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Protein

Integrin alpha-5

Gene

itga5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi270Calcium 1By similarity1
Metal bindingi272Calcium 1By similarity1
Metal bindingi274Calcium 1By similarity1
Metal bindingi276Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi278Calcium 1By similarity1
Metal bindingi324Calcium 2By similarity1
Metal bindingi326Calcium 2By similarity1
Metal bindingi328Calcium 2By similarity1
Metal bindingi330Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi332Calcium 2By similarity1
Metal bindingi390Calcium 3By similarity1
Metal bindingi392Calcium 3By similarity1
Metal bindingi394Calcium 3By similarity1
Metal bindingi398Calcium 3By similarity1
Metal bindingi454Calcium 4By similarity1
Metal bindingi456Calcium 4By similarity1
Metal bindingi458Calcium 4By similarity1
Metal bindingi460Calcium 4; via carbonyl oxygenBy similarity1
Metal bindingi462Calcium 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi270 – 278By similarity9
Calcium bindingi324 – 332Sequence analysis9
Calcium bindingi390 – 398Sequence analysis9
Calcium bindingi454 – 462Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-5
Alternative name(s):
Fibronectin receptor subunit alpha
Integrin alpha-F
VLA-5
Cleaved into the following 2 chains:
Gene namesi
Name:itga5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866304 itga5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 996ExtracellularSequence analysisAdd BLAST964
Transmembranei997 – 1022HelicalSequence analysisAdd BLAST26
Topological domaini1023 – 1050CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001625533 – 1050Integrin alpha-5Add BLAST1018
ChainiPRO_000001625633 – 932Integrin alpha-5 heavy chainSequence analysisAdd BLAST900
ChainiPRO_0000016257933 – 1050Integrin alpha-5 light chainSequence analysisAdd BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi90 ↔ 99By similarity
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 166By similarity
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi182 ↔ 195By similarity
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi502 ↔ 513By similarity
Glycosylationi507N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi519 ↔ 575By similarity
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi636 ↔ 642By similarity
Glycosylationi649N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi708 ↔ 721By similarity
Glycosylationi714N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi763N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi861N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi862 ↔ 910Interchain (between heavy and light chains)By similarity
Disulfide bondi917 ↔ 922By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1.

Structurei

3D structure databases

ProteinModelPortaliQ06274
SMRiQ06274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 99FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati116 – 175FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Repeati183 – 235FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati249 – 301FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati302 – 367FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati368 – 426FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati430 – 493FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1025 – 1029GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006186
KOiK06484

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLPRGSRVP GLVATFLFPV LCALLTFSSV RGFNLAVEQP AVYTGASGSF
60 70 80 90 100
FGFSVDFYLP DAQSISILVG APKANTSQPG VFEGGAVFYC PWQRNGTNCT
110 120 130 140 150
EISFDSHGDR QRELFDTPQP KHMESKSEQW FGATVRAHGK TILACAPRYS
160 170 180 190 200
WRTEKEEKRS DPVGTCYLSV NNFTTFVEYS PCRTDFSDAA GQGYCQGGFS
210 220 230 240 250
AEFTKSGRVL LGGPGSYFWQ GQVITATQDE IQEAYYPEYF VLEYKKQMQT
260 270 280 290 300
RQAASSYDDS YFGYSVAVGE FSEDATEDFV VGVPKGNITY GYVTILNGTD
310 320 330 340 350
LRSLYNFSGE QMASYFGYSV SATDLNSDGL DDLLIGAPLF MDRTHDGRVQ
360 370 380 390 400
EVGRVYVYLQ GDHMESTPHL ILTGMEEYGR FGSSIASLGD LDQDGFNDIA
410 420 430 440 450
IGAPFGGEAQ RGAVFIFNGQ PGGVDSKPSQ VLQGQWGSSQ QPSFFGLSTR
460 470 480 490 500
GGHDLDGNGY PDLIVGAFGV DTTLVYRGRP IIHASASLSI SPNMFNPEEK
510 520 530 540 550
TCTLEGNASA VSCINLSFCL NASGKHVPNS IGIKVELQLD QTKQKGAVKR
560 570 580 590 600
ALFLKTRQPQ LTQTIHLLNG GKEECRAMKI YLREESEFRD KLSPIYVGLN
610 620 630 640 650
FSLDPLAPAD AHGLMPIFNY KTKNYIEQKA QIQLDCGEDN ICVPDLKLNV
660 670 680 690 700
SGDRKSVYLG DENFLTLFFN AQNLGGGAYE AELYVTLPPE AEYSGIVRNN
710 720 730 740 750
EHLLILPCAY EMENQTRLVI CDLGNPMKAG ASLAGGLRFT VPHLRDSSHK
760 770 780 790 800
VQFDFQIRSK NQNNSQSETV HLALNVEAHS TVSFFGASKP DSVIFPVANW
810 820 830 840 850
KPGRNPVTGQ EAGPEVKHVY ELVNFGPSSI SQGILELRCP MRVNKEYAMY
860 870 880 890 900
VMSYAVQGLT NCTSNHPANA LHLQHSPTDH PPTLNPKTVH HVERRDTARL
910 920 930 940 950
ISGSSNVLKC NEPHVDCFHL HCDVGPLEKQ KRAILRVNFL VWANTFMQKE
960 970 980 990 1000
NQGFTLQCDA LYHIQKLPYK ILPHVYPKGT HQVDTAIHWA KPESSYGVPL
1010 1020 1030 1040 1050
WIIILAILIG LLLLALLIYV LYKLGFFKRS YQYGTAMEKA ELKPQAASEA
Length:1,050
Mass (Da):115,962
Last modified:November 1, 1996 - v1
Checksum:i10ED961535B8D918
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12683 mRNA Translation: AAA99668.1
L10191 mRNA Translation: AAA16249.1
PIRiI51527
RefSeqiNP_001081072.1, NM_001087603.1
UniGeneiXl.1049
Xl.34931

Genome annotation databases

GeneIDi394366
KEGGixla:394366

Similar proteinsi

Entry informationi

Entry nameiITA5_XENLA
AccessioniPrimary (citable) accession number: Q06274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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