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Entry version 182 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Rho-type GTPase-activating protein 2

Gene

RGA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) for CDC42 and/or RHO1.

Miscellaneous

Present with 254 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29928-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-194840 Rho GTPase cycle
R-SCE-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho-type GTPase-activating protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGA2
Ordered Locus Names:YDR379W
ORF Names:D9481.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YDR379W

Saccharomyces Genome Database

More...
SGDi
S000002787 RGA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759001 – 1009Rho-type GTPase-activating protein 2Add BLAST1009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei763PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06407

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06407

PRoteomics IDEntifications database

More...
PRIDEi
Q06407

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06407

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32438, 67 interactors

Database of interacting proteins

More...
DIPi
DIP-2995N

Protein interaction database and analysis system

More...
IntActi
Q06407, 9 interactors

Molecular INTeraction database

More...
MINTi
Q06407

STRING: functional protein association networks

More...
STRINGi
4932.YDR379W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06407 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06407

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 68LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST58
Domaini69 – 129LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini788 – 1006Rho-GAPPROSITE-ProRule annotationAdd BLAST219

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003874_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06407

KEGG Orthology (KO)

More...
KOi
K19839

Identification of Orthologs from Complete Genome Data

More...
OMAi
LICNNCT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001781 Znf_LIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412 LIM, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132 LIM, 2 hits
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06407-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD
60 70 80 90 100
SDFLVLDIGT LICYDCSDKC TNCGDKIDDT AIILPSSNEA YCSNCFRCCR
110 120 130 140 150
CSNRIKNLKY AKTKRGLCCM DCHEKLLRKK QLLLENQTKN SSKEDFPIKL
160 170 180 190 200
PERSVKRPLS PTRINGKSDV STNNTAISKN LVSSNEDQQL TPQVLVSQER
210 220 230 240 250
DESSLNDNND NDNSKDREET SSHARTVSID DILNSTLEHD SNSIEEQSLV
260 270 280 290 300
DNEDYINKMG EDVTYRLLKP QRANRDSIVV KDPRIPNSNS NANRFFSIYD
310 320 330 340 350
KEETDKDDTD NKENEIIVNT PRNSTDKITS PLNSPMAVQM NEEVEPPHGL
360 370 380 390 400
ALTLSEATKE NNKSSQGIQT STSKSMNHVS PITRTDTVEM KTSTSSSTLR
410 420 430 440 450
LSDNGSFSRP QTADNLLPHK KVAPSPNKKL SRSFSLKSKN FVHNLKSKTS
460 470 480 490 500
EMLDPKHPHH STSIQESDTH SGWGVSSTHT NIRKSKAKKN PVSRGQSDST
510 520 530 540 550
IYNTLPQHGN FTVPEFNHKK AQSSLGSISK KQNSNDTATN RRINGSFTSS
560 570 580 590 600
SSGHHIAMFR TPPLESGPLF KRPSLSSESA HHRSSSLQTS RSTNALLEDD
610 620 630 640 650
STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK KLLQDVENLR
660 670 680 690 700
LAKERLLNDV DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK
710 720 730 740 750
GSISNASPKP RFWKIFSSAK DHQVGDLESQ QRSPNSSSGG TTNIAQKEIS
760 770 780 790 800
SPKLIRVHDE LPSPGKVPLS PSPKRLDYTP DGSHLYGSSL QARCAYEKST
810 820 830 840 850
VPIIIRCCID RIEKDDIGLN MEGLYRKSGS QTLVEEIENE FAQNNSLHSD
860 870 880 890 900
TLSPKLNALL NQDIHAVASV LKRYLRKLPD PVLSFSIYDA LIDLVRNNQL
910 920 930 940 950
IERLPLNNDK FLDSPQKVTI YEMVLKSLLE IFKILPVEHQ EVLKVLAAHI
960 970 980 990 1000
GKVRRCSERN LMNLHNLSLV FAPSLIHDFD GEKDIVDMKE RNYIVEFILG

NYRDIFKQA
Length:1,009
Mass (Da):113,291
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA13BA1DF8B35D98
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28373 Genomic DNA Translation: AAB64815.1
BK006938 Genomic DNA Translation: DAA12221.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61174

NCBI Reference Sequences

More...
RefSeqi
NP_010667.1, NM_001180687.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR379W_mRNA; YDR379W; YDR379W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR379W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28373 Genomic DNA Translation: AAB64815.1
BK006938 Genomic DNA Translation: DAA12221.1
PIRiS61174
RefSeqiNP_010667.1, NM_001180687.1

3D structure databases

SMRiQ06407
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32438, 67 interactors
DIPiDIP-2995N
IntActiQ06407, 9 interactors
MINTiQ06407
STRINGi4932.YDR379W

PTM databases

iPTMnetiQ06407

Proteomic databases

MaxQBiQ06407
PaxDbiQ06407
PRIDEiQ06407

Genome annotation databases

EnsemblFungiiYDR379W_mRNA; YDR379W; YDR379W
GeneIDi851985
KEGGisce:YDR379W

Organism-specific databases

EuPathDBiFungiDB:YDR379W
SGDiS000002787 RGA2

Phylogenomic databases

GeneTreeiENSGT00950000182819
HOGENOMiCLU_003874_1_0_1
InParanoidiQ06407
KOiK19839
OMAiLICNNCT

Enzyme and pathway databases

BioCyciYEAST:G3O-29928-MONOMER
ReactomeiR-SCE-194840 Rho GTPase cycle
R-SCE-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06407
RNActiQ06407 protein

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 2 hits
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGA2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06407
Secondary accession number(s): D6VT11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: June 17, 2020
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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