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Protein

Putative POU domain, class 5, transcription factor 1B

Gene

POU5F1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Shows weak transcriptional activator activity.1 Publication

Caution

Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed in cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative POU domain, class 5, transcription factor 1B
Alternative name(s):
Oct4-pg1
Octamer-binding protein 3-like
Octamer-binding transcription factor 3-like
Gene namesi
Name:POU5F1B
Synonyms:OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5FLC20, POU5FLC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000212993.4
HGNCiHGNC:9223 POU5F1B
MIMi615739 gene
neXtProtiNX_Q06416

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5462
OpenTargetsiENSG00000212993
PharmGKBiPA33547

Polymorphism and mutation databases

BioMutaiPOU5F1B
DMDMi357528826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007531 – 359Putative POU domain, class 5, transcription factor 1BAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111PhosphoserineBy similarity1
Modified residuei235PhosphothreonineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei288PhosphoserineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ06416
MaxQBiQ06416
PaxDbiQ06416
PeptideAtlasiQ06416
PRIDEiQ06416
ProteomicsDBi58443

PTM databases

iPTMnetiQ06416
PhosphoSitePlusiQ06416

Expressioni

Tissue specificityi

Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.2 Publications

Gene expression databases

BgeeiENSG00000212993 Expressed in 24 organ(s), highest expression level in cortex of kidney
GenevisibleiQ06416 HS

Organism-specific databases

HPAiHPA058267

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375557

Structurei

3D structure databases

ProteinModelPortaliQ06416
SMRiQ06416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 212POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000089941
InParanoidiQ06416
KOiK09367
OrthoDBiEOG091G0U0S
PhylomeDBiQ06416
TreeFamiTF316413

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR015585 POU_dom_5
PANTHERiPTHR11636:SF86 PTHR11636:SF86, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q06416-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG
110 120 130 140 150
VGVESNSNGA SPEPCTVPPG AVKLEKEKLE QNPEKSQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLI LGVLFGKVFS QKTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA
310 320 330 340 350
GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI

TLGSPMHSN
Length:359
Mass (Da):38,588
Last modified:November 16, 2011 - v2
Checksum:i9AF853B116FCB75A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → T in ADE48599 (PubMed:21341266).Curated1
Sequence conflicti13P → L in ADE48609 (PubMed:21341266).Curated1
Sequence conflicti13P → L in ADW77452 (PubMed:21341266).Curated1
Sequence conflicti14P → T in ADW77351 (PubMed:21341266).Curated1
Sequence conflicti23 – 25WGA → GGP in ADE48566 (PubMed:21341266).Curated3
Sequence conflicti23 – 25WGA → GGP in ADE48597 (PubMed:21341266).Curated3
Sequence conflicti31D → G in ADE48567 (PubMed:21341266).Curated1
Sequence conflicti31D → V in ADE48570 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77415 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77416 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77417 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77420 (PubMed:21341266).Curated1
Sequence conflicti35W → R in ADW77421 (PubMed:21341266).Curated1
Sequence conflicti39Q → R in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti76C → R in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti79Q → H in ADW77469 (PubMed:21341266).Curated1
Sequence conflicti91E → V in ADE48610 (PubMed:21341266).Curated1
Sequence conflicti91E → V in ADW77455 (PubMed:21341266).Curated1
Sequence conflicti106N → S in ADE48612 (PubMed:21341266).Curated1
Sequence conflicti107S → Y in ADW77513 (PubMed:21341266).Curated1
Sequence conflicti107S → Y in ADW77518 (PubMed:21341266).Curated1
Sequence conflicti129L → Q in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti130E → G in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti132N → D in ADW77447 (PubMed:21341266).Curated1
Sequence conflicti138D → G in ADE48599 (PubMed:21341266).Curated1
Sequence conflicti150A → T in ADE48616 (PubMed:21341266).Curated1
Sequence conflicti152L → F in ADW77351 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77490 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77499 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77502 (PubMed:21341266).Curated1
Sequence conflicti155Q → R in ADW77503 (PubMed:21341266).Curated1
Sequence conflicti160L → P in ADW77417 (PubMed:21341266).Curated1
Sequence conflicti163T → A in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77415 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77420 (PubMed:21341266).Curated1
Sequence conflicti169L → F in ADW77421 (PubMed:21341266).Curated1
Sequence conflicti169L → P in ADE48561 (PubMed:21341266).Curated1
Sequence conflicti169L → R in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti196N → D in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti197M → I in CAA77953 (PubMed:1408763).Curated1
Sequence conflicti201R → W in ADE48615 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77493 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77501 (PubMed:21341266).Curated1
Sequence conflicti208V → E in ADW77506 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADE48593 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77355 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77358 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77387 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77418 (PubMed:21341266).Curated1
Sequence conflicti211A → T in ADW77423 (PubMed:21341266).Curated1
Sequence conflicti235T → A in ADW77518 (PubMed:21341266).Curated1
Sequence conflicti235T → A in ADW77513 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77488 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77496 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77504 (PubMed:21341266).Curated1
Sequence conflicti241V → M in ADW77507 (PubMed:21341266).Curated1
Sequence conflicti246E → G in ADW77492 (PubMed:21341266).Curated1
Sequence conflicti249F → L in ADW77474 (PubMed:21341266).Curated1
Sequence conflicti249F → L in ADW77481 (PubMed:21341266).Curated1
Sequence conflicti250L → P in ADE48580 (PubMed:21341266).Curated1
Sequence conflicti250L → Q in ADW77475 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77488 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77496 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77504 (PubMed:21341266).Curated1
Sequence conflicti259I → T in ADW77507 (PubMed:21341266).Curated1
Sequence conflicti264Q → H in ADE48609 (PubMed:21341266).Curated1
Sequence conflicti264Q → H in ADW77452 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77477 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77476 (PubMed:21341266).Curated1
Sequence conflicti264Q → L in ADW77467 (PubMed:21341266).Curated1
Sequence conflicti272V → M in ADW77472 (PubMed:21341266).Curated1
Sequence conflicti272V → M in ADW77479 (PubMed:21341266).Curated1
Sequence conflicti276 – 278WFC → CFG in ADW77495 (PubMed:21341266).Curated3
Sequence conflicti282Q → R in ADW77494 (PubMed:21341266).Curated1
Sequence conflicti284G → S in ADW77469 (PubMed:21341266).Curated1
Sequence conflicti295E → V in ADE48583 (PubMed:21341266).Curated1
Sequence conflicti318H → Q in ADW77444 (PubMed:21341266).Curated1
Sequence conflicti318H → Q in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77476 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77467 (PubMed:21341266).Curated1
Sequence conflicti321T → I in ADW77477 (PubMed:21341266).Curated1
Sequence conflicti326S → G in ADW77444 (PubMed:21341266).Curated1
Sequence conflicti326S → G in ADW77445 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77447 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77448 (PubMed:21341266).Curated1
Sequence conflicti331A → T in ADW77451 (PubMed:21341266).Curated1
Sequence conflicti340E → V in ADE48570 (PubMed:21341266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06743233L → R1 PublicationCorresponds to variant dbSNP:rs1061394Ensembl.1
Natural variantiVAR_06743369L → F. Corresponds to variant dbSNP:rs1061395Ensembl.1
Natural variantiVAR_067434176G → E1 PublicationCorresponds to variant dbSNP:rs6998061Ensembl.1
Natural variantiVAR_067435182K → T2 PublicationsCorresponds to variant dbSNP:rs13273814Ensembl.1
Natural variantiVAR_067436214N → D2 PublicationsCorresponds to variant dbSNP:rs13274084Ensembl.1
Natural variantiVAR_067437238E → Q1 PublicationCorresponds to variant dbSNP:rs7002225Ensembl.1
Natural variantiVAR_067438313P → L. Corresponds to variant dbSNP:rs556361752Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11901 Genomic DNA Translation: CAA77953.1
DQ120688 Genomic DNA Translation: ABB92462.1
AF268615 mRNA Translation: AAG53083.1
AF268618 mRNA Translation: AAG53085.1
DQ486513 mRNA Translation: ABF29403.1
GU480835 mRNA Translation: ADE48561.1
GU480840 mRNA Translation: ADE48566.1
GU480841 mRNA Translation: ADE48567.1
GU480842 mRNA Translation: ADE48568.1
GU480845 mRNA Translation: ADE48570.1
GU480864 mRNA Translation: ADE48580.1
GU480868 mRNA Translation: ADE48583.1
GU480878 mRNA Translation: ADE48591.1
GU480880 mRNA Translation: ADE48593.1
GU480883 mRNA Translation: ADE48596.1
GU480886 mRNA Translation: ADE48597.1
GU480889 mRNA Translation: ADE48599.1
GU480896 mRNA Translation: ADE48604.1
GU480902 mRNA Translation: ADE48606.1
GU480905 mRNA Translation: ADE48609.1
GU480906 mRNA Translation: ADE48610.1
GU480908 mRNA Translation: ADE48612.1
GU480911 mRNA Translation: ADE48614.1
GU480912 mRNA Translation: ADE48615.1
GU480913 mRNA Translation: ADE48616.1
HQ122710 mRNA Translation: ADW77351.1
HQ122711 mRNA Translation: ADW77352.1
HQ122712 mRNA Translation: ADW77353.1
HQ122713 mRNA Translation: ADW77354.1
HQ122714 mRNA Translation: ADW77355.1
HQ122716 mRNA Translation: ADW77356.1
HQ122717 mRNA Translation: ADW77357.1
HQ122718 mRNA Translation: ADW77358.1
HQ122719 mRNA Translation: ADW77359.1
HQ122721 mRNA Translation: ADW77360.1
HQ122749 mRNA Translation: ADW77385.1
HQ122750 mRNA Translation: ADW77386.1
HQ122751 mRNA Translation: ADW77387.1
HQ122752 mRNA Translation: ADW77388.1
HQ122781 mRNA Translation: ADW77415.1
HQ122782 mRNA Translation: ADW77416.1
HQ122783 mRNA Translation: ADW77417.1
HQ122784 mRNA Translation: ADW77418.1
HQ122785 mRNA Translation: ADW77419.1
HQ122786 mRNA Translation: ADW77420.1
HQ122787 mRNA Translation: ADW77421.1
HQ122788 mRNA Translation: ADW77422.1
HQ122789 mRNA Translation: ADW77423.1
HQ122790 mRNA Translation: ADW77424.1
HQ122816 mRNA Translation: ADW77444.1
HQ122817 mRNA Translation: ADW77445.1
HQ122818 mRNA Translation: ADW77446.1
HQ122819 mRNA Translation: ADW77447.1
HQ122820 mRNA Translation: ADW77448.1
HQ122821 mRNA Translation: ADW77449.1
HQ122822 mRNA Translation: ADW77450.1
HQ122823 mRNA Translation: ADW77451.1
HQ122824 mRNA Translation: ADW77452.1
HQ122825 mRNA Translation: ADW77453.1
HQ122826 mRNA Translation: ADW77454.1
HQ122827 mRNA Translation: ADW77455.1
HQ122841 mRNA Translation: ADW77467.1
HQ122842 mRNA Translation: ADW77468.1
HQ122843 mRNA Translation: ADW77469.1
HQ122844 mRNA Translation: ADW77470.1
HQ122845 mRNA Translation: ADW77471.1
HQ122846 mRNA Translation: ADW77472.1
HQ122848 mRNA Translation: ADW77473.1
HQ122849 mRNA Translation: ADW77474.1
HQ122851 mRNA Translation: ADW77475.1
HQ122852 mRNA Translation: ADW77476.1
HQ122853 mRNA Translation: ADW77477.1
HQ122854 mRNA Translation: ADW77478.1
HQ122855 mRNA Translation: ADW77479.1
HQ122856 mRNA Translation: ADW77480.1
HQ122857 mRNA Translation: ADW77481.1
HQ122864 mRNA Translation: ADW77487.1
HQ122865 mRNA Translation: ADW77488.1
HQ122866 mRNA Translation: ADW77489.1
HQ122867 mRNA Translation: ADW77490.1
HQ122868 mRNA Translation: ADW77491.1
HQ122869 mRNA Translation: ADW77492.1
HQ122870 mRNA Translation: ADW77493.1
HQ122871 mRNA Translation: ADW77494.1
HQ122874 mRNA Translation: ADW77495.1
HQ122876 mRNA Translation: ADW77496.1
HQ122877 mRNA Translation: ADW77497.1
HQ122878 mRNA Translation: ADW77498.1
HQ122879 mRNA Translation: ADW77499.1
HQ122880 mRNA Translation: ADW77500.1
HQ122881 mRNA Translation: ADW77501.1
HQ122882 mRNA Translation: ADW77502.1
HQ122883 mRNA Translation: ADW77503.1
HQ122884 mRNA Translation: ADW77504.1
HQ122885 mRNA Translation: ADW77505.1
HQ122886 mRNA Translation: ADW77506.1
HQ122887 mRNA Translation: ADW77507.1
HQ122891 mRNA Translation: ADW77511.1
HQ122892 mRNA Translation: ADW77512.1
HQ122893 mRNA Translation: ADW77513.1
HQ122895 mRNA Translation: ADW77514.1
HQ122898 mRNA Translation: ADW77515.1
HQ122900 mRNA Translation: ADW77516.1
HQ122902 mRNA Translation: ADW77517.1
HQ122903 mRNA Translation: ADW77518.1
AC016883 Genomic DNA No translation available.
CCDSiCCDS55274.1
RefSeqiNP_001153014.1, NM_001159542.1
UniGeneiHs.450254

Genome annotation databases

EnsembliENST00000465342; ENSP00000419298; ENSG00000212993
ENST00000645438; ENSP00000495779; ENSG00000212993
GeneIDi5462
KEGGihsa:5462
UCSCiuc003ysf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11901 Genomic DNA Translation: CAA77953.1
DQ120688 Genomic DNA Translation: ABB92462.1
AF268615 mRNA Translation: AAG53083.1
AF268618 mRNA Translation: AAG53085.1
DQ486513 mRNA Translation: ABF29403.1
GU480835 mRNA Translation: ADE48561.1
GU480840 mRNA Translation: ADE48566.1
GU480841 mRNA Translation: ADE48567.1
GU480842 mRNA Translation: ADE48568.1
GU480845 mRNA Translation: ADE48570.1
GU480864 mRNA Translation: ADE48580.1
GU480868 mRNA Translation: ADE48583.1
GU480878 mRNA Translation: ADE48591.1
GU480880 mRNA Translation: ADE48593.1
GU480883 mRNA Translation: ADE48596.1
GU480886 mRNA Translation: ADE48597.1
GU480889 mRNA Translation: ADE48599.1
GU480896 mRNA Translation: ADE48604.1
GU480902 mRNA Translation: ADE48606.1
GU480905 mRNA Translation: ADE48609.1
GU480906 mRNA Translation: ADE48610.1
GU480908 mRNA Translation: ADE48612.1
GU480911 mRNA Translation: ADE48614.1
GU480912 mRNA Translation: ADE48615.1
GU480913 mRNA Translation: ADE48616.1
HQ122710 mRNA Translation: ADW77351.1
HQ122711 mRNA Translation: ADW77352.1
HQ122712 mRNA Translation: ADW77353.1
HQ122713 mRNA Translation: ADW77354.1
HQ122714 mRNA Translation: ADW77355.1
HQ122716 mRNA Translation: ADW77356.1
HQ122717 mRNA Translation: ADW77357.1
HQ122718 mRNA Translation: ADW77358.1
HQ122719 mRNA Translation: ADW77359.1
HQ122721 mRNA Translation: ADW77360.1
HQ122749 mRNA Translation: ADW77385.1
HQ122750 mRNA Translation: ADW77386.1
HQ122751 mRNA Translation: ADW77387.1
HQ122752 mRNA Translation: ADW77388.1
HQ122781 mRNA Translation: ADW77415.1
HQ122782 mRNA Translation: ADW77416.1
HQ122783 mRNA Translation: ADW77417.1
HQ122784 mRNA Translation: ADW77418.1
HQ122785 mRNA Translation: ADW77419.1
HQ122786 mRNA Translation: ADW77420.1
HQ122787 mRNA Translation: ADW77421.1
HQ122788 mRNA Translation: ADW77422.1
HQ122789 mRNA Translation: ADW77423.1
HQ122790 mRNA Translation: ADW77424.1
HQ122816 mRNA Translation: ADW77444.1
HQ122817 mRNA Translation: ADW77445.1
HQ122818 mRNA Translation: ADW77446.1
HQ122819 mRNA Translation: ADW77447.1
HQ122820 mRNA Translation: ADW77448.1
HQ122821 mRNA Translation: ADW77449.1
HQ122822 mRNA Translation: ADW77450.1
HQ122823 mRNA Translation: ADW77451.1
HQ122824 mRNA Translation: ADW77452.1
HQ122825 mRNA Translation: ADW77453.1
HQ122826 mRNA Translation: ADW77454.1
HQ122827 mRNA Translation: ADW77455.1
HQ122841 mRNA Translation: ADW77467.1
HQ122842 mRNA Translation: ADW77468.1
HQ122843 mRNA Translation: ADW77469.1
HQ122844 mRNA Translation: ADW77470.1
HQ122845 mRNA Translation: ADW77471.1
HQ122846 mRNA Translation: ADW77472.1
HQ122848 mRNA Translation: ADW77473.1
HQ122849 mRNA Translation: ADW77474.1
HQ122851 mRNA Translation: ADW77475.1
HQ122852 mRNA Translation: ADW77476.1
HQ122853 mRNA Translation: ADW77477.1
HQ122854 mRNA Translation: ADW77478.1
HQ122855 mRNA Translation: ADW77479.1
HQ122856 mRNA Translation: ADW77480.1
HQ122857 mRNA Translation: ADW77481.1
HQ122864 mRNA Translation: ADW77487.1
HQ122865 mRNA Translation: ADW77488.1
HQ122866 mRNA Translation: ADW77489.1
HQ122867 mRNA Translation: ADW77490.1
HQ122868 mRNA Translation: ADW77491.1
HQ122869 mRNA Translation: ADW77492.1
HQ122870 mRNA Translation: ADW77493.1
HQ122871 mRNA Translation: ADW77494.1
HQ122874 mRNA Translation: ADW77495.1
HQ122876 mRNA Translation: ADW77496.1
HQ122877 mRNA Translation: ADW77497.1
HQ122878 mRNA Translation: ADW77498.1
HQ122879 mRNA Translation: ADW77499.1
HQ122880 mRNA Translation: ADW77500.1
HQ122881 mRNA Translation: ADW77501.1
HQ122882 mRNA Translation: ADW77502.1
HQ122883 mRNA Translation: ADW77503.1
HQ122884 mRNA Translation: ADW77504.1
HQ122885 mRNA Translation: ADW77505.1
HQ122886 mRNA Translation: ADW77506.1
HQ122887 mRNA Translation: ADW77507.1
HQ122891 mRNA Translation: ADW77511.1
HQ122892 mRNA Translation: ADW77512.1
HQ122893 mRNA Translation: ADW77513.1
HQ122895 mRNA Translation: ADW77514.1
HQ122898 mRNA Translation: ADW77515.1
HQ122900 mRNA Translation: ADW77516.1
HQ122902 mRNA Translation: ADW77517.1
HQ122903 mRNA Translation: ADW77518.1
AC016883 Genomic DNA No translation available.
CCDSiCCDS55274.1
RefSeqiNP_001153014.1, NM_001159542.1
UniGeneiHs.450254

3D structure databases

ProteinModelPortaliQ06416
SMRiQ06416
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375557

PTM databases

iPTMnetiQ06416
PhosphoSitePlusiQ06416

Polymorphism and mutation databases

BioMutaiPOU5F1B
DMDMi357528826

Proteomic databases

EPDiQ06416
MaxQBiQ06416
PaxDbiQ06416
PeptideAtlasiQ06416
PRIDEiQ06416
ProteomicsDBi58443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000465342; ENSP00000419298; ENSG00000212993
ENST00000645438; ENSP00000495779; ENSG00000212993
GeneIDi5462
KEGGihsa:5462
UCSCiuc003ysf.4 human

Organism-specific databases

CTDi5462
DisGeNETi5462
EuPathDBiHostDB:ENSG00000212993.4
GeneCardsiPOU5F1B
HGNCiHGNC:9223 POU5F1B
HPAiHPA058267
MIMi615739 gene
neXtProtiNX_Q06416
OpenTargetsiENSG00000212993
PharmGKBiPA33547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000089941
InParanoidiQ06416
KOiK09367
OrthoDBiEOG091G0U0S
PhylomeDBiQ06416
TreeFamiTF316413

Miscellaneous databases

GenomeRNAii5462
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000212993 Expressed in 24 organ(s), highest expression level in cortex of kidney
GenevisibleiQ06416 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR015585 POU_dom_5
PANTHERiPTHR11636:SF86 PTHR11636:SF86, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP5F1B_HUMAN
AccessioniPrimary (citable) accession number: Q06416
Secondary accession number(s): D5K9S4
, D5K9S9, D5K9T0, D5K9T1, D5K9T3, D5K9U3, D5K9U6, D5K9V4, D5K9V6, D5K9W0, D5K9W2, D5K9W7, D5K9X2, D5K9X3, D5K9X5, D5K9X8, D5K9X9, E9LRB1, E9LRB2, E9LRH5, E9LRH6, E9LRH7, E9LRK4, E9LRK5, E9LRK7, E9LRK8, E9LRM7, E9LRM9, E9LRN2, E9LRN4, E9LRN5, E9LRP8, E9LRQ0, E9LRQ2, E9LRQ3, E9LRQ4, E9LRQ5, E9LRS3, Q2VIK6, Q9BZV7, Q9BZV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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