UniProtKB - Q06330 (SUH_HUMAN)
Recombining binding protein suppressor of hairless
RBPJ
Functioni
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 58 – 65 | 8 | ||
DNA bindingi | 192 – 201 | 10 | ||
DNA bindingi | 265 – 297 | Add BLAST | 33 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein N-terminus binding Source: Ensembl
- repressing transcription factor binding Source: CAFA
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: CAFA
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
GO - Biological processi
- angiogenesis Source: BHF-UCL
- aortic valve development Source: Ensembl
- arterial endothelial cell fate commitment Source: Ensembl
- atrioventricular canal development Source: BHF-UCL
- auditory receptor cell fate commitment Source: Ensembl
- B cell differentiation Source: Ensembl
- blood vessel endothelial cell fate specification Source: BHF-UCL
- blood vessel lumenization Source: BHF-UCL
- blood vessel remodeling Source: Ensembl
- cardiac left ventricle morphogenesis Source: BHF-UCL
- club cell differentiation Source: Ensembl
- defense response to bacterium Source: Ensembl
- dorsal aorta morphogenesis Source: BHF-UCL
- endocardium morphogenesis Source: BHF-UCL
- epidermal cell fate specification Source: Ensembl
- epithelial to mesenchymal transition Source: BHF-UCL
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- hair follicle maturation Source: Ensembl
- humoral immune response Source: Ensembl
- inflammatory response to antigenic stimulus Source: Ensembl
- interleukin-4 production Source: Ensembl
- keratinocyte differentiation Source: Ensembl
- labyrinthine layer blood vessel development Source: BHF-UCL
- myeloid dendritic cell differentiation Source: Ensembl
- negative regulation of cell differentiation Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of ossification Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- Notch signaling involved in heart development Source: BHF-UCL
- Notch signaling pathway Source: BHF-UCL
- outflow tract morphogenesis Source: BHF-UCL
- pituitary gland development Source: Ensembl
- positive regulation of BMP signaling pathway Source: BHF-UCL
- positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: Ensembl
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
- positive regulation of ephrin receptor signaling pathway Source: BHF-UCL
- positive regulation of ERBB signaling pathway Source: BHF-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of Notch signaling pathway Source: Reactome
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
- positive regulation of transcription of Notch receptor target Source: UniProtKB
- pulmonary valve development Source: Ensembl
- regulation of timing of cell differentiation Source: Ensembl
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
- sebaceous gland development Source: Ensembl
- secondary heart field specification Source: Ensembl
- somatic stem cell population maintenance Source: Ensembl
- somitogenesis Source: Ensembl
- transcription initiation from RNA polymerase II promoter Source: Reactome
- ventricular septum morphogenesis Source: Ensembl
- ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Notch signaling pathway, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q06330 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-210744, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563, NOTCH2 intracellular domain regulates transcription R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-350054, Notch-HLH transcription pathway R-HSA-8941856, RUNX3 regulates NOTCH signaling R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | Q06330 |
SIGNORi | Q06330 |
Names & Taxonomyi
Protein namesi | Recommended name: Recombining binding protein suppressor of hairlessAlternative name(s): CBF-1 J kappa-recombination signal-binding protein RBP-J kappa Short name: RBP-J Short name: RBP-JK Renal carcinoma antigen NY-REN-30 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168214.20 |
HGNCi | HGNC:5724, RBPJ |
MIMi | 147183, gene |
neXtProti | NX_Q06330 |
Subcellular locationi
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleolus Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- MAML1-RBP-Jkappa- ICN1 complex Source: UniProtKB
- transcription regulator complex Source: GO_Central
- transcription repressor complex Source: CAFA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Adams-Oliver syndrome 3 (AOS3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068929 | 63 | E → G in AOS3; shows decreased binding to the HES1 promoter compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907270EnsemblClinVar. | 1 | |
Natural variantiVAR_068930 | 169 | K → E in AOS3; shows decreased binding to the HES1 promoter compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907271EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 3516 |
GeneReviewsi | RBPJ |
MalaCardsi | RBPJ |
MIMi | 614814, phenotype |
OpenTargetsi | ENSG00000168214 |
Orphaneti | 974, Adams-Oliver syndrome |
PharmGKBi | PA34292 |
Miscellaneous databases
Pharosi | Q06330, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105709 |
Polymorphism and mutation databases
BioMutai | RBPJ |
DMDMi | 338817983 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208567 | 1 – 500 | Recombining binding protein suppressor of hairlessAdd BLAST | 500 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 175 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q06330 |
jPOSTi | Q06330 |
MassIVEi | Q06330 |
MaxQBi | Q06330 |
PaxDbi | Q06330 |
PeptideAtlasi | Q06330 |
PRIDEi | Q06330 |
ProteomicsDBi | 58432 [Q06330-1] 58433 [Q06330-2] 58434 [Q06330-3] 58435 [Q06330-4] 58436 [Q06330-5] 58437 [Q06330-6] 58438 [Q06330-7] |
TopDownProteomicsi | Q06330-3 [Q06330-3] |
PTM databases
iPTMneti | Q06330 |
PhosphoSitePlusi | Q06330 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168214, Expressed in corpus callosum and 254 other tissues |
ExpressionAtlasi | Q06330, baseline and differential |
Genevisiblei | Q06330, HS |
Organism-specific databases
HPAi | ENSG00000168214, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with activated NOTCH1, NOTCH2 or NOTCH3.
Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1.
Interacts with EP300, MAML1 and PTF1A.
Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6.
Interacts with RITA1/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway.
Interacts with SNW1.
Interacts with CHCHD2 and CXXC5 (PubMed:23303788).
Interacts with BEND6 (via BEN domain).
Interacts with NKAPL (By similarity).
Interacts with ZMIZ1.
Interacts with RBM15 (By similarity).
By similarity11 PublicationsBinary interactionsi
Hide detailsQ06330
Isoform 6 [Q06330-6]
With | #Exp. | IntAct |
---|---|---|
NOTCH1 [P46531] | 6 | EBI-12599287,EBI-636374 |
GO - Molecular functioni
- protein N-terminus binding Source: Ensembl
- repressing transcription factor binding Source: CAFA
- RNA polymerase II repressing transcription factor binding Source: BHF-UCL
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109736, 141 interactors |
CORUMi | Q06330 |
DIPi | DIP-33326N |
ELMi | Q06330 |
IntActi | Q06330, 120 interactors |
MINTi | Q06330 |
STRINGi | 9606.ENSP00000345206 |
Chemistry databases
BindingDBi | Q06330 |
Miscellaneous databases
RNActi | Q06330, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q06330 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q06330 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 355 – 445 | IPT/TIGAdd BLAST | 91 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3743, Eukaryota |
GeneTreei | ENSGT00390000005197 |
HOGENOMi | CLU_022207_2_1_1 |
InParanoidi | Q06330 |
OMAi | DMPHFGL |
OrthoDBi | 444988at2759 |
PhylomeDBi | Q06330 |
TreeFami | TF314117 |
Family and domain databases
CDDi | cd01176, IPT_RBP-Jkappa, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.1450, 1 hit |
IDEALi | IID00380 |
InterProi | View protein in InterPro IPR015350, Beta-trefoil_DNA-bd_dom IPR036358, BTD_sf IPR040159, CLS_fam IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008967, p53-like_TF_DNA-bd IPR015351, RBP-J/Cbf11/Cbf12_DNA-bd IPR037095, RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007, RBP-Jkappa_IPT |
PANTHERi | PTHR10665, PTHR10665, 1 hit |
Pfami | View protein in Pfam PF09270, BTD, 1 hit PF09271, LAG1-DNAbind, 1 hit |
SMARTi | View protein in SMART SM01268, BTD, 1 hit SM01267, LAG1_DNAbind, 1 hit |
SUPFAMi | SSF110217, SSF110217, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDHTEGSPAE EPPAHAPSPG KFGERPPPKR LTREAMRNYL KERGDQTVLI
60 70 80 90 100
LHAKVAQKSY GNEKRFFCPP PCVYLMGSGW KKKKEQMERD GCSEQESQPC
110 120 130 140 150
AFIGIGNSDQ EMQQLNLEGK NYCTAKTLYI SDSDKRKHFM LSVKMFYGNS
160 170 180 190 200
DDIGVFLSKR IKVISKPSKK KQSLKNADLC IASGTKVALF NRLRSQTVST
210 220 230 240 250
RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG YIHYGQTVKL
260 270 280 290 300
VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL
310 320 330 340 350
SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP
360 370 380 390 400
VTPVPVVESL QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES
410 420 430 440 450
MLCVVPDISA FREGWRWVRQ PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP
460 470 480 490 500
RPHCSAAGAI LRANSSQVPP NESNTNSEGS YTNASTNSTS VTSSTATVVS
The sequence of this isoform differs from the canonical sequence as follows:
1-75: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-89: Missing.
90-95: DGCSEQ → MAWIKR
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6R927 | D6R927_HUMAN | Recombining-binding protein suppres... | RBPJ | 382 | Annotation score: | ||
D6R946 | D6R946_HUMAN | Recombining-binding protein suppres... | RBPJ | 178 | Annotation score: | ||
D6RBQ8 | D6RBQ8_HUMAN | Recombining-binding protein suppres... | RBPJ | 157 | Annotation score: | ||
D6REC2 | D6REC2_HUMAN | Recombining-binding protein suppres... | RBPJ | 113 | Annotation score: | ||
D6R9K5 | D6R9K5_HUMAN | Recombining-binding protein suppres... | RBPJ | 110 | Annotation score: | ||
D6R9X3 | D6R9X3_HUMAN | Recombining-binding protein suppres... | RBPJ | 107 | Annotation score: | ||
D6RA45 | D6RA45_HUMAN | Recombining-binding protein suppres... | RBPJ | 189 | Annotation score: | ||
D6RAT2 | D6RAT2_HUMAN | Recombining-binding protein suppres... | RBPJ | 94 | Annotation score: | ||
D6RB37 | D6RB37_HUMAN | Recombining-binding protein suppres... | RBPJ | 143 | Annotation score: | ||
D6RCM1 | D6RCM1_HUMAN | Recombining-binding protein suppres... | RBPJ | 229 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | S → L in AAA60258 (PubMed:8406481).Curated | 1 | |
Sequence conflicti | 7 | S → L in AAA16253 (PubMed:8406481).Curated | 1 | |
Sequence conflicti | 7 | S → L in AAA16254 (PubMed:8406481).Curated | 1 | |
Sequence conflicti | 140 – 141 | ML → IF in AAA60258 (PubMed:8406481).Curated | 2 | |
Sequence conflicti | 240 | G → V in AAA60258 (PubMed:8406481).Curated | 1 | |
Sequence conflicti | 248 | V → C in AAA60258 (PubMed:8406481).Curated | 1 | |
Sequence conflicti | 265 | R → M in AAA60258 (PubMed:8406481).Curated | 1 | |
Sequence conflicti | 270 | Q → H in AAA60258 (PubMed:8406481).Curated | 1 | |
Sequence conflicti | 462 | R → P in AAA60258 (PubMed:8406481).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068929 | 63 | E → G in AOS3; shows decreased binding to the HES1 promoter compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907270EnsemblClinVar. | 1 | |
Natural variantiVAR_068930 | 169 | K → E in AOS3; shows decreased binding to the HES1 promoter compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907271EnsemblClinVar. | 1 | |
Natural variantiVAR_028994 | 291 | K → E. Corresponds to variant dbSNP:rs1064372Ensembl. | 1 | |
Natural variantiVAR_028995 | 334 | D → H. Corresponds to variant dbSNP:rs1064376Ensembl. | 1 | |
Natural variantiVAR_057244 | 408 | I → V. Corresponds to variant dbSNP:rs1064381EnsemblClinVar. | 1 | |
Natural variantiVAR_028996 | 419 | R → Q. Corresponds to variant dbSNP:rs1064384Ensembl. | 1 | |
Natural variantiVAR_028997 | 425 | P → S. Corresponds to variant dbSNP:rs1064387Ensembl. | 1 | |
Natural variantiVAR_028998 | 456 | A → V1 PublicationCorresponds to variant dbSNP:rs1064402Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002718 | 1 – 89 | Missing in isoform APCR-3. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_002717 | 1 – 75 | Missing in isoform APCR-1. 1 PublicationAdd BLAST | 75 | |
Alternative sequenceiVSP_021572 | 1 – 35 | Missing in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_021573 | 1 – 20 | MDHTE…APSPG → MGGCR in isoform 4. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_021574 | 1 – 20 | MDHTE…APSPG → MAWIKR in isoform 6. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_042637 | 1 – 19 | MDHTE…HAPSP → MAPVVT in isoform 7. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_002719 | 90 – 95 | DGCSEQ → MAWIKR in isoform APCR-3. 1 Publication | 6 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000342295; ENSP00000345206; ENSG00000168214 [Q06330-1] ENST00000342320; ENSP00000340124; ENSG00000168214 [Q06330-6] ENST00000345843; ENSP00000305815; ENSG00000168214 [Q06330-4] ENST00000348160; ENSP00000339699; ENSG00000168214 [Q06330-7] ENST00000355476; ENSP00000347659; ENSG00000168214 [Q06330-6] ENST00000361572; ENSP00000354528; ENSG00000168214 [Q06330-1] ENST00000507561; ENSP00000423907; ENSG00000168214 [Q06330-5] |
GeneIDi | 3516 |
KEGGi | hsa:3516 |
UCSCi | uc003grx.3, human [Q06330-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2F8X | X-ray | 3.25 | C | 23-449 | [»] | |
3NBN | X-ray | 3.45 | A/D | 23-448 | [»] | |
3V79 | X-ray | 3.85 | C | 23-449 | [»] | |
6PY8 | X-ray | 3.75 | C/E | 23-466 | [»] | |
SMRi | Q06330 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109736, 141 interactors |
CORUMi | Q06330 |
DIPi | DIP-33326N |
ELMi | Q06330 |
IntActi | Q06330, 120 interactors |
MINTi | Q06330 |
STRINGi | 9606.ENSP00000345206 |
Chemistry databases
BindingDBi | Q06330 |
ChEMBLi | CHEMBL4105709 |
PTM databases
iPTMneti | Q06330 |
PhosphoSitePlusi | Q06330 |
Polymorphism and mutation databases
BioMutai | RBPJ |
DMDMi | 338817983 |
Proteomic databases
EPDi | Q06330 |
jPOSTi | Q06330 |
MassIVEi | Q06330 |
MaxQBi | Q06330 |
PaxDbi | Q06330 |
PeptideAtlasi | Q06330 |
PRIDEi | Q06330 |
ProteomicsDBi | 58432 [Q06330-1] 58433 [Q06330-2] 58434 [Q06330-3] 58435 [Q06330-4] 58436 [Q06330-5] 58437 [Q06330-6] 58438 [Q06330-7] |
TopDownProteomicsi | Q06330-3 [Q06330-3] |
Protocols and materials databases
Antibodypediai | 10265, 351 antibodies |
DNASUi | 3516 |
Genome annotation databases
Organism-specific databases
CTDi | 3516 |
DisGeNETi | 3516 |
EuPathDBi | HostDB:ENSG00000168214.20 |
GeneCardsi | RBPJ |
GeneReviewsi | RBPJ |
HGNCi | HGNC:5724, RBPJ |
HPAi | ENSG00000168214, Low tissue specificity |
MalaCardsi | RBPJ |
MIMi | 147183, gene 614814, phenotype |
neXtProti | NX_Q06330 |
OpenTargetsi | ENSG00000168214 |
Orphaneti | 974, Adams-Oliver syndrome |
PharmGKBi | PA34292 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3743, Eukaryota |
GeneTreei | ENSGT00390000005197 |
HOGENOMi | CLU_022207_2_1_1 |
InParanoidi | Q06330 |
OMAi | DMPHFGL |
OrthoDBi | 444988at2759 |
PhylomeDBi | Q06330 |
TreeFami | TF314117 |
Enzyme and pathway databases
PathwayCommonsi | Q06330 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-210744, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563, NOTCH2 intracellular domain regulates transcription R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-350054, Notch-HLH transcription pathway R-HSA-8941856, RUNX3 regulates NOTCH signaling R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | Q06330 |
SIGNORi | Q06330 |
Miscellaneous databases
BioGRID-ORCSi | 3516, 18 hits in 848 CRISPR screens |
ChiTaRSi | RBPJ, human |
EvolutionaryTracei | Q06330 |
GeneWikii | RBPJ |
GenomeRNAii | 3516 |
Pharosi | Q06330, Tbio |
PROi | PR:Q06330 |
RNActi | Q06330, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168214, Expressed in corpus callosum and 254 other tissues |
ExpressionAtlasi | Q06330, baseline and differential |
Genevisiblei | Q06330, HS |
Family and domain databases
CDDi | cd01176, IPT_RBP-Jkappa, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.1450, 1 hit |
IDEALi | IID00380 |
InterProi | View protein in InterPro IPR015350, Beta-trefoil_DNA-bd_dom IPR036358, BTD_sf IPR040159, CLS_fam IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008967, p53-like_TF_DNA-bd IPR015351, RBP-J/Cbf11/Cbf12_DNA-bd IPR037095, RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007, RBP-Jkappa_IPT |
PANTHERi | PTHR10665, PTHR10665, 1 hit |
Pfami | View protein in Pfam PF09270, BTD, 1 hit PF09271, LAG1-DNAbind, 1 hit |
SMARTi | View protein in SMART SM01268, BTD, 1 hit SM01267, LAG1_DNAbind, 1 hit |
SUPFAMi | SSF110217, SSF110217, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SUH_HUMAN | |
Accessioni | Q06330Primary (citable) accession number: Q06330 Secondary accession number(s): B4DY22, Q5XKH9, Q6P1N3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations