Paired mesoderm homeobox protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein."
    Scott K.K., Norris R.A., Potter S.S., Norrington D.W., Baybo M.A., Hicklin D.M., Kern M.J.
    DNA Cell Biol 22:95-105(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• HMG box domain binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from mutant phenotypeⁱ
  • "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein."
    Scott K.K., Norris R.A., Potter S.S., Norrington D.W., Baybo M.A., Hicklin D.M., Kern M.J.
    DNA Cell Biol 22:95-105(2003) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI

GO - Biological processⁱ

• artery morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Loss of function of the Prx1 and Prx2 homeobox genes alters architecture of the great elastic arteries and ductus arteriosus."
    Bergwerff M., Gittenberger-de Groot A.C., Wisse L.J., DeRuiter M.C., Wessels A., Martin J.F., Olson E.N., Kern M.J.
    Virchows Arch 436:12-19(2000) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: MGIInferred from genetic interactionⁱ
  • "prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme."
    Lu M.F., Cheng H.T., Kern M.J., Potter S.S., Tran B., Diekwisch T.G., Martin J.F.
    Development 126:495-504(1999) [PubMed] [Europe PMC] [Abstract]
• embryonic cranial skeleton morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs."
    ten Berge D., Brouwer A., Korving J., Martin J.F., Meijlink F.
    Development 125:3831-3842(1998) [PubMed] [Europe PMC] [Abstract]
• embryonic limb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs."
    ten Berge D., Brouwer A., Korving J., Martin J.F., Meijlink F.
    Development 125:3831-3842(1998) [PubMed] [Europe PMC] [Abstract]
  • "Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis."
    Lu M.F., Cheng H.T., Lacy A.R., Kern M.J., Argao E.A., Potter S.S., Olson E.N., Martin J.F.
    Dev Biol 205:145-157(1999) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis."
    ten Berge D., Brouwer A., Korving J., Reijnen M.J., van Raaij E.J., Verbeek F., Gaffield W., Meijlink F.
    Development 128:2929-2938(2001) [PubMed] [Europe PMC] [Abstract]
  • "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs."
    ten Berge D., Brouwer A., Korving J., Martin J.F., Meijlink F.
    Development 125:3831-3842(1998) [PubMed] [Europe PMC] [Abstract]
  • "prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme."
    Lu M.F., Cheng H.T., Kern M.J., Potter S.S., Tran B., Diekwisch T.G., Martin J.F.
    Development 126:495-504(1999) [PubMed] [Europe PMC] [Abstract]
• inner ear morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs."
    ten Berge D., Brouwer A., Korving J., Martin J.F., Meijlink F.
    Development 125:3831-3842(1998) [PubMed] [Europe PMC] [Abstract]
• middle ear morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs."
    ten Berge D., Brouwer A., Korving J., Martin J.F., Meijlink F.
    Development 125:3831-3842(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mesenchymal cell proliferation Source: MGIInferred from genetic interactionⁱ
  • "Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis."
    ten Berge D., Brouwer A., Korving J., Reijnen M.J., van Raaij E.J., Verbeek F., Gaffield W., Meijlink F.
    Development 128:2929-2938(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of smoothened signaling pathway Source: MGIInferred from genetic interactionⁱ
  • "Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis."
    ten Berge D., Brouwer A., Korving J., Reijnen M.J., van Raaij E.J., Verbeek F., Gaffield W., Meijlink F.
    Development 128:2929-2938(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from mutant phenotypeⁱ
  • "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein."
    Scott K.K., Norris R.A., Potter S.S., Norrington D.W., Baybo M.A., Hicklin D.M., Kern M.J.
    DNA Cell Biol 22:95-105(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• HMG box domain binding Source: UniProtKBInferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR 
        60         70         80         90        100
AAGPVSGPAE ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR 
       110        120        130        140        150
NRTTFNSSQL QALERVFERT HYPDAFVREE LARRVNLSEA RVQVWFQNRR 
       160        170        180        190        200
AKFRRNERAM LATRSASLLK SYGQEAAIEQ PVAPRPTTMS PDYLSWPASS 
       210        220        230        240 
PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH SQVPTVN    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families