UniProtKB - Q06190 (P2R3A_HUMAN)
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
PPP2R3A
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 985 – 996 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- protein-macromolecule adaptor activity Source: BHF-UCL
- protein phosphatase regulator activity Source: GO_Central
GO - Biological processi
- eye photoreceptor cell differentiation Source: BHF-UCL
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
- positive regulation of protein catabolic process Source: BHF-UCL
- protein dephosphorylation Source: UniProtKB
- regulation of cell migration involved in somitogenic axis elongation Source: BHF-UCL
- somatic muscle development Source: BHF-UCL
- somite development Source: BHF-UCL
- Wnt signaling pathway involved in somitogenesis Source: BHF-UCL
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q06190 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alphaAlternative name(s): PP2A subunit B isoform PR72/PR130 PP2A subunit B isoform R3 isoform PP2A subunit B isoforms B''-PR72/PR130 PP2A subunit B isoforms B72/B130 Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B |
Gene namesi | Name:PPP2R3A Synonyms:PPP2R3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9307, PPP2R3A |
MIMi | 604944, gene |
neXtProti | NX_Q06190 |
VEuPathDBi | HostDB:ENSG00000073711.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5523 |
OpenTargetsi | ENSG00000073711 |
PharmGKBi | PA35523 |
Miscellaneous databases
Pharosi | Q06190, Tbio |
Genetic variation databases
BioMutai | PPP2R3A |
DMDMi | 543720 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071443 | 1 – 1150 | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alphaAdd BLAST | 1150 |
Proteomic databases
EPDi | Q06190 |
jPOSTi | Q06190 |
MassIVEi | Q06190 |
MaxQBi | Q06190 |
PaxDbi | Q06190 |
PeptideAtlasi | Q06190 |
PRIDEi | Q06190 |
ProteomicsDBi | 4724 58420 [Q06190-1] 58421 [Q06190-2] |
PTM databases
iPTMneti | Q06190 |
PhosphoSitePlusi | Q06190 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000073711, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | Q06190, baseline and differential |
Genevisiblei | Q06190, HS |
Organism-specific databases
HPAi | ENSG00000073711, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Binary interactionsi
Hide detailsIsoform PR130 [Q06190-1]
With | #Exp. | IntAct |
---|---|---|
NKD1 [Q969G9] | 4 | EBI-949204,EBI-1538217 |
Isoform PR72 [Q06190-2]
With | #Exp. | IntAct |
---|---|---|
NKD1 [Q969G9] | 3 | EBI-949210,EBI-1538217 |
Protein-protein interaction databases
BioGRIDi | 111515, 38 interactors |
CORUMi | Q06190 |
DIPi | DIP-29397N |
IntActi | Q06190, 22 interactors |
MINTi | Q06190 |
STRINGi | 9606.ENSP00000264977 |
Miscellaneous databases
RNActi | Q06190, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q06190 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 758 – 793 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 972 – 1007 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 670 – 695 | Pro-richAdd BLAST | 26 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2562, Eukaryota |
GeneTreei | ENSGT00940000154659 |
HOGENOMi | CLU_276803_0_0_1 |
OMAi | HFGNDEN |
OrthoDBi | 255081at2759 |
PhylomeDBi | Q06190 |
TreeFami | TF105554 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR041534, EF-hand_13 IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF17958, EF-hand_13, 1 hit PF13499, EF-hand_7, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS
60 70 80 90 100
VCADLLHIPV SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG
110 120 130 140 150
STFQNTYNLK DIAGEAISFA SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS
160 170 180 190 200
FNRRSVDLDL LCGHYNNDGN APSFGLLRSS SVEEKPLSHR NSLDTNLTSM
210 220 230 240 250
FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS EDLKKCTDII
260 270 280 290 300
KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG
310 320 330 340 350
NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT
360 370 380 390 400
IELQNDKPNS RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM
410 420 430 440 450
NPLENVSSDD LMETLYIEEE SDGKKALDKG QKTENGPSHE LLKVNEHRAE
460 470 480 490 500
FPEHATHLKK CPTPMQNEIG KIFEKSFVNL PKEDCKSKVS KFEEGDQRDF
510 520 530 540 550
TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL NSHSQLTGQT
560 570 580 590 600
LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED
610 620 630 640 650
FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD
660 670 680 690 700
TTSAVLIQQT PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV
710 720 730 740 750
VNAPLSINIP RFYFPEGLPD TCSNHEQTLS RIETAFMDIE EQKADIYEMG
760 770 780 790 800
KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA QSFIAMWRKL LNNHHDDASK
810 820 830 840 850
FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE FHSRYITTVI
860 870 880 890 900
QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF
910 920 930 940 950
YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI
960 970 980 990 1000
QKEGRMSYAD FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF
1010 1020 1030 1040 1050
YEEQCERMEA MGIEPLPFHD LLCQMLDLVK PAVDGKITLR DLKRCRMAHI
1060 1070 1080 1090 1100
FYDTFFNLEK YLDHEQRDPF AVQKDVENDG PEPSDWDRFA AEEYETLVAE
1110 1120 1130 1140 1150
ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK CGKLQSVDEE
The sequence of this isoform differs from the canonical sequence as follows:
1-621: Missing.
622-665: MQILQETLTT...LIQQTPEVIK → MMIKETSLRR...KRLKSFQQTQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C1M1 | H7C1M1_HUMAN | Serine/threonine-protein phosphatas... | PPP2R3A | 191 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051739 | 67 | D → G. Corresponds to variant dbSNP:rs9814557Ensembl. | 1 | |
Natural variantiVAR_061760 | 67 | D → N. Corresponds to variant dbSNP:rs57374999Ensembl. | 1 | |
Natural variantiVAR_051740 | 108 | N → S. Corresponds to variant dbSNP:rs36020282Ensembl. | 1 | |
Natural variantiVAR_051741 | 171 | A → S. Corresponds to variant dbSNP:rs6779903Ensembl. | 1 | |
Natural variantiVAR_051742 | 481 | P → A. Corresponds to variant dbSNP:rs34901937Ensembl. | 1 | |
Natural variantiVAR_051743 | 642 | S → G. Corresponds to variant dbSNP:rs17197552Ensembl. | 1 | |
Natural variantiVAR_051744 | 695 | P → L. Corresponds to variant dbSNP:rs9826032Ensembl. | 1 | |
Natural variantiVAR_022095 | 745 | D → N. Corresponds to variant dbSNP:rs16843645Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045203 | 1 – 736 | Missing in isoform 3. 1 PublicationAdd BLAST | 736 | |
Alternative sequenceiVSP_005107 | 1 – 621 | Missing in isoform PR72. 2 PublicationsAdd BLAST | 621 | |
Alternative sequenceiVSP_005108 | 622 – 665 | MQILQ…PEVIK → MMIKETSLRRDPDLRGELAF LARGCDFVLPSRFKKRLKSF QQTQ in isoform PR72. 2 PublicationsAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07590 mRNA Translation: AAB02613.1 L12146 mRNA Translation: AAB02614.1 AK293012 mRNA Translation: BAF85701.1 AK298059 mRNA Translation: BAG60353.1 AK316258 mRNA Translation: BAH14629.1 AC072039 Genomic DNA No translation available. AC092991 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79122.1 CH471052 Genomic DNA Translation: EAW79123.1 AL389975 mRNA Translation: CAB97532.1 |
CCDSi | CCDS3087.1 [Q06190-1] CCDS3088.1 [Q06190-2] CCDS54642.1 [Q06190-3] |
PIRi | A47114 B47114 |
RefSeqi | NP_001177376.1, NM_001190447.1 [Q06190-3] NP_002709.2, NM_002718.4 [Q06190-1] NP_871626.1, NM_181897.2 [Q06190-2] XP_006713749.1, XM_006713686.3 [Q06190-1] XP_011511258.1, XM_011512956.2 [Q06190-1] |
Genome annotation databases
Ensembli | ENST00000264977; ENSP00000264977; ENSG00000073711 [Q06190-1] ENST00000334546; ENSP00000334748; ENSG00000073711 [Q06190-2] ENST00000490467; ENSP00000419344; ENSG00000073711 [Q06190-3] |
GeneIDi | 5523 |
KEGGi | hsa:5523 |
UCSCi | uc003eqv.3, human [Q06190-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07590 mRNA Translation: AAB02613.1 L12146 mRNA Translation: AAB02614.1 AK293012 mRNA Translation: BAF85701.1 AK298059 mRNA Translation: BAG60353.1 AK316258 mRNA Translation: BAH14629.1 AC072039 Genomic DNA No translation available. AC092991 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79122.1 CH471052 Genomic DNA Translation: EAW79123.1 AL389975 mRNA Translation: CAB97532.1 |
CCDSi | CCDS3087.1 [Q06190-1] CCDS3088.1 [Q06190-2] CCDS54642.1 [Q06190-3] |
PIRi | A47114 B47114 |
RefSeqi | NP_001177376.1, NM_001190447.1 [Q06190-3] NP_002709.2, NM_002718.4 [Q06190-1] NP_871626.1, NM_181897.2 [Q06190-2] XP_006713749.1, XM_006713686.3 [Q06190-1] XP_011511258.1, XM_011512956.2 [Q06190-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4I5J | X-ray | 2.09 | A | 786-1070 | [»] | |
4I5K | X-ray | 2.90 | A/B | 786-1070 | [»] | |
SMRi | Q06190 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111515, 38 interactors |
CORUMi | Q06190 |
DIPi | DIP-29397N |
IntActi | Q06190, 22 interactors |
MINTi | Q06190 |
STRINGi | 9606.ENSP00000264977 |
PTM databases
iPTMneti | Q06190 |
PhosphoSitePlusi | Q06190 |
Genetic variation databases
BioMutai | PPP2R3A |
DMDMi | 543720 |
Proteomic databases
EPDi | Q06190 |
jPOSTi | Q06190 |
MassIVEi | Q06190 |
MaxQBi | Q06190 |
PaxDbi | Q06190 |
PeptideAtlasi | Q06190 |
PRIDEi | Q06190 |
ProteomicsDBi | 4724 58420 [Q06190-1] 58421 [Q06190-2] |
Protocols and materials databases
Antibodypediai | 33406, 230 antibodies |
Genome annotation databases
Ensembli | ENST00000264977; ENSP00000264977; ENSG00000073711 [Q06190-1] ENST00000334546; ENSP00000334748; ENSG00000073711 [Q06190-2] ENST00000490467; ENSP00000419344; ENSG00000073711 [Q06190-3] |
GeneIDi | 5523 |
KEGGi | hsa:5523 |
UCSCi | uc003eqv.3, human [Q06190-1] |
Organism-specific databases
CTDi | 5523 |
DisGeNETi | 5523 |
GeneCardsi | PPP2R3A |
HGNCi | HGNC:9307, PPP2R3A |
HPAi | ENSG00000073711, Tissue enhanced (skeletal) |
MIMi | 604944, gene |
neXtProti | NX_Q06190 |
OpenTargetsi | ENSG00000073711 |
PharmGKBi | PA35523 |
VEuPathDBi | HostDB:ENSG00000073711.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2562, Eukaryota |
GeneTreei | ENSGT00940000154659 |
HOGENOMi | CLU_276803_0_0_1 |
OMAi | HFGNDEN |
OrthoDBi | 255081at2759 |
PhylomeDBi | Q06190 |
TreeFami | TF105554 |
Enzyme and pathway databases
PathwayCommonsi | Q06190 |
Miscellaneous databases
BioGRID-ORCSi | 5523, 7 hits in 989 CRISPR screens |
ChiTaRSi | PPP2R3A, human |
GeneWikii | PPP2R3A |
GenomeRNAii | 5523 |
Pharosi | Q06190, Tbio |
PROi | PR:Q06190 |
RNActi | Q06190, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000073711, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | Q06190, baseline and differential |
Genevisiblei | Q06190, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR041534, EF-hand_13 IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF17958, EF-hand_13, 1 hit PF13499, EF-hand_7, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P2R3A_HUMAN | |
Accessioni | Q06190Primary (citable) accession number: Q06190 Secondary accession number(s): A8KAE7 Q9NPQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references