Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 141 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Regulator of the glycerol channel 1

Gene

RGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positive regulator of FPS1 glycerol channel required for the glycerol efflux.

2 Publications

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication
Does not bind efficiently to phosphoinositides and does not associate with membranes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • positive regulation of glycerol transport Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of the glycerol channel 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGC1
Ordered Locus Names:YPR115W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000006319, RGC1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPR115W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002424881 – 1083Regulator of the glycerol channel 1Add BLAST1083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei136PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei813PhosphoserineCombined sources1
Modified residuei817PhosphothreonineCombined sources1
Modified residuei857PhosphothreonineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei918PhosphoserineCombined sources1
Modified residuei966PhosphoserineCombined sources1
Modified residuei969PhosphoserineCombined sources1
Modified residuei975PhosphoserineCombined sources1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1081PhosphoserineCombined sources1
Modified residuei1082PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06108

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q06108

PRoteomics IDEntifications database

More...
PRIDEi
Q06108

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06108

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36282, 99 interactors

Database of interacting proteins

More...
DIPi
DIP-1970N

Protein interaction database and analysis system

More...
IntActi
Q06108, 32 interactors

Molecular INTeraction database

More...
MINTi
Q06108

STRING: functional protein association networks

More...
STRINGi
4932.YPR115W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q06108, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini495 – 606PHAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni69 – 89DisorderedSequence analysisAdd BLAST21
Regioni534 – 582DisorderedSequence analysisAdd BLAST49
Regioni979 – 1083DisorderedSequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 35Polar residuesSequence analysisAdd BLAST35
Compositional biasi70 – 84Polar residuesSequence analysisAdd BLAST15
Compositional biasi544 – 570Polar residuesSequence analysisAdd BLAST27
Compositional biasi979 – 994Polar residuesSequence analysisAdd BLAST16
Compositional biasi1015 – 1029Polar residuesSequence analysisAdd BLAST15
Compositional biasi1044 – 1061Polar residuesSequence analysisAdd BLAST18
Compositional biasi1069 – 1083Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RGC1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU0Q, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008754_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q06108

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSACHIP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR001849, PH_domain

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06108-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDYFTFPKQ ENGGISKQPA TPGSTRSSSR NLELPKNYRS FGGSSDELAS
60 70 80 90 100
MYSADSQYLM DMIPDSLTLK NEPASGNTQM NGPDGKENKD IKLDEYILPK
110 120 130 140 150
TDPRSPYYIN MPIPKKLPKS EGKARAKQKV NRADPSDLDV ENIYETSGEF
160 170 180 190 200
VREYPTDILI DRFHKWKKIL KSLIAYFREA AYSQEQIARI NYQMKNAVKF
210 220 230 240 250
AFLTDLEDET NKLVDPSISK LPTKKPQPVP LAAQKLDSKY DTDVEQPQSI
260 270 280 290 300
QSVPSEEVAS ASSGFMKFGS GSIQDIQVIL KKYHLSLGSQ QYKISKEILA
310 320 330 340 350
YIIPKLTDLR KDLTTKMKEI KELNGDFKTN IGEHIKITSR LLNKYIASVK
360 370 380 390 400
LLDEASTSGD KQGEKLKPKH DPYLLKLQLD LQLKRQLLEE NYLREAFLNL
410 420 430 440 450
QSAALQLEKI VYSKIQSALQ RYSALIDSEA RLMIKNLCHE LQQGILSRPP
460 470 480 490 500
AVEWDNFVSH HPTCLMNLKS TDPPPQPRRL SDIVYPNMKS PLAKCIRVGY
510 520 530 540 550
LLKKTESSKS FTKGYFVLTT NYLHEFKSSD FFLDSKSPRS KNKPVVEQSD
560 570 580 590 600
ISRVNKDGTN AGSHPSSKGT QDPKLTKRRK GLSSSNLYPI SSLSLNDCSL
610 620 630 640 650
KDSTDSTFVL QGYASYHSPE DTCTKESSTT SDLACPTKTL ASNKGKHQRT
660 670 680 690 700
PSALSMVSVP KFLKSSSVPK EQKKAKEEAN INKKSICEKR VEWTFKIFSA
710 720 730 740 750
SLEPTPEESK NFKKWVQDIK ALTSFNSTQE RSNFIEEKIL KSRNHNNGKS
760 770 780 790 800
SQRSKNSTYI TPVDSFVNLS EKVTPSSSVT TLNTRKRANR PRYIDIPKSA
810 820 830 840 850
NMNAGAMNSV YRSKVNTPAI DENGNLAIVG ETKNSAPQNG MSYTIRTPCK
860 870 880 890 900
SPYSPYTGEG MLYNRSADNL MASSSRKASA PGEVPQIAVS NHGDEAIIPA
910 920 930 940 950
SAYSDSSHKS SRASSVASIH NQRVDFYPSP LMNLPGVSPS CLALDGNANG
960 970 980 990 1000
YFGIPLNCNS EARRGSDLSP FEMESPLFEE NRTQNCSGSR KSSACHIPHQ
1010 1020 1030 1040 1050
CGPRKEGNDS RLIYGNEKGA SQSRLTLKEP LTSKGVEAPY SSLKKTYSAE
1060 1070 1080
NVPLTSTVSN DKSLHSRKEG STNTVPATSA SSK
Length:1,083
Mass (Da):120,395
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28D63D32843BFE08
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32445 Genomic DNA Translation: AAB68085.1
BK006949 Genomic DNA Translation: DAA11530.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59780

NCBI Reference Sequences

More...
RefSeqi
NP_015440.1, NM_001184212.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR115W_mRNA; YPR115W; YPR115W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR115W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA Translation: AAB68085.1
BK006949 Genomic DNA Translation: DAA11530.1
PIRiS59780
RefSeqiNP_015440.1, NM_001184212.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36282, 99 interactors
DIPiDIP-1970N
IntActiQ06108, 32 interactors
MINTiQ06108
STRINGi4932.YPR115W

PTM databases

iPTMnetiQ06108

Proteomic databases

MaxQBiQ06108
PaxDbiQ06108
PRIDEiQ06108

Genome annotation databases

EnsemblFungiiYPR115W_mRNA; YPR115W; YPR115W
GeneIDi856231
KEGGisce:YPR115W

Organism-specific databases

SGDiS000006319, RGC1
VEuPathDBiFungiDB:YPR115W

Phylogenomic databases

eggNOGiENOG502QU0Q, Eukaryota
GeneTreeiENSGT00940000176324
HOGENOMiCLU_008754_0_0_1
InParanoidiQ06108
OMAiSSACHIP

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06108
RNActiQ06108, protein

Family and domain databases

InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR001849, PH_domain
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGC1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06108
Secondary accession number(s): D6W4B4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again