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Protein

Uteroglobin

Gene

Scgb1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPhospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Clara cell 17 kDa protein
Clara cell phospholipid-binding protein
Short name:
CCPBP
Clara cells 10 kDa secretory protein
Short name:
CC10
PCB-binding protein
Secretoglobin family 1A member 1
Gene namesi
Name:Scgb1a1
Synonyms:Cc10, Ugb, Utg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:98919 Scgb1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003636622 – 96UteroglobinAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24Interchain (with C-90)By similarity
Disulfide bondi90Interchain (with C-24)By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ06318
PeptideAtlasiQ06318
PRIDEiQ06318

PTM databases

PhosphoSitePlusiQ06318

Expressioni

Tissue specificityi

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Developmental stagei

Appears on the eighteenth day of gestation in the airway epithelium.

Inductioni

By glucocorticoids.

Gene expression databases

BgeeiENSMUSG00000024653 Expressed in 65 organ(s), highest expression level in lung
CleanExiMM_SCGB1A1
ExpressionAtlasiQ06318 baseline and differential
GenevisibleiQ06318 MM

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

IntActiQ06318, 1 interactor
MINTiQ06318
STRINGi10090.ENSMUSP00000025554

Structurei

3D structure databases

ProteinModelPortaliQ06318
SMRiQ06318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J459 Eukaryota
ENOG4111966 LUCA
GeneTreeiENSGT00530000064300
HOGENOMiHOG000220914
HOVERGENiHBG018062
InParanoidiQ06318
OMAiFSPDQDM
OrthoDBiEOG091G15B2
PhylomeDBiQ06318
TreeFamiTF338407

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
IPR000329 Uteroglobin
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
PRINTSiPR00486 UTEROGLOBIN
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06318-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN
60 70 80 90
PGSDLQNAGT QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF
Length:96
Mass (Da):10,519
Last modified:June 1, 1994 - v1
Checksum:i21103A8839497E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04503 mRNA Translation: AAA03625.1
L24372 Genomic DNA Translation: AAA65446.1
X67702 mRNA Translation: CAA47936.1
U01247 Unassigned DNA Translation: AAA16141.1
BC027518 mRNA Translation: AAH27518.1
CCDSiCCDS37911.1
PIRiA53025 UGMS
RefSeqiNP_035811.1, NM_011681.2
UniGeneiMm.2258

Genome annotation databases

EnsembliENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653
GeneIDi22287
KEGGimmu:22287
UCSCiuc008gom.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04503 mRNA Translation: AAA03625.1
L24372 Genomic DNA Translation: AAA65446.1
X67702 mRNA Translation: CAA47936.1
U01247 Unassigned DNA Translation: AAA16141.1
BC027518 mRNA Translation: AAH27518.1
CCDSiCCDS37911.1
PIRiA53025 UGMS
RefSeqiNP_035811.1, NM_011681.2
UniGeneiMm.2258

3D structure databases

ProteinModelPortaliQ06318
SMRiQ06318
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ06318, 1 interactor
MINTiQ06318
STRINGi10090.ENSMUSP00000025554

PTM databases

PhosphoSitePlusiQ06318

Proteomic databases

PaxDbiQ06318
PeptideAtlasiQ06318
PRIDEiQ06318

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653
GeneIDi22287
KEGGimmu:22287
UCSCiuc008gom.1 mouse

Organism-specific databases

CTDi7356
MGIiMGI:98919 Scgb1a1

Phylogenomic databases

eggNOGiENOG410J459 Eukaryota
ENOG4111966 LUCA
GeneTreeiENSGT00530000064300
HOGENOMiHOG000220914
HOVERGENiHBG018062
InParanoidiQ06318
OMAiFSPDQDM
OrthoDBiEOG091G15B2
PhylomeDBiQ06318
TreeFamiTF338407

Miscellaneous databases

ChiTaRSiScgb1a1 mouse
PROiPR:Q06318
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024653 Expressed in 65 organ(s), highest expression level in lung
CleanExiMM_SCGB1A1
ExpressionAtlasiQ06318 baseline and differential
GenevisibleiQ06318 MM

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
IPR000329 Uteroglobin
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
PRINTSiPR00486 UTEROGLOBIN
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUTER_MOUSE
AccessioniPrimary (citable) accession number: Q06318
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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