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Protein

Proheparin-binding EGF-like growth factor

Gene

Hbegf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).By similarity

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD
  • heparin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Heparin-binding

Enzyme and pathway databases

ReactomeiR-RNO-1227986 Signaling by ERBB2
R-RNO-1236394 Signaling by ERBB4
R-RNO-1250196 SHC1 events in ERBB2 signaling
R-RNO-1250342 PI3K events in ERBB4 signaling
R-RNO-1250347 SHC1 events in ERBB4 signaling
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-1963640 GRB2 events in ERBB2 signaling
R-RNO-1963642 PI3K events in ERBB2 signaling
R-RNO-2179392 EGFR Transactivation by Gastrin
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6785631 ERBB2 Regulates Cell Motility
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8847993 ERBB2 Activates PTK6 Signaling
R-RNO-8857538 PTK6 promotes HIF1A stabilization
R-RNO-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Proheparin-binding EGF-like growth factor
Cleaved into the following chain:
Heparin-binding EGF-like growth factor
Short name:
HB-EGF
Short name:
HBEGF
Gene namesi
Name:Hbegf
Synonyms:Dtr, Hegfl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi2526 Hbegf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 160ExtracellularSequence analysisAdd BLAST137
Transmembranei161 – 184HelicalSequence analysisAdd BLAST24
Topological domaini185 – 208CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000030280624 – 208Proheparin-binding EGF-like growth factorAdd BLAST185
PropeptideiPRO_000000762024 – 62By similarityAdd BLAST39
ChainiPRO_000000762163 – 148Heparin-binding EGF-like growth factorAdd BLAST86
PropeptideiPRO_0000007622149 – 208C-terminalSequence analysisAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi108 ↔ 121PROSITE-ProRule annotation
Disulfide bondi116 ↔ 132PROSITE-ProRule annotation
Disulfide bondi134 ↔ 143PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ06175
PRIDEiQ06175

Expressioni

Tissue specificityi

Most abundant in skeletal muscle, lung, spleen brain and heart.1 Publication

Gene expression databases

BgeeiENSRNOG00000018646 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ06175 RN

Interactioni

Subunit structurei

Interacts with FBLN1. Interacts with EGFR and ERBB4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025157

Structurei

3D structure databases

ProteinModelPortaliQ06175
SMRiQ06175
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 144EGF-likePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMHM Eukaryota
ENOG41120D3 LUCA
GeneTreeiENSGT00530000063708
HOGENOMiHOG000026782
HOVERGENiHBG053952
InParanoidiQ06175
KOiK08523
OMAiYSYDHTT
OrthoDBiEOG091G0RK4
PhylomeDBiQ06175

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06175-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAATSNP DPPTGTTNQL
60 70 80 90 100
LPTGADRAQE VQDLEGTDLD LFKVAFSSKP QALATPGKEK NGKKKRKGKG
110 120 130 140 150
LGKKRDPCLK KYKDYCIHGE CRYLKELRIP SCHCLPGYHG QRCHGLTLPV
160 170 180 190 200
ENPLYTYDHT TVLAVVAVVL SSVCLLVIVG LLMFRYHRRG GYDLESEEKV

KLGMASSH
Length:208
Mass (Da):22,843
Last modified:February 1, 1995 - v1
Checksum:iDDBD045E116D064C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05489 mRNA Translation: AAA81780.1
PIRiJC1409
RefSeqiNP_037077.1, NM_012945.1
UniGeneiRn.10148

Genome annotation databases

EnsembliENSRNOT00000025157; ENSRNOP00000025157; ENSRNOG00000018646
GeneIDi25433
KEGGirno:25433
UCSCiRGD:2526 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05489 mRNA Translation: AAA81780.1
PIRiJC1409
RefSeqiNP_037077.1, NM_012945.1
UniGeneiRn.10148

3D structure databases

ProteinModelPortaliQ06175
SMRiQ06175
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025157

Proteomic databases

PaxDbiQ06175
PRIDEiQ06175

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025157; ENSRNOP00000025157; ENSRNOG00000018646
GeneIDi25433
KEGGirno:25433
UCSCiRGD:2526 rat

Organism-specific databases

CTDi1839
RGDi2526 Hbegf

Phylogenomic databases

eggNOGiENOG410IMHM Eukaryota
ENOG41120D3 LUCA
GeneTreeiENSGT00530000063708
HOGENOMiHOG000026782
HOVERGENiHBG053952
InParanoidiQ06175
KOiK08523
OMAiYSYDHTT
OrthoDBiEOG091G0RK4
PhylomeDBiQ06175

Enzyme and pathway databases

ReactomeiR-RNO-1227986 Signaling by ERBB2
R-RNO-1236394 Signaling by ERBB4
R-RNO-1250196 SHC1 events in ERBB2 signaling
R-RNO-1250342 PI3K events in ERBB4 signaling
R-RNO-1250347 SHC1 events in ERBB4 signaling
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-1963640 GRB2 events in ERBB2 signaling
R-RNO-1963642 PI3K events in ERBB2 signaling
R-RNO-2179392 EGFR Transactivation by Gastrin
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6785631 ERBB2 Regulates Cell Motility
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8847993 ERBB2 Activates PTK6 Signaling
R-RNO-8857538 PTK6 promotes HIF1A stabilization
R-RNO-8863795 Downregulation of ERBB2 signaling

Miscellaneous databases

PROiPR:Q06175

Gene expression databases

BgeeiENSRNOG00000018646 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ06175 RN

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBEGF_RAT
AccessioniPrimary (citable) accession number: Q06175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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