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UniProtKB - Q06407 (RGA2_YEAST)

Entry version 191 (25 May 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Rho-type GTPase-activating protein 2

Gene

RGA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) for CDC42 and/or RHO1.

Miscellaneous

Present with 254 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-6798695, Neutrophil degranulation
R-SCE-8980692, RHOA GTPase cycle
R-SCE-9013148, CDC42 GTPase cycle
R-SCE-9013405, RHOD GTPase cycle
R-SCE-9013423, RAC3 GTPase cycle
R-SCE-9013424, RHOV GTPase cycle
R-SCE-9035034, RHOF GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho-type GTPase-activating protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGA2
Ordered Locus Names:YDR379W
ORF Names:D9481.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000002787, RGA2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YDR379W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759001 – 1009Rho-type GTPase-activating protein 2Add BLAST1009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei763PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q06407

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06407

PRoteomics IDEntifications database

More...PRIDEi		Q06407

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q06407

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		32438, 70 interactors

Database of interacting proteins

More...DIPi		DIP-2995N

Protein interaction database and analysis system

More...IntActi		Q06407, 9 interactors

Molecular INTeraction database

More...MINTi		Q06407

STRING: functional protein association networks

More...STRINGi		4932.YDR379W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q06407, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q06407

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q06407

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 68LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST58
Domaini69 – 129LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini788 – 1006Rho-GAPPROSITE-ProRule annotationAdd BLAST219

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni143 – 228DisorderedSequence analysisAdd BLAST86
Regioni358 – 433DisorderedSequence analysisAdd BLAST76
Regioni449 – 608DisorderedSequence analysisAdd BLAST160
Regioni664 – 709DisorderedSequence analysisAdd BLAST46
Regioni723 – 780DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi164 – 202Polar residuesSequence analysisAdd BLAST39
Compositional biasi203 – 225Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi358 – 413Polar residuesSequence analysisAdd BLAST56
Compositional biasi449 – 464Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi465 – 481Polar residuesSequence analysisAdd BLAST17
Compositional biasi492 – 556Polar residuesSequence analysisAdd BLAST65
Compositional biasi579 – 600Polar residuesSequence analysisAdd BLAST22
Compositional biasi677 – 704Polar residuesSequence analysisAdd BLAST28
Compositional biasi728 – 749Polar residuesSequence analysisAdd BLAST22

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1453, Eukaryota
KOG1704, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234635

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003874_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q06407

Identification of Orthologs from Complete Genome Data

More...OMAi		CSACNNK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR001781, Znf_LIM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00412, LIM, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132, LIM, 2 hits
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06407-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD 
        60         70         80         90        100
SDFLVLDIGT LICYDCSDKC TNCGDKIDDT AIILPSSNEA YCSNCFRCCR 
       110        120        130        140        150
CSNRIKNLKY AKTKRGLCCM DCHEKLLRKK QLLLENQTKN SSKEDFPIKL 
       160        170        180        190        200
PERSVKRPLS PTRINGKSDV STNNTAISKN LVSSNEDQQL TPQVLVSQER 
       210        220        230        240        250
DESSLNDNND NDNSKDREET SSHARTVSID DILNSTLEHD SNSIEEQSLV 
       260        270        280        290        300
DNEDYINKMG EDVTYRLLKP QRANRDSIVV KDPRIPNSNS NANRFFSIYD 
       310        320        330        340        350
KEETDKDDTD NKENEIIVNT PRNSTDKITS PLNSPMAVQM NEEVEPPHGL 
       360        370        380        390        400
ALTLSEATKE NNKSSQGIQT STSKSMNHVS PITRTDTVEM KTSTSSSTLR 
       410        420        430        440        450
LSDNGSFSRP QTADNLLPHK KVAPSPNKKL SRSFSLKSKN FVHNLKSKTS 
       460        470        480        490        500
EMLDPKHPHH STSIQESDTH SGWGVSSTHT NIRKSKAKKN PVSRGQSDST 
       510        520        530        540        550
IYNTLPQHGN FTVPEFNHKK AQSSLGSISK KQNSNDTATN RRINGSFTSS 
       560        570        580        590        600
SSGHHIAMFR TPPLESGPLF KRPSLSSESA HHRSSSLQTS RSTNALLEDD 
       610        620        630        640        650
STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK KLLQDVENLR 
       660        670        680        690        700
LAKERLLNDV DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK 
       710        720        730        740        750
GSISNASPKP RFWKIFSSAK DHQVGDLESQ QRSPNSSSGG TTNIAQKEIS 
       760        770        780        790        800
SPKLIRVHDE LPSPGKVPLS PSPKRLDYTP DGSHLYGSSL QARCAYEKST 
       810        820        830        840        850
VPIIIRCCID RIEKDDIGLN MEGLYRKSGS QTLVEEIENE FAQNNSLHSD 
       860        870        880        890        900
TLSPKLNALL NQDIHAVASV LKRYLRKLPD PVLSFSIYDA LIDLVRNNQL 
       910        920        930        940        950
IERLPLNNDK FLDSPQKVTI YEMVLKSLLE IFKILPVEHQ EVLKVLAAHI 
       960        970        980        990       1000
GKVRRCSERN LMNLHNLSLV FAPSLIHDFD GEKDIVDMKE RNYIVEFILG 

NYRDIFKQA
Length:1,009
Mass (Da):113,291
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA13BA1DF8B35D98
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U28373 Genomic DNA Translation: AAB64815.1
BK006938 Genomic DNA Translation: DAA12221.1

Protein sequence database of the Protein Information Resource

More...PIRi		S61174

NCBI Reference Sequences

More...RefSeqi		NP_010667.1, NM_001180687.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YDR379W_mRNA; YDR379W; YDR379W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		851985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YDR379W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28373 Genomic DNA Translation: AAB64815.1
BK006938 Genomic DNA Translation: DAA12221.1
PIRiS61174
RefSeqiNP_010667.1, NM_001180687.1

3D structure databases

AlphaFoldDBiQ06407
SMRiQ06407
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32438, 70 interactors
DIPiDIP-2995N
IntActiQ06407, 9 interactors
MINTiQ06407
STRINGi4932.YDR379W

PTM databases

iPTMnetiQ06407

Proteomic databases

MaxQBiQ06407
PaxDbiQ06407
PRIDEiQ06407

Genome annotation databases

EnsemblFungiiYDR379W_mRNA; YDR379W; YDR379W
GeneIDi851985
KEGGisce:YDR379W

Organism-specific databases

SGDiS000002787, RGA2
VEuPathDBiFungiDB:YDR379W

Phylogenomic databases

eggNOGiKOG1453, Eukaryota
KOG1704, Eukaryota
GeneTreeiENSGT01030000234635
HOGENOMiCLU_003874_1_0_1
InParanoidiQ06407
OMAiCSACNNK

Enzyme and pathway databases

ReactomeiR-SCE-6798695, Neutrophil degranulation
R-SCE-8980692, RHOA GTPase cycle
R-SCE-9013148, CDC42 GTPase cycle
R-SCE-9013405, RHOD GTPase cycle
R-SCE-9013423, RAC3 GTPase cycle
R-SCE-9013424, RHOV GTPase cycle
R-SCE-9035034, RHOF GTPase cycle

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q06407
RNActiQ06407, protein

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR001781, Znf_LIM
PfamiView protein in Pfam
PF00412, LIM, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00132, LIM, 2 hits
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGA2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06407
Secondary accession number(s): D6VT11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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