UniProtKB - Q06219 (NR4A2_MOUSE)
Nuclear receptor subfamily 4 group A member 2
Nr4a2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 260 – 335 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 263 – 283 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 299 – 323 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- glucocorticoid receptor binding Source: UniProtKB
- nuclear receptor activity Source: MGI
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- adult locomotory behavior Source: MGI
- cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
- cellular response to extracellular stimulus Source: MGI
- cellular response to oxidative stress Source: MGI
- central nervous system neuron differentiation Source: MGI
- central nervous system projection neuron axonogenesis Source: MGI
- dopamine biosynthetic process Source: MGI
- dopamine metabolic process Source: MGI
- dopaminergic neuron differentiation Source: UniProtKB
- fat cell differentiation Source: UniProtKB
- gene expression Source: MGI
- general adaptation syndrome Source: MGI
- habenula development Source: MGI
- negative regulation of apoptotic signaling pathway Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- nervous system development Source: MGI
- neuron differentiation Source: MGI
- neuron maturation Source: MGI
- neuron migration Source: MGI
- positive regulation of catalytic activity Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- post-embryonic development Source: MGI
- regulation of dopamine metabolic process Source: MGI
- regulation of gene expression Source: MGI
- regulation of respiratory gaseous exchange Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to amphetamine Source: MGI
- response to hypoxia Source: MGI
- response to inorganic substance Source: MGI
- response to insecticide Source: MGI
- transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 4 group A member 2Alternative name(s): NUR-related factor 1 Orphan nuclear receptor NURR1 |
Gene namesi | Name:Nr4a2 Synonyms:Nurr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352456, Nr4a2 |
Subcellular locationi
Nucleus
- nuclear speck Source: MGI
- nucleoplasm Source: Reactome
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053719 | 1 – 598 | Nuclear receptor subfamily 4 group A member 2Add BLAST | 598 |
Proteomic databases
PaxDbi | Q06219 |
PRIDEi | Q06219 |
ProteomicsDBi | 293968 [Q06219-1] 293969 [Q06219-2] |
PTM databases
iPTMneti | Q06219 |
PhosphoSitePlusi | Q06219 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000026826, Expressed in habenula and 290 other tissues |
ExpressionAtlasi | Q06219, baseline and differential |
Genevisiblei | Q06219, MM |
Interactioni
Subunit structurei
Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3.
Interacts with PER2.
2 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- glucocorticoid receptor binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 201880, 3 interactors |
IntActi | Q06219, 5 interactors |
STRINGi | 10090.ENSMUSP00000028166 |
Miscellaneous databases
RNActi | Q06219, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 360 – 595 | NR LBDPROSITE-ProRule annotationAdd BLAST | 236 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 287 – 314 | Bipartite nuclear localization signal (NLS1)By similarityAdd BLAST | 28 | |
Motifi | 338 – 350 | Nuclear localization signal (NLS1)By similarityAdd BLAST | 13 | |
Motifi | 443 – 452 | nuclear export sequence (NES1)By similarity | 10 | |
Motifi | 568 – 577 | nuclear export sequence (NES2)By similarity | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 80 – 138 | Gln-richAdd BLAST | 59 | |
Compositional biasi | 127 – 233 | Pro-richAdd BLAST | 107 | |
Compositional biasi | 346 – 391 | Pro-richAdd BLAST | 46 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 263 – 283 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 299 – 323 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4217, Eukaryota |
GeneTreei | ENSGT00950000183038 |
InParanoidi | Q06219 |
PhylomeDBi | Q06219 |
TreeFami | TF315430 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR003070, Nuc_orph_rcpt IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003073, NURR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01284, NUCLEARECPTR PR01287, NURRNUCRCPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE
60 70 80 90 100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY
110 120 130 140 150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP STPSFQVQHS PMWDDPGSLH
160 170 180 190 200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV
210 220 230 240 250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS
260 270 280 290 300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL
310 320 330 340 350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK
360 370 380 390 400
SPQDPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT
410 420 430 440 450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR
460 470 480 490 500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI
510 520 530 540 550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN
560 570 580 590
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
The sequence of this isoform differs from the canonical sequence as follows:
455-455: S → I
456-598: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9R1W4 | Q9R1W4_MOUSE | Nuclear receptor subfamily 4 group ... | Nr4a2 Nurr2 | 392 | Annotation score: | ||
A2AQQ8 | A2AQQ8_MOUSE | Nuclear receptor subfamily 4 group ... | Nr4a2 | 535 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003710 | 455 | S → I in isoform NURR1A. Curated | 1 | |
Alternative sequenceiVSP_003711 | 456 – 598 | Missing in isoform NURR1A. CuratedAdd BLAST | 143 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S53744 mRNA Translation: AAB25138.1 U86783 Genomic DNA Translation: AAC53153.1 U86783 Genomic DNA Translation: AAC53154.1 |
CCDSi | CCDS16043.1 [Q06219-1] |
PIRi | A46225 |
RefSeqi | NP_001132981.1, NM_001139509.1 [Q06219-1] NP_038641.1, NM_013613.2 [Q06219-1] XP_011237335.1, XM_011239033.2 [Q06219-1] XP_011237336.1, XM_011239034.2 [Q06219-1] |
Genome annotation databases
Ensembli | ENSMUST00000028166; ENSMUSP00000028166; ENSMUSG00000026826 [Q06219-1] ENSMUST00000112629; ENSMUSP00000108248; ENSMUSG00000026826 [Q06219-1] |
GeneIDi | 18227 |
KEGGi | mmu:18227 |
UCSCi | uc008jrw.2, mouse [Q06219-1] uc012bvn.1, mouse [Q06219-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S53744 mRNA Translation: AAB25138.1 U86783 Genomic DNA Translation: AAC53153.1 U86783 Genomic DNA Translation: AAC53154.1 |
CCDSi | CCDS16043.1 [Q06219-1] |
PIRi | A46225 |
RefSeqi | NP_001132981.1, NM_001139509.1 [Q06219-1] NP_038641.1, NM_013613.2 [Q06219-1] XP_011237335.1, XM_011239033.2 [Q06219-1] XP_011237336.1, XM_011239034.2 [Q06219-1] |
3D structure databases
BMRBi | Q06219 |
SMRi | Q06219 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201880, 3 interactors |
IntActi | Q06219, 5 interactors |
STRINGi | 10090.ENSMUSP00000028166 |
Chemistry databases
ChEMBLi | CHEMBL3879839 |
PTM databases
iPTMneti | Q06219 |
PhosphoSitePlusi | Q06219 |
Proteomic databases
PaxDbi | Q06219 |
PRIDEi | Q06219 |
ProteomicsDBi | 293968 [Q06219-1] 293969 [Q06219-2] |
Protocols and materials databases
Antibodypediai | 621, 394 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028166; ENSMUSP00000028166; ENSMUSG00000026826 [Q06219-1] ENSMUST00000112629; ENSMUSP00000108248; ENSMUSG00000026826 [Q06219-1] |
GeneIDi | 18227 |
KEGGi | mmu:18227 |
UCSCi | uc008jrw.2, mouse [Q06219-1] uc012bvn.1, mouse [Q06219-2] |
Organism-specific databases
CTDi | 4929 |
MGIi | MGI:1352456, Nr4a2 |
Phylogenomic databases
eggNOGi | KOG4217, Eukaryota |
GeneTreei | ENSGT00950000183038 |
InParanoidi | Q06219 |
PhylomeDBi | Q06219 |
TreeFami | TF315430 |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway |
Miscellaneous databases
BioGRID-ORCSi | 18227, 2 hits in 52 CRISPR screens |
ChiTaRSi | Nr4a2, mouse |
PROi | PR:Q06219 |
RNActi | Q06219, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026826, Expressed in habenula and 290 other tissues |
ExpressionAtlasi | Q06219, baseline and differential |
Genevisiblei | Q06219, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR003070, Nuc_orph_rcpt IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003073, NURR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01284, NUCLEARECPTR PR01287, NURRNUCRCPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NR4A2_MOUSE | |
Accessioni | Q06219Primary (citable) accession number: Q06219 Secondary accession number(s): O08690 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families