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Protein

Glucose transporter 1B/1C/1D/1F/2B

Gene

THT1B

more
Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose transporter 1B/1C/1D/1F/2B
Gene namesi
Name:THT1B
AND
Name:THT1C
AND
Name:THT1D
AND
Name:THT1F
AND
Name:THT2B
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 118ExtracellularSequence analysisAdd BLAST54
Transmembranei119 – 139Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini140 – 151CytoplasmicSequence analysisAdd BLAST12
Transmembranei152 – 172Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini173 – 175ExtracellularSequence analysis3
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 213CytoplasmicSequence analysisAdd BLAST17
Transmembranei214 – 234Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini235 – 249ExtracellularSequence analysisAdd BLAST15
Transmembranei250 – 270Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini271 – 299CytoplasmicSequence analysisAdd BLAST29
Transmembranei300 – 320Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini321 – 338ExtracellularSequence analysisAdd BLAST18
Transmembranei339 – 359Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini360 – 372CytoplasmicSequence analysisAdd BLAST13
Transmembranei373 – 393Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini394 – 403ExtracellularSequence analysis10
Transmembranei404 – 424Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini425 – 436CytoplasmicSequence analysisAdd BLAST12
Transmembranei437 – 457Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini458 – 475ExtracellularSequence analysisAdd BLAST18
Transmembranei476 – 496Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini497 – 527CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503841 – 527Glucose transporter 1B/1C/1D/1F/2BAdd BLAST527

Expressioni

Developmental stagei

Expressed specifically in bloodstream forms.

Structurei

3D structure databases

ProteinModelPortaliQ06221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q06221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTERRDNVSH APDAIEGPND GAHAEDTSPG FFSLENLGVA QVQVVGGTLN
60 70 80 90 100
GYVIGYVAVY LLLYLTATEC KFTTEGACGG RKIYGCKWSG TTCKFENPKC
110 120 130 140 150
SEGSDPSDSC KNEVAYTSVY SGIFACAMIV GSMVGSIIAG KCITTFGLKK
160 170 180 190 200
SFIIVSITCT IACVVVQVAI EYNNYYALCT GRVLIGLGVG ILCSVFPMYV
210 220 230 240 250
NENAHPKLCK MDGVLFQVFT TLGIMLAAML GLILDKTGAS KEEANMAGRL
260 270 280 290 300
HVFSAVPLGL SVAMFLVGMF LRESTATFAQ DDDGKADGGM DPNEYGWGQM
310 320 330 340 350
LWPLFMGAVT AGTLQLTGIN AVMNYAPKIT ENLGMDPSLG NFLVMAWNFV
360 370 380 390 400
TSLVAIPLAS RFTMRQMFIT CSFVASCMCL FLCGIPVFPG VAGKEVKNGV
410 420 430 440 450
ATTGIALFIA AFEFGVGSCF FVLAQDLFPP SFRPKGGSFV VMMQFIFNIL
460 470 480 490 500
INLLYPITTE AISGGATGNQ DKGQAVAFIL FGLIGLICSV LQFFYLYPYD
510 520
ANQDHENDHG GEPVEQKTYP VEASPRN
Length:527
Mass (Da):56,470
Last modified:February 1, 1995 - v1
Checksum:i32E34915A2A12876
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69091 Genomic DNA Translation: CAA48834.1
X69091 Genomic DNA Translation: CAA48835.1
X69091 Genomic DNA Translation: CAA48836.1
X69091 Genomic DNA Translation: CAA48838.1
X69091 Genomic DNA Translation: CAA48840.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69091 Genomic DNA Translation: CAA48834.1
X69091 Genomic DNA Translation: CAA48835.1
X69091 Genomic DNA Translation: CAA48836.1
X69091 Genomic DNA Translation: CAA48838.1
X69091 Genomic DNA Translation: CAA48840.1

3D structure databases

ProteinModelPortaliQ06221
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTH11_TRYBB
AccessioniPrimary (citable) accession number: Q06221
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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