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Entry version 142 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

E3 ubiquitin-protein ligase linker protein MMS1

Gene

MMS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Involved in the regulation of TY1 transposition.11 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-34293-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase linker protein MMS1
Alternative name(s):
Methyl methanesulfonate-sensitivity protein 1
Regulator of Ty1 transposition protein 108
Synthetically lethal with MCM10 protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MMS1
Synonyms:KIM3, RTT108, SLM6
Ordered Locus Names:YPR164W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YPR164W

Saccharomyces Genome Database

More...
SGDi
S000006368 MMS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002578201 – 1407E3 ubiquitin-protein ligase linker protein MMS1Add BLAST1407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1294PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06211

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06211

PRoteomics IDEntifications database

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PRIDEi
Q06211

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q06211

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06211

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of multiple cullin-RING ligases (CRLs) composed of 4 subunits: the RING protein HRT1, the cullin RTT101, a linker protein MMS1, and one of many alternative substrate receptors belonging to a protein family described as DCAF (DDB1- and CUL4-associated factor). Component of a RTT101(MMS1-MMS22) complex with the substrate receptor MMS22. This complex further interacts with RTT107 and CTF4 to form RTT101-MMS1-MMS22-RTT107 and RTT101-MMS1-MMS22-CTF4 complexes respectively. Component of a RTT101(MSS1-CRT10) complex with the substrate receptor CRT10. Component of a RTT101(MSS1-ESC2) complex with the potential substrate receptor ESC2. Component of a RTT101(MSS1-ORC5) complex with the potential substrate receptor ORC5. Interacts with RTT101 (via N-ter). Interacts (via N-ter) with MMS22 (via C-ter). Interacts with CRT10.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
36337, 254 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1157 CUL8-MMS1-MMS22-ESC4 E3 ubiquitin ligase complex
CPX-1165 CUL8-MMS1-MMS22-CTF4 E3 ubiquitin ligase complex
CPX-1166 CUL8-MMS1-ESC2 E3 ubiquitin ligase complex
CPX-1167 CUL8-MMS1-ORC5 E3 ubiquitin ligase complex

Database of interacting proteins

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DIPi
DIP-6310N

Protein interaction database and analysis system

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IntActi
Q06211, 10 interactors

Molecular INTeraction database

More...
MINTi
Q06211

STRING: functional protein association networks

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STRINGi
4932.YPR164W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q06211

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 600Required for interaction with MMS22Add BLAST600

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q06211

Identification of Orthologs from Complete Genome Data

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OMAi
ICKFFEF

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLRTHGLD RYEHYIRRPS DFGKLELQDW LNHKSFRVSP NLLIDSSTTR
60 70 80 90 100
EWNEPELFYQ NTEDETWVRP CVGPKLEPSM MMLRYHDSNI GQMPQFCYPI
110 120 130 140 150
SSPINFKPVL KYILQERSEL SDGFPQKYNT LIGSLFDIDK NPETLDDSDI
160 170 180 190 200
EALDDIEMSS DSGNVKEPKI ELQALEEIQQ KHFSLIVSNN GIFQTGSTSI
210 220 230 240 250
TYIQSGISGS IAIKPNNVAI LILLTQPSGH LLSILPLDDG KETYLLQYWN
260 270 280 290 300
LGQKGQWNII KHQNEKQFVL IHKELGICKF FEFHLPFTFQ LVNNLTLTDS
310 320 330 340 350
VIMNGSFFPT NYTDLDPYFI IFITAIRYER IVYFVIEWNN NEIKKKEVYQ
360 370 380 390 400
LTVFDGEKTN MTIPIGLNAC LVETPLKFSL VSANQIMSGE TEFHSFQLKA
410 420 430 440 450
LKGIKSFFPA PLLLLKLQEL HPHTFKKFQY CTIISSSTGN ICFCVTERST
460 470 480 490 500
IVNGNLKFYE LTRFKGLKSI SPLPSNPINL DSRSSSYVLV VISFSRTLEL
510 520 530 540 550
TLSLEDLRCL DKKDVIKPLK NITFKHTIDS STEENSQILA FTSSKFYNTH
560 570 580 590 600
TGSNINDTRN SQVWLTSPNA ITQPCIDYKL RKTHQLIHLK QFQIFRHLRI
610 620 630 640 650
WKCKNLDIAL LQRLGINQSN TESSLIFATD AVSNNRIFLL DLTMTTTIDN
660 670 680 690 700
DDPVQGLINI EDLLCDTENE TILLNFTKNN LIQVTRDTIY IDPIGGDKEL
710 720 730 740 750
RKISPGWEFE NVTYNDGILI VWNAGLGCVS YIENIDAVDE SGALVSNLSS
760 770 780 790 800
SKGMSKFFKQ LGTVTSVNFQ IKESTDDPTK YDIWILLPDC VIRTPFSDWI
810 820 830 840 850
SDSLDFSDVY ILSVQQALIN GPYFCSLDYE SYFEVHTLQN NCFKKGSRCT
860 870 880 890 900
SRVNFQGKDI KFRSFGVNQC LAFSAFEIFV INLTPIHDSR ELDFYKLKLP
910 920 930 940 950
HLGNNNSILE VCPDIENNQL FILYSDGLRI LELSYLTSNN GNFLLKSTRS
960 970 980 990 1000
KNKKFLYLDK INRMLVLNQD LREWECIRLS DGKAVGLDSQ LLKDDSEEIL
1010 1020 1030 1040 1050
EIKELPIATE DNPLEKKTVL LISFTSSLKL VLLTAAKNKI SNQIIDSYKL
1060 1070 1080 1090 1100
DNSRLLNHLV ITPRGEIFFL DYKVMGTDNE MSFNKLKVTK HCIDQEERNN
1110 1120 1130 1140 1150
TTLRLTLETR FTFKSWSTVK TFTVVGDNII ATTNMGEKLY LIKDFSSSSD
1160 1170 1180 1190 1200
ESRRVYPLEM YPDSKVQKII PLNECCFVVA AYCGNRNDLD SRLIFYSLPT
1210 1220 1230 1240 1250
IKVGLNNETG SLPDEYGNGR VDDIFEVDFP EGFQFGTMAL YDVLHGERHV
1260 1270 1280 1290 1300
NRYSEGIRSE NDEAEVALRQ RRNLLLFWRN HSSTPKPSLR RAATIVYEDH
1310 1320 1330 1340 1350
VSSRYFEDIS SILGSTAMRT KRLSPYNAVA LDKPIQDISY DPAVQTLYVL
1360 1370 1380 1390 1400
MADQTIHKFG KDRLPCQDEY EPRWNSGYLV SRRSIVKSDL ICEVGLWNLS

DNCKNTV
Length:1,407
Mass (Da):161,238
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC698C422631A7D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25840 Genomic DNA Translation: AAB68151.1
U14001 Genomic DNA Translation: AAG02022.1
BK006949 Genomic DNA Translation: DAA11581.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59823

NCBI Reference Sequences

More...
RefSeqi
NP_015490.1, NM_001184261.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR164W_mRNA; YPR164W_mRNA; YPR164W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR164W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25840 Genomic DNA Translation: AAB68151.1
U14001 Genomic DNA Translation: AAG02022.1
BK006949 Genomic DNA Translation: DAA11581.1
PIRiS59823
RefSeqiNP_015490.1, NM_001184261.1

3D structure databases

ProteinModelPortaliQ06211
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36337, 254 interactors
ComplexPortaliCPX-1157 CUL8-MMS1-MMS22-ESC4 E3 ubiquitin ligase complex
CPX-1165 CUL8-MMS1-MMS22-CTF4 E3 ubiquitin ligase complex
CPX-1166 CUL8-MMS1-ESC2 E3 ubiquitin ligase complex
CPX-1167 CUL8-MMS1-ORC5 E3 ubiquitin ligase complex
DIPiDIP-6310N
IntActiQ06211, 10 interactors
MINTiQ06211
STRINGi4932.YPR164W

PTM databases

iPTMnetiQ06211

Proteomic databases

MaxQBiQ06211
PaxDbiQ06211
PRIDEiQ06211
TopDownProteomicsiQ06211

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR164W_mRNA; YPR164W_mRNA; YPR164W
GeneIDi856293
KEGGisce:YPR164W

Organism-specific databases

EuPathDBiFungiDB:YPR164W
SGDiS000006368 MMS1

Phylogenomic databases

InParanoidiQ06211
OMAiICKFFEF

Enzyme and pathway databases

BioCyciYEAST:G3O-34293-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06211

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMS1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06211
Secondary accession number(s): D6W4G5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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