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Protein

Condensin complex subunit 1

Gene

YCS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.1 Publication

Miscellaneous

Present with 2540 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32371-MONOMER
ReactomeiR-SCE-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 1
Alternative name(s):
XCAP-D2 homolog
Gene namesi
Name:YCS4
Synonyms:LOC7
Ordered Locus Names:YLR272C
ORF Names:L8479.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR272C
SGDiS000004262 YCS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950461 – 1176Condensin complex subunit 1Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei464PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ06156
PaxDbiQ06156
PRIDEiQ06156

PTM databases

CarbonylDBiQ06156
iPTMnetiQ06156

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31539, 235 interactors
ComplexPortaliCPX-1869 Nuclear condensin complex
IntActiQ06156, 9 interactors
MINTiQ06156
STRINGi4932.YLR272C

Structurei

3D structure databases

ProteinModelPortaliQ06156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CND1 (condensin subunit 1) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000017108
HOGENOMiHOG000193429
InParanoidiQ06156
KOiK06677
OMAiHLDGENY
OrthoDBiEOG092C07CA

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N
PANTHERiPTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 2 hits
PF12922 Cnd1_N, 1 hit
PIRSFiPIRSF017127 Condensin_D2, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequencei

Sequence statusi: Complete.

Q06156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGFSLSEYL TKFQTTDRES YPRLQDPSRE LNVIIDQLAV SPEQIDASPD
60 70 80 90 100
SLEALIDLCH DFPHLTPKLQ TQLSYLISSS LSNLSKDIKA NLSSNVNFTE
110 120 130 140 150
IGGLIPQWKR HLEEYGYLIQ VLLTFLQDEL HKVSSQSTNL NRSAKNSKND
160 170 180 190 200
SANVELFKRD CNQMENLLES ITKLLEINLS KIFQTTPEKD LFIGLFTRPL
210 220 230 240 250
FVLLEIEPVT KVSSLKMFIQ RILAMCVKNH GQSSSIQSSL MTNLTYFLHL
260 270 280 290 300
SVFNAELLKL LNDEYNYPQL TEDILKEIST RVFNAKDTTG PKAISNFLIK
310 320 330 340 350
LSELSPGIML RQMNLVITLL NNSSITLRCS VVEACGNIVA ELAQDPQTME
360 370 380 390 400
HYKQQIAVLI ELLEERFQDS NPYVRTKAIQ GCSKICDLSS KFNKSKAKFT
410 420 430 440 450
SLAVRSLQDR SSLVRRNSVK LLSKLLLKHP FKAIHGSQLR LSEWEEYLKG
460 470 480 490 500
SESQLNSTLK KVESQETLND TIERSLIEEE VEQDEGQCRT ELEGSFNKSA
510 520 530 540 550
ELSRIENEVE NINATNTSVL MKLKLMIVYY KDAISFIKEI HKSIELISNL
560 570 580 590 600
LFSKNRNEVL ESMDFLVLAD AFDIELSEFG IKKMLHLVWM KGTNDEGTSI
610 620 630 640 650
SVHLIECYKQ LFLTAPDSCN MQEKAAHIAK NLINLSIGAS IADLASLEQL
660 670 680 690 700
LGMMYEQKLI DQHVINILWA IYNSASKASM QKEQNVNNRD SEKGFSKEQI
710 720 730 740 750
HGSIIILGML SLADNEIALK GLESLLNIGL GAVGLKDLTL CRYSCLALER
760 770 780 790 800
MVPKRSTIIT KAINQELEDV AVKKLYAIII NYTKDNEYYP MCEQALSALF
810 820 830 840 850
TISSKPDILA TDLIREKTMM TFGKPEEEDS ILSLEQSSRV VSLSQLLFIV
860 870 880 890 900
GQVAIKTLVY LEKCEAEFKK RKIEAETRNG KVKNQGADVT NTTQDNGGDK
910 920 930 940 950
ELEMIGGTNE DDFTDAIQFV KENELLFGEK SILGKFCPIV EEIVSNSSRF
960 970 980 990 1000
SDPMLQRTAT LCLEKLMCLS SKYCEKSLPL LITVMEKSPD PTIRSNAVLG
1010 1020 1030 1040 1050
LGDMAVCFNN LVDENTDYLY RRLHDENLMV QRTCLMTVTF LILAGQVKVK
1060 1070 1080 1090 1100
GQLGEMAKCL DNPDQGISDM CRLFFTELAS KDNAIYNGFI DIFSNLSSDD
1110 1120 1130 1140 1150
LLGKESFKKI IKFLLTFIDK ERHQKQLNEK LVGRLRKCET QKQWDDIAFV
1160 1170
LNNLPYKNED VTALLEQGFK VVSAKE
Length:1,176
Mass (Da):132,967
Last modified:November 1, 1996 - v1
Checksum:i0C1BEFEF6D057D18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17244 Genomic DNA Translation: AAB67384.1
U17245 Genomic DNA Translation: AAB67369.1
BK006945 Genomic DNA Translation: DAA09585.1
PIRiS51408
RefSeqiNP_013374.1, NM_001182159.1

Genome annotation databases

EnsemblFungiiYLR272C; YLR272C; YLR272C
GeneIDi850977
KEGGisce:YLR272C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17244 Genomic DNA Translation: AAB67384.1
U17245 Genomic DNA Translation: AAB67369.1
BK006945 Genomic DNA Translation: DAA09585.1
PIRiS51408
RefSeqiNP_013374.1, NM_001182159.1

3D structure databases

ProteinModelPortaliQ06156
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31539, 235 interactors
ComplexPortaliCPX-1869 Nuclear condensin complex
IntActiQ06156, 9 interactors
MINTiQ06156
STRINGi4932.YLR272C

PTM databases

CarbonylDBiQ06156
iPTMnetiQ06156

Proteomic databases

MaxQBiQ06156
PaxDbiQ06156
PRIDEiQ06156

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR272C; YLR272C; YLR272C
GeneIDi850977
KEGGisce:YLR272C

Organism-specific databases

EuPathDBiFungiDB:YLR272C
SGDiS000004262 YCS4

Phylogenomic databases

GeneTreeiENSGT00390000017108
HOGENOMiHOG000193429
InParanoidiQ06156
KOiK06677
OMAiHLDGENY
OrthoDBiEOG092C07CA

Enzyme and pathway databases

BioCyciYEAST:G3O-32371-MONOMER
ReactomeiR-SCE-2514853 Condensation of Prometaphase Chromosomes

Miscellaneous databases

PROiPR:Q06156

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N
PANTHERiPTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 2 hits
PF12922 Cnd1_N, 1 hit
PIRSFiPIRSF017127 Condensin_D2, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCND1_YEAST
AccessioniPrimary (citable) accession number: Q06156
Secondary accession number(s): D6VYR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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