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Protein

Nuclear receptor subfamily 4 group A member 2

Gene

Nr4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi260 – 335Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri263 – 283NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri299 – 323NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: MGI
  • glucocorticoid receptor binding Source: UniProtKB
  • nuclear receptor activity Source: MGI
  • protein heterodimerization activity Source: UniProtKB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • steroid hormone receptor activity Source: InterPro
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
  • cellular response to extracellular stimulus Source: MGI
  • cellular response to oxidative stress Source: MGI
  • central nervous system neuron differentiation Source: MGI
  • central nervous system projection neuron axonogenesis Source: MGI
  • dopamine biosynthetic process Source: MGI
  • dopamine metabolic process Source: MGI
  • dopaminergic neuron differentiation Source: UniProtKB
  • fat cell differentiation Source: UniProtKB
  • gene expression Source: MGI
  • general adaptation syndrome Source: MGI
  • habenula development Source: MGI
  • negative regulation of apoptotic signaling pathway Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • nervous system development Source: MGI
  • neuron differentiation Source: MGI
  • neuron maturation Source: MGI
  • neuron migration Source: MGI
  • positive regulation of catalytic activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • post-embryonic development Source: MGI
  • regulation of dopamine metabolic process Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of respiratory gaseous exchange Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • response to amphetamine Source: MGI
  • response to hypoxia Source: MGI
  • response to inorganic substance Source: MGI
  • response to insecticide Source: MGI
  • transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 2
Alternative name(s):
NUR-related factor 1
Orphan nuclear receptor NURR1
Gene namesi
Name:Nr4a2
Synonyms:Nurr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1352456 Nr4a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3879839

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537191 – 598Nuclear receptor subfamily 4 group A member 2Add BLAST598

Proteomic databases

PaxDbiQ06219
PRIDEiQ06219

PTM databases

iPTMnetiQ06219
PhosphoSitePlusiQ06219

Expressioni

Tissue specificityi

Brain.

Developmental stagei

Expression begins in the embryo, increases in neonates and decreases in the adult.

Gene expression databases

BgeeiENSMUSG00000026826
CleanExiMM_NR4A2
ExpressionAtlasiQ06219 baseline and differential
GenevisibleiQ06219 MM

Interactioni

Subunit structurei

Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • glucocorticoid receptor binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi201880, 2 interactors
IntActiQ06219, 5 interactors
STRINGi10090.ENSMUSP00000028166

Structurei

3D structure databases

ProteinModelPortaliQ06219
SMRiQ06219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 595NR LBDPROSITE-ProRule annotationAdd BLAST236

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi287 – 314Bipartite nuclear localization signal (NLS1)By similarityAdd BLAST28
Motifi338 – 350Nuclear localization signal (NLS1)By similarityAdd BLAST13
Motifi443 – 452nuclear export sequence (NES1)By similarity10
Motifi568 – 577nuclear export sequence (NES2)By similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 138Gln-richAdd BLAST59
Compositional biasi127 – 233Pro-richAdd BLAST107
Compositional biasi346 – 391Pro-richAdd BLAST46

Domaini

the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (By similarity).By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 283NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri299 – 323NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4217 Eukaryota
ENOG410YWNC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000230925
HOVERGENiHBG052663
InParanoidiQ06219
KOiK08558
OMAiNPIRKQA
OrthoDBiEOG091G0GUM
PhylomeDBiQ06219
TreeFamiTF315430

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR003070 Nuc_orph_rcpt
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003073 NURR_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01284 NUCLEARECPTR
PR01287 NURRNUCRCPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NURR1 (identifier: Q06219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE
60 70 80 90 100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY
110 120 130 140 150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP STPSFQVQHS PMWDDPGSLH
160 170 180 190 200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV
210 220 230 240 250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS
260 270 280 290 300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL
310 320 330 340 350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK
360 370 380 390 400
SPQDPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT
410 420 430 440 450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR
460 470 480 490 500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI
510 520 530 540 550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN
560 570 580 590
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
Length:598
Mass (Da):66,593
Last modified:June 1, 1994 - v1
Checksum:iD1AC5EB2FFB8D366
GO
Isoform NURR1A (identifier: Q06219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-455: S → I
     456-598: Missing.

Show »
Length:455
Mass (Da):50,458
Checksum:iA3B91CFBAAD62D13
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003710455S → I in isoform NURR1A. Curated1
Alternative sequenceiVSP_003711456 – 598Missing in isoform NURR1A. CuratedAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53744 mRNA Translation: AAB25138.1
U86783 Genomic DNA Translation: AAC53153.1
U86783 Genomic DNA Translation: AAC53154.1
CCDSiCCDS16043.1 [Q06219-1]
PIRiA46225
RefSeqiNP_001132981.1, NM_001139509.1 [Q06219-1]
NP_038641.1, NM_013613.2 [Q06219-1]
XP_011237335.1, XM_011239033.2 [Q06219-1]
XP_011237336.1, XM_011239034.2 [Q06219-1]
UniGeneiMm.3507

Genome annotation databases

EnsembliENSMUST00000028166; ENSMUSP00000028166; ENSMUSG00000026826 [Q06219-1]
ENSMUST00000112629; ENSMUSP00000108248; ENSMUSG00000026826 [Q06219-1]
GeneIDi18227
KEGGimmu:18227
UCSCiuc008jrw.2 mouse [Q06219-1]
uc012bvn.1 mouse [Q06219-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNR4A2_MOUSE
AccessioniPrimary (citable) accession number: Q06219
Secondary accession number(s): O08690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 18, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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