Nuclear receptor subfamily 4 group A member 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "p57(Kip2) cooperates with Nurr1 in developing dopamine cells."
    Joseph B., Wallen-Mackenzie A., Benoit G., Murata T., Joodmardi E., Okret S., Perlmann T.
    Proc Natl Acad Sci U S A 100:15619-15624(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid receptor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor."
    Martens C., Bilodeau S., Maira M., Gauthier Y., Drouin J.
    Mol. Endocrinol. 19:885-897(2005) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Dopamine neuron agenesis in Nurr1-deficient mice."
    Zetterstrom R.H., Solomin L., Jansson L., Hoffer B.J., Olson L., Perlmann T.
    Science 276:248-250(1997) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons."
    Jacobs F.M., van der Linden A.J., Wang Y., von Oerthel L., Sul H.S., Burbach J.P., Smidt M.P.
    Development 136:2363-2373(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors."
    Sacchetti P., Dwornik H., Formstecher P., Rachez C., Lefebvre P.
    J Biol Chem 277:35088-35096(2002) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1."
    Zetterstrom R.H., Solomin L., Mitsiadis T., Olson L., Perlmann T.
    Mol Endocrinol 10:1656-1666(1996) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• adult locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • "Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity."
    Eells J.B., Lipska B.K., Yeung S.K., Misler J.A., Nikodem V.M.
    Behav Brain Res 136:267-275(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to corticotropin-releasing hormone stimulus Source: UniProtKBInferred from direct assayⁱ
  • "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to extracellular stimulus Source: MGIInferred from direct assayⁱ
  • "Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1."
    Zetterstrom R.H., Solomin L., Mitsiadis T., Olson L., Perlmann T.
    Mol Endocrinol 10:1656-1666(1996) [PubMed] [Europe PMC] [Abstract]
• cellular response to oxidative stress Source: MGIInferred from mutant phenotypeⁱ
  • "NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection."
    Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T.
    Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010) [PubMed] [Europe PMC] [Abstract]
• central nervous system neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Nigrostriatal innervation is preserved in Nurr1-null mice, although dopaminergic neuron precursors are arrested from terminal differentiation."
    Witta J., Baffi J.S., Palkovits M., Mezey E., Castillo S.O., Nikodem V.M.
    Brain Res Mol Brain Res 84:67-78(2000) [PubMed] [Europe PMC] [Abstract]
• central nervous system projection neuron axonogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice."
    Wallen A., Zetterstrom R.H., Solomin L., Arvidsson M., Olson L., Perlmann T.
    Exp Cell Res 253:737-746(1999) [PubMed] [Europe PMC] [Abstract]
• dopamine biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice."
    Eells J.B., Misler J.A., Nikodem V.M.
    Brain Res Bull 70:186-195(2006) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene."
    Castillo S.O., Baffi J.S., Palkovits M., Goldstein D.S., Kopin I.J., Witta J., Magnuson M.A., Nikodem V.M.
    Mol Cell Neurosci 11:36-46(1998) [PubMed] [Europe PMC] [Abstract]
• dopamine metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity."
    Eells J.B., Lipska B.K., Yeung S.K., Misler J.A., Nikodem V.M.
    Behav Brain Res 136:267-275(2002) [PubMed] [Europe PMC] [Abstract]
• dopaminergic neuron differentiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression."
    Jacobs F.M., van Erp S., van der Linden A.J., von Oerthel L., Burbach J.P., Smidt M.P.
    Development 136:531-540(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SFPQ; NCOR2; SIN3A AND HDAC1.
• fat cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • "Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1."
    Chao L.C., Bensinger S.J., Villanueva C.J., Wroblewski K., Tontonoz P.
    Mol. Endocrinol. 22:2596-2608(2008) [PubMed] [Europe PMC] [Abstract]
• gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Differential expression of tyrosine hydroxylase in catecholaminergic neurons of neonatal wild-type and Nurr1-deficient mice."
    Baffi J.S., Palkovits M., Castillo S.O., Mezey E., Nikodem V.M.
    Neuroscience 93:631-642(1999) [PubMed] [Europe PMC] [Abstract]
• general adaptation syndrome Source: MGIInferred from mutant phenotypeⁱ
  • "Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity."
    Eells J.B., Lipska B.K., Yeung S.K., Misler J.A., Nikodem V.M.
    Behav Brain Res 136:267-275(2002) [PubMed] [Europe PMC] [Abstract]
• habenula development Source: MGIInferred from mutant phenotypeⁱ
  • "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development."
    Quina L.A., Wang S., Ng L., Turner E.E.
    J Neurosci 29:14309-14322(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic signaling pathway Source: MGI
• negative regulation of neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice."
    Wallen A., Zetterstrom R.H., Solomin L., Arvidsson M., Olson L., Perlmann T.
    Exp Cell Res 253:737-746(1999) [PubMed] [Europe PMC] [Abstract]
  • "NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection."
    Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T.
    Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGI
• nervous system development Source: MGIInferred from mutant phenotypeⁱ
  • "Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem."
    Wallen A A., Castro D.S., Zetterstrom R.H., Karlen M., Olson L., Ericson J., Perlmann T.
    Mol Cell Neurosci 18:649-663(2001) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine neuron agenesis in Nurr1-deficient mice."
    Zetterstrom R.H., Solomin L., Jansson L., Hoffer B.J., Olson L., Perlmann T.
    Science 276:248-250(1997) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons."
    Smits S.M., Ponnio T., Conneely O.M., Burbach J.P., Smidt M.P.
    Eur J Neurosci 18:1731-1738(2003) [PubMed] [Europe PMC] [Abstract]
  • "Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons."
    Saucedo-Cardenas O., Quintana-Hau J.D., Le W.D., Smidt M.P., Cox J.J., De Mayo F., Burbach J.P., Conneely O.M.
    Proc Natl Acad Sci U S A 95:4013-4018(1998) [PubMed] [Europe PMC] [Abstract]
• neuron maturation Source: MGIInferred from mutant phenotypeⁱ
  • "Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice."
    Wallen A., Zetterstrom R.H., Solomin L., Arvidsson M., Olson L., Perlmann T.
    Exp Cell Res 253:737-746(1999) [PubMed] [Europe PMC] [Abstract]
• neuron migration Source: MGIInferred from mutant phenotypeⁱ
  • "Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice."
    Wallen A., Zetterstrom R.H., Solomin L., Arvidsson M., Olson L., Perlmann T.
    Exp Cell Res 253:737-746(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of catalytic activity Source: MGIInferred from mutant phenotypeⁱ
  • "Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation."
    Chartoff E.H., Marck B.T., Matsumoto A.M., Dorsa D.M., Palmiter R.D.
    Proc Natl Acad Sci U S A 98:10451-10456(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1."
    Zetterstrom R.H., Solomin L., Mitsiadis T., Olson L., Perlmann T.
    Mol Endocrinol 10:1656-1666(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]
  • "TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77."
    Rambaud J., Desroches J., Balsalobre A., Drouin J.
    J. Biol. Chem. 284:14147-14156(2009) [PubMed] [Europe PMC] [Abstract]
• post-embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene."
    Castillo S.O., Baffi J.S., Palkovits M., Goldstein D.S., Kopin I.J., Witta J., Magnuson M.A., Nikodem V.M.
    Mol Cell Neurosci 11:36-46(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of dopamine metabolic process Source: MGIInferred from direct assayⁱ
  • "Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells."
    Hermanson E., Joseph B., Castro D., Lindqvist E., Aarnisalo P., Wallen A., Benoit G., Hengerer B., Olson L., Perlmann T.
    Exp Cell Res 288:324-334(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons."
    Jacobs F.M., van der Linden A.J., Wang Y., von Oerthel L., Sul H.S., Burbach J.P., Smidt M.P.
    Development 136:2363-2373(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of respiratory gaseous exchange Source: MGIInferred from mutant phenotypeⁱ
  • "Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice."
    Nsegbe E., Wallen-Mackenzie A., Dauger S., Roux J.C., Shvarev Y., Lagercrantz H., Perlmann T., Herlenius E.
    J Physiol 556:43-59(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: MGIInferred from mutant phenotypeⁱ
  • "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development."
    Quina L.A., Wang S., Ng L., Turner E.E.
    J Neurosci 29:14309-14322(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to amphetamine Source: MGIInferred from mutant phenotypeⁱ
  • "Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity."
    Eells J.B., Lipska B.K., Yeung S.K., Misler J.A., Nikodem V.M.
    Behav Brain Res 136:267-275(2002) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: MGIInferred from mutant phenotypeⁱ
  • "Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice."
    Nsegbe E., Wallen-Mackenzie A., Dauger S., Roux J.C., Shvarev Y., Lagercrantz H., Perlmann T., Herlenius E.
    J Physiol 556:43-59(2004) [PubMed] [Europe PMC] [Abstract]
• response to inorganic substance Source: MGIInferred from sequence orthologyⁱ
  • Ref.1

    "Identification of a new brain-specific transcription factor, NURR1."
    Law S.W., Conneely O.M., DeMayo F.J., O'Malley B.W.
    Mol. Endocrinol. 6:2129-2135(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM NURR1).
• response to insecticide Source: MGIInferred from sequence orthologyⁱ
  • "HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT: induction upon membrane depolarization and seizures."
    Pena de Ortiz S., Jamieson G.A. Jr.
    Brain Res Mol Brain Res 38:1-13(1996) [PubMed] [Europe PMC] [Abstract]
• transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.3

    "Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression."
    Jacobs F.M., van Erp S., van der Linden A.J., von Oerthel L., Burbach J.P., Smidt M.P.
    Development 136:531-540(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SFPQ; NCOR2; SIN3A AND HDAC1.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• glucocorticoid receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor."
    Martens C., Bilodeau S., Maira M., Gauthier Y., Drouin J.
    Mol. Endocrinol. 19:885-897(2005) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE 
        60         70         80         90        100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY 
       110        120        130        140        150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP STPSFQVQHS PMWDDPGSLH 
       160        170        180        190        200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV 
       210        220        230        240        250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS 
       260        270        280        290        300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 
       310        320        330        340        350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK 
       360        370        380        390        400
SPQDPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT 
       410        420        430        440        450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR 
       460        470        480        490        500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI 
       510        520        530        540        550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN 
       560        570        580        590 
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF   

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE 
        60         70         80         90        100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY 
       110        120        130        140        150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP STPSFQVQHS PMWDDPGSLH 
       160        170        180        190        200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV 
       210        220        230        240        250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS 
       260        270        280        290        300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 
       310        320        330        340        350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK 
       360        370        380        390        400
SPQDPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT 
       410        420        430        440        450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR 

LAYRI                                                  

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families