG
460 470 480 490 500
WAGNGYLCGK DTDIDGYPDE ALPCPDKNCK KDNCVYVPNS GQEDTDKDNI
510 520 530 540 550
GDACDEDADG DGILNEQDNC VLAANIDQKN SDQDIFGDAC DNCRLTLNND
560 570 580 590 600
QRDTDNDGKG DACDDDMDGD GIKNILDNCQ RVPNVDQKDK DGDGVGDICD
610 620 630 640 650
SCPDIINPNQ SDIDNDLVGD SCDTNQDSDG DGHQDSTDNC PTVINSNQLD
660 670 680 690 700
TDKDGIGDEC DDDDDNDGIP DTVPPGPDNC KLVPNPGQED DNNDGVGDVC
710 720 730 740 750
EADFDQDTVI DRIDVCPENA EITLTDFRAY QTVVLDPEGD AQIDPNWIVL
760 770 780 790 800
NQGMEIVQTM NSDPGLAVGY TAFNGVDFEG TFHVNTMTDD DYAGFIFGYQ
810 820 830 840 850
DSSSFYVVMW KQTEQTYWQA TPFRAVAEPG IQLKAVKSKS GPGEHLRNAL
860 870 880 890 900
WHTGDTNDQV RLLWKDPRNV GWKDKVSYRW FLQHRPQVGY IRARFYEGTE
910 920 930 940 950
LVADSGVTVD TTMRGGRLGV FCFSQENIIW SNLKYRCNDT IPEDFQAFQA

QQFSS
Length:955
Mass (Da):104,918
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AAE9FBBD9E9187B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z19091 mRNA Translation: CAA79518.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45441

NCBI Reference Sequences

More...
RefSeqi
NP_001081597.1, NM_001088128.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:397943

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19091 mRNA Translation: CAA79518.1
PIRiA45441
RefSeqiNP_001081597.1, NM_001088128.1

3D structure databases

SMRiQ06441
ModBaseiSearch...

Proteomic databases

PRIDEiQ06441

Genome annotation databases

GeneIDi397943
KEGGixla:397943

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
397943
XenbaseiXB-GENE-17336850, thbs4.L

Phylogenomic databases

KOiK04659
OrthoDBi120983at2759

Family and domain databases

Gene3Di4.10.1080.10, 3 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G
IPR024665, Thbs/COMP_coiled-coil
IPR003367, Thrombospondin_3-like_rpt
IPR017897, Thrombospondin_3_rpt
IPR008859, Thrombospondin_C
IPR028974, TSP_type-3_rpt
PfamiView protein in Pfam
PF11598, COMP, 1 hit
PF07645, EGF_CA, 2 hits
PF02412, TSP_3, 6 hits
PF05735, TSP_C, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 3 hits
SM00210, TSPN, 1 hit
SUPFAMiSSF103647, SSF103647, 3 hits
SSF49899, SSF49899, 2 hits
SSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 3 hits
PS01187, EGF_CA, 2 hits
PS51234, TSP3, 8 hits
PS51236, TSP_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSP4_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06441
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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