Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: InterPro
• protein-macromolecule adaptor activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase regulator activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• eye photoreceptor cell differentiation Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: BHF-UCLInferred from genetic interactionⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of canonical Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Vredeveld L.C., Destree O., Bernards R.
    Proc. Natl. Acad. Sci. U.S.A. 103:5397-5402(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein catabolic process Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]
• protein dephosphorylation Source: UniProtKB <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform."
    Mayer R.E., Hendrix P., Cron P., Matthies R., Stone S.R., Goris J., Merlevede W., Hofsteenge J., Hemmings B.A.
    Biochemistry 30:3589-3597(1991) [PubMed] [Europe PMC] [Abstract]
• regulation of cell motility involved in somitogenic axis elongation Source: BHF-UCLInferred from genetic interactionⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]
• somatic muscle development Source: BHF-UCLInferred from genetic interactionⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]
• somite development Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Vredeveld L.C., Destree O., Bernards R.
    Proc. Natl. Acad. Sci. U.S.A. 103:5397-5402(2006) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway involved in somitogenesis Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein-macromolecule adaptor activity Source: BHF-UCLInferred from direct assayⁱ
  • "PR72, a novel regulator of Wnt signaling required for Naked cuticle function."
    Creyghton M.P., Roeel G., Eichhorn P.J.A., Hijmans E.M., Maurer I., Destree O., Bernards R.
    Genes Dev. 19:376-386(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS 
        60         70         80         90        100
VCADLLHIPV SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG 
       110        120        130        140        150
STFQNTYNLK DIAGEAISFA SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS 
       160        170        180        190        200
FNRRSVDLDL LCGHYNNDGN APSFGLLRSS SVEEKPLSHR NSLDTNLTSM 
       210        220        230        240        250
FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS EDLKKCTDII 
       260        270        280        290        300
KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG 
       310        320        330        340        350
NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT 
       360        370        380        390        400
IELQNDKPNS RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM 
       410        420        430        440        450
NPLENVSSDD LMETLYIEEE SDGKKALDKG QKTENGPSHE LLKVNEHRAE 
       460        470        480        490        500
FPEHATHLKK CPTPMQNEIG KIFEKSFVNL PKEDCKSKVS KFEEGDQRDF 
       510        520        530        540        550
TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL NSHSQLTGQT 
       560        570        580        590        600
LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED 
       610        620        630        640        650
FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD 
       660        670        680        690        700
TTSAVLIQQT PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV 
       710        720        730        740        750
VNAPLSINIP RFYFPEGLPD TCSNHEQTLS RIETAFMDIE EQKADIYEMG 
       760        770        780        790        800
KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA QSFIAMWRKL LNNHHDDASK 
       810        820        830        840        850
FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE FHSRYITTVI 
       860        870        880        890        900
QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF 
       910        920        930        940        950
YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI 
       960        970        980        990       1000
QKEGRMSYAD FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF 
      1010       1020       1030       1040       1050
YEEQCERMEA MGIEPLPFHD LLCQMLDLVK PAVDGKITLR DLKRCRMAHI 
      1060       1070       1080       1090       1100
FYDTFFNLEK YLDHEQRDPF AVQKDVENDG PEPSDWDRFA AEEYETLVAE 
      1110       1120       1130       1140       1150
ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK CGKLQSVDEE 

        10         20         30         40         50
MMIKETSLRR DPDLRGELAF LARGCDFVLP SRFKKRLKSF QQTQIQNKPE 
        60         70         80         90        100
KKPGTPLPPP ATSPSSPRPL SPVPHVNNVV NAPLSINIPR FYFPEGLPDT 
       110        120        130        140        150
CSNHEQTLSR IETAFMDIEE QKADIYEMGK IAKVCGCPLY WKAPMFRAAG 
       160        170        180        190        200
GEKTGFVTAQ SFIAMWRKLL NNHHDDASKF ICLLAKPNCS SLEQEDFIPL 
       210        220        230        240        250
LQDVVDTHPG LTFLKDAPEF HSRYITTVIQ RIFYTVNRSW SGKITSTEIR 
       260        270        280        290        300
KSNFLQTLAL LEEEEDINQI TDYFSYEHFY VIYCKFWELD TDHDLYISQA 
       310        320        330        340        350
DLSRYNDQAS SSRIIERIFS GAVTRGKTIQ KEGRMSYADF VWFLISEEDK 
       360        370        380        390        400
RNPTSIEYWF RCMDVDGDGV LSMYELEYFY EEQCERMEAM GIEPLPFHDL 
       410        420        430        440        450
LCQMLDLVKP AVDGKITLRD LKRCRMAHIF YDTFFNLEKY LDHEQRDPFA 
       460        470        480        490        500
VQKDVENDGP EPSDWDRFAA EEYETLVAEE SAQAQFQEGF EDYETDEPAS 
       510        520 
PSEFGNKSNK ILSASLPEKC GKLQSVDEE                        

        10         20         30         40         50
MDIEEQKADI YEMGKIAKVC GCPLYWKAPM FRAAGGEKTG FVTAQSFIAM 
        60         70         80         90        100
WRKLLNNHHD DASKFICLLA KPNCSSLEQE DFIPLLQDVV DTHPGLTFLK 
       110        120        130        140        150
DAPEFHSRYI TTVIQRIFYT VNRSWSGKIT STEIRKSNFL QTLALLEEEE 
       160        170        180        190        200
DINQITDYFS YEHFYVIYCK FWELDTDHDL YISQADLSRY NDQASSSRII 
       210        220        230        240        250
ERIFSGAVTR GKTIQKEGRM SYADFVWFLI SEEDKRNPTS IEYWFRCMDV 
       260        270        280        290        300
DGDGVLSMYE LEYFYEEQCE RMEAMGIEPL PFHDLLCQML DLVKPAVDGK 
       310        320        330        340        350
ITLRDLKRCR MAHIFYDTFF NLEKYLDHEQ RDPFAVQKDV ENDGPEPSDW 
       360        370        380        390        400
DRFAAEEYET LVAEESAQAQ FQEGFEDYET DEPASPSEFG NKSNKILSAS 
       410 
LPEKCGKLQS VDEE                                        

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM