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UniProtKB - Q06432 (CCG1_HUMAN)
Protein
Voltage-dependent calcium channel gamma-1 subunit
Gene
CACNG1
Organism
Homo sapiens (Human)
Status
Functioni
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
By similarityGO - Molecular functioni
- calcium channel regulator activity Source: UniProtKB
- voltage-gated calcium channel activity Source: Ensembl
GO - Biological processi
- regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: UniProtKB
- sarcoplasmic reticulum calcium ion transport Source: Ensembl
Keywordsi
Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q06432 |
SignaLinki | Q06432 |
Protein family/group databases
TCDBi | 8.A.16.1.1, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent calcium channel gamma-1 subunitAlternative name(s): Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma |
Gene namesi | Name:CACNG1 Synonyms:CACNLG2 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1405, CACNG1 |
MIMi | 114209, gene |
neXtProti | NX_Q06432 |
VEuPathDBi | HostDB:ENSG00000108878 |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- L-type voltage-gated calcium channel complex Source: UniProtKB
- sarcolemma Source: UniProtKB
- T-tubule Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicCurated | 10 | |
Transmembranei | 11 – 29 | HelicalBy similarityAdd BLAST | 19 | |
Topological domaini | 30 – 108 | ExtracellularCuratedAdd BLAST | 79 | |
Transmembranei | 109 – 129 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 130 – 134 | CytoplasmicCurated | 5 | |
Transmembranei | 135 – 155 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 156 – 179 | ExtracellularCuratedAdd BLAST | 24 | |
Transmembranei | 180 – 204 | HelicalBy similarityAdd BLAST | 25 | |
Topological domaini | 205 – 222 | CytoplasmicCuratedAdd BLAST | 18 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 786 |
OpenTargetsi | ENSG00000108878 |
PharmGKBi | PA26015 |
Miscellaneous databases
Pharosi | Q06432, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2363032 |
DrugBanki | DB13746, Bioallethrin DB11148, Butamben DB00343, Diltiazem DB00228, Enflurane DB00153, Ergocalciferol DB00898, Ethanol DB04842, Fluspirilene DB00308, Ibutilide DB00528, Lercanidipine DB00421, Spironolactone |
DrugCentrali | Q06432 |
Genetic variation databases
BioMutai | CACNG1 |
DMDMi | 1168946 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164669 | 1 – 222 | Voltage-dependent calcium channel gamma-1 subunitAdd BLAST | 222 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 57 ↔ 80 | By similarity | ||
Glycosylationi | 79 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q06432 |
PaxDbi | Q06432 |
PeptideAtlasi | Q06432 |
PRIDEi | Q06432 |
ProteomicsDBi | 58446 |
PTM databases
GlyGeni | Q06432, 2 sites |
iPTMneti | Q06432 |
PhosphoSitePlusi | Q06432 |
Expressioni
Tissue specificityi
Skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000108878, Expressed in gastrocnemius and 106 other tissues |
Genevisiblei | Q06432, HS |
Organism-specific databases
HPAi | ENSG00000108878, Group enriched (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
By similarityBinary interactionsi
Q06432
Protein-protein interaction databases
BioGRIDi | 107240, 42 interactors |
ComplexPortali | CPX-3192, Skeletal muscle VGCC complex |
IntActi | Q06432, 17 interactors |
STRINGi | 9606.ENSP00000226021 |
Chemistry databases
BindingDBi | Q06432 |
Miscellaneous databases
RNActi | Q06432, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QT5N, Eukaryota |
GeneTreei | ENSGT00390000007786 |
HOGENOMi | CLU_093876_0_0_1 |
InParanoidi | Q06432 |
OMAi | CACTGFV |
OrthoDBi | 1261253at2759 |
PhylomeDBi | Q06432 |
TreeFami | TF331651 |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR005421, VDCC_g1su IPR008368, VDCC_gsu |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01601, VDCCGAMMA1 |
i Sequence
Sequence statusi: Complete.
Q06432-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH
60 70 80 90 100
FGLWRICTKR IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ
110 120 130 140 150
KEYSISAAAI AIFSLGFIIL GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC
160 170 180 190 200
ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW SFACACAAFI LLFLGGLALL
210 220
LFSLPRMPRN PWESCMDAEP EH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012063 | 196 | G → S. Corresponds to variant dbSNP:rs1799938Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07738 mRNA Translation: AAA51904.1 AK313852 mRNA Translation: BAG36580.1 CH471099 Genomic DNA Translation: EAW89022.1 BC069493 mRNA Translation: AAH69493.1 BC113486 mRNA Translation: AAI13487.1 BC113492 mRNA Translation: AAI13493.1 Z19603 Genomic DNA Translation: CAA79671.1 Z19587 Genomic DNA Translation: CAB62573.1 Sequence problems. |
CCDSi | CCDS11668.1 |
PIRi | A46658 |
RefSeqi | NP_000718.1, NM_000727.3 |
Genome annotation databases
Ensembli | ENST00000226021; ENSP00000226021; ENSG00000108878 |
GeneIDi | 786 |
KEGGi | hsa:786 |
MANE-Selecti | ENST00000226021.5; ENSP00000226021.3; NM_000727.4; NP_000718.1 |
UCSCi | uc002jfu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07738 mRNA Translation: AAA51904.1 AK313852 mRNA Translation: BAG36580.1 CH471099 Genomic DNA Translation: EAW89022.1 BC069493 mRNA Translation: AAH69493.1 BC113486 mRNA Translation: AAI13487.1 BC113492 mRNA Translation: AAI13493.1 Z19603 Genomic DNA Translation: CAA79671.1 Z19587 Genomic DNA Translation: CAB62573.1 Sequence problems. |
CCDSi | CCDS11668.1 |
PIRi | A46658 |
RefSeqi | NP_000718.1, NM_000727.3 |
3D structure databases
SMRi | Q06432 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107240, 42 interactors |
ComplexPortali | CPX-3192, Skeletal muscle VGCC complex |
IntActi | Q06432, 17 interactors |
STRINGi | 9606.ENSP00000226021 |
Chemistry databases
BindingDBi | Q06432 |
ChEMBLi | CHEMBL2363032 |
DrugBanki | DB13746, Bioallethrin DB11148, Butamben DB00343, Diltiazem DB00228, Enflurane DB00153, Ergocalciferol DB00898, Ethanol DB04842, Fluspirilene DB00308, Ibutilide DB00528, Lercanidipine DB00421, Spironolactone |
DrugCentrali | Q06432 |
Protein family/group databases
TCDBi | 8.A.16.1.1, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family |
PTM databases
GlyGeni | Q06432, 2 sites |
iPTMneti | Q06432 |
PhosphoSitePlusi | Q06432 |
Genetic variation databases
BioMutai | CACNG1 |
DMDMi | 1168946 |
Proteomic databases
MassIVEi | Q06432 |
PaxDbi | Q06432 |
PeptideAtlasi | Q06432 |
PRIDEi | Q06432 |
ProteomicsDBi | 58446 |
Protocols and materials databases
Antibodypediai | 19201, 186 antibodies from 28 providers |
DNASUi | 786 |
Genome annotation databases
Ensembli | ENST00000226021; ENSP00000226021; ENSG00000108878 |
GeneIDi | 786 |
KEGGi | hsa:786 |
MANE-Selecti | ENST00000226021.5; ENSP00000226021.3; NM_000727.4; NP_000718.1 |
UCSCi | uc002jfu.4, human |
Organism-specific databases
CTDi | 786 |
DisGeNETi | 786 |
GeneCardsi | CACNG1 |
HGNCi | HGNC:1405, CACNG1 |
HPAi | ENSG00000108878, Group enriched (skeletal muscle, tongue) |
MIMi | 114209, gene |
neXtProti | NX_Q06432 |
OpenTargetsi | ENSG00000108878 |
PharmGKBi | PA26015 |
VEuPathDBi | HostDB:ENSG00000108878 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT5N, Eukaryota |
GeneTreei | ENSGT00390000007786 |
HOGENOMi | CLU_093876_0_0_1 |
InParanoidi | Q06432 |
OMAi | CACTGFV |
OrthoDBi | 1261253at2759 |
PhylomeDBi | Q06432 |
TreeFami | TF331651 |
Enzyme and pathway databases
PathwayCommonsi | Q06432 |
SignaLinki | Q06432 |
Miscellaneous databases
BioGRID-ORCSi | 786, 16 hits in 1033 CRISPR screens |
GeneWikii | CACNG1 |
GenomeRNAii | 786 |
Pharosi | Q06432, Tbio |
PROi | PR:Q06432 |
RNActi | Q06432, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108878, Expressed in gastrocnemius and 106 other tissues |
Genevisiblei | Q06432, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR005421, VDCC_g1su IPR008368, VDCC_gsu |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01601, VDCCGAMMA1 |
MobiDBi | Search... |
Entry informationi
Entry namei | CCG1_HUMAN | |
Accessioni | Q06432Primary (citable) accession number: Q06432 Secondary accession number(s): B2R9N3, Q14D59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families