UniProtKB - Q06318 (UTER_MOUSE)
Protein
Uteroglobin
Gene
Scgb1a1
Organism
Mus musculus (Mouse)
Status
Functioni
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
GO - Molecular functioni
- phospholipase A2 inhibitor activity Source: UniProtKB-KW
- polychlorinated biphenyl binding Source: MGI
GO - Biological processi
- negative regulation of interferon-gamma production Source: MGI
- negative regulation of interleukin-13 production Source: MGI
- negative regulation of interleukin-4 production Source: MGI
- negative regulation of interleukin-5 production Source: MGI
- negative regulation of T cell proliferation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of inflammatory response Source: MGI
- regulation of mRNA stability Source: MGI
- response to cytokine Source: MGI
- response to drug Source: Ensembl
- response to fibroblast growth factor Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to ozone Source: Ensembl
- response to silicon dioxide Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- signal transduction Source: InterPro
Keywordsi
Molecular function | Phospholipase A2 inhibitor |
Names & Taxonomyi
Protein namesi | Recommended name: UteroglobinAlternative name(s): Clara cell 17 kDa protein Clara cell phospholipid-binding protein Short name: CCPBP Clara cells 10 kDa secretory protein Short name: CC10 PCB-binding protein Secretoglobin family 1A member 1 |
Gene namesi | Name:Scgb1a1 Synonyms:Cc10, Ugb, Utg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98919, Scgb1a1 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- rough endoplasmic reticulum Source: MGI
Extracellular region or secreted
- extracellular space Source: MGI
Nucleus
- nuclear envelope Source: MGI
Other locations
- cytoplasm Source: MGI
- secretory granule Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000036366 | 22 – 96 | UteroglobinAdd BLAST | 75 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 | Interchain (with C-90)By similarity | ||
Disulfide bondi | 90 | Interchain (with C-24)By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
CPTACi | non-CPTAC-3520 |
PaxDbi | Q06318 |
PeptideAtlasi | Q06318 |
PRIDEi | Q06318 |
PTM databases
PhosphoSitePlusi | Q06318 |
Expressioni
Tissue specificityi
Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Developmental stagei
Appears on the eighteenth day of gestation in the airway epithelium.
Inductioni
By glucocorticoids.
Gene expression databases
Bgeei | ENSMUSG00000024653, Expressed in carotid body and 78 other tissues |
ExpressionAtlasi | Q06318, baseline and differential |
Genevisiblei | Q06318, MM |
Interactioni
Subunit structurei
Antiparallel homodimer; disulfide-linked (By similarity). Interaction with LMBR1L is controversial (By similarity).
By similarityProtein-protein interaction databases
IntActi | Q06318, 1 interactor |
MINTi | Q06318 |
STRINGi | 10090.ENSMUSP00000025554 |
Miscellaneous databases
RNActi | Q06318, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the secretoglobin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SXFT, Eukaryota |
GeneTreei | ENSGT00940000155073 |
HOGENOMi | CLU_166234_1_0_1 |
InParanoidi | Q06318 |
OMAi | SPDQDMR |
OrthoDBi | 1608982at2759 |
PhylomeDBi | Q06318 |
TreeFami | TF338407 |
Family and domain databases
CDDi | cd00633, Secretoglobin, 1 hit |
InterProi | View protein in InterPro IPR016126, Secretoglobin IPR043215, Secretoglobin_1C-like IPR035960, Secretoglobin_sf IPR000329, Uteroglobin |
PANTHERi | PTHR10136, PTHR10136, 1 hit |
Pfami | View protein in Pfam PF01099, Uteroglobin, 1 hit |
PRINTSi | PR00486, UTEROGLOBIN |
SUPFAMi | SSF48201, SSF48201, 1 hit |
PROSITEi | View protein in PROSITE PS51311, SCGB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q06318-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN
60 70 80 90
PGSDLQNAGT QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04503 mRNA Translation: AAA03625.1 L24372 Genomic DNA Translation: AAA65446.1 X67702 mRNA Translation: CAA47936.1 U01247 Unassigned DNA Translation: AAA16141.1 BC027518 mRNA Translation: AAH27518.1 |
CCDSi | CCDS37911.1 |
PIRi | A53025, UGMS |
RefSeqi | NP_035811.1, NM_011681.2 |
Genome annotation databases
Ensembli | ENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653 |
GeneIDi | 22287 |
KEGGi | mmu:22287 |
UCSCi | uc008gom.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04503 mRNA Translation: AAA03625.1 L24372 Genomic DNA Translation: AAA65446.1 X67702 mRNA Translation: CAA47936.1 U01247 Unassigned DNA Translation: AAA16141.1 BC027518 mRNA Translation: AAH27518.1 |
CCDSi | CCDS37911.1 |
PIRi | A53025, UGMS |
RefSeqi | NP_035811.1, NM_011681.2 |
3D structure databases
SMRi | Q06318 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q06318, 1 interactor |
MINTi | Q06318 |
STRINGi | 10090.ENSMUSP00000025554 |
PTM databases
PhosphoSitePlusi | Q06318 |
Proteomic databases
CPTACi | non-CPTAC-3520 |
PaxDbi | Q06318 |
PeptideAtlasi | Q06318 |
PRIDEi | Q06318 |
Protocols and materials databases
Antibodypediai | 14807, 385 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653 |
GeneIDi | 22287 |
KEGGi | mmu:22287 |
UCSCi | uc008gom.1, mouse |
Organism-specific databases
CTDi | 7356 |
MGIi | MGI:98919, Scgb1a1 |
Phylogenomic databases
eggNOGi | ENOG502SXFT, Eukaryota |
GeneTreei | ENSGT00940000155073 |
HOGENOMi | CLU_166234_1_0_1 |
InParanoidi | Q06318 |
OMAi | SPDQDMR |
OrthoDBi | 1608982at2759 |
PhylomeDBi | Q06318 |
TreeFami | TF338407 |
Miscellaneous databases
BioGRID-ORCSi | 22287, 0 hits in 17 CRISPR screens |
ChiTaRSi | Scgb1a1, mouse |
PROi | PR:Q06318 |
RNActi | Q06318, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024653, Expressed in carotid body and 78 other tissues |
ExpressionAtlasi | Q06318, baseline and differential |
Genevisiblei | Q06318, MM |
Family and domain databases
CDDi | cd00633, Secretoglobin, 1 hit |
InterProi | View protein in InterPro IPR016126, Secretoglobin IPR043215, Secretoglobin_1C-like IPR035960, Secretoglobin_sf IPR000329, Uteroglobin |
PANTHERi | PTHR10136, PTHR10136, 1 hit |
Pfami | View protein in Pfam PF01099, Uteroglobin, 1 hit |
PRINTSi | PR00486, UTEROGLOBIN |
SUPFAMi | SSF48201, SSF48201, 1 hit |
PROSITEi | View protein in PROSITE PS51311, SCGB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UTER_MOUSE | |
Accessioni | Q06318Primary (citable) accession number: Q06318 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families