Rho-type GTPase-activating protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GTPase activator activity Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "GTPase-activating proteins for Cdc42."
    Smith G.R., Givan S.A., Cullen P., Sprague G.F. Jr.
    Eukaryot. Cell 1:469-480(2002) [PubMed] [Europe PMC] [Abstract]
  • "Transbilayer phospholipid flipping regulates Cdc42p signaling during polarized cell growth via Rga GTPase-activating proteins."
    Saito K., Fujimura-Kamada K., Hanamatsu H., Kato U., Umeda M., Kozminski K.G., Tanaka K.
    Dev Cell 13:743-751(2007) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae."
    Newman J.R., Wolf E., Kim P.S.
    Proc Natl Acad Sci U S A 97:13203-13208(2000) [PubMed] [Europe PMC] [Abstract]
  • "An in vivo map of the yeast protein interactome."
    Tarassov K., Messier V., Landry C.R., Radinovic S., Serna Molina M.M., Shames I., Malitskaya Y., Vogel J., Bussey H., Michnick S.W.
    Science 320:1465-1470(2008) [PubMed] [Europe PMC] [Abstract]
  • "The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs."
    Marchant A., Cisneros A.F., Dube A.K., Gagnon-Arsenault I., Ascencio D., Jain H., Aube S., Eberlein C., Evans-Yamamoto D., Yachie N., Landry C.R.
    Elife 8:0-0(2019) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW

GO - Biological processⁱ

• positive regulation of GTPase activity Source: SGDInferred from direct assayⁱ
  • "GTPase-activating proteins for Cdc42."
    Smith G.R., Givan S.A., Cullen P., Sprague G.F. Jr.
    Eukaryot. Cell 1:469-480(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of GTPase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• septin ring organization Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "GTPase-activating proteins for Cdc42."
    Smith G.R., Givan S.A., Cullen P., Sprague G.F. Jr.
    Eukaryot. Cell 1:469-480(2002) [PubMed] [Europe PMC] [Abstract]
  • "The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast."
    Caviston J.P., Longtine M., Pringle J.R., Bi E.
    Mol Biol Cell 14:4051-4066(2003) [PubMed] [Europe PMC] [Abstract]
• small GTPase mediated signal transduction Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "GTPase-activating proteins for Cdc42."
    Smith G.R., Givan S.A., Cullen P., Sprague G.F. Jr.
    Eukaryot. Cell 1:469-480(2002) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae."
    Newman J.R., Wolf E., Kim P.S.
    Proc Natl Acad Sci U S A 97:13203-13208(2000) [PubMed] [Europe PMC] [Abstract]
  • "An in vivo map of the yeast protein interactome."
    Tarassov K., Messier V., Landry C.R., Radinovic S., Serna Molina M.M., Shames I., Malitskaya Y., Vogel J., Bussey H., Michnick S.W.
    Science 320:1465-1470(2008) [PubMed] [Europe PMC] [Abstract]
  • "The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs."
    Marchant A., Cisneros A.F., Dube A.K., Gagnon-Arsenault I., Ascencio D., Jain H., Aube S., Eberlein C., Evans-Yamamoto D., Yachie N., Landry C.R.
    Elife 8:0-0(2019) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD 
        60         70         80         90        100
SDFLVLDIGT LICYDCSDKC TNCGDKIDDT AIILPSSNEA YCSNCFRCCR 
       110        120        130        140        150
CSNRIKNLKY AKTKRGLCCM DCHEKLLRKK QLLLENQTKN SSKEDFPIKL 
       160        170        180        190        200
PERSVKRPLS PTRINGKSDV STNNTAISKN LVSSNEDQQL TPQVLVSQER 
       210        220        230        240        250
DESSLNDNND NDNSKDREET SSHARTVSID DILNSTLEHD SNSIEEQSLV 
       260        270        280        290        300
DNEDYINKMG EDVTYRLLKP QRANRDSIVV KDPRIPNSNS NANRFFSIYD 
       310        320        330        340        350
KEETDKDDTD NKENEIIVNT PRNSTDKITS PLNSPMAVQM NEEVEPPHGL 
       360        370        380        390        400
ALTLSEATKE NNKSSQGIQT STSKSMNHVS PITRTDTVEM KTSTSSSTLR 
       410        420        430        440        450
LSDNGSFSRP QTADNLLPHK KVAPSPNKKL SRSFSLKSKN FVHNLKSKTS 
       460        470        480        490        500
EMLDPKHPHH STSIQESDTH SGWGVSSTHT NIRKSKAKKN PVSRGQSDST 
       510        520        530        540        550
IYNTLPQHGN FTVPEFNHKK AQSSLGSISK KQNSNDTATN RRINGSFTSS 
       560        570        580        590        600
SSGHHIAMFR TPPLESGPLF KRPSLSSESA HHRSSSLQTS RSTNALLEDD 
       610        620        630        640        650
STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK KLLQDVENLR 
       660        670        680        690        700
LAKERLLNDV DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK 
       710        720        730        740        750
GSISNASPKP RFWKIFSSAK DHQVGDLESQ QRSPNSSSGG TTNIAQKEIS 
       760        770        780        790        800
SPKLIRVHDE LPSPGKVPLS PSPKRLDYTP DGSHLYGSSL QARCAYEKST 
       810        820        830        840        850
VPIIIRCCID RIEKDDIGLN MEGLYRKSGS QTLVEEIENE FAQNNSLHSD 
       860        870        880        890        900
TLSPKLNALL NQDIHAVASV LKRYLRKLPD PVLSFSIYDA LIDLVRNNQL 
       910        920        930        940        950
IERLPLNNDK FLDSPQKVTI YEMVLKSLLE IFKILPVEHQ EVLKVLAAHI 
       960        970        980        990       1000
GKVRRCSERN LMNLHNLSLV FAPSLIHDFD GEKDIVDMKE RNYIVEFILG 

NYRDIFKQA                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome IV
   Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names