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Entry version 129 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

E3 ubiquitin-protein ligase substrate receptor MMS22

Gene

MMS22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-MMS22). RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition.8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32404-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase substrate receptor MMS22
Alternative name(s):
Methyl methanesulfonate-sensitivity protein 22
Synthetically lethal with MCM10 protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MMS22
Synonyms:SLM2
Ordered Locus Names:YLR320W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YLR320W

Saccharomyces Genome Database

More...
SGDi
S000004312 MMS22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002578211 – 1454E3 ubiquitin-protein ligase substrate receptor MMS22Add BLAST1454

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06164

PRoteomics IDEntifications database

More...
PRIDEi
Q06164

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a cullin-RING ligase (CRL) composed of 4 subunits: the RING protein HRT1, the cullin RTT101, a linker protein MMS1, and the substrate receptor MMS22. This complex further interacts with RTT107 and CTF4 to form RTT101-MMS1-MMS22-RTT107 and RTT101-MMS1-MMS22-CTF4 complexes respectively.

Interacts (via C-ter) with MMS1 (via N-ter).

Interacts with RTT107.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31584, 1072 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1157 CUL8-MMS1-MMS22-ESC4 E3 ubiquitin ligase complex
CPX-1165 CUL8-MMS1-MMS22-CTF4 E3 ubiquitin ligase complex

Database of interacting proteins

More...
DIPi
DIP-6567N

Protein interaction database and analysis system

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IntActi
Q06164, 15 interactors

Molecular INTeraction database

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MINTi
Q06164

STRING: functional protein association networks

More...
STRINGi
4932.YLR320W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q06164

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1201 – 1454Required for interaction with MMS1Add BLAST254

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MMS22 family.Curated

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06164

Identification of Orthologs from Complete Genome Data

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OMAi
IHFYQIA

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019021 Mms22
IPR013220 Mms22_budding_yeast

The PANTHER Classification System

More...
PANTHERi
PTHR28122 PTHR28122, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09462 Mus7, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF007808 MMS22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06164-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVDEPNPIV ISDSEATDEE ISIIYEPEFN ENYLWAEENV QEASRSQKIV
60 70 80 90 100
TERLSLDSTA GESCTPSVVT DTQVTTGLRW SLRKRKAIQK MPYSLERIKH
110 120 130 140 150
RQLLEGYDIS SFDSISNQLT LPKNASTVIH SNDILLTKRT GKPLDEQKDV
160 170 180 190 200
TIDSIKPENS SVQSQRYDSD EEIPKKRHRT FKDLDQDIVF QSGDSTEDEQ
210 220 230 240 250
DLASTNLQNT QNDEVIFRGR VLNVRTGYRG VLPRVAWEKS LQKQQSSKVT
260 270 280 290 300
KRKTQLLNHK GVAKRKMNRS AHIEDEEQNL LNDLIAPDDE LDIEENAPPD
310 320 330 340 350
IYLGNLPEDR EANEKELKEL QEYYESKYSE DAQSAGTSGF NLNEEYRNEP
360 370 380 390 400
VYELEYDGPG SCISHVSYKD QPIIYLNSRH SDSGFSEQYN ISAEDNQSVI
410 420 430 440 450
SLDAAEEHND GIIDKMLVKP KRIKATNDAN FLNTKSKRVR RYKYKYRNSC
460 470 480 490 500
LAPSTKAIKV GKRSAHKSHL AANNPVSFVS KKNHVIDDYF FEELESQSLE
510 520 530 540 550
QDDSSSLKPQ KKRRKKKAPI YSSFSADLES RRKPVFNTVV EVPTNRYAFT
560 570 580 590 600
KPNVRNRDSI NHDMEFEEED SNQELGPIMV VLDSILLKKP FEPPNFFKIQ
610 620 630 640 650
LSDKSFLLSK LNPADIATSL QKIFRVIIDK GITDTELVHF NESLIAFLVH
660 670 680 690 700
LDMPELFDLI GEFHREFRSK VNSLRKKAKP IHFFQIAACQ LMFLEISRYN
710 720 730 740 750
KISAAAKFDM DVKLLDHIVS FFKLLSVCYD SVMKNPMQYL YTSYYILSAV
760 770 780 790 800
VDVIHKKEAL WDLFQKHPFS PHISLLLVNI FPTKVCRWQV LRLDSEFQPL
810 820 830 840 850
SSAFRFINYC IETCNWNVTN SLILSLDRIF KRRRFSDFEE ESDLSQNNKI
860 870 880 890 900
IYPPTNQLTS RLMFNRYLHL LTLCELSSSD TQRVIPMGDI SMNDSLSVLK
910 920 930 940 950
NRLNLLIVLA TRFDLNLEKR FQELTRPLYS KEYLNLHTQN TVRTITTLIM
960 970 980 990 1000
QASLSFLEIS RIKNHPFSGK FIASLFDKLV LQQPSISGVT ENFLKEFTNL
1010 1020 1030 1040 1050
VSKMKRKSVS MLKFLYPSLV AMSQENIFES SFFLLLQVYL KSLDVLGPTW
1060 1070 1080 1090 1100
VQNYLFQFIK SKAQENERWI ECYCQIGKFL VDSGIFTWWT FFTYNGLDAA
1110 1120 1130 1140 1150
LHFQLAFHSL IIDFCDTDSF ELLKKPLYSI ASDLLLISKD DAFYHFLSNL
1160 1170 1180 1190 1200
LKRAHIIVAD LKPVSDENEL LRLAYIFSKA LKKNAYQDLL AVFLSLAKKH
1210 1220 1230 1240 1250
YDEGDISRNF LAKYLEFLNK NCLTELRNNQ LFISLRRELG ISSDEDEKCA
1260 1270 1280 1290 1300
FWDSFNEAGD ILSKAAFVET GIVQACCTGN EIDGYLDNLS TLFTSTMLES
1310 1320 1330 1340 1350
PFAFFSDLVI AHIFENRPFF DVNIKNFLLS HFIDLFNKVL KMKFEQVSPD
1360 1370 1380 1390 1400
EFAELCKVYR ALCIECATDD TFNSNSDLIA AKDAFLVSVL RIADGFWEHD
1410 1420 1430 1440 1450
KLLQLRMLDS NMNIPNQIPH TTLQSSLSAI VIKIIESNIG KIEASEPFKT

FKNT
Length:1,454
Mass (Da):167,683
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE9797D4A12A7488
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U20618 Genomic DNA Translation: AAB64521.1
BK006945 Genomic DNA Translation: DAA09629.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53398

NCBI Reference Sequences

More...
RefSeqi
NP_013424.1, NM_001182209.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR320W_mRNA; YLR320W; YLR320W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR320W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20618 Genomic DNA Translation: AAB64521.1
BK006945 Genomic DNA Translation: DAA09629.1
PIRiS53398
RefSeqiNP_013424.1, NM_001182209.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6J0XX-ray2.31E/F/G/H22-37[»]
SMRiQ06164
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi31584, 1072 interactors
ComplexPortaliCPX-1157 CUL8-MMS1-MMS22-ESC4 E3 ubiquitin ligase complex
CPX-1165 CUL8-MMS1-MMS22-CTF4 E3 ubiquitin ligase complex
DIPiDIP-6567N
IntActiQ06164, 15 interactors
MINTiQ06164
STRINGi4932.YLR320W

Proteomic databases

PaxDbiQ06164
PRIDEiQ06164

Genome annotation databases

EnsemblFungiiYLR320W_mRNA; YLR320W; YLR320W
GeneIDi851030
KEGGisce:YLR320W

Organism-specific databases

EuPathDBiFungiDB:YLR320W
SGDiS000004312 MMS22

Phylogenomic databases

InParanoidiQ06164
OMAiIHFYQIA

Enzyme and pathway databases

BioCyciYEAST:G3O-32404-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06164

Family and domain databases

InterProiView protein in InterPro
IPR019021 Mms22
IPR013220 Mms22_budding_yeast
PANTHERiPTHR28122 PTHR28122, 4 hits
PfamiView protein in Pfam
PF09462 Mus7, 1 hit
PIRSFiPIRSF007808 MMS22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMS22_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06164
Secondary accession number(s): D6VYW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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