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Entry version 154 (08 May 2019)
Sequence version 2 (16 Nov 2011)
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Protein

Putative POU domain, class 5, transcription factor 1B

Gene

POU5F1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Shows weak transcriptional activator activity.1 Publication

Caution

Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed in cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative POU domain, class 5, transcription factor 1B
Alternative name(s):
Oct4-pg1
Octamer-binding protein 3-like
Octamer-binding transcription factor 3-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POU5F1B
Synonyms:OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5FLC20, POU5FLC8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9223 POU5F1B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615739 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q06416

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5462

Open Targets

More...
OpenTargetsi
ENSG00000212993

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33547

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POU5F1B

Domain mapping of disease mutations (DMDM)

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DMDMi
357528826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007531 – 359Putative POU domain, class 5, transcription factor 1BAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei111PhosphoserineBy similarity1
Modified residuei235PhosphothreonineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei288PhosphoserineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q06416

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q06416

MaxQB - The MaxQuant DataBase

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MaxQBi
Q06416

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q06416

PeptideAtlas

More...
PeptideAtlasi
Q06416

PRoteomics IDEntifications database

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PRIDEi
Q06416

ProteomicsDB human proteome resource

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ProteomicsDBi
58443

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q06416

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q06416

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000212993 Expressed in 24 organ(s), highest expression level in cortex of kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q06416 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA058267

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419298

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q06416

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 212POU-specificPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3802 Eukaryota
ENOG410XQ7X LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155046

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000089941

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06416

KEGG Orthology (KO)

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KOi
K09367

Identification of Orthologs from Complete Genome Data

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OMAi
LQISHIA

Database of Orthologous Groups

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OrthoDBi
841019at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q06416

TreeFam database of animal gene trees

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TreeFami
TF316413

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR015585 POU_dom_5

The PANTHER Classification System

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PANTHERi
PTHR11636:SF86 PTHR11636:SF86, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00028 POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06416-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG
110 120 130 140 150
VGVESNSNGA SPEPCTVPPG AVKLEKEKLE QNPEKSQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLI LGVLFGKVFS QKTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA
310 320 330 340 350
GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI

TLGSPMHSN
Length:359
Mass (Da):38,588
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9AF853B116FCB75A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10A → T in ADE48599 (PubMed:21341266).Curated1
Sequence conflicti13P → L in ADE48609 (PubMed:21341266).Curated1
Sequence conflicti13P → L in ADW77452 (PubMed:21341266).Curated1
Sequence conflicti14P → T in ADW77351 (PubMed:21341266).Curated1
Sequence conflicti23 – 25WGA → GGP in ADE48566 (PubMed:21341266).Curated3
Sequence conflicti23 – 25WGA → GGP in ADE48597 (PubMed:21341266).Curated3
Sequence conflicti31D → G in ADE48567 (PubMed:21341266).Curated1
Sequence conflicti31D → V in ADE48570 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77415 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77416 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77417 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77420 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77421 (PubMed:21341266).Curated1
Sequence conflicti39Q → R in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti76C → R in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti79Q → H in ADW77469 (PubMed:21341266).Curated1
Sequence conflicti91E → V in ADE48610 (PubMed:21341266).Curated1
Sequence conflicti91E → V in ADW77455 (PubMed:21341266).Curated1
Sequence conflicti106N → S in ADE48612 (PubMed:21341266).Curated1
Sequence conflicti107S → Y in ADW77513 (PubMed:21341266).Curated1
Sequence conflicti107S → Y in ADW77518 (PubMed:21341266).Curated1
Sequence conflicti129L → Q in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti130E → G in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti132N → D in ADW77447 (PubMed:21341266).Curated1
Sequence conflicti138D → G in ADE48599 (PubMed:21341266).Curated1
Sequence conflicti150A → T in ADE48616 (PubMed:21341266).Curated1
Sequence conflicti152L → F in ADW77351 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77490 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77499 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77502 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77503 (PubMed:21341266).Curated1
Sequence conflicti160L → P in ADW77417 (PubMed:21341266).Curated1
Sequence conflicti163T → A in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77415 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77420 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77421 (PubMed:21341266).Curated1
Sequence conflicti169L → P in ADE48561 (PubMed:21341266).Curated1
Sequence conflicti169L → R in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti196N → D in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti197M → I in CAA77953 (PubMed:1408763).Curated1
Sequence conflicti201R → W in ADE48615 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77493 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77501 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77506 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADE48593 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77355 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77358 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77387 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77418 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77423 (PubMed:21341266).Curated1
Sequence conflicti235T → A in ADW77518 (PubMed:21341266).Curated1
Sequence conflicti235T → A in ADW77513 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77488 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77496 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77504 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77507 (PubMed:21341266).Curated1
Sequence conflicti246E → G in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti249F → L in ADW77474 (PubMed:21341266).Curated1
Sequence conflicti249F → L in ADW77481 (PubMed:21341266).Curated1
Sequence conflicti250L → P in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti250L → Q in ADW77475 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77488 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77496 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77504 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77507 (PubMed:21341266).Curated1
Sequence conflicti264Q → H in ADE48609 (PubMed:21341266).Curated1
Sequence conflicti264Q → H in ADW77452 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77477 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77476 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77467 (PubMed:21341266).Curated1
Sequence conflicti272V → M in ADW77472 (PubMed:21341266).Curated1
Sequence conflicti272V → M in ADW77479 (PubMed:21341266).Curated1
Sequence conflicti276 – 278WFC → CFG in ADW77495 (PubMed:21341266).Curated3
Sequence conflicti282Q → R in ADW77494 (PubMed:21341266).Curated1
Sequence conflicti284G → S in ADW77469 (PubMed:21341266).Curated1
Sequence conflicti295E → V in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti318H → Q in ADW77444 (PubMed:21341266).Curated1
Sequence conflicti318H → Q in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77476 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77467 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77477 (PubMed:21341266).Curated1
Sequence conflicti326S → G in ADW77444 (PubMed:21341266).Curated1
Sequence conflicti326S → G in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77447 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77448 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77451 (PubMed:21341266).Curated1
Sequence conflicti340E → V in ADE48570 (PubMed:21341266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06743233L → R1 PublicationCorresponds to variant dbSNP:rs1061394Ensembl.1
Natural variantiVAR_06743369L → F. Corresponds to variant dbSNP:rs1061395Ensembl.1
Natural variantiVAR_067434176G → E1 PublicationCorresponds to variant dbSNP:rs6998061Ensembl.1
Natural variantiVAR_067435182K → T2 PublicationsCorresponds to variant dbSNP:rs13273814Ensembl.1
Natural variantiVAR_067436214N → D2 PublicationsCorresponds to variant dbSNP:rs13274084Ensembl.1
Natural variantiVAR_067437238E → Q1 PublicationCorresponds to variant dbSNP:rs7002225Ensembl.1
Natural variantiVAR_067438313P → L. Corresponds to variant dbSNP:rs556361752Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z11901 Genomic DNA Translation: CAA77953.1
DQ120688 Genomic DNA Translation: ABB92462.1
AF268615 mRNA Translation: AAG53083.1
AF268618 mRNA Translation: AAG53085.1
DQ486513 mRNA Translation: ABF29403.1
GU480835 mRNA Translation: ADE48561.1
GU480840 mRNA Translation: ADE48566.1
GU480841 mRNA Translation: ADE48567.1
GU480842 mRNA Translation: ADE48568.1
GU480845 mRNA Translation: ADE48570.1
GU480864 mRNA Translation: ADE48580.1
GU480868 mRNA Translation: ADE48583.1
GU480878 mRNA Translation: ADE48591.1
GU480880 mRNA Translation: ADE48593.1
GU480883 mRNA Translation: ADE48596.1
GU480886 mRNA Translation: ADE48597.1
GU480889 mRNA Translation: ADE48599.1
GU480896 mRNA Translation: ADE48604.1
GU480902 mRNA Translation: ADE48606.1
GU480905 mRNA Translation: ADE48609.1
GU480906 mRNA Translation: ADE48610.1
GU480908 mRNA Translation: ADE48612.1
GU480911 mRNA Translation: ADE48614.1
GU480912 mRNA Translation: ADE48615.1
GU480913 mRNA Translation: ADE48616.1
HQ122710 mRNA Translation: ADW77351.1
HQ122711 mRNA Translation: ADW77352.1
HQ122712 mRNA Translation: ADW77353.1
HQ122713 mRNA Translation: ADW77354.1
HQ122714 mRNA Translation: ADW77355.1
HQ122716 mRNA Translation: ADW77356.1
HQ122717 mRNA Translation: ADW77357.1
HQ122718 mRNA Translation: ADW77358.1
HQ122719 mRNA Translation: ADW77359.1
HQ122721 mRNA Translation: ADW77360.1
HQ122749 mRNA Translation: ADW77385.1
HQ122750 mRNA Translation: ADW77386.1
HQ122751 mRNA Translation: ADW77387.1
HQ122752 mRNA Translation: ADW77388.1
HQ122781 mRNA Translation: ADW77415.1
HQ122782 mRNA Translation: ADW77416.1
HQ122783 mRNA Translation: ADW77417.1
HQ122784 mRNA Translation: ADW77418.1
HQ122785 mRNA Translation: ADW77419.1
HQ122786 mRNA Translation: ADW77420.1
HQ122787 mRNA Translation: ADW77421.1
HQ122788 mRNA Translation: ADW77422.1
HQ122789 mRNA Translation: ADW77423.1
HQ122790 mRNA Translation: ADW77424.1
HQ122816 mRNA Translation: ADW77444.1
HQ122817 mRNA Translation: ADW77445.1
HQ122818 mRNA Translation: ADW77446.1
HQ122819 mRNA Translation: ADW77447.1
HQ122820 mRNA Translation: ADW77448.1
HQ122821 mRNA Translation: ADW77449.1
HQ122822 mRNA Translation: ADW77450.1
HQ122823 mRNA Translation: ADW77451.1
HQ122824 mRNA Translation: ADW77452.1
HQ122825 mRNA Translation: ADW77453.1
HQ122826 mRNA Translation: ADW77454.1
HQ122827 mRNA Translation: ADW77455.1
HQ122841 mRNA Translation: ADW77467.1
HQ122842 mRNA Translation: ADW77468.1
HQ122843 mRNA Translation: ADW77469.1
HQ122844 mRNA Translation: ADW77470.1
HQ122845 mRNA Translation: ADW77471.1
HQ122846 mRNA Translation: ADW77472.1
HQ122848 mRNA Translation: ADW77473.1
HQ122849 mRNA Translation: ADW77474.1
HQ122851 mRNA Translation: ADW77475.1
HQ122852 mRNA Translation: ADW77476.1
HQ122853 mRNA Translation: ADW77477.1
HQ122854 mRNA Translation: ADW77478.1
HQ122855 mRNA Translation: ADW77479.1
HQ122856 mRNA Translation: ADW77480.1
HQ122857 mRNA Translation: ADW77481.1
HQ122864 mRNA Translation: ADW77487.1
HQ122865 mRNA Translation: ADW77488.1
HQ122866 mRNA Translation: ADW77489.1
HQ122867 mRNA Translation: ADW77490.1
HQ122868 mRNA Translation: ADW77491.1
HQ122869 mRNA Translation: ADW77492.1
HQ122870 mRNA Translation: ADW77493.1
HQ122871 mRNA Translation: ADW77494.1
HQ122874 mRNA Translation: ADW77495.1
HQ122876 mRNA Translation: ADW77496.1
HQ122877 mRNA Translation: ADW77497.1
HQ122878 mRNA Translation: ADW77498.1
HQ122879 mRNA Translation: ADW77499.1
HQ122880 mRNA Translation: ADW77500.1
HQ122881 mRNA Translation: ADW77501.1
HQ122882 mRNA Translation: ADW77502.1
HQ122883 mRNA Translation: ADW77503.1
HQ122884 mRNA Translation: ADW77504.1
HQ122885 mRNA Translation: ADW77505.1
HQ122886 mRNA Translation: ADW77506.1
HQ122887 mRNA Translation: ADW77507.1
HQ122891 mRNA Translation: ADW77511.1
HQ122892 mRNA Translation: ADW77512.1
HQ122893 mRNA Translation: ADW77513.1
HQ122895 mRNA Translation: ADW77514.1
HQ122898 mRNA Translation: ADW77515.1
HQ122900 mRNA Translation: ADW77516.1
HQ122902 mRNA Translation: ADW77517.1
HQ122903 mRNA Translation: ADW77518.1
AC016883 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS55274.1

NCBI Reference Sequences

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RefSeqi
NP_001153014.1, NM_001159542.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000465342; ENSP00000419298; ENSG00000212993
ENST00000645438; ENSP00000495779; ENSG00000212993

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5462

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5462

UCSC genome browser

More...
UCSCi
uc003ysf.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11901 Genomic DNA Translation: CAA77953.1
DQ120688 Genomic DNA Translation: ABB92462.1
AF268615 mRNA Translation: AAG53083.1
AF268618 mRNA Translation: AAG53085.1
DQ486513 mRNA Translation: ABF29403.1
GU480835 mRNA Translation: ADE48561.1
GU480840 mRNA Translation: ADE48566.1
GU480841 mRNA Translation: ADE48567.1
GU480842 mRNA Translation: ADE48568.1
GU480845 mRNA Translation: ADE48570.1
GU480864 mRNA Translation: ADE48580.1
GU480868 mRNA Translation: ADE48583.1
GU480878 mRNA Translation: ADE48591.1
GU480880 mRNA Translation: ADE48593.1
GU480883 mRNA Translation: ADE48596.1
GU480886 mRNA Translation: ADE48597.1
GU480889 mRNA Translation: ADE48599.1
GU480896 mRNA Translation: ADE48604.1
GU480902 mRNA Translation: ADE48606.1
GU480905 mRNA Translation: ADE48609.1
GU480906 mRNA Translation: ADE48610.1
GU480908 mRNA Translation: ADE48612.1
GU480911 mRNA Translation: ADE48614.1
GU480912 mRNA Translation: ADE48615.1
GU480913 mRNA Translation: ADE48616.1
HQ122710 mRNA Translation: ADW77351.1
HQ122711 mRNA Translation: ADW77352.1
HQ122712 mRNA Translation: ADW77353.1
HQ122713 mRNA Translation: ADW77354.1
HQ122714 mRNA Translation: ADW77355.1
HQ122716 mRNA Translation: ADW77356.1
HQ122717 mRNA Translation: ADW77357.1
HQ122718 mRNA Translation: ADW77358.1
HQ122719 mRNA Translation: ADW77359.1
HQ122721 mRNA Translation: ADW77360.1
HQ122749 mRNA Translation: ADW77385.1
HQ122750 mRNA Translation: ADW77386.1
HQ122751 mRNA Translation: ADW77387.1
HQ122752 mRNA Translation: ADW77388.1
HQ122781 mRNA Translation: ADW77415.1
HQ122782 mRNA Translation: ADW77416.1
HQ122783 mRNA Translation: ADW77417.1
HQ122784 mRNA Translation: ADW77418.1
HQ122785 mRNA Translation: ADW77419.1
HQ122786 mRNA Translation: ADW77420.1
HQ122787 mRNA Translation: ADW77421.1
HQ122788 mRNA Translation: ADW77422.1
HQ122789 mRNA Translation: ADW77423.1
HQ122790 mRNA Translation: ADW77424.1
HQ122816 mRNA Translation: ADW77444.1
HQ122817 mRNA Translation: ADW77445.1
HQ122818 mRNA Translation: ADW77446.1
HQ122819 mRNA Translation: ADW77447.1
HQ122820 mRNA Translation: ADW77448.1
HQ122821 mRNA Translation: ADW77449.1
HQ122822 mRNA Translation: ADW77450.1
HQ122823 mRNA Translation: ADW77451.1
HQ122824 mRNA Translation: ADW77452.1
HQ122825 mRNA Translation: ADW77453.1
HQ122826 mRNA Translation: ADW77454.1
HQ122827 mRNA Translation: ADW77455.1
HQ122841 mRNA Translation: ADW77467.1
HQ122842 mRNA Translation: ADW77468.1
HQ122843 mRNA Translation: ADW77469.1
HQ122844 mRNA Translation: ADW77470.1
HQ122845 mRNA Translation: ADW77471.1
HQ122846 mRNA Translation: ADW77472.1
HQ122848 mRNA Translation: ADW77473.1
HQ122849 mRNA Translation: ADW77474.1
HQ122851 mRNA Translation: ADW77475.1
HQ122852 mRNA Translation: ADW77476.1
HQ122853 mRNA Translation: ADW77477.1
HQ122854 mRNA Translation: ADW77478.1
HQ122855 mRNA Translation: ADW77479.1
HQ122856 mRNA Translation: ADW77480.1
HQ122857 mRNA Translation: ADW77481.1
HQ122864 mRNA Translation: ADW77487.1
HQ122865 mRNA Translation: ADW77488.1
HQ122866 mRNA Translation: ADW77489.1
HQ122867 mRNA Translation: ADW77490.1
HQ122868 mRNA Translation: ADW77491.1
HQ122869 mRNA Translation: ADW77492.1
HQ122870 mRNA Translation: ADW77493.1
HQ122871 mRNA Translation: ADW77494.1
HQ122874 mRNA Translation: ADW77495.1
HQ122876 mRNA Translation: ADW77496.1
HQ122877 mRNA Translation: ADW77497.1
HQ122878 mRNA Translation: ADW77498.1
HQ122879 mRNA Translation: ADW77499.1
HQ122880 mRNA Translation: ADW77500.1
HQ122881 mRNA Translation: ADW77501.1
HQ122882 mRNA Translation: ADW77502.1
HQ122883 mRNA Translation: ADW77503.1
HQ122884 mRNA Translation: ADW77504.1
HQ122885 mRNA Translation: ADW77505.1
HQ122886 mRNA Translation: ADW77506.1
HQ122887 mRNA Translation: ADW77507.1
HQ122891 mRNA Translation: ADW77511.1
HQ122892 mRNA Translation: ADW77512.1
HQ122893 mRNA Translation: ADW77513.1
HQ122895 mRNA Translation: ADW77514.1
HQ122898 mRNA Translation: ADW77515.1
HQ122900 mRNA Translation: ADW77516.1
HQ122902 mRNA Translation: ADW77517.1
HQ122903 mRNA Translation: ADW77518.1
AC016883 Genomic DNA No translation available.
CCDSiCCDS55274.1
RefSeqiNP_001153014.1, NM_001159542.1

3D structure databases

SMRiQ06416
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419298

PTM databases

iPTMnetiQ06416
PhosphoSitePlusiQ06416

Polymorphism and mutation databases

BioMutaiPOU5F1B
DMDMi357528826

Proteomic databases

EPDiQ06416
jPOSTiQ06416
MaxQBiQ06416
PaxDbiQ06416
PeptideAtlasiQ06416
PRIDEiQ06416
ProteomicsDBi58443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000465342; ENSP00000419298; ENSG00000212993
ENST00000645438; ENSP00000495779; ENSG00000212993
GeneIDi5462
KEGGihsa:5462
UCSCiuc003ysf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5462
DisGeNETi5462

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POU5F1B
HGNCiHGNC:9223 POU5F1B
HPAiHPA058267
MIMi615739 gene
neXtProtiNX_Q06416
OpenTargetsiENSG00000212993
PharmGKBiPA33547

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00940000155046
HOGENOMiHOG000089941
InParanoidiQ06416
KOiK09367
OMAiLQISHIA
OrthoDBi841019at2759
PhylomeDBiQ06416
TreeFamiTF316413

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5462

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000212993 Expressed in 24 organ(s), highest expression level in cortex of kidney
GenevisibleiQ06416 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR015585 POU_dom_5
PANTHERiPTHR11636:SF86 PTHR11636:SF86, 2 hits
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP5F1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06416
Secondary accession number(s): D5K9S4
, D5K9S9, D5K9T0, D5K9T1, D5K9T3, D5K9U3, D5K9U6, D5K9V4, D5K9V6, D5K9W0, D5K9W2, D5K9W7, D5K9X2, D5K9X3, D5K9X5, D5K9X8, D5K9X9, E9LRB1, E9LRB2, E9LRH5, E9LRH6, E9LRH7, E9LRK4, E9LRK5, E9LRK7, E9LRK8, E9LRM7, E9LRM9, E9LRN2, E9LRN4, E9LRN5, E9LRP8, E9LRQ0, E9LRQ2, E9LRQ3, E9LRQ4, E9LRQ5, E9LRS3, Q2VIK6, Q9BZV7, Q9BZV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 16, 2011
Last modified: May 8, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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