UniProtKB - Q06348 (PRRX2_MOUSE)
Protein
Paired mesoderm homeobox protein 2
Gene
Prrx2
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 98 – 157 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- HMG box domain binding Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- artery morphogenesis Source: MGI
- cartilage development Source: MGI
- embryonic cranial skeleton morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- inner ear morphogenesis Source: MGI
- middle ear morphogenesis Source: MGI
- positive regulation of mesenchymal cell proliferation Source: MGI
- positive regulation of smoothened signaling pathway Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Paired mesoderm homeobox protein 2Short name: PRX-2 Alternative name(s): Homeobox protein S8 |
Gene namesi | Name:Prrx2 Synonyms:Prx2, S8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98218, Prrx2 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049256 | 1 – 247 | Paired mesoderm homeobox protein 2Add BLAST | 247 |
Proteomic databases
MaxQBi | Q06348 |
PaxDbi | Q06348 |
PRIDEi | Q06348 |
PTM databases
PhosphoSitePlusi | Q06348 |
Expressioni
Tissue specificityi
In the embryo, expressed in craniofacial mesenchyme, limb, heart, somites and sclerotomes. Absent from central and peripheral nervous systems, splanchnopleure and ectodermal derivatives.
Interactioni
GO - Molecular functioni
- HMG box domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 203059, 3 interactors |
IntActi | Q06348, 1 interactor |
MINTi | Q06348 |
STRINGi | 10090.ENSMUSP00000040332 |
Miscellaneous databases
RNActi | Q06348, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 224 – 237 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 4 – 9 | Poly-Ala | 6 |
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
InParanoidi | Q06348 |
OrthoDBi | 1413050at2759 |
PhylomeDBi | Q06348 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom IPR043378, PRRX1/2 |
PANTHERi | PTHR46385, PTHR46385, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q06348-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR
60 70 80 90 100
AAGPVSGPAE ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR
110 120 130 140 150
NRTTFNSSQL QALERVFERT HYPDAFVREE LARRVNLSEA RVQVWFQNRR
160 170 180 190 200
AKFRRNERAM LATRSASLLK SYGQEAAIEQ PVAPRPTTMS PDYLSWPASS
210 220 230 240
PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH SQVPTVN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2APZ7 | A2APZ7_MOUSE | Paired mesoderm homeobox protein 2 | Prrx2 | 247 | Annotation score: | ||
Q9CY80 | Q9CY80_MOUSE | Paired mesoderm homeobox protein 2 | Prrx2 | 175 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52875 mRNA Translation: CAA37055.1 X14572 mRNA Translation: CAA32710.1 Sequence problems. |
CCDSi | CCDS15888.1 |
PIRi | I48410, S18038 |
RefSeqi | NP_033142.2, NM_009116.2 |
Genome annotation databases
GeneIDi | 20204 |
KEGGi | mmu:20204 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52875 mRNA Translation: CAA37055.1 X14572 mRNA Translation: CAA32710.1 Sequence problems. |
CCDSi | CCDS15888.1 |
PIRi | I48410, S18038 |
RefSeqi | NP_033142.2, NM_009116.2 |
3D structure databases
SMRi | Q06348 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203059, 3 interactors |
IntActi | Q06348, 1 interactor |
MINTi | Q06348 |
STRINGi | 10090.ENSMUSP00000040332 |
PTM databases
PhosphoSitePlusi | Q06348 |
Proteomic databases
MaxQBi | Q06348 |
PaxDbi | Q06348 |
PRIDEi | Q06348 |
Genome annotation databases
GeneIDi | 20204 |
KEGGi | mmu:20204 |
Organism-specific databases
CTDi | 51450 |
MGIi | MGI:98218, Prrx2 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
InParanoidi | Q06348 |
OrthoDBi | 1413050at2759 |
PhylomeDBi | Q06348 |
Miscellaneous databases
BioGRID-ORCSi | 20204, 0 hits in 17 CRISPR screens |
ChiTaRSi | Prrx2, mouse |
PROi | PR:Q06348 |
RNActi | Q06348, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom IPR043378, PRRX1/2 |
PANTHERi | PTHR46385, PTHR46385, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRRX2_MOUSE | |
Accessioni | Q06348Primary (citable) accession number: Q06348 Secondary accession number(s): Q61651 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families