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UniProtKB - Q06190 (P2R3A_HUMAN)

Entry version 187 (07 Apr 2021)
Sequence version 1 (01 Jun 1994)
Previous versions | rss
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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Gene

PPP2R3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi985 – 996PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q06190

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Alternative name(s):
PP2A subunit B isoform PR72/PR130
PP2A subunit B isoform R3 isoform
PP2A subunit B isoforms B''-PR72/PR130
PP2A subunit B isoforms B72/B130
Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP2R3A
Synonyms:PPP2R3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9307, PPP2R3A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604944, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q06190

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000073711.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5523

Open Targets

More...OpenTargetsi		ENSG00000073711

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35523

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q06190, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP2R3A

Domain mapping of disease mutations (DMDM)

More...DMDMi		543720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714431 – 1150Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alphaAdd BLAST1150

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q06190

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q06190

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q06190

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q06190

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06190

PeptideAtlas

More...PeptideAtlasi		Q06190

PRoteomics IDEntifications database

More...PRIDEi		Q06190

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4724
58420 [Q06190-1]
58421 [Q06190-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q06190

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q06190

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, placenta, lung, muscle and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000073711, Expressed in biceps brachii and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q06190, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q06190, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000073711, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111515, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q06190

Database of interacting proteins

More...DIPi		DIP-29397N

Protein interaction database and analysis system

More...IntActi		Q06190, 22 interactors

Molecular INTeraction database

More...MINTi		Q06190

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264977

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q06190, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q06190

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini758 – 793EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini972 – 1007EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi670 – 695Pro-richAdd BLAST26

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2562, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154659

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_276803_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		HFGNDEN

Database of Orthologous Groups

More...OrthoDBi		255081at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q06190

TreeFam database of animal gene trees

More...TreeFami		TF105554

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR041534, EF-hand_13
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17958, EF-hand_13, 1 hit
PF13499, EF-hand_7, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform PR130 (identifier: Q06190-1) [UniParc]FASTAAdd to basket
Also known as: 130 kDa

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS 
        60         70         80         90        100
VCADLLHIPV SQFKDADLNS MFLPHENGLS SAEGDYPQQA FTGIPRVKRG 
       110        120        130        140        150
STFQNTYNLK DIAGEAISFA SGKIKEFSFE KLKNSNHAAY RKGRKVKSDS 
       160        170        180        190        200
FNRRSVDLDL LCGHYNNDGN APSFGLLRSS SVEEKPLSHR NSLDTNLTSM 
       210        220        230        240        250
FLQNFSEEDL VTQILEKHKI DNFSSGTDIK MCLDILLKCS EDLKKCTDII 
       260        270        280        290        300
KQCIKKKSGS SISEGSGNDT ISSSETVYMN VMTRLASYLK KLPFEFMQSG 
       310        320        330        340        350
NNEALDLTEL ISNMPSLQLT PFSPVFGTEQ PPKYEDVVQL SASDSGRFQT 
       360        370        380        390        400
IELQNDKPNS RKMDTVQSIP NNSTNSLYNL EVNDPRTLKA VQVQSQSLTM 
       410        420        430        440        450
NPLENVSSDD LMETLYIEEE SDGKKALDKG QKTENGPSHE LLKVNEHRAE 
       460        470        480        490        500
FPEHATHLKK CPTPMQNEIG KIFEKSFVNL PKEDCKSKVS KFEEGDQRDF 
       510        520        530        540        550
TNSSSQEEID KLLMDLESFS QKMETSLREP LAKGKNSNFL NSHSQLTGQT 
       560        570        580        590        600
LVDLEPKSKV SSPIEKVSPS CLTRIIETNG HKIEEEDRAL LLRILESIED 
       610        620        630        640        650
FAQELVECKS SRGSLSQEKE MMQILQETLT TSSQANLSVC RSPVGDKAKD 
       660        670        680        690        700
TTSAVLIQQT PEVIKIQNKP EKKPGTPLPP PATSPSSPRP LSPVPHVNNV 
       710        720        730        740        750
VNAPLSINIP RFYFPEGLPD TCSNHEQTLS RIETAFMDIE EQKADIYEMG 
       760        770        780        790        800
KIAKVCGCPL YWKAPMFRAA GGEKTGFVTA QSFIAMWRKL LNNHHDDASK 
       810        820        830        840        850
FICLLAKPNC SSLEQEDFIP LLQDVVDTHP GLTFLKDAPE FHSRYITTVI 
       860        870        880        890        900
QRIFYTVNRS WSGKITSTEI RKSNFLQTLA LLEEEEDINQ ITDYFSYEHF 
       910        920        930        940        950
YVIYCKFWEL DTDHDLYISQ ADLSRYNDQA SSSRIIERIF SGAVTRGKTI 
       960        970        980        990       1000
QKEGRMSYAD FVWFLISEED KRNPTSIEYW FRCMDVDGDG VLSMYELEYF 
      1010       1020       1030       1040       1050
YEEQCERMEA MGIEPLPFHD LLCQMLDLVK PAVDGKITLR DLKRCRMAHI 
      1060       1070       1080       1090       1100
FYDTFFNLEK YLDHEQRDPF AVQKDVENDG PEPSDWDRFA AEEYETLVAE 
      1110       1120       1130       1140       1150
ESAQAQFQEG FEDYETDEPA SPSEFGNKSN KILSASLPEK CGKLQSVDEE
Length:1,150
Mass (Da):130,278
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97A31BA4206518A3
GO
Isoform PR72 (identifier: Q06190-2) [UniParc]FASTAAdd to basket
Also known as: 72 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.
     622-665: MQILQETLTT...LIQQTPEVIK → MMIKETSLRR...KRLKSFQQTQ

Show »
Length:529
Mass (Da):61,097
Checksum:i3782D0D800A5F6D4
GO
Isoform 3 (identifier: Q06190-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-736: Missing.

Show »
Length:414
Mass (Da):48,178
Checksum:i3F0B982FF10C8AD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1M1H7C1M1_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3A
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05173967D → G. Corresponds to variant dbSNP:rs9814557Ensembl.1
Natural variantiVAR_06176067D → N. Corresponds to variant dbSNP:rs57374999Ensembl.1
Natural variantiVAR_051740108N → S. Corresponds to variant dbSNP:rs36020282Ensembl.1
Natural variantiVAR_051741171A → S. Corresponds to variant dbSNP:rs6779903Ensembl.1
Natural variantiVAR_051742481P → A. Corresponds to variant dbSNP:rs34901937Ensembl.1
Natural variantiVAR_051743642S → G. Corresponds to variant dbSNP:rs17197552Ensembl.1
Natural variantiVAR_051744695P → L. Corresponds to variant dbSNP:rs9826032Ensembl.1
Natural variantiVAR_022095745D → N. Corresponds to variant dbSNP:rs16843645Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452031 – 736Missing in isoform 3. 1 PublicationAdd BLAST736
Alternative sequenceiVSP_0051071 – 621Missing in isoform PR72. 2 PublicationsAdd BLAST621
Alternative sequenceiVSP_005108622 – 665MQILQ…PEVIK → MMIKETSLRRDPDLRGELAF LARGCDFVLPSRFKKRLKSF QQTQ in isoform PR72. 2 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L07590 mRNA Translation: AAB02613.1
L12146 mRNA Translation: AAB02614.1
AK293012 mRNA Translation: BAF85701.1
AK298059 mRNA Translation: BAG60353.1
AK316258 mRNA Translation: BAH14629.1
AC072039 Genomic DNA No translation available.
AC092991 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79122.1
CH471052 Genomic DNA Translation: EAW79123.1
AL389975 mRNA Translation: CAB97532.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3087.1 [Q06190-1]
CCDS3088.1 [Q06190-2]
CCDS54642.1 [Q06190-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A47114
B47114

NCBI Reference Sequences

More...RefSeqi		NP_001177376.1, NM_001190447.1 [Q06190-3]
NP_002709.2, NM_002718.4 [Q06190-1]
NP_871626.1, NM_181897.2 [Q06190-2]
XP_006713749.1, XM_006713686.3 [Q06190-1]
XP_011511258.1, XM_011512956.2 [Q06190-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264977; ENSP00000264977; ENSG00000073711 [Q06190-1]
ENST00000334546; ENSP00000334748; ENSG00000073711 [Q06190-2]
ENST00000490467; ENSP00000419344; ENSG00000073711 [Q06190-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5523

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5523

UCSC genome browser

More...UCSCi		uc003eqv.3, human [Q06190-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07590 mRNA Translation: AAB02613.1
L12146 mRNA Translation: AAB02614.1
AK293012 mRNA Translation: BAF85701.1
AK298059 mRNA Translation: BAG60353.1
AK316258 mRNA Translation: BAH14629.1
AC072039 Genomic DNA No translation available.
AC092991 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79122.1
CH471052 Genomic DNA Translation: EAW79123.1
AL389975 mRNA Translation: CAB97532.1
CCDSiCCDS3087.1 [Q06190-1]
CCDS3088.1 [Q06190-2]
CCDS54642.1 [Q06190-3]
PIRiA47114
B47114
RefSeqiNP_001177376.1, NM_001190447.1 [Q06190-3]
NP_002709.2, NM_002718.4 [Q06190-1]
NP_871626.1, NM_181897.2 [Q06190-2]
XP_006713749.1, XM_006713686.3 [Q06190-1]
XP_011511258.1, XM_011512956.2 [Q06190-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I5JX-ray2.09A786-1070[»]
4I5KX-ray2.90A/B786-1070[»]
SMRiQ06190
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111515, 38 interactors
CORUMiQ06190
DIPiDIP-29397N
IntActiQ06190, 22 interactors
MINTiQ06190
STRINGi9606.ENSP00000264977

PTM databases

iPTMnetiQ06190
PhosphoSitePlusiQ06190

Genetic variation databases

BioMutaiPPP2R3A
DMDMi543720

Proteomic databases

EPDiQ06190
jPOSTiQ06190
MassIVEiQ06190
MaxQBiQ06190
PaxDbiQ06190
PeptideAtlasiQ06190
PRIDEiQ06190
ProteomicsDBi4724
58420 [Q06190-1]
58421 [Q06190-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33406, 230 antibodies

Genome annotation databases

EnsembliENST00000264977; ENSP00000264977; ENSG00000073711 [Q06190-1]
ENST00000334546; ENSP00000334748; ENSG00000073711 [Q06190-2]
ENST00000490467; ENSP00000419344; ENSG00000073711 [Q06190-3]
GeneIDi5523
KEGGihsa:5523
UCSCiuc003eqv.3, human [Q06190-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5523
DisGeNETi5523

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP2R3A
HGNCiHGNC:9307, PPP2R3A
HPAiENSG00000073711, Tissue enhanced (skeletal)
MIMi604944, gene
neXtProtiNX_Q06190
OpenTargetsiENSG00000073711
PharmGKBiPA35523
VEuPathDBiHostDB:ENSG00000073711.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2562, Eukaryota
GeneTreeiENSGT00940000154659
HOGENOMiCLU_276803_0_0_1
OMAiHFGNDEN
OrthoDBi255081at2759
PhylomeDBiQ06190
TreeFamiTF105554

Enzyme and pathway databases

PathwayCommonsiQ06190

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5523, 7 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPP2R3A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PPP2R3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5523
PharosiQ06190, Tbio

Protein Ontology

More...PROi		PR:Q06190
RNActiQ06190, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000073711, Expressed in biceps brachii and 249 other tissues
ExpressionAtlasiQ06190, baseline and differential
GenevisibleiQ06190, HS

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR041534, EF-hand_13
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
PfamiView protein in Pfam
PF17958, EF-hand_13, 1 hit
PF13499, EF-hand_7, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2R3A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06190
Secondary accession number(s): A8KAE7
, B4DNU1, B7ZAE3, Q06189, Q9NPQ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 7, 2021
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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