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Protein

Protein RIF2

Gene

RIF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres.1 Publication

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • telomeric DNA binding Source: SGD

GO - Biological processi

  • telomere capping Source: SGD
  • telomere maintenance via telomerase Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32506-MONOMER

Protein family/group databases

MoonDBiQ06208 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RIF2
Alternative name(s):
RAP1-interacting factor 2
Gene namesi
Name:RIF2
Ordered Locus Names:YLR453C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

SGDiS000004445 RIF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973371 – 395Protein RIF2Add BLAST395

Proteomic databases

MaxQBiQ06208
PaxDbiQ06208
PRIDEiQ06208

Interactioni

Subunit structurei

Interacts with RIF1 and RAP1 C-terminus.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RAP1P119385EBI-15199,EBI-14821

Protein-protein interaction databases

BioGridi31711, 115 interactors
ComplexPortaliCPX-2112 Telosome
DIPiDIP-4290N
IntActiQ06208, 2 interactors
STRINGi4932.YLR453C

Structurei

Secondary structure

1395
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ06208
SMRiQ06208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK11119
OMAiIDHIVYF
OrthoDBiEOG092C385T

Sequencei

Sequence statusi: Complete.

Q06208-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHVDSDFAP IRRSKKVVDS DKIVKAISDD LEQKNFTVLR KLNLVPIKKS
60 70 80 90 100
VSSPKVCKPS PVKERVDHVF YQKFKSMALQ ELGTNYLSIS YVPSLSKFLS
110 120 130 140 150
KNLRSMKNCI VFFDKVEHIH QYAGIDRAVS ETLSLVDINV VIIEMNDYLM
160 170 180 190 200
KEGIQSSKSK ECIESMGQAS YSGQLDFEAS EKPSNHTSDL MMMVMRKINN
210 220 230 240 250
DESIDHIVYF KFEQLDKLST STIIEPSKLT EFINVLSVLE KSNNIAFKVL
260 270 280 290 300
IYSNNVSISS LLSTSLKKKL NTKYTVFEMP ILTCAQEQEY LKKMIKFTFD
310 320 330 340 350
SGSKLLQSYN SLVTCQLNNK ESNLAIFFEF LKVFPHPFTY LFNAYTEIIV
360 370 380 390
QSRTFDELLD KIRNRLTIKN YPHSAYNFKK NQRLPLKLTR KVHDR
Length:395
Mass (Da):45,643
Last modified:November 1, 1996 - v1
Checksum:iFF6E3A22C8805DE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti387K → R in AAT92879 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22382 Genomic DNA Translation: AAB67535.1
AY692860 Genomic DNA Translation: AAT92879.1
BK006945 Genomic DNA Translation: DAA09753.1
PIRiS55975
RefSeqiNP_013558.3, NM_001182341.3

Genome annotation databases

EnsemblFungiiYLR453C; YLR453C; YLR453C
GeneIDi851174
KEGGisce:YLR453C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22382 Genomic DNA Translation: AAB67535.1
AY692860 Genomic DNA Translation: AAT92879.1
BK006945 Genomic DNA Translation: DAA09753.1
PIRiS55975
RefSeqiNP_013558.3, NM_001182341.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BJ1X-ray2.94A65-380[»]
4BJ5X-ray3.29A/B1-395[»]
D/F36-48[»]
4BJ6X-ray3.26A/B35-395[»]
D/F36-48[»]
ProteinModelPortaliQ06208
SMRiQ06208
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31711, 115 interactors
ComplexPortaliCPX-2112 Telosome
DIPiDIP-4290N
IntActiQ06208, 2 interactors
STRINGi4932.YLR453C

Protein family/group databases

MoonDBiQ06208 Predicted

Proteomic databases

MaxQBiQ06208
PaxDbiQ06208
PRIDEiQ06208

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR453C; YLR453C; YLR453C
GeneIDi851174
KEGGisce:YLR453C

Organism-specific databases

SGDiS000004445 RIF2

Phylogenomic databases

KOiK11119
OMAiIDHIVYF
OrthoDBiEOG092C385T

Enzyme and pathway databases

BioCyciYEAST:G3O-32506-MONOMER

Miscellaneous databases

PROiPR:Q06208

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiRIF2_YEAST
AccessioniPrimary (citable) accession number: Q06208
Secondary accession number(s): D6VZ87, E9P8Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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