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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Gene

PPP2R3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi985 – 996PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein binding, bridging Source: BHF-UCL
  • protein phosphatase regulator activity Source: ProtInc

GO - Biological processi

  • eye photoreceptor cell differentiation Source: BHF-UCL
  • negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of protein catabolic process Source: BHF-UCL
  • protein dephosphorylation Source: UniProtKB
  • regulation of cell motility involved in somitogenic axis elongation Source: BHF-UCL
  • somatic muscle development Source: BHF-UCL
  • somite development Source: BHF-UCL
  • Wnt signaling pathway involved in somitogenesis Source: BHF-UCL

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Alternative name(s):
PP2A subunit B isoform PR72/PR130
PP2A subunit B isoform R3 isoform
PP2A subunit B isoforms B''-PR72/PR130
PP2A subunit B isoforms B72/B130
Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
Gene namesi
Name:PPP2R3A
Synonyms:PPP2R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000073711.10
HGNCiHGNC:9307 PPP2R3A
MIMi604944 gene
neXtProtiNX_Q06190

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi5523
OpenTargetsiENSG00000073711
PharmGKBiPA35523

Polymorphism and mutation databases

BioMutaiPPP2R3A
DMDMi543720

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714431 – 1150Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alphaAdd BLAST1150

Proteomic databases

EPDiQ06190
MaxQBiQ06190
PaxDbiQ06190
PeptideAtlasiQ06190
PRIDEiQ06190
ProteomicsDBi58420
58421 [Q06190-2]

PTM databases

iPTMnetiQ06190
PhosphoSitePlusiQ06190

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, muscle and kidney.

Gene expression databases

BgeeiENSG00000073711
CleanExiHS_PPP2R3A
ExpressionAtlasiQ06190 baseline and differential
GenevisibleiQ06190 HS

Organism-specific databases

HPAiHPA035829
HPA035830
HPA065338

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Binary interactionsi

WithEntry#Exp.IntActNotes
NKD1Q969G94EBI-949204,EBI-1538217

GO - Molecular functioni

  • protein binding, bridging Source: BHF-UCL

Protein-protein interaction databases

BioGridi111515, 30 interactors
CORUMiQ06190
DIPiDIP-29397N
IntActiQ06190, 9 interactors
MINTiQ06190
STRINGi9606.ENSP00000264977

Structurei

Secondary structure

11150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi797 – 805Combined sources9
Beta strandi811 – 813Combined sources3
Helixi815 – 818Combined sources4
Helixi819 – 828Combined sources10
Turni830 – 832Combined sources3
Helixi833 – 837Combined sources5
Helixi839 – 857Combined sources19
Beta strandi861 – 863Combined sources3
Helixi867 – 871Combined sources5
Helixi875 – 882Combined sources8
Helixi888 – 890Combined sources3
Turni892 – 895Combined sources4
Helixi897 – 910Combined sources14
Beta strandi915 – 919Combined sources5
Helixi920 – 923Combined sources4
Turni924 – 929Combined sources6
Helixi933 – 939Combined sources7
Turni940 – 944Combined sources5
Helixi958 – 969Combined sources12
Helixi974 – 984Combined sources11
Beta strandi989 – 992Combined sources4
Helixi994 – 1010Combined sources17
Helixi1018 – 1029Combined sources12
Helixi1039 – 1045Combined sources7
Helixi1048 – 1056Combined sources9
Helixi1058 – 1062Combined sources5

3D structure databases

ProteinModelPortaliQ06190
SMRiQ06190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini758 – 793EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini972 – 1007EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi670 – 695Pro-richAdd BLAST26

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2562 Eukaryota
ENOG410XRBK LUCA
GeneTreeiENSGT00530000063265
HOGENOMiHOG000013216
HOVERGENiHBG000013
KOiK11583
OMAiSCLTRII
OrthoDBiEOG091G03UQ
PhylomeDBiQ06190
TreeFamiTF105554

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PR130 (identifier: Q06190-1) [UniParc]FASTAAdd to basket
Also known as: 130 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS
60 70 80 90 100
VCADLLHIPV SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG
110 120 130 140 150
STFQNTYNLK DIAGEAISFA SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS
160 170 180 190 200
FNRRSVDLDL LCGHYNNDGN APSFGLLRSS SVEEKPLSHR NSLDTNLTSM
210 220 230 240 250
FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS EDLKKCTDII
260 270 280 290 300
KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG
310 320 330 340 350
NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT
360 370 380 390 400
IELQNDKPNS RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM
410 420 430 440 450
NPLENVSSDD LMETLYIEEE SDGKKALDKG QKTENGPSHE LLKVNEHRAE
460 470 480 490 500
FPEHATHLKK CPTPMQNEIG KIFEKSFVNL PKEDCKSKVS KFEEGDQRDF
510 520 530 540 550
TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL NSHSQLTGQT
560 570 580 590 600
LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED
610 620 630 640 650
FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD
660 670 680 690 700
TTSAVLIQQT PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV
710 720 730 740 750
VNAPLSINIP RFYFPEGLPD TCSNHEQTLS RIETAFMDIE EQKADIYEMG
760 770 780 790 800
KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA QSFIAMWRKL LNNHHDDASK
810 820 830 840 850
FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE FHSRYITTVI
860 870 880 890 900
QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF
910 920 930 940 950
YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI
960 970 980 990 1000
QKEGRMSYAD FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF
1010 1020 1030 1040 1050
YEEQCERMEA MGIEPLPFHD LLCQMLDLVK PAVDGKITLR DLKRCRMAHI
1060 1070 1080 1090 1100
FYDTFFNLEK YLDHEQRDPF AVQKDVENDG PEPSDWDRFA AEEYETLVAE
1110 1120 1130 1140 1150
ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK CGKLQSVDEE
Length:1,150
Mass (Da):130,278
Last modified:June 1, 1994 - v1
Checksum:i97A31BA4206518A3
GO
Isoform PR72 (identifier: Q06190-2) [UniParc]FASTAAdd to basket
Also known as: 72 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.
     622-665: MQILQETLTT...LIQQTPEVIK → MMIKETSLRR...KRLKSFQQTQ

Show »
Length:529
Mass (Da):61,097
Checksum:i3782D0D800A5F6D4
GO
Isoform 3 (identifier: Q06190-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-736: Missing.

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):48,178
Checksum:i3F0B982FF10C8AD9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05173967D → G. Corresponds to variant dbSNP:rs9814557Ensembl.1
Natural variantiVAR_06176067D → N. Corresponds to variant dbSNP:rs57374999Ensembl.1
Natural variantiVAR_051740108N → S. Corresponds to variant dbSNP:rs36020282Ensembl.1
Natural variantiVAR_051741171A → S. Corresponds to variant dbSNP:rs6779903Ensembl.1
Natural variantiVAR_051742481P → A. Corresponds to variant dbSNP:rs34901937Ensembl.1
Natural variantiVAR_051743642S → G. Corresponds to variant dbSNP:rs17197552Ensembl.1
Natural variantiVAR_051744695P → L. Corresponds to variant dbSNP:rs9826032Ensembl.1
Natural variantiVAR_022095745D → N. Corresponds to variant dbSNP:rs16843645Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452031 – 736Missing in isoform 3. 1 PublicationAdd BLAST736
Alternative sequenceiVSP_0051071 – 621Missing in isoform PR72. 2 PublicationsAdd BLAST621
Alternative sequenceiVSP_005108622 – 665MQILQ…PEVIK → MMIKETSLRRDPDLRGELAF LARGCDFVLPSRFKKRLKSF QQTQ in isoform PR72. 2 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07590 mRNA Translation: AAB02613.1
L12146 mRNA Translation: AAB02614.1
AK293012 mRNA Translation: BAF85701.1
AK298059 mRNA Translation: BAG60353.1
AK316258 mRNA Translation: BAH14629.1
AC072039 Genomic DNA No translation available.
AC092991 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79122.1
CH471052 Genomic DNA Translation: EAW79123.1
AL389975 mRNA Translation: CAB97532.1
CCDSiCCDS3087.1 [Q06190-1]
CCDS3088.1 [Q06190-2]
CCDS54642.1 [Q06190-3]
PIRiA47114
B47114
RefSeqiNP_001177376.1, NM_001190447.1 [Q06190-3]
NP_002709.2, NM_002718.4 [Q06190-1]
NP_871626.1, NM_181897.2 [Q06190-2]
XP_006713749.1, XM_006713686.3 [Q06190-1]
XP_011511258.1, XM_011512956.2 [Q06190-1]
UniGeneiHs.518155

Genome annotation databases

EnsembliENST00000264977; ENSP00000264977; ENSG00000073711 [Q06190-1]
ENST00000334546; ENSP00000334748; ENSG00000073711 [Q06190-2]
ENST00000490467; ENSP00000419344; ENSG00000073711 [Q06190-3]
GeneIDi5523
KEGGihsa:5523
UCSCiuc003eqv.3 human [Q06190-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP2R3A_HUMAN
AccessioniPrimary (citable) accession number: Q06190
Secondary accession number(s): A8KAE7
, B4DNU1, B7ZAE3, Q06189, Q9NPQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 18, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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