Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 179 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

ADP-ribosylation factor-binding protein GGA1

Gene

GGA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of membrane traffic through the trans-Golgi network.

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosylation factor-binding protein GGA1
Alternative name(s):
Golgi-localized, gamma ear-containing, ARF-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GGA1
Ordered Locus Names:YDR358W
ORF Names:D9476.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002766, GGA1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDR358W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002126861 – 557ADP-ribosylation factor-binding protein GGA1Add BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei348PhosphothreonineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06336

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06336

PRoteomics IDEntifications database

More...
PRIDEi
Q06336

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q06336

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06336

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to ARF1 and ARF2.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32414, 126 interactors

Protein interaction database and analysis system

More...
IntActi
Q06336, 5 interactors

Molecular INTeraction database

More...
MINTi
Q06336

STRING: functional protein association networks

More...
STRINGi
4932.YDR358W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06336, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1557
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q06336

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 165VHSPROSITE-ProRule annotationAdd BLAST137
Domaini192 – 317GATPROSITE-ProRule annotationAdd BLAST126
Domaini440 – 556GAEPROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1087, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017092_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06336

Identification of Orthologs from Complete Genome Data

More...
OMAi
XAWADAF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.160, 1 hit
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR008942, ENTH_VHS
IPR008153, GAE_dom
IPR004152, GAT_dom
IPR038425, GAT_sf
IPR041198, GGA_N-GAT
IPR002014, VHS_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02883, Alpha_adaptinC2, 1 hit
PF03127, GAT, 1 hit
PF18308, GGA_N-GAT, 1 hit
PF00790, VHS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00809, Alpha_adaptinC2, 1 hit
SM00288, VHS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464, SSF48464, 1 hit
SSF49348, SSF49348, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50180, GAE, 1 hit
PS50909, GAT, 1 hit
PS50179, VHS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06336-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQRIELTSE PVRKPRSTES SLLRKIQRAC RSTLPEPDLG LNLDVADYIN
60 70 80 90 100
SKQGATPREA VLAIEKLVNN GDTQAAVFAL SLLDVLVKNC GYSIHLQISR
110 120 130 140 150
KEFLNDLVKR FPEQPPLRYS KVQQMILEAI EEWYQTICKH ASYKDDLQYI
160 170 180 190 200
NDMHKLLKYK GYTFPKVGSE NLAVLRPNDQ LRTPSELQEE QERAQAAKLE
210 220 230 240 250
ELLRSGKPDD LKEANKLMKI MAGFKDDTKV AVKQAINNEL NKLKRKADLF
260 270 280 290 300
NEMLTSADEP DLENEAIQEL YGDLKSAQPK FKKLIEEERD DDALVSNLSK
310 320 330 340 350
FNDLVIQLLK RYKSIKGMKE EELNVPDTNE PAKELNLIDF DDDTTANTPS
360 370 380 390 400
VTSPSKSLQP FDDLLGDFNK VSLSSPKSPQ ENDTVVDILG DAHSKSSGID
410 420 430 440 450
LLDFDSQPGE SKTALSAYSN SIVLPNGLLN SSSNSKEITA QSQRHILNQS
460 470 480 490 500
DHLRIDYELT RESMTKLRLV IFYSNISSDP ITNFALLVAS PKGTTLSLQP
510 520 530 540 550
QSGNMLQSNS RDGIKQIASV EGISVNLGKP IKLKWKANYC TKGDSKEESG

TTSLPTI
Length:557
Mass (Da):62,320
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBA76787F998DBD7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28372 Genomic DNA Translation: AAB64793.1
BK006938 Genomic DNA Translation: DAA12197.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61154

NCBI Reference Sequences

More...
RefSeqi
NP_010645.1, NM_001180666.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR358W_mRNA; YDR358W; YDR358W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR358W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28372 Genomic DNA Translation: AAB64793.1
BK006938 Genomic DNA Translation: DAA12197.1
PIRiS61154
RefSeqiNP_010645.1, NM_001180666.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CN1X-ray2.31A/B/C/D433-557[»]
5CN2X-ray2.25A/B433-557[»]
SMRiQ06336
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32414, 126 interactors
IntActiQ06336, 5 interactors
MINTiQ06336
STRINGi4932.YDR358W

PTM databases

iPTMnetiQ06336

Proteomic databases

MaxQBiQ06336
PaxDbiQ06336
PRIDEiQ06336
TopDownProteomicsiQ06336

Genome annotation databases

EnsemblFungiiYDR358W_mRNA; YDR358W; YDR358W
GeneIDi851960
KEGGisce:YDR358W

Organism-specific databases

SGDiS000002766, GGA1
VEuPathDBiFungiDB:YDR358W

Phylogenomic databases

eggNOGiKOG1087, Eukaryota
GeneTreeiENSGT00940000176423
HOGENOMiCLU_017092_0_0_1
InParanoidiQ06336
OMAiXAWADAF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06336
RNActiQ06336, protein

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR008942, ENTH_VHS
IPR008153, GAE_dom
IPR004152, GAT_dom
IPR038425, GAT_sf
IPR041198, GGA_N-GAT
IPR002014, VHS_dom
PfamiView protein in Pfam
PF02883, Alpha_adaptinC2, 1 hit
PF03127, GAT, 1 hit
PF18308, GGA_N-GAT, 1 hit
PF00790, VHS, 1 hit
SMARTiView protein in SMART
SM00809, Alpha_adaptinC2, 1 hit
SM00288, VHS, 1 hit
SUPFAMiSSF48464, SSF48464, 1 hit
SSF49348, SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180, GAE, 1 hit
PS50909, GAT, 1 hit
PS50179, VHS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGA1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06336
Secondary accession number(s): D6VSY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again