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UniProtKB - Q06033 (ITIH3_HUMAN)

Entry version 148 (13 Feb 2019)
Sequence version 2 (04 Dec 2007)
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Protein

Inter-alpha-trypsin inhibitor heavy chain H3

Gene

ITIH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endopeptidase inhibitor activity Source: ProtInc
  • serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H3
Short name:
ITI heavy chain H3
Short name:
ITI-HC3
Short name:
Inter-alpha-inhibitor heavy chain 3
Alternative name(s):
Serum-derived hyaluronan-associated protein
Short name:
SHAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITIH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000162267.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:6168 ITIH3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		146650 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q06033

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3699

Open Targets

More...OpenTargetsi		ENSG00000162267

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29966

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ITIH3

Domain mapping of disease mutations (DMDM)

More...DMDMi		166203665

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001652921 – 34Add BLAST14
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001653035 – 651Inter-alpha-trypsin inhibitor heavy chain H3Add BLAST617
PropeptideiPRO_0000016531652 – 890Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi580N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei651Aspartate 1-(chondroitin 4-sulfate)-ester1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q06033

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q06033

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q06033

PeptideAtlas

More...PeptideAtlasi		Q06033

PRoteomics IDEntifications database

More...PRIDEi		Q06033

ProteomicsDB human proteome resource

More...ProteomicsDBi		58409
58410 [Q06033-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q06033

GlyConnect protein glycosylation platform

More...GlyConnecti		1421

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q06033

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q06033

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162267 Expressed in 111 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q06033 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q06033 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA017373

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109905, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q06033, 5 interactors

Molecular INTeraction database

More...MINTi		Q06033

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000415769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q06033

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q06033

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 158VITPROSITE-ProRule annotationAdd BLAST130
Domaini284 – 467VWFAPROSITE-ProRule annotationAdd BLAST184

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IEJB Eukaryota
COG2304 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154554

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000000680

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG057734

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q06033

Identification of Orthologs from Complete Genome Data

More...OMAi		KVACWFV

Database of Orthologous Groups

More...OrthoDBi		955432at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q06033

TreeFam database of animal gene trees

More...TreeFami		TF328982

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q06033-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFAWWPCLI LALLSSLAAS GFPRSPFRLL GKRSLPEGVA NGIEVYSTKI 
        60         70         80         90        100
NSKVTSRFAH NVVTMRAVNR ADTAKEVSFD VELPKTAFIT NFTLTIDGVT 
       110        120        130        140        150
YPGNVKEKEV AKKQYEKAVS QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV 
       160        170        180        190        200
TFELTYEELL KRHKGKYEMY LKVQPKQLVK HFEIEVDIFE PQGISMLDAE 
       210        220        230        240        250
ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT DSLLNGDFTI 
       260        270        280        290        300
TYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNVAFVID ISGSMAGRKL 
       310        320        330        340        350
EQTKEALLRI LEDMQEEDYL NFILFSGDVS TWKEHLVQAT PENLQEARTF 
       360        370        380        390        400
VKSMEDKGMT NINDGLLRGI SMLNKAREEH RIPERSTSIV IMLTDGDANV 
       410        420        430        440        450
GESRPEKIQE NVRNAIGGKF PLYNLGFGNN LNYNFLENMA LENHGFARRI 
       460        470        480        490        500
YEDSDADLQL QGFYEEVANP LLTGVEMEYP ENAILDLTQN TYQHFYDGSE 
       510        520        530        540        550
IVVAGRLVDE DMNSFKADVK GHGATNDLTF TEEVDMKEME KALQERDYIF 
       560        570        580        590        600
GNYIERLWAY LTIEQLLEKR KNAHGEEKEN LTARALDLSL KYHFVTPLTS 
       610        620        630        640        650
MVVTKPEDNE DERAIADKPG EDAEATPVSP AMSYLTSYQP PQNPYYYVDG 
       660        670        680        690        700
DPHFIIQIPE KDDALCFNID EAPGTVLRLI QDAVTGLTVN GQITGDKRGS 
       710        720        730        740        750
PDSKTRKTYF GKLGIANAQM DFQVEVTTEK ITLWNRAVPS TFSWLDTVTV 
       760        770        780        790        800
TQDGLSMMIN RKNMVVSFGD GVTFVVVLHQ VWKKHPVHRD FLGFYVVDSH 
       810        820        830        840        850
RMSAQTHGLL GQFFQPFDFK VSDIRPGSDP TKPDATLVVK NHQLIVTRGS 
       860        870        880        890
QKDYRKDASI GTKVVCWFVH NNGEGLIDGV HTDYIVPNLF
Length:890
Mass (Da):99,849
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03B2B768784CB440
GO
Isoform 2 (identifier: Q06033-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MAFAWWPCLILALLSSLAASG → MVALSHLGSALQLGSLC

Show »
Length:886
Mass (Da):99,328
Checksum:i0B717C8073BE7EF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ET33E7ET33_HUMAN
Inter-alpha-trypsin inhibitor heavy...
ITIH3
698Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW43A0A087WW43_HUMAN
Inter-alpha-trypsin inhibitor heavy...
ITIH3
670Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA32821 differs from that shown. Reason: Frameshift at positions 732, 736 and 739.Curated
The sequence CAA47439 differs from that shown. Reason: Frameshift at positions 21, 732, 736 and 739.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113K → N in BAD97203 (Ref. 3) Curated1
Sequence conflicti113K → N in BAD96477 (Ref. 3) Curated1
Sequence conflicti348R → K in CAA32821 (PubMed:2465147).Curated1
Sequence conflicti361N → G in CAA32821 (PubMed:2465147).Curated1
Sequence conflicti515F → L in CAC79611 (PubMed:9756925).Curated1
Sequence conflicti667F → L in BAD97203 (Ref. 3) Curated1
Sequence conflicti667F → L in BAD96477 (Ref. 3) Curated1
Sequence conflicti716A → R in CAA47439 (PubMed:7681778).Curated1
Sequence conflicti716A → R in CAA32821 (PubMed:2465147).Curated1
Sequence conflicti851Q → H in CAA32821 (PubMed:2465147).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049647315Q → K1 PublicationCorresponds to variant dbSNP:rs3617Ensembl.1
Natural variantiVAR_049648340T → M. Corresponds to variant dbSNP:rs35271262Ensembl.1
Natural variantiVAR_061275640P → L. Corresponds to variant dbSNP:rs60805548Ensembl.1
Natural variantiVAR_049649751T → A. Corresponds to variant dbSNP:rs9883888Ensembl.1
Natural variantiVAR_049650825R → Q. Corresponds to variant dbSNP:rs2710330Ensembl.1
Natural variantiVAR_049651858A → V. Corresponds to variant dbSNP:rs2710329Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0298421 – 21MAFAW…LAASG → MVALSHLGSALQLGSLC in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X67055 mRNA Translation: CAA47439.1 Frameshift.
X99854 Genomic DNA Translation: CAC79611.1
AK222757 mRNA Translation: BAD96477.1
AK223483 mRNA Translation: BAD97203.1
AC006254 Genomic DNA No translation available.
BC107604 mRNA Translation: AAI07605.1
BC107605 mRNA Translation: AAI07606.1
BC107814 mRNA Translation: AAI07815.1
X14690 mRNA Translation: CAA32821.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46845.1 [Q06033-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S30350

NCBI Reference Sequences

More...RefSeqi		NP_002208.3, NM_002217.3 [Q06033-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.76716

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000449956; ENSP00000415769; ENSG00000162267 [Q06033-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3699

UCSC genome browser

More...UCSCi		uc003dfv.3 human [Q06033-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67055 mRNA Translation: CAA47439.1 Frameshift.
X99854 Genomic DNA Translation: CAC79611.1
AK222757 mRNA Translation: BAD96477.1
AK223483 mRNA Translation: BAD97203.1
AC006254 Genomic DNA No translation available.
BC107604 mRNA Translation: AAI07605.1
BC107605 mRNA Translation: AAI07606.1
BC107814 mRNA Translation: AAI07815.1
X14690 mRNA Translation: CAA32821.1 Frameshift.
CCDSiCCDS46845.1 [Q06033-1]
PIRiS30350
RefSeqiNP_002208.3, NM_002217.3 [Q06033-1]
UniGeneiHs.76716

3D structure databases

ProteinModelPortaliQ06033
SMRiQ06033
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109905, 8 interactors
IntActiQ06033, 5 interactors
MINTiQ06033
STRINGi9606.ENSP00000415769

PTM databases

CarbonylDBiQ06033
GlyConnecti1421
iPTMnetiQ06033
PhosphoSitePlusiQ06033

Polymorphism and mutation databases

BioMutaiITIH3
DMDMi166203665

Proteomic databases

jPOSTiQ06033
MaxQBiQ06033
PaxDbiQ06033
PeptideAtlasiQ06033
PRIDEiQ06033
ProteomicsDBi58409
58410 [Q06033-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000449956; ENSP00000415769; ENSG00000162267 [Q06033-1]
GeneIDi3699
KEGGihsa:3699
UCSCiuc003dfv.3 human [Q06033-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3699
DisGeNETi3699
EuPathDBiHostDB:ENSG00000162267.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ITIH3

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0024346
HGNCiHGNC:6168 ITIH3
HPAiHPA017373
MIMi146650 gene
neXtProtiNX_Q06033
OpenTargetsiENSG00000162267
PharmGKBiPA29966

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IEJB Eukaryota
COG2304 LUCA
GeneTreeiENSGT00940000154554
HOGENOMiHOG000000680
HOVERGENiHBG057734
InParanoidiQ06033
OMAiKVACWFV
OrthoDBi955432at2759
PhylomeDBiQ06033
TreeFamiTF328982

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ITIH3 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ITIH3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3699

Protein Ontology

More...PROi		PR:Q06033

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162267 Expressed in 111 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ06033 baseline and differential
GenevisibleiQ06033 HS

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITIH3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q06033
Secondary accession number(s): Q3B7H5
, Q53F06, Q6LAM2, Q99085
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 4, 2007
Last modified: February 13, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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