We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q06407 (RGA2_YEAST)
Protein
Rho-type GTPase-activating protein 2
Gene
RGA2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
GTPase-activating protein (GAP) for CDC42 and/or RHO1.
Miscellaneous
Present with 254 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- GTPase activator activity Source: SGD
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of GTPase activity Source: SGD
- regulation of GTPase activity Source: GO_Central
- septin ring organization Source: SGD
- small GTPase mediated signal transduction Source: SGD
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SCE-6798695, Neutrophil degranulation R-SCE-8980692, RHOA GTPase cycle R-SCE-9013148, CDC42 GTPase cycle R-SCE-9013405, RHOD GTPase cycle R-SCE-9013423, RAC3 GTPase cycle R-SCE-9013424, RHOV GTPase cycle R-SCE-9035034, RHOF GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Rho-type GTPase-activating protein 2 |
Gene namesi | Name:RGA2 Ordered Locus Names:YDR379W ORF Names:D9481.4 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002787, RGA2 |
VEuPathDBi | FungiDB:YDR379W |
Subcellular locationi
Cytoskeleton
- cellular bud neck split septin rings Source: SGD
Other locations
- cytoplasm Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075900 | 1 – 1009 | Rho-type GTPase-activating protein 2Add BLAST | 1009 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 763 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q06407 |
PaxDbi | Q06407 |
PRIDEi | Q06407 |
PTM databases
iPTMneti | Q06407 |
Interactioni
Binary interactionsi
Q06407
With | #Exp. | IntAct |
---|---|---|
ENT1 [Q12518] | 6 | EBI-15060,EBI-31494 |
ENT2 [Q05785] | 2 | EBI-15060,EBI-35928 |
itself | 3 | EBI-15060,EBI-15060 |
Epn1 [O88339] from Rattus norvegicus. | 2 | EBI-15060,EBI-7066728 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 32438, 70 interactors |
DIPi | DIP-2995N |
IntActi | Q06407, 9 interactors |
MINTi | Q06407 |
STRINGi | 4932.YDR379W |
Miscellaneous databases
RNActi | Q06407, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 68 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 69 – 129 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 788 – 1006 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 219 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 143 – 228 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 358 – 433 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 449 – 608 | DisorderedSequence analysisAdd BLAST | 160 | |
Regioni | 664 – 709 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 723 – 780 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 164 – 202 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 203 – 225 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 358 – 413 | Polar residuesSequence analysisAdd BLAST | 56 | |
Compositional biasi | 449 – 464 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 465 – 481 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 492 – 556 | Polar residuesSequence analysisAdd BLAST | 65 | |
Compositional biasi | 579 – 600 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 677 – 704 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 728 – 749 | Polar residuesSequence analysisAdd BLAST | 22 |
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG1453, Eukaryota KOG1704, Eukaryota |
GeneTreei | ENSGT01030000234635 |
HOGENOMi | CLU_003874_1_0_1 |
InParanoidi | Q06407 |
OMAi | CSACNNK |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 2 hits SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit PS50238, RHOGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q06407-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD
60 70 80 90 100
SDFLVLDIGT LICYDCSDKC TNCGDKIDDT AIILPSSNEA YCSNCFRCCR
110 120 130 140 150
CSNRIKNLKY AKTKRGLCCM DCHEKLLRKK QLLLENQTKN SSKEDFPIKL
160 170 180 190 200
PERSVKRPLS PTRINGKSDV STNNTAISKN LVSSNEDQQL TPQVLVSQER
210 220 230 240 250
DESSLNDNND NDNSKDREET SSHARTVSID DILNSTLEHD SNSIEEQSLV
260 270 280 290 300
DNEDYINKMG EDVTYRLLKP QRANRDSIVV KDPRIPNSNS NANRFFSIYD
310 320 330 340 350
KEETDKDDTD NKENEIIVNT PRNSTDKITS PLNSPMAVQM NEEVEPPHGL
360 370 380 390 400
ALTLSEATKE NNKSSQGIQT STSKSMNHVS PITRTDTVEM KTSTSSSTLR
410 420 430 440 450
LSDNGSFSRP QTADNLLPHK KVAPSPNKKL SRSFSLKSKN FVHNLKSKTS
460 470 480 490 500
EMLDPKHPHH STSIQESDTH SGWGVSSTHT NIRKSKAKKN PVSRGQSDST
510 520 530 540 550
IYNTLPQHGN FTVPEFNHKK AQSSLGSISK KQNSNDTATN RRINGSFTSS
560 570 580 590 600
SSGHHIAMFR TPPLESGPLF KRPSLSSESA HHRSSSLQTS RSTNALLEDD
610 620 630 640 650
STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK KLLQDVENLR
660 670 680 690 700
LAKERLLNDV DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK
710 720 730 740 750
GSISNASPKP RFWKIFSSAK DHQVGDLESQ QRSPNSSSGG TTNIAQKEIS
760 770 780 790 800
SPKLIRVHDE LPSPGKVPLS PSPKRLDYTP DGSHLYGSSL QARCAYEKST
810 820 830 840 850
VPIIIRCCID RIEKDDIGLN MEGLYRKSGS QTLVEEIENE FAQNNSLHSD
860 870 880 890 900
TLSPKLNALL NQDIHAVASV LKRYLRKLPD PVLSFSIYDA LIDLVRNNQL
910 920 930 940 950
IERLPLNNDK FLDSPQKVTI YEMVLKSLLE IFKILPVEHQ EVLKVLAAHI
960 970 980 990 1000
GKVRRCSERN LMNLHNLSLV FAPSLIHDFD GEKDIVDMKE RNYIVEFILG
NYRDIFKQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28373 Genomic DNA Translation: AAB64815.1 BK006938 Genomic DNA Translation: DAA12221.1 |
PIRi | S61174 |
RefSeqi | NP_010667.1, NM_001180687.1 |
Genome annotation databases
EnsemblFungii | YDR379W_mRNA; YDR379W; YDR379W |
GeneIDi | 851985 |
KEGGi | sce:YDR379W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28373 Genomic DNA Translation: AAB64815.1 BK006938 Genomic DNA Translation: DAA12221.1 |
PIRi | S61174 |
RefSeqi | NP_010667.1, NM_001180687.1 |
3D structure databases
AlphaFoldDBi | Q06407 |
SMRi | Q06407 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32438, 70 interactors |
DIPi | DIP-2995N |
IntActi | Q06407, 9 interactors |
MINTi | Q06407 |
STRINGi | 4932.YDR379W |
PTM databases
iPTMneti | Q06407 |
Proteomic databases
MaxQBi | Q06407 |
PaxDbi | Q06407 |
PRIDEi | Q06407 |
Genome annotation databases
EnsemblFungii | YDR379W_mRNA; YDR379W; YDR379W |
GeneIDi | 851985 |
KEGGi | sce:YDR379W |
Organism-specific databases
SGDi | S000002787, RGA2 |
VEuPathDBi | FungiDB:YDR379W |
Phylogenomic databases
eggNOGi | KOG1453, Eukaryota KOG1704, Eukaryota |
GeneTreei | ENSGT01030000234635 |
HOGENOMi | CLU_003874_1_0_1 |
InParanoidi | Q06407 |
OMAi | CSACNNK |
Enzyme and pathway databases
Reactomei | R-SCE-6798695, Neutrophil degranulation R-SCE-8980692, RHOA GTPase cycle R-SCE-9013148, CDC42 GTPase cycle R-SCE-9013405, RHOD GTPase cycle R-SCE-9013423, RAC3 GTPase cycle R-SCE-9013424, RHOV GTPase cycle R-SCE-9035034, RHOF GTPase cycle |
Miscellaneous databases
PROi | PR:Q06407 |
RNActi | Q06407, protein |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 2 hits SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit PS50238, RHOGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RGA2_YEAST | |
Accessioni | Q06407Primary (citable) accession number: Q06407 Secondary accession number(s): D6VT11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names