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Protein

Proteasome activator complex subunit 1

Gene

PSME1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

  • endopeptidase activator activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 1
Alternative name(s):
11S regulator complex subunit alpha
Short name:
REG-alpha
Activator of multicatalytic protease subunit 1
Interferon gamma up-regulated I-5111 protein
Short name:
IGUP I-5111
Proteasome activator 28 subunit alpha
Short name:
PA28a
Short name:
PA28alpha
Gene namesi
Name:PSME1
Synonyms:IFI5111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000092010.14
HGNCiHGNC:9568 PSME1
MIMi600654 gene
neXtProtiNX_Q06323

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

Pathology & Biotechi

Organism-specific databases

DisGeNETi5720
OpenTargetsiENSG00000092010
PharmGKBiPA33914

Polymorphism and mutation databases

DMDMi1170519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001617791 – 249Proteasome activator complex subunit 1Add BLAST249

Proteomic databases

EPDiQ06323
PaxDbiQ06323
PeptideAtlasiQ06323
PRIDEiQ06323
ProteomicsDBi58431
TopDownProteomicsiQ06323-1 [Q06323-1]

2D gel databases

DOSAC-COBS-2DPAGEiQ06323
OGPiQ06323
SWISS-2DPAGEiQ06323

PTM databases

iPTMnetiQ06323
PhosphoSitePlusiQ06323
SwissPalmiQ06323

Expressioni

Inductioni

By IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000092010 Expressed in 227 organ(s), highest expression level in leukocyte
CleanExiHS_PSME1
ExpressionAtlasiQ06323 baseline and differential
GenevisibleiQ06323 HS

Organism-specific databases

HPAiHPA006632

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PSME2Q9UL465EBI-712149,EBI-741630

Protein-protein interaction databases

BioGridi111692, 79 interactors
CORUMiQ06323
IntActiQ06323, 27 interactors
MINTiQ06323
STRINGi9606.ENSP00000372155

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ06323
SMRiQ06323
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06323

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

eggNOGiKOG4470 Eukaryota
ENOG410XQVX LUCA
GeneTreeiENSGT00510000046374
HOGENOMiHOG000282822
HOVERGENiHBG053745
InParanoidiQ06323
KOiK06696
OMAiGPPCGPI
OrthoDBiEOG091G0GX7
PhylomeDBiQ06323
TreeFamiTF106236

Family and domain databases

Gene3Di1.20.120.180, 1 hit
1.20.5.120, 1 hit
InterProiView protein in InterPro
IPR003186 PA28_C
IPR036997 PA28_C_sf
IPR036996 PA28_N_sf
IPR009077 Proteasome_activ_PA28
IPR003185 Proteasome_activ_PA28_N
IPR036252 Proteasome_activ_sf
PANTHERiPTHR10660 PTHR10660, 1 hit
PfamiView protein in Pfam
PF02251 PA28_alpha, 1 hit
PF02252 PA28_beta, 1 hit
SUPFAMiSSF47216 SSF47216, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q06323-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN
60 70 80 90 100
EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP
110 120 130 140 150
CGPVNCNEKI VVLLQRLKPE IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV
160 170 180 190 200
AVQEKVFELM TSLHTKLEGF HTQISKYFSE RGDAVTKAAK QPHVGDYRQL
210 220 230 240
VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY
Length:249
Mass (Da):28,723
Last modified:November 1, 1995 - v1
Checksum:i5E27727E5A0B0AAB
GO
Isoform 2 (identifier: Q06323-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-249: AVLYDIILKNFEKLKKPRGETKGMIY → VRRQGQGRGGQRQLSQATHSLTLQARG

Note: Gene prediction based on EST data.
Show »
Length:250
Mass (Da):28,602
Checksum:iD860008F47D35F97
GO
Isoform 3 (identifier: Q06323-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-233: AVLYDIILKN → VRRLCYMTSS
     234-249: Missing.

Note: Gene prediction based on EST data.
Show »
Length:233
Mass (Da):26,870
Checksum:i4B9A7BFE858CC6D9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKK6H0YKK6_HUMAN
Proteasome activator complex subuni...
PSME1
90Annotation score:
H0YLU2H0YLU2_HUMAN
Proteasome activator complex subuni...
PSME1
114Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01199355S → N. Corresponds to variant dbSNP:rs1803830Ensembl.1
Natural variantiVAR_011994244T → K. Corresponds to variant dbSNP:rs14930Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046880224 – 249AVLYD…KGMIY → VRRQGQGRGGQRQLSQATHS LTLQARG in isoform 2. CuratedAdd BLAST26
Alternative sequenceiVSP_055166224 – 233AVLYDIILKN → VRRLCYMTSS in isoform 3. Curated10
Alternative sequenceiVSP_055167234 – 249Missing in isoform 3. CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07633 mRNA Translation: AAA16521.1
U10360 Genomic DNA Translation: AAA53230.1
AF078829 Genomic DNA Translation: AAF02217.1
BT019337 mRNA Translation: AAV38144.1
AK312211 mRNA Translation: BAG35144.1
CR456780 mRNA Translation: CAG33061.1
AL136295 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66105.1
BC000352 mRNA Translation: AAH00352.1
BC007503 mRNA Translation: AAH07503.1
AB007137 Genomic DNA Translation: BAA28836.1
CCDSiCCDS41930.1 [Q06323-2]
CCDS61415.1 [Q06323-3]
CCDS9612.1 [Q06323-1]
PIRiA54859
RefSeqiNP_001268457.1, NM_001281528.1 [Q06323-3]
NP_006254.1, NM_006263.3 [Q06323-1]
UniGeneiHs.75348

Genome annotation databases

EnsembliENST00000206451; ENSP00000206451; ENSG00000092010 [Q06323-1]
ENST00000382708; ENSP00000372155; ENSG00000092010 [Q06323-2]
ENST00000561435; ENSP00000453976; ENSG00000092010 [Q06323-3]
ENST00000643169; ENSP00000493882; ENSG00000284916 [Q06323-3]
ENST00000645537; ENSP00000495095; ENSG00000284916 [Q06323-1]
ENST00000646132; ENSP00000496083; ENSG00000284916 [Q06323-2]
GeneIDi5720
KEGGihsa:5720
UCSCiuc001wmg.4 human [Q06323-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07633 mRNA Translation: AAA16521.1
U10360 Genomic DNA Translation: AAA53230.1
AF078829 Genomic DNA Translation: AAF02217.1
BT019337 mRNA Translation: AAV38144.1
AK312211 mRNA Translation: BAG35144.1
CR456780 mRNA Translation: CAG33061.1
AL136295 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66105.1
BC000352 mRNA Translation: AAH00352.1
BC007503 mRNA Translation: AAH07503.1
AB007137 Genomic DNA Translation: BAA28836.1
CCDSiCCDS41930.1 [Q06323-2]
CCDS61415.1 [Q06323-3]
CCDS9612.1 [Q06323-1]
PIRiA54859
RefSeqiNP_001268457.1, NM_001281528.1 [Q06323-3]
NP_006254.1, NM_006263.3 [Q06323-1]
UniGeneiHs.75348

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVOX-ray2.80A/C/E/G/I/K/M4-63[»]
B/D/F/H/J/L/N104-242[»]
ProteinModelPortaliQ06323
SMRiQ06323
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111692, 79 interactors
CORUMiQ06323
IntActiQ06323, 27 interactors
MINTiQ06323
STRINGi9606.ENSP00000372155

PTM databases

iPTMnetiQ06323
PhosphoSitePlusiQ06323
SwissPalmiQ06323

Polymorphism and mutation databases

DMDMi1170519

2D gel databases

DOSAC-COBS-2DPAGEiQ06323
OGPiQ06323
SWISS-2DPAGEiQ06323

Proteomic databases

EPDiQ06323
PaxDbiQ06323
PeptideAtlasiQ06323
PRIDEiQ06323
ProteomicsDBi58431
TopDownProteomicsiQ06323-1 [Q06323-1]

Protocols and materials databases

DNASUi5720
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206451; ENSP00000206451; ENSG00000092010 [Q06323-1]
ENST00000382708; ENSP00000372155; ENSG00000092010 [Q06323-2]
ENST00000561435; ENSP00000453976; ENSG00000092010 [Q06323-3]
ENST00000643169; ENSP00000493882; ENSG00000284916 [Q06323-3]
ENST00000645537; ENSP00000495095; ENSG00000284916 [Q06323-1]
ENST00000646132; ENSP00000496083; ENSG00000284916 [Q06323-2]
GeneIDi5720
KEGGihsa:5720
UCSCiuc001wmg.4 human [Q06323-1]

Organism-specific databases

CTDi5720
DisGeNETi5720
EuPathDBiHostDB:ENSG00000092010.14
GeneCardsiPSME1
HGNCiHGNC:9568 PSME1
HPAiHPA006632
MIMi600654 gene
neXtProtiNX_Q06323
OpenTargetsiENSG00000092010
PharmGKBiPA33914
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4470 Eukaryota
ENOG410XQVX LUCA
GeneTreeiENSGT00510000046374
HOGENOMiHOG000282822
HOVERGENiHBG053745
InParanoidiQ06323
KOiK06696
OMAiGPPCGPI
OrthoDBiEOG091G0GX7
PhylomeDBiQ06323
TreeFamiTF106236

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiPSME1 human
EvolutionaryTraceiQ06323
GeneWikiiPSME1
GenomeRNAii5720
PROiPR:Q06323
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092010 Expressed in 227 organ(s), highest expression level in leukocyte
CleanExiHS_PSME1
ExpressionAtlasiQ06323 baseline and differential
GenevisibleiQ06323 HS

Family and domain databases

Gene3Di1.20.120.180, 1 hit
1.20.5.120, 1 hit
InterProiView protein in InterPro
IPR003186 PA28_C
IPR036997 PA28_C_sf
IPR036996 PA28_N_sf
IPR009077 Proteasome_activ_PA28
IPR003185 Proteasome_activ_PA28_N
IPR036252 Proteasome_activ_sf
PANTHERiPTHR10660 PTHR10660, 1 hit
PfamiView protein in Pfam
PF02251 PA28_alpha, 1 hit
PF02252 PA28_beta, 1 hit
SUPFAMiSSF47216 SSF47216, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSME1_HUMAN
AccessioniPrimary (citable) accession number: Q06323
Secondary accession number(s): A6NJG9
, H0YNE3, Q6IBM2, Q9UEF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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