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Protein

Regenerating islet-derived protein 3-alpha

Gene

REG3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • identical protein binding Source: IntAct
  • oligosaccharide binding Source: GO_Central
  • peptidoglycan binding Source: GO_Central
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial
Biological processAcute phase, Inflammatory response
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Protein family/group databases

MEROPSiI63.002
TCDBi1.C.111.1.2 the regiii (regiii) family
UniLectiniQ06141

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 3-alpha
Short name:
REG-3-alpha
Alternative name(s):
Hepatointestinal pancreatic protein
Short name:
HIP/PAP
Human proislet peptide
Pancreatitis-associated protein 1
Regenerating islet-derived protein III-alpha
Short name:
Reg III-alpha
Cleaved into the following 2 chains:
Gene namesi
Name:REG3A
Synonyms:HIP, PAP, PAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000172016.15
HGNCiHGNC:8601 REG3A
MIMi167805 gene
neXtProtiNX_Q06141

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi114E → Q: Reduces peptidoglycan binding and antibacterial activity. 1 Publication1
Mutagenesisi118E → Q: Reduces antibacterial activity but no effect on peptidoglycan binding. 1 Publication1

Organism-specific databases

DisGeNETi5068
OpenTargetsiENSG00000172016
PharmGKBiPA32931

Polymorphism and mutation databases

BioMutaiREG3A
DMDMi464341

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001742927 – 175Regenerating islet-derived protein 3-alpha 16.5 kDa formAdd BLAST149
PropeptideiPRO_000042274127 – 371 PublicationAdd BLAST11
ChainiPRO_000042274238 – 175Regenerating islet-derived protein 3-alpha 15 kDa formAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 51PROSITE-ProRule annotation
Disulfide bondi68 ↔ 171PROSITE-ProRule annotation
Disulfide bondi146 ↔ 163PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ06141
PaxDbiQ06141
PeptideAtlasiQ06141
PRIDEiQ06141
ProteomicsDBi58418

Miscellaneous databases

PMAP-CutDBiQ06141

Expressioni

Tissue specificityi

Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.2 Publications

Inductioni

Appears in pancreatic juice after induction of pancreatic inflammation.

Gene expression databases

BgeeiENSG00000172016 Expressed in 101 organ(s), highest expression level in duodenum
CleanExiHS_REG3A
ExpressionAtlasiQ06141 baseline and differential
GenevisibleiQ06141 HS

Organism-specific databases

HPAiHPA047894
HPA048334
HPA060705

Interactioni

Subunit structurei

Interacts with EXTL3.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111103, 7 interactors
DIPiDIP-60688N
IntActiQ06141, 1 interactor
STRINGi9606.ENSP00000304311

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ06141
SMRiQ06141
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ06141

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 172C-type lectinPROSITE-ProRule annotationAdd BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116EPN3

Domaini

The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ06141
OMAiNCDVKLP
OrthoDBiEOG091G0MDY
PhylomeDBiQ06141

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q06141-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPMALPSV SWMLLSCLML LSQVQGEEPQ RELPSARIRC PKGSKAYGSH
60 70 80 90 100
CYALFLSPKS WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS
110 120 130 140 150
YVWIGLHDPT QGTEPNGEGW EWSSSDVMNY FAWERNPSTI SSPGHCASLS
160 170
RSTAFLRWKD YNCNVRLPYV CKFTD
Length:175
Mass (Da):19,395
Last modified:February 1, 1994 - v1
Checksum:iC51149FAC22EB68C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173 – 175FTD → VH in AAA36415 (PubMed:1469087).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13510 mRNA Translation: BAA02728.1
M84337 mRNA Translation: AAA36415.1
S51768 mRNA Translation: AAB24642.1
X68641 mRNA Translation: CAA48605.1
L15533 Genomic DNA Translation: AAA60020.1
BC036776 mRNA Translation: AAH36776.1
CCDSiCCDS1965.1
PIRiA49616
RefSeqiNP_002571.1, NM_002580.2
NP_620354.1, NM_138937.2
NP_620355.1, NM_138938.2
UniGeneiHs.567312

Genome annotation databases

EnsembliENST00000305165; ENSP00000304311; ENSG00000172016
ENST00000393878; ENSP00000377456; ENSG00000172016
ENST00000409839; ENSP00000386630; ENSG00000172016
GeneIDi5068
KEGGihsa:5068

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Pancreatitis-associated protein 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13510 mRNA Translation: BAA02728.1
M84337 mRNA Translation: AAA36415.1
S51768 mRNA Translation: AAB24642.1
X68641 mRNA Translation: CAA48605.1
L15533 Genomic DNA Translation: AAA60020.1
BC036776 mRNA Translation: AAH36776.1
CCDSiCCDS1965.1
PIRiA49616
RefSeqiNP_002571.1, NM_002580.2
NP_620354.1, NM_138937.2
NP_620355.1, NM_138938.2
UniGeneiHs.567312

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UV0X-ray1.78A27-175[»]
2GO0NMR-A39-175[»]
4MTHX-ray1.47A38-175[»]
ProteinModelPortaliQ06141
SMRiQ06141
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111103, 7 interactors
DIPiDIP-60688N
IntActiQ06141, 1 interactor
STRINGi9606.ENSP00000304311

Protein family/group databases

MEROPSiI63.002
TCDBi1.C.111.1.2 the regiii (regiii) family
UniLectiniQ06141

Polymorphism and mutation databases

BioMutaiREG3A
DMDMi464341

Proteomic databases

EPDiQ06141
PaxDbiQ06141
PeptideAtlasiQ06141
PRIDEiQ06141
ProteomicsDBi58418

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305165; ENSP00000304311; ENSG00000172016
ENST00000393878; ENSP00000377456; ENSG00000172016
ENST00000409839; ENSP00000386630; ENSG00000172016
GeneIDi5068
KEGGihsa:5068

Organism-specific databases

CTDi5068
DisGeNETi5068
EuPathDBiHostDB:ENSG00000172016.15
GeneCardsiREG3A
HGNCiHGNC:8601 REG3A
HPAiHPA047894
HPA048334
HPA060705
MIMi167805 gene
neXtProtiNX_Q06141
OpenTargetsiENSG00000172016
PharmGKBiPA32931
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ06141
OMAiNCDVKLP
OrthoDBiEOG091G0MDY
PhylomeDBiQ06141

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

ChiTaRSiREG3A human
EvolutionaryTraceiQ06141
GeneWikiiREG3A
GenomeRNAii5068
PMAP-CutDBiQ06141
PROiPR:Q06141
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172016 Expressed in 101 organ(s), highest expression level in duodenum
CleanExiHS_REG3A
ExpressionAtlasiQ06141 baseline and differential
GenevisibleiQ06141 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG3A_HUMAN
AccessioniPrimary (citable) accession number: Q06141
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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