UniProtKB - Q06103 (RPN7_YEAST)
Protein
26S proteasome regulatory subunit RPN7
Gene
RPN7
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity
Miscellaneous
Present with 51900 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- enzyme regulator activity Source: InterPro
- structural molecule activity Source: SGD
GO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: SGD
Enzyme and pathway databases
Reactomei | R-SCE-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-SCE-5668541, TNFR2 non-canonical NF-kB pathway R-SCE-5689880, Ub-specific processing proteases R-SCE-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit RPN7 |
Gene namesi | Name:RPN7 Ordered Locus Names:YPR108W ORF Names:P8283.8 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006312, RPN7 |
VEuPathDBi | FungiDB:YPR108W |
Subcellular locationi
Nucleus
- nucleus Source: SGD
Other locations
- proteasome regulatory particle Source: GO_Central
- proteasome regulatory particle, lid subcomplex Source: SGD
Keywords - Cellular componenti
ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000173845 | 2 – 429 | 26S proteasome regulatory subunit RPN7Add BLAST | 428 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 77 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q06103 |
PaxDbi | Q06103 |
PRIDEi | Q06103 |
PTM databases
iPTMneti | Q06103 |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 36274, 495 interactors |
ComplexPortali | CPX-2262, 26S Proteasome complex |
DIPi | DIP-2880N |
IntActi | Q06103, 33 interactors |
MINTi | Q06103 |
STRINGi | 4932.YPR108W |
Miscellaneous databases
RNActi | Q06103, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q06103 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 131 – 164 | TPRAdd BLAST | 34 | |
Domaini | 223 – 395 | PCIPROSITE-ProRule annotationAdd BLAST | 173 |
Keywords - Domaini
TPR repeatPhylogenomic databases
eggNOGi | KOG0687, Eukaryota |
GeneTreei | ENSGT00510000046608 |
HOGENOMi | CLU_031814_1_1_1 |
InParanoidi | Q06103 |
OMAi | VDYIDQE |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035268, PSMD6 IPR019585, Rpn7/CSN1 IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR14145:SF1, PTHR14145:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF10602, RPN7, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q06103-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDVEEKSQE VEYVDPTVNR VPNYEVSEKA FLLTQSKVSI EQRKEAAEFV
60 70 80 90 100
LAKIKEEEMA PYYKYLCEEY LVNNGQSDLE HDEKSDSLNE WIKFDQELYN
110 120 130 140 150
ELCKKNESKI KELNEKIQKL EEDDEGELEQ AQAWINLGEY YAQIGDKDNA
160 170 180 190 200
EKTLGKSLSK AISTGAKIDV MLTIARLGFF YNDQLYVKEK LEAVNSMIEK
210 220 230 240 250
GGDWERRNRY KTYYGIHCLA VRNFKEAAKL LVDSLATFTS IELTSYESIA
260 270 280 290 300
TYASVTGLFT LERTDLKSKV IDSPELLSLI STTAALQSIS SLTISLYASD
310 320 330 340 350
YASYFPYLLE TYANVLIPCK YLNRHADFFV REMRRKVYAQ LLESYKTLSL
360 370 380 390 400
KSMASAFGVS VAFLDNDLGK FIPNKQLNCV IDRVNGIVET NRPDNKNAQY
410 420
HLLVKQGDGL LTKLQKYGAA VRLTGSDRV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | S → G in AAT92788 (PubMed:17322287).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32445 Genomic DNA Translation: AAB68078.1 AY692769 Genomic DNA Translation: AAT92788.1 BK006949 Genomic DNA Translation: DAA11522.1 |
PIRi | S59773 |
RefSeqi | NP_015433.1, NM_001184205.1 |
Genome annotation databases
EnsemblFungii | YPR108W_mRNA; YPR108W; YPR108W |
GeneIDi | 856223 |
KEGGi | sce:YPR108W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32445 Genomic DNA Translation: AAB68078.1 AY692769 Genomic DNA Translation: AAT92788.1 BK006949 Genomic DNA Translation: DAA11522.1 |
PIRi | S59773 |
RefSeqi | NP_015433.1, NM_001184205.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J47 | electron microscopy | - | R | 397-422 | [»] | |
3JCK | electron microscopy | 3.50 | D | 1-429 | [»] | |
3JCO | electron microscopy | 4.80 | R | 1-429 | [»] | |
3JCP | electron microscopy | 4.60 | R | 1-429 | [»] | |
4CR2 | electron microscopy | 7.70 | R | 1-429 | [»] | |
4CR3 | electron microscopy | 9.30 | R | 1-429 | [»] | |
4CR4 | electron microscopy | 8.80 | R | 1-429 | [»] | |
5A5B | electron microscopy | 9.50 | R | 1-429 | [»] | |
5MPB | electron microscopy | 7.80 | R | 1-429 | [»] | |
5MPC | electron microscopy | 7.70 | R | 1-429 | [»] | |
5MPD | electron microscopy | 4.10 | R | 1-429 | [»] | |
5MPE | electron microscopy | 4.50 | R | 1-429 | [»] | |
5WVI | electron microscopy | 6.30 | R | 1-429 | [»] | |
5WVK | electron microscopy | 4.20 | R | 1-429 | [»] | |
6FVT | electron microscopy | 4.10 | R | 20-424 | [»] | |
6FVU | electron microscopy | 4.50 | R | 20-424 | [»] | |
6FVV | electron microscopy | 5.40 | R | 20-424 | [»] | |
6FVW | electron microscopy | 4.50 | R | 20-424 | [»] | |
6FVX | electron microscopy | 4.90 | R | 20-424 | [»] | |
6FVY | electron microscopy | 6.10 | R | 20-424 | [»] | |
6J2C | electron microscopy | 7.00 | R | 1-429 | [»] | |
6J2N | electron microscopy | 7.50 | R | 1-429 | [»] | |
6J2Q | electron microscopy | 3.80 | R | 1-429 | [»] | |
6J2X | electron microscopy | 3.80 | R | 1-429 | [»] | |
6J30 | electron microscopy | 4.50 | R | 1-429 | [»] | |
SMRi | Q06103 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36274, 495 interactors |
ComplexPortali | CPX-2262, 26S Proteasome complex |
DIPi | DIP-2880N |
IntActi | Q06103, 33 interactors |
MINTi | Q06103 |
STRINGi | 4932.YPR108W |
PTM databases
iPTMneti | Q06103 |
Proteomic databases
MaxQBi | Q06103 |
PaxDbi | Q06103 |
PRIDEi | Q06103 |
Genome annotation databases
EnsemblFungii | YPR108W_mRNA; YPR108W; YPR108W |
GeneIDi | 856223 |
KEGGi | sce:YPR108W |
Organism-specific databases
SGDi | S000006312, RPN7 |
VEuPathDBi | FungiDB:YPR108W |
Phylogenomic databases
eggNOGi | KOG0687, Eukaryota |
GeneTreei | ENSGT00510000046608 |
HOGENOMi | CLU_031814_1_1_1 |
InParanoidi | Q06103 |
OMAi | VDYIDQE |
Enzyme and pathway databases
Reactomei | R-SCE-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-SCE-5668541, TNFR2 non-canonical NF-kB pathway R-SCE-5689880, Ub-specific processing proteases R-SCE-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q06103 |
RNActi | Q06103, protein |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035268, PSMD6 IPR019585, Rpn7/CSN1 IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR14145:SF1, PTHR14145:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF10602, RPN7, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPN7_YEAST | |
Accessioni | Q06103Primary (citable) accession number: Q06103 Secondary accession number(s): D6W4A6, E9P8W9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references