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Protein

ATP synthase subunit e, mitochondrial

Gene

Atp5me

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit e, mitochondrialCurated
Short name:
ATPase subunit e
Alternative name(s):
ATP synthase membrane subunit eCurated
Gene namesi
Name:Atp5meBy similarity
Synonyms:Atp5i, Atp5k, Lfm-1, Lfm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:106636 Atp5k

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000716852 – 71ATP synthase subunit e, mitochondrialAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysineCombined sources1
Modified residuei68PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ06185
MaxQBiQ06185
PaxDbiQ06185
PeptideAtlasiQ06185
PRIDEiQ06185
TopDownProteomicsiQ06185

PTM databases

iPTMnetiQ06185
PhosphoSitePlusiQ06185

Expressioni

Tissue specificityi

Mammary gland, liver, kidney, heart, spleen, brain and lung.

Gene expression databases

BgeeiENSMUSG00000050856
ExpressionAtlasiQ06185 baseline and differential
GenevisibleiQ06185 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198259, 3 interactors
IntActiQ06185, 2 interactors
MINTiQ06185
STRINGi10090.ENSMUSP00000051222

Structurei

3D structure databases

ProteinModelPortaliQ06185
SMRiQ06185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase e subunit family.Curated

Phylogenomic databases

eggNOGiKOG4326 Eukaryota
ENOG410XYSS LUCA
GeneTreeiENSGT00390000005102
HOGENOMiHOG000231826
HOVERGENiHBG050613
InParanoidiQ06185
KOiK02129
OMAiEQERIYK
OrthoDBiEOG091G13NK
PhylomeDBiQ06185
TreeFamiTF314719

Family and domain databases

InterProiView protein in InterPro
IPR008386 ATP_synth_F0_esu_mt
PANTHERiPTHR12427 PTHR12427, 1 hit
PfamiView protein in Pfam
PF05680 ATP-synt_E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPPVQVSPL IKFGRYSALI IGMAYGAKRY SYLKPRAEEE RRIAAEEKKR
60 70
LDELKRIERE LAEAQDDSIL K
Length:71
Mass (Da):8,236
Last modified:January 23, 2007 - v2
Checksum:i0379C3E14C098F12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13F → S in AAC52713 (PubMed:8702853).Curated1
Sequence conflicti48K → R in AAC52713 (PubMed:8702853).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S52977 mRNA Translation: AAB24947.1
U59283 Genomic DNA Translation: AAC52713.1
BC028438 mRNA Translation: AAH28438.1
CCDSiCCDS39204.1
PIRiJC1412
RefSeqiNP_031533.2, NM_007507.2
UniGeneiMm.136093

Genome annotation databases

EnsembliENSMUST00000049628; ENSMUSP00000051222; ENSMUSG00000050856
GeneIDi11958
KEGGimmu:11958
UCSCiuc008yoa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATP5I_MOUSE
AccessioniPrimary (citable) accession number: Q06185
Secondary accession number(s): P70342
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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