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Entry version 151 (31 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Conserved oligomeric Golgi complex subunit 4

Gene

COG4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG4 is required for normal endoplasmic reticulum function and is also involved in calcium regulation. Possesses ATPase activity.3 Publications

Miscellaneous

Present with 1620 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-34245-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 4
Short name:
COG complex subunit 4
Alternative name(s):
Complexed with DOR1 protein 1
Component of oligomeric Golgi complex 4
Protein SEC38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG4
Synonyms:COD1, SEC38, SGF1
Ordered Locus Names:YPR105C
ORF Names:P8283.16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YPR105C

Saccharomyces Genome Database

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SGDi
S000006309 COG4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135081 – 861Conserved oligomeric Golgi complex subunit 4Add BLAST861

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q06096

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q06096

PRoteomics IDEntifications database

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PRIDEi
Q06096

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q06096

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
36271, 589 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1840 Golgi transport complex

Database of interacting proteins

More...
DIPi
DIP-2003N

Protein interaction database and analysis system

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IntActi
Q06096, 26 interactors

Molecular INTeraction database

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MINTi
Q06096

STRING: functional protein association networks

More...
STRINGi
4932.YPR105C

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG4 family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074729

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q06096

KEGG Orthology (KO)

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KOi
K20291

Identification of Orthologs from Complete Genome Data

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OMAi
SECQQRV

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013167 COG_su4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08318 COG4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00762 Cog4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q06096-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGQKSNASW ESSIIEGQLS KNLARYTLLL DKLSTLSQID KLSEVIANDY
60 70 80 90 100
AKQSKQLNAF VQQSQSSLNK ESRKLELQRT NLTTTLTQFH ETVATISSSN
110 120 130 140 150
ARAKAIHDDI ETVDQERALV NKTLQFVKDV RTLKNNISLA HSALETKDYL
160 170 180 190 200
VAATAINEIR SLPDKKLIVS EFAKKVVPSS EIPEEPAILI KNWCKELTSL
210 220 230 240 250
FQEQFMEATR TQDIKELTLM FKMFPMIGQD VLGLDLYSKY VCDIIADESR
260 270 280 290 300
KIMSNSMENS TKFQGFFSQV LLHLFKIVST IINDHSKVIA TCYGKKHMVH
310 320 330 340 350
VMEKVEKEAD LQASLILDIF METRKIERTI HDINEWEHSQ KNEDVNIDSN
360 370 380 390 400
QSDIETDGET EKSSIISIHD LALLIMEFSQ ILQNWSMYSR FYSVKWNEFS
410 420 430 440 450
DLHPHVLQPP PPIADGKFAL KLKQDKVFDE FQVFVLNHLQ RSFRNSISLE
460 470 480 490 500
ELPSLNDLIT AVPLNDHDNI SYPVTSVLDD LILLVRKNLI SVVNTGQFKL
510 520 530 540 550
LASFLNELVK FFQNRFLVKF MQNKFKLLQS KLASNVSLKR YIPKGEEQSA
560 570 580 590 600
TSRSVSPPAN KFSPLSRFTF RGAAASALTN IQSNLQAVVA EDEDSILALH
610 620 630 640 650
HYLIYLNTLY LSKVYVHRLL SIEILEDDSQ RILRDNFPFD NDAAQLQNLI
660 670 680 690 700
INSEKLVLEQ TDKLSKWAVK YLFQNILQNR VRNLLGTVFV NSASSNSSTS
710 720 730 740 750
NQKNVSRDYS AGSNQKNYIT SIEDFEDLSQ INSFNSKWNQ LIIPYKNILH
760 770 780 790 800
NEAYAELLSV IVDYIVTTLE QRIWTLEFNE LGVTKLDREL SLFIGNMCGL
810 820 830 840 850
NYNLREKFLK LTQIVLLLGL DDDNFDLTTG DIKDDFNGTF DWVINSQERI
860
KARNMKIDRT Q
Length:861
Mass (Da):98,666
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22F265AB2AD91533
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32445 Genomic DNA Translation: AAB68075.1
AY692743 Genomic DNA Translation: AAT92762.1
BK006949 Genomic DNA Translation: DAA11519.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59770

NCBI Reference Sequences

More...
RefSeqi
NP_015430.1, NM_001184202.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR105C_mRNA; YPR105C_mRNA; YPR105C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR105C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32445 Genomic DNA Translation: AAB68075.1
AY692743 Genomic DNA Translation: AAT92762.1
BK006949 Genomic DNA Translation: DAA11519.1
PIRiS59770
RefSeqiNP_015430.1, NM_001184202.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi36271, 589 interactors
ComplexPortaliCPX-1840 Golgi transport complex
DIPiDIP-2003N
IntActiQ06096, 26 interactors
MINTiQ06096
STRINGi4932.YPR105C

PTM databases

iPTMnetiQ06096

Proteomic databases

MaxQBiQ06096
PaxDbiQ06096
PRIDEiQ06096

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR105C_mRNA; YPR105C_mRNA; YPR105C
GeneIDi856220
KEGGisce:YPR105C

Organism-specific databases

EuPathDBiFungiDB:YPR105C
SGDiS000006309 COG4

Phylogenomic databases

GeneTreeiENSGT00940000154065
HOGENOMiHOG000074729
InParanoidiQ06096
KOiK20291
OMAiSECQQRV

Enzyme and pathway databases

BioCyciYEAST:G3O-34245-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q06096

Family and domain databases

InterProiView protein in InterPro
IPR013167 COG_su4
PfamiView protein in Pfam
PF08318 COG4, 1 hit
SMARTiView protein in SMART
SM00762 Cog4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG4_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06096
Secondary accession number(s): D6W4A3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 1, 1996
Last modified: July 31, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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