RBPJ

Functionⁱ

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).By similarity2 Publications

Caution

Despite some similarity with the "phage" integrase family, it has no recombinase activity.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	58 – 65		8
DNA bindingⁱ	192 – 201		10
DNA bindingⁱ	265 – 297	Add BLAST	33

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding
Source: UniProtKB
Traceable author statementⁱ
- 9874765
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: MGI
Inferred from direct assayⁱ
- 18663143
DNA-binding transcription factor activity
Source: UniProtKB
Traceable author statementⁱ
- 9874765
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein N-terminus binding Source: Ensembl
recombinase activity
Source: UniProtKB
Non-traceable author statementⁱ
- 8406481
repressing transcription factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 16691198
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: CAFA
Inferred from direct assayⁱ
- 16691198
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16287852
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: BHF-UCL
aortic valve development Source: Ensembl
arterial endothelial cell fate commitment Source: Ensembl
atrioventricular canal development Source: BHF-UCL
auditory receptor cell fate commitment Source: Ensembl
B cell differentiation Source: Ensembl
blood vessel endothelial cell fate specification Source: BHF-UCL
blood vessel lumenization Source: BHF-UCL
blood vessel remodeling Source: Ensembl
cardiac left ventricle morphogenesis Source: BHF-UCL
Clara cell differentiation Source: Ensembl
defense response to bacterium Source: Ensembl
DNA recombination
Source: UniProtKB
Non-traceable author statementⁱ
- 8406481
dorsal aorta morphogenesis Source: BHF-UCL
endocardium morphogenesis Source: BHF-UCL
epidermal cell fate specification Source: Ensembl
epithelial to mesenchymal transition Source: BHF-UCL
epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
hair follicle maturation Source: Ensembl
humoral immune response Source: Ensembl
inflammatory response to antigenic stimulus Source: Ensembl
interleukin-4 secretion Source: Ensembl
keratinocyte differentiation Source: Ensembl
labyrinthine layer blood vessel development Source: BHF-UCL
myeloid dendritic cell differentiation Source: Ensembl
negative regulation of cell differentiation Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 25038826
negative regulation of ossification Source: BHF-UCL
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 10713164
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18663143
Notch signaling involved in heart development
Source: BHF-UCL
Inferred by curatorⁱ
- 21311046
Notch signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18663143
outflow tract morphogenesis Source: BHF-UCL
pituitary gland development Source: Ensembl
positive regulation of BMP signaling pathway Source: BHF-UCL
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: Ensembl
positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
positive regulation of ephrin receptor signaling pathway Source: BHF-UCL
positive regulation of ERBB signaling pathway Source: BHF-UCL
positive regulation of gene expression Source: BHF-UCL
positive regulation of Notch signaling pathway Source: Reactome
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18663143
- 20890042
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788
positive regulation of transcription of Notch receptor target
Source: UniProtKB
Inferred from direct assayⁱ
- 21102556
pulmonary valve development Source: Ensembl
regulation of timing of cell differentiation Source: Ensembl
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
sebaceous gland development Source: Ensembl
secondary heart field specification Source: Ensembl
somatic stem cell population maintenance Source: Ensembl
somitogenesis Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome
ventricular septum morphogenesis Source: Ensembl
ventricular trabecula myocardium morphogenesis Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563 NOTCH2 intracellular domain regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-350054 Notch-HLH transcription pathway R-HSA-8941856 RUNX3 regulates NOTCH signaling R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
SignaLinkⁱ	Q06330
SIGNORⁱ	Q06330

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Recombining binding protein suppressor of hairless Alternative name(s): CBF-1 J kappa-recombination signal-binding protein RBP-J kappa Short name: RBP-J Short name: RBP-JK Renal carcinoma antigen NY-REN-30
Gene namesⁱ	Name:RBPJImported Synonyms:IGKJRB, IGKJRB1, RBPJK, RBPSUH
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168214.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5724 RBPJ
MIMⁱ	147183 gene
neXtProtⁱ	NX_Q06330

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Adams-Oliver syndrome 3 (AOS3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant form of Adams-Oliver syndrome, a disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. AOS3 patients manifest characteristic vertex scalp defects and terminal limb defects, but without congenital heart defects, other associated defects, or immune defects.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3516
GeneReviewsⁱ	RBPJ
MalaCards human disease database More...MalaCardsⁱ	RBPJ
MIMⁱ	614814 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000168214
Orphanetⁱ	974 Adams-Oliver syndrome
PharmGKBⁱ	PA34292

Polymorphism and mutation databases

BioMutaⁱ	RBPJ
DMDMⁱ	338817983

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208567	1 – 500	Recombining binding protein suppressor of hairlessAdd BLAST		500

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	175	N6-acetyllysineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q06330
jPOSTⁱ	Q06330
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q06330
PaxDbⁱ	Q06330
PeptideAtlas More...PeptideAtlasⁱ	Q06330
PRIDEⁱ	Q06330
ProteomicsDBⁱ	58432 58433 [Q06330-2] 58434 [Q06330-3] 58435 [Q06330-4] 58436 [Q06330-5] 58437 [Q06330-6] 58438 [Q06330-7]
TopDownProteomicsⁱ	Q06330-3 [Q06330-3]

PTM databases

iPTMnetⁱ	Q06330
PhosphoSitePlusⁱ	Q06330

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168214 Expressed in 242 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_RBPJ
ExpressionAtlasⁱ	Q06330 baseline and differential
Genevisibleⁱ	Q06330 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060647

HPAⁱ

HPA060647

Interactionⁱ

Subunit structureⁱ

Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6. Interacts with RITA1/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Interacts with SNW1. Interacts with CHCHD2 and CXXC5 (PubMed:23303788). Interacts with BEND6 (via BEN domain). Interacts with NKAPL (By similarity). Interacts with ZMIZ1. Interacts with RBM15 (By similarity).By similarity11 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	7	EBI-632552,EBI-930964
ATXN1L	P0C7T5	7	EBI-632552,EBI-8624731
EBNA2	P12978	2	EBI-632552,EBI-8052923	From Epstein-Barr virus (strain B95-8).
EBNA3	P12977	4	EBI-632552,EBI-993115	From Epstein-Barr virus (strain B95-8).
EBNA4	P03203	4	EBI-632552,EBI-9346250	From Epstein-Barr virus (strain B95-8).
EBNA6	P03204	3	EBI-632552,EBI-9255985	From Epstein-Barr virus (strain B95-8).
FBXO42	Q6P3S6	3	EBI-632552,EBI-2506081
KDM1A	O60341	4	EBI-632552,EBI-710124
NCOR2	Q9Y618	3	EBI-632552,EBI-80830
NOTCH1	P46531	12	EBI-632552,EBI-636374
Notch1	Q01705	3	EBI-632552,EBI-1392707	From Mus musculus.
PHF8	Q9UPP1	2	EBI-632552,EBI-1560800
RITA1	Q96K30	10	EBI-632552,EBI-2836148
rita1	P0CJ62	2	EBI-632552,EBI-8517225	From Xenopus laevis.
SMARCA4	P51532	2	EBI-632552,EBI-302489
SNW1	Q13573	2	EBI-632552,EBI-632715
SPEN	Q96T58	2	EBI-632552,EBI-765739
TP53	P04637	5	EBI-632552,EBI-366083

GO - Molecular functionⁱ

protein N-terminus binding Source: Ensembl
repressing transcription factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 16691198
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16287852
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109736, 134 interactors
CORUMⁱ	Q06330
Database of interacting proteins More...DIPⁱ	DIP-33326N
ELMⁱ	Q06330
IntActⁱ	Q06330, 114 interactors
Molecular INTeraction database More...MINTⁱ	Q06330
STRINGⁱ	9606.ENSP00000345206

Chemistry databases

BindingDBⁱ	Q06330

BindingDBⁱ

Q06330

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	33 – 41	Combined sources	9
Beta strandⁱ	50 – 57	Combined sources	8
Beta strandⁱ	72 – 74	Combined sources	3
Helixⁱ	79 – 88	Combined sources	10
Turnⁱ	89 – 91	Combined sources	3
Turnⁱ	94 – 96	Combined sources	3
Beta strandⁱ	102 – 105	Combined sources	4
Beta strandⁱ	118 – 121	Combined sources	4
Beta strandⁱ	137 – 139	Combined sources	3
Beta strandⁱ	141 – 146	Combined sources	6
Beta strandⁱ	152 – 157	Combined sources	6
Beta strandⁱ	161 – 166	Combined sources	6
Beta strandⁱ	174 – 176	Combined sources	3
Beta strandⁱ	178 – 180	Combined sources	3
Beta strandⁱ	185 – 191	Combined sources	7
Helixⁱ	193 – 195	Combined sources	3
Turnⁱ	197 – 199	Combined sources	3
Beta strandⁱ	204 – 206	Combined sources	3
Beta strandⁱ	209 – 211	Combined sources	3
Beta strandⁱ	220 – 225	Combined sources	6
Beta strandⁱ	231 – 234	Combined sources	4
Beta strandⁱ	246 – 255	Combined sources	10
Beta strandⁱ	262 – 268	Combined sources	7
Beta strandⁱ	271 – 275	Combined sources	5
Beta strandⁱ	284 – 289	Combined sources	6
Beta strandⁱ	291 – 295	Combined sources	5
Beta strandⁱ	297 – 299	Combined sources	3
Beta strandⁱ	302 – 306	Combined sources	5
Beta strandⁱ	319 – 321	Combined sources	3
Beta strandⁱ	328 – 336	Combined sources	9
Beta strandⁱ	343 – 345	Combined sources	3
Beta strandⁱ	356 – 362	Combined sources	7
Helixⁱ	366 – 368	Combined sources	3
Beta strandⁱ	370 – 377	Combined sources	8
Beta strandⁱ	382 – 386	Combined sources	5
Beta strandⁱ	389 – 391	Combined sources	3
Beta strandⁱ	393 – 397	Combined sources	5
Beta strandⁱ	400 – 404	Combined sources	5
Helixⁱ	408 – 411	Combined sources	4
Beta strandⁱ	412 – 414	Combined sources	3
Beta strandⁱ	426 – 430	Combined sources	5
Beta strandⁱ	431 – 433	Combined sources	3
Beta strandⁱ	435 – 437	Combined sources	3

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2F8X	X-ray	3.25	C	23-449	[»]
	3NBN	X-ray	3.45	A/D	23-448	[»]
	3V79	X-ray	3.85	C	23-449	[»]
ProteinModelPortalⁱ	Q06330
SMRⁱ	Q06330
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q06330

EvolutionaryTraceⁱ

Q06330

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	355 – 445	IPT/TIGAdd BLAST		91

Sequence similaritiesⁱ

Belongs to the Su(H) family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3743 Eukaryota ENOG410XV7K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005197
HOGENOMⁱ	HOG000253907
HOVERGENⁱ	HBG006618
InParanoidⁱ	Q06330
KEGG Orthology (KO) More...KOⁱ	K06053
OMAⁱ	DMPHFGL
Database of Orthologous Groups More...OrthoDBⁱ	805081at2759
PhylomeDBⁱ	Q06330
TreeFamⁱ	TF314117

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01176 IPT_RBP-Jkappa, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.1450, 1 hit
InterProⁱ	View protein in InterPro IPR015350 Beta-trefoil_DNA-bd_dom IPR036358 BTD_sf IPR040159 CLS_fam IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR008967 p53-like_TF_DNA-bd IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007 RBP-Jkappa_IPT
PANTHERⁱ	PTHR10665 PTHR10665, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09270 BTD, 1 hit PF09271 LAG1-DNAbind, 1 hit
SMARTⁱ	View protein in SMART SM01268 BTD, 1 hit SM01267 LAG1_DNAbind, 1 hit
SUPFAMⁱ	SSF110217 SSF110217, 1 hit SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 16 potential isoforms that are computationally mapped.Show all Align All

Isoform APCR-2 (identifier: Q06330-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHTEGSPAE EPPAHAPSPG KFGERPPPKR LTREAMRNYL KERGDQTVLI 
        60         70         80         90        100
LHAKVAQKSY GNEKRFFCPP PCVYLMGSGW KKKKEQMERD GCSEQESQPC 
       110        120        130        140        150
AFIGIGNSDQ EMQQLNLEGK NYCTAKTLYI SDSDKRKHFM LSVKMFYGNS 
       160        170        180        190        200
DDIGVFLSKR IKVISKPSKK KQSLKNADLC IASGTKVALF NRLRSQTVST 
       210        220        230        240        250
RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG YIHYGQTVKL 
       260        270        280        290        300
VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL 
       310        320        330        340        350
SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP 
       360        370        380        390        400
VTPVPVVESL QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES 
       410        420        430        440        450
MLCVVPDISA FREGWRWVRQ PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP 
       460        470        480        490        500
RPHCSAAGAI LRANSSQVPP NESNTNSEGS YTNASTNSTS VTSSTATVVS

Length:500

Mass (Da):55,637

Last modified:June 28, 2011 - v3

Checksum:ⁱ91E50D2DE9087EDA

GO

Isoform APCR-1 (identifier: Q06330-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-75: Missing.

« Hide

        10         20         30         40         50
MGSGWKKKKE QMERDGCSEQ ESQPCAFIGI GNSDQEMQQL NLEGKNYCTA 
        60         70         80         90        100
KTLYISDSDK RKHFMLSVKM FYGNSDDIGV FLSKRIKVIS KPSKKKQSLK 
       110        120        130        140        150
NADLCIASGT KVALFNRLRS QTVSTRYLHV EGGNFHASSQ QWGAFFIHLL 
       160        170        180        190        200
DDDESEGEEF TVRDGYIHYG QTVKLVCSVT GMALPRLIIR KVDKQTALLD 
       210        220        230        240        250
ADDPVSQLHK CAFYLKDTER MYLCLSQERI IQFQATPCPK EPNKEMINDG 
       260        270        280        290        300
ASWTIISTDK AEYTFYEGMG PVLAPVTPVP VVESLQLNGG GDVAMLELTG 
       310        320        330        340        350
QNFTPNLRVW FGDVEAETMY RCGESMLCVV PDISAFREGW RWVRQPVQVP 
       360        370        380        390        400
VTLVRNDGII YSTSLTFTYT PEPGPRPHCS AAGAILRANS SQVPPNESNT 
       410        420 
NSEGSYTNAS TNSTSVTSST ATVVS

Show »

Length:425

Mass (Da):47,180

Checksum:ⁱ31CC3FCBED8E739E

GO

Isoform APCR-3 (identifier: Q06330-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-89: Missing.
90-95: DGCSEQ → MAWIKR

« Hide

        10         20         30         40         50
MAWIKRESQP CAFIGIGNSD QEMQQLNLEG KNYCTAKTLY ISDSDKRKHF 
        60         70         80         90        100
MLSVKMFYGN SDDIGVFLSK RIKVISKPSK KKQSLKNADL CIASGTKVAL 
       110        120        130        140        150
FNRLRSQTVS TRYLHVEGGN FHASSQQWGA FFIHLLDDDE SEGEEFTVRD 
       160        170        180        190        200
GYIHYGQTVK LVCSVTGMAL PRLIIRKVDK QTALLDADDP VSQLHKCAFY 
       210        220        230        240        250
LKDTERMYLC LSQERIIQFQ ATPCPKEPNK EMINDGASWT IISTDKAEYT 
       260        270        280        290        300
FYEGMGPVLA PVTPVPVVES LQLNGGGDVA MLELTGQNFT PNLRVWFGDV 
       310        320        330        340        350
EAETMYRCGE SMLCVVPDIS AFREGWRWVR QPVQVPVTLV RNDGIIYSTS 
       360        370        380        390        400
LTFTYTPEPG PRPHCSAAGA ILRANSSQVP PNESNTNSEG SYTNASTNST 
       410 
SVTSSTATVV S

Show »

Length:411

Mass (Da):45,642

Checksum:ⁱF213446BAF8AA7BF

GO

Isoform 4 (identifier: Q06330-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-20: MDHTEGSPAEEPPAHAPSPG → MGGCR

« Hide

        10         20         30         40         50
MGGCRKFGER PPPKRLTREA MRNYLKERGD QTVLILHAKV AQKSYGNEKR 
        60         70         80         90        100
FFCPPPCVYL MGSGWKKKKE QMERDGCSEQ ESQPCAFIGI GNSDQEMQQL 
       110        120        130        140        150
NLEGKNYCTA KTLYISDSDK RKHFMLSVKM FYGNSDDIGV FLSKRIKVIS 
       160        170        180        190        200
KPSKKKQSLK NADLCIASGT KVALFNRLRS QTVSTRYLHV EGGNFHASSQ 
       210        220        230        240        250
QWGAFFIHLL DDDESEGEEF TVRDGYIHYG QTVKLVCSVT GMALPRLIIR 
       260        270        280        290        300
KVDKQTALLD ADDPVSQLHK CAFYLKDTER MYLCLSQERI IQFQATPCPK 
       310        320        330        340        350
EPNKEMINDG ASWTIISTDK AEYTFYEGMG PVLAPVTPVP VVESLQLNGG 
       360        370        380        390        400
GDVAMLELTG QNFTPNLRVW FGDVEAETMY RCGESMLCVV PDISAFREGW 
       410        420        430        440        450
RWVRQPVQVP VTLVRNDGII YSTSLTFTYT PEPGPRPHCS AAGAILRANS 
       460        470        480 
SQVPPNESNT NSEGSYTNAS TNSTSVTSST ATVVS

Show »

Length:485

Mass (Da):54,146

Checksum:ⁱF0907B0A36490025

GO

Isoform 5 (identifier: Q06330-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-35: Missing.

« Hide

        10         20         30         40         50
MRNYLKERGD QTVLILHAKV AQKSYGNEKR FFCPPPCVYL MGSGWKKKKE 
        60         70         80         90        100
QMERDGCSEQ ESQPCAFIGI GNSDQEMQQL NLEGKNYCTA KTLYISDSDK 
       110        120        130        140        150
RKHFMLSVKM FYGNSDDIGV FLSKRIKVIS KPSKKKQSLK NADLCIASGT 
       160        170        180        190        200
KVALFNRLRS QTVSTRYLHV EGGNFHASSQ QWGAFFIHLL DDDESEGEEF 
       210        220        230        240        250
TVRDGYIHYG QTVKLVCSVT GMALPRLIIR KVDKQTALLD ADDPVSQLHK 
       260        270        280        290        300
CAFYLKDTER MYLCLSQERI IQFQATPCPK EPNKEMINDG ASWTIISTDK 
       310        320        330        340        350
AEYTFYEGMG PVLAPVTPVP VVESLQLNGG GDVAMLELTG QNFTPNLRVW 
       360        370        380        390        400
FGDVEAETMY RCGESMLCVV PDISAFREGW RWVRQPVQVP VTLVRNDGII 
       410        420        430        440        450
YSTSLTFTYT PEPGPRPHCS AAGAILRANS SQVPPNESNT NSEGSYTNAS 
       460 
TNSTSVTSST ATVVS

Show »

Length:465

Mass (Da):51,877

Checksum:ⁱ683E1FC7CC0FACC8

GO

Isoform 6 (identifier: Q06330-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-20: MDHTEGSPAEEPPAHAPSPG → MAWIKR

« Hide

        10         20         30         40         50
MAWIKRKFGE RPPPKRLTRE AMRNYLKERG DQTVLILHAK VAQKSYGNEK 
        60         70         80         90        100
RFFCPPPCVY LMGSGWKKKK EQMERDGCSE QESQPCAFIG IGNSDQEMQQ 
       110        120        130        140        150
LNLEGKNYCT AKTLYISDSD KRKHFMLSVK MFYGNSDDIG VFLSKRIKVI 
       160        170        180        190        200
SKPSKKKQSL KNADLCIASG TKVALFNRLR SQTVSTRYLH VEGGNFHASS 
       210        220        230        240        250
QQWGAFFIHL LDDDESEGEE FTVRDGYIHY GQTVKLVCSV TGMALPRLII 
       260        270        280        290        300
RKVDKQTALL DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP 
       310        320        330        340        350
KEPNKEMIND GASWTIISTD KAEYTFYEGM GPVLAPVTPV PVVESLQLNG 
       360        370        380        390        400
GGDVAMLELT GQNFTPNLRV WFGDVEAETM YRCGESMLCV VPDISAFREG 
       410        420        430        440        450
WRWVRQPVQV PVTLVRNDGI IYSTSLTFTY TPEPGPRPHC SAAGAILRAN 
       460        470        480 
SSQVPPNESN TNSEGSYTNA STNSTSVTSS TATVVS

Show »

Length:486

Mass (Da):54,427

Checksum:ⁱ31FD3B3D01B13C4C

GO

Isoform 7 (identifier: Q06330-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-19: MDHTEGSPAEEPPAHAPSP → MAPVVT

« Hide

        10         20         30         40         50
MAPVVTGKFG ERPPPKRLTR EAMRNYLKER GDQTVLILHA KVAQKSYGNE 
        60         70         80         90        100
KRFFCPPPCV YLMGSGWKKK KEQMERDGCS EQESQPCAFI GIGNSDQEMQ 
       110        120        130        140        150
QLNLEGKNYC TAKTLYISDS DKRKHFMLSV KMFYGNSDDI GVFLSKRIKV 
       160        170        180        190        200
ISKPSKKKQS LKNADLCIAS GTKVALFNRL RSQTVSTRYL HVEGGNFHAS 
       210        220        230        240        250
SQQWGAFFIH LLDDDESEGE EFTVRDGYIH YGQTVKLVCS VTGMALPRLI 
       260        270        280        290        300
IRKVDKQTAL LDADDPVSQL HKCAFYLKDT ERMYLCLSQE RIIQFQATPC 
       310        320        330        340        350
PKEPNKEMIN DGASWTIIST DKAEYTFYEG MGPVLAPVTP VPVVESLQLN 
       360        370        380        390        400
GGGDVAMLEL TGQNFTPNLR VWFGDVEAET MYRCGESMLC VVPDISAFRE 
       410        420        430        440        450
GWRWVRQPVQ VPVTLVRNDG IIYSTSLTFT YTPEPGPRPH CSAAGAILRA 
       460        470        480 
NSSQVPPNES NTNSEGSYTN ASTNSTSVTS STATVVS

Show »

Length:487

Mass (Da):54,297

Checksum:ⁱBF5DE1E391B0E947

GO

Computationally mapped potential isoform sequencesⁱ

There are 16 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	D6R927	D6R927_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	382	Annotation score:
	D6RA45	D6RA45_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	189	Annotation score:
	D6RAT2	D6RAT2_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	94	Annotation score:
	D6RB37	D6RB37_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	143	Annotation score:
	D6RBQ8	D6RBQ8_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	157	Annotation score:
	D6RCM1	D6RCM1_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	229	Annotation score:
	D6R946	D6R946_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	178	Annotation score:
	D6RIZ8	D6RIZ8_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	97	Annotation score:
	D6R9X3	D6R9X3_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	107	Annotation score:
	D6REC2	D6REC2_HUMAN	Recombining-binding protein suppres... Recombining-binding protein suppressor of hairless	RBPJ	113	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAA16254 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	7	S → L in AAA60258 (PubMed:8406481).Curated	1
Sequence conflictⁱ	7	S → L in AAA16253 (PubMed:8406481).Curated	1
Sequence conflictⁱ	7	S → L in AAA16254 (PubMed:8406481).Curated	1
Sequence conflictⁱ	140 – 141	ML → IF in AAA60258 (PubMed:8406481).Curated	2
Sequence conflictⁱ	240	G → V in AAA60258 (PubMed:8406481).Curated	1
Sequence conflictⁱ	248	V → C in AAA60258 (PubMed:8406481).Curated	1
Sequence conflictⁱ	265	R → M in AAA60258 (PubMed:8406481).Curated	1
Sequence conflictⁱ	270	Q → H in AAA60258 (PubMed:8406481).Curated	1
Sequence conflictⁱ	462	R → P in AAA60258 (PubMed:8406481).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068929	63	E → G in AOS3; shows decreased binding to the HES1 promoter compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907270EnsemblClinVar.	1
Natural variantⁱVAR_068930	169	K → E in AOS3; shows decreased binding to the HES1 promoter compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907271EnsemblClinVar.	1
Natural variantⁱVAR_028994	291	K → E. Corresponds to variant dbSNP:rs1064372Ensembl.	1
Natural variantⁱVAR_028995	334	D → H. Corresponds to variant dbSNP:rs1064376Ensembl.	1
Natural variantⁱVAR_057244	408	I → V. Corresponds to variant dbSNP:rs1064381Ensembl.	1
Natural variantⁱVAR_028996	419	R → Q. Corresponds to variant dbSNP:rs1064384Ensembl.	1
Natural variantⁱVAR_028997	425	P → S. Corresponds to variant dbSNP:rs1064387Ensembl.	1
Natural variantⁱVAR_028998	456	A → V1 PublicationCorresponds to variant dbSNP:rs1064402Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002718	1 – 89	Missing in isoform APCR-3. 1 PublicationAdd BLAST	89
Alternative sequenceⁱVSP_002717	1 – 75	Missing in isoform APCR-1. 1 PublicationAdd BLAST	75
Alternative sequenceⁱVSP_021572	1 – 35	Missing in isoform 5. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_021573	1 – 20	MDHTE…APSPG → MGGCR in isoform 4. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_021574	1 – 20	MDHTE…APSPG → MAWIKR in isoform 6. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_042637	1 – 19	MDHTE…HAPSP → MAPVVT in isoform 7. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_002719	90 – 95	DGCSEQ → MAWIKR in isoform APCR-3. 1 Publication	6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07872 mRNA Translation: AAA60258.1 L07874 mRNA Translation: AAA16253.1 L07875 mRNA Translation: AAA16254.1 Different initiation. L07876 mRNA Translation: AAA16356.1 AK302230 mRNA Translation: BAG63584.1 AC093637 Genomic DNA No translation available. AC097109 Genomic DNA No translation available. AC097714 Genomic DNA No translation available. AC111003 Genomic DNA No translation available. BC020780 mRNA Translation: AAH20780.1 BC053531 mRNA No translation available. BC064976 mRNA Translation: AAH64976.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33969.1 [Q06330-6] CCDS3436.1 [Q06330-4] CCDS3437.1 [Q06330-1] CCDS43219.1 [Q06330-7] CCDS87214.1 [Q06330-5]
PIRⁱ	A47214
NCBI Reference Sequences More...RefSeqⁱ	NP_005340.2, NM_005349.3 [Q06330-1] NP_056958.3, NM_015874.4 [Q06330-7] NP_976028.1, NM_203283.2 [Q06330-4] NP_976029.1, NM_203284.2 [Q06330-6] XP_005248218.1, XM_005248161.3 [Q06330-6] XP_011512142.1, XM_011513840.2 [Q06330-6] XP_016863661.1, XM_017008172.1 XP_016863662.1, XM_017008173.1 [Q06330-6] XP_016863663.1, XM_017008174.1 [Q06330-6] XP_016863664.1, XM_017008175.1 [Q06330-6]
UniGeneⁱ	Hs.479396

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q06330	RBPJ isoform 12		PANTR		500	UniRef100_Q06330
Recombining-binding protein suppressor of hairless (Fragment)		HUMAN		178
RBPJ isoform 20 (Fragment)		PANTR		178
Q06330-2	Recombining binding protein suppressor of hairless (Drosophila), isoform CRA_a		HUMAN		425	UniRef100_A0A024R9Q8
Recombination signal binding protein for immunoglobulin kappa J region		MACFA		425
RBPJ isoform 5		PANTR		465
RBPJ isoform 4		PONAB		465
Isoform 5 of Recombining binding protein suppressor of hairless		HUMAN		465
+1
Q06330-4	RBPJ isoform 10		PANTR		485	UniRef100_H2R2Q6
Recombination signal binding protein for immunoglobulin kappa J region		PAPAN		485
Recombination signal binding protein for immunoglobulin kappa J region		MANLE		485
Recombination signal binding protein for immunoglobulin kappa J region		GORGO		485
Recombination signal binding protein for immunoglobulin kappa J region		MACFA		485
Q06330-5	Recombining binding protein suppressor of hairless (Drosophila), isoform CRA_a		HUMAN		425	UniRef100_A0A024R9Q8
Recombination signal binding protein for immunoglobulin kappa J region		MACFA		425
RBPJ isoform 5		PANTR		465
RBPJ isoform 4		PONAB		465
Isoform APCR-1 of Recombining binding protein suppressor of hairless		HUMAN		425
+1
Q06330-6	RBPJ isoform 1		PANTR		486	UniRef100_A0A2J8NVV9
Recombination signal binding protein for immunoglobulin kappa J region		MACFA		486
Recombination signal binding protein for immunoglobulin kappa J region		RHIRO		486
Recombination signal binding protein for immunoglobulin kappa J region		PAPAN		486
Recombination signal binding protein for immunoglobulin kappa J region		MANLE		486
+1
Q06330-7	RBPJ isoform 11		PANTR		487	UniRef100_A0A2J8NVV2
Recombination signal binding protein for immunoglobulin kappa J region		PAPAN		487
Recombination signal binding protein for immunoglobulin kappa J region		GORGO		487
Recombination signal binding protein for immunoglobulin kappa J region		MACFA		487

Protein	Similar proteins		Species	Score	Length	Source
Q06330	RBPJ isoform 12		PANTR		500	UniRef90_Q06330
Recombining-binding protein suppressor of hairless (Fragment)		HUMAN		178
Recombination signal binding protein for immunoglobulin kappa J region		RHIBE		531
Recombination signal binding protein for immunoglobulin kappa J region		SAIBB		530
Recombination signal binding protein for immunoglobulin kappa J region		MACFA		529
+556
Q06330-3	Recombination signal binding protein for immunoglobulin kappa J region		CHICK		407	UniRef90_Q06330-3
Recombination signal binding protein for immunoglobulin kappa J region		CHLSB		357
Recombining binding protein suppressor of hairless-like protein (Fragment)		HORSE		333
UPI0007B40217		MONDO		395
UPI000C7C2E19		SARHA		395

Protein	Similar proteins		Species	Score	Length	Source
Q06330	RBPJ isoform 12		PANTR		500	UniRef50_Q06330
Recombining-binding protein suppressor of hairless (Fragment)		HUMAN		178
Recombination signal binding protein for immunoglobulin kappa J region		RHIBE		531
Recombination signal binding protein for immunoglobulin kappa J region		SAIBB		530
Recombination signal binding protein for immunoglobulin kappa J region		PAPAN		529
+726
Q06330-3	Recombination signal binding protein for immunoglobulin kappa J region		CHICK		407	UniRef50_Q06330-3
Recombination signal binding protein for immunoglobulin kappa J region		CHLSB		357
Recombining binding protein suppressor of hairless-like protein (Fragment)		HORSE		333
Uncharacterized protein (Fragment)		PECGO		341
suppressor of hairless protein-like		DIACI		424
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07872 mRNA Translation: AAA60258.1 L07874 mRNA Translation: AAA16253.1 L07875 mRNA Translation: AAA16254.1 Different initiation. L07876 mRNA Translation: AAA16356.1 AK302230 mRNA Translation: BAG63584.1 AC093637 Genomic DNA No translation available. AC097109 Genomic DNA No translation available. AC097714 Genomic DNA No translation available. AC111003 Genomic DNA No translation available. BC020780 mRNA Translation: AAH20780.1 BC053531 mRNA No translation available. BC064976 mRNA Translation: AAH64976.1
CCDSⁱ	CCDS33969.1 [Q06330-6] CCDS3436.1 [Q06330-4] CCDS3437.1 [Q06330-1] CCDS43219.1 [Q06330-7] CCDS87214.1 [Q06330-5]
PIRⁱ	A47214
RefSeqⁱ	NP_005340.2, NM_005349.3 [Q06330-1] NP_056958.3, NM_015874.4 [Q06330-7] NP_976028.1, NM_203283.2 [Q06330-4] NP_976029.1, NM_203284.2 [Q06330-6] XP_005248218.1, XM_005248161.3 [Q06330-6] XP_011512142.1, XM_011513840.2 [Q06330-6] XP_016863661.1, XM_017008172.1 XP_016863662.1, XM_017008173.1 [Q06330-6] XP_016863663.1, XM_017008174.1 [Q06330-6] XP_016863664.1, XM_017008175.1 [Q06330-6]
UniGeneⁱ	Hs.479396

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2F8X	X-ray	3.25	C	23-449	[»]
	3NBN	X-ray	3.45	A/D	23-448	[»]
	3V79	X-ray	3.85	C	23-449	[»]
ProteinModelPortalⁱ	Q06330
SMRⁱ	Q06330
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109736, 134 interactors
CORUMⁱ	Q06330
DIPⁱ	DIP-33326N
ELMⁱ	Q06330
IntActⁱ	Q06330, 114 interactors
MINTⁱ	Q06330
STRINGⁱ	9606.ENSP00000345206

Chemistry databases

BindingDBⁱ	Q06330

BindingDBⁱ

Q06330

PTM databases

iPTMnetⁱ	Q06330
PhosphoSitePlusⁱ	Q06330

Polymorphism and mutation databases

BioMutaⁱ	RBPJ
DMDMⁱ	338817983

Proteomic databases

EPDⁱ	Q06330
jPOSTⁱ	Q06330
MaxQBⁱ	Q06330
PaxDbⁱ	Q06330
PeptideAtlasⁱ	Q06330
PRIDEⁱ	Q06330
ProteomicsDBⁱ	58432 58433 [Q06330-2] 58434 [Q06330-3] 58435 [Q06330-4] 58436 [Q06330-5] 58437 [Q06330-6] 58438 [Q06330-7]
TopDownProteomicsⁱ	Q06330-3 [Q06330-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3516
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000342295; ENSP00000345206; ENSG00000168214 [Q06330-1] ENST00000342320; ENSP00000340124; ENSG00000168214 [Q06330-6] ENST00000345843; ENSP00000305815; ENSG00000168214 [Q06330-4] ENST00000348160; ENSP00000339699; ENSG00000168214 [Q06330-7] ENST00000355476; ENSP00000347659; ENSG00000168214 [Q06330-6] ENST00000361572; ENSP00000354528; ENSG00000168214 [Q06330-1] ENST00000507561; ENSP00000423907; ENSG00000168214 [Q06330-5]
GeneIDⁱ	3516
KEGGⁱ	hsa:3516
UCSCⁱ	uc003grx.3 human [Q06330-1]

Organism-specific databases

CTDⁱ	3516
DisGeNETⁱ	3516
EuPathDBⁱ	HostDB:ENSG00000168214.20
GeneCardsⁱ	RBPJ
GeneReviewsⁱ	RBPJ
HGNCⁱ	HGNC:5724 RBPJ
HPAⁱ	HPA060647
MalaCardsⁱ	RBPJ
MIMⁱ	147183 gene 614814 phenotype
neXtProtⁱ	NX_Q06330
OpenTargetsⁱ	ENSG00000168214
Orphanetⁱ	974 Adams-Oliver syndrome
PharmGKBⁱ	PA34292
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3743 Eukaryota ENOG410XV7K LUCA
GeneTreeⁱ	ENSGT00390000005197
HOGENOMⁱ	HOG000253907
HOVERGENⁱ	HBG006618
InParanoidⁱ	Q06330
KOⁱ	K06053
OMAⁱ	DMPHFGL
OrthoDBⁱ	805081at2759
PhylomeDBⁱ	Q06330
TreeFamⁱ	TF314117

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563 NOTCH2 intracellular domain regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-350054 Notch-HLH transcription pathway R-HSA-8941856 RUNX3 regulates NOTCH signaling R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
SignaLinkⁱ	Q06330
SIGNORⁱ	Q06330

Miscellaneous databases

ChiTaRSⁱ	RBPJ human
EvolutionaryTraceⁱ	Q06330
GeneWikiⁱ	RBPJ
GenomeRNAiⁱ	3516
Protein Ontology More...PROⁱ	PR:Q06330
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168214 Expressed in 242 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_RBPJ
ExpressionAtlasⁱ	Q06330 baseline and differential
Genevisibleⁱ	Q06330 HS

Family and domain databases

CDDⁱ	cd01176 IPT_RBP-Jkappa, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.1450, 1 hit
InterProⁱ	View protein in InterPro IPR015350 Beta-trefoil_DNA-bd_dom IPR036358 BTD_sf IPR040159 CLS_fam IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR008967 p53-like_TF_DNA-bd IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007 RBP-Jkappa_IPT
PANTHERⁱ	PTHR10665 PTHR10665, 1 hit
Pfamⁱ	View protein in Pfam PF09270 BTD, 1 hit PF09271 LAG1-DNAbind, 1 hit
SMARTⁱ	View protein in SMART SM01268 BTD, 1 hit SM01267 LAG1_DNAbind, 1 hit
SUPFAMⁱ	SSF110217 SSF110217, 1 hit SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SUH_HUMAN
Accessionⁱ	Q06330Primary (citable) accession number: Q06330 Secondary accession number(s): B4DY22, Q5XKH9, Q6P1N3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 28, 2011
	Last modified:	January 16, 2019
	This is version 188 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM

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UniProtKB - Q06330 (SUH_HUMAN)

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Recombining binding protein suppressor of hairless

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ