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Protein

Mitochondrial dicarboxylate transporter

Gene

DIC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate. Required for growth on ethanol and acetate.4 Publications

Miscellaneous

Present with 3390 molecules/cell in log phase SD medium.1 Publication

Kineticsi

  1. KM=1.55 mM for malonate3 Publications
  1. Vmax=3 µmol/min/mg enzyme3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Phosphate transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32424-MONOMER
ReactomeiR-SCE-1614517 Sulfide oxidation to sulfate
R-SCE-167826 The fatty acid cycling model
R-SCE-167827 The proton buffering model
R-SCE-428643 Organic anion transporters
R-SCE-70263 Gluconeogenesis
SABIO-RKiQ06143

Protein family/group databases

TCDBi2.A.29.2.3 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial dicarboxylate transporter
Alternative name(s):
DTP
Dicarboxylate carrier 1
Gene namesi
Name:DIC1
Ordered Locus Names:YLR348C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR348C
SGDiS000004340 DIC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei58 – 76Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei105 – 126Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei170 – 189Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei265 – 283Helical; Name=6Sequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330051 – 298Mitochondrial dicarboxylate transporterAdd BLAST298

Proteomic databases

MaxQBiQ06143
PaxDbiQ06143
PRIDEiQ06143

Interactioni

Subunit structurei

Homodimer. Binds to the TIM22 translocation complex during import.1 Publication

Protein-protein interaction databases

BioGridi31611, 115 interactors
DIPiDIP-8816N
IntActiQ06143, 3 interactors
STRINGi4932.YLR348C

Structurei

3D structure databases

ProteinModelPortaliQ06143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 95Solcar 1Add BLAST85
Repeati103 – 195Solcar 2Add BLAST93
Repeati205 – 289Solcar 3Add BLAST85

Domaini

The C-terminal Solcar repeat is required for association with the TIM22 translocation complex during import.1 Publication

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119170
HOGENOMiHOG000165139
InParanoidiQ06143
KOiK13577
OMAiLKTRAMN
OrthoDBiEOG092C44NO

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q06143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNAKESAG KNIKYPWWYG GAAGIFATMV THPLDLAKVR LQAAPMPKPT
60 70 80 90 100
LFRMLESILA NEGVVGLYSG LSAAVLRQCT YTTVRFGAYD LLKENVIPRE
110 120 130 140 150
QLTNMAYLLP CSMFSGAIGG LAGNFADVVN IRMQNDSALE AAKRRNYKNA
160 170 180 190 200
IDGVYKIYRY EGGLKTLFTG WKPNMVRGIL MTASQVVTYD VFKNYLVTKL
210 220 230 240 250
DFDASKNYTH LTASLLAGLV ATTVCSPADV MKTRIMNGSG DHQPALKILA
260 270 280 290
DAVRKEGPSF MFRGWLPSFT RLGPFTMLIF FAIEQLKKHR VGMPKEDK
Length:298
Mass (Da):32,992
Last modified:November 1, 1996 - v1
Checksum:iC66A1F963450453D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79459 Genomic DNA Translation: AAB71336.1
U19028 Genomic DNA Translation: AAB67266.1
BK006945 Genomic DNA Translation: DAA09653.1
PIRiS51351
RefSeqiNP_013452.1, NM_001182237.1

Genome annotation databases

EnsemblFungiiYLR348C; YLR348C; YLR348C
GeneIDi851063
KEGGisce:YLR348C

Similar proteinsi

Entry informationi

Entry nameiDIC1_YEAST
AccessioniPrimary (citable) accession number: Q06143
Secondary accession number(s): D6VYY7, P87332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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